DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cnx14D and CNE1

DIOPT Version :9

Sequence 1:	NP_573131.1	Gene:	Cnx14D / 32620	FlyBaseID:	FBgn0264077	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_009343.1	Gene:	CNE1 / 851241	SGDID:	S000000054	Length:	502	Species:	Saccharomyces cerevisiae

Alignment Length:	414	Identity:	130/414 - (31%)
Similarity:	192/414 - (46%)	Gaps:	31/414 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FADHFD---DVEASRKRWVLSQAKKNDIADEIAKYDGIWNWESPQRIFWANDLGLVLKSKAKHAA 120
            |.:||.   :.:...:.|:.|:|..|: ..:|  |...|.....:....|.|.|:.:::....|.
Yeast    33 FWEHFQAYTNTKHLNQEWITSEAVNNE-GSKI--YGAQWRLSQGRLQGSAWDKGIAVRTGNAAAM 94

  Fly   121 IAAPFRQPFDFKSNKPLVVQYELTLQEGQDCGGSYLKLLSAGKGTEQLNRF-NDKTPYTIMFGPD 184
            |......|.:......||||||:.|.....|||:::||:|.....|.|..: .|.....::||||
Yeast    95 IGHLLETPINVSETDTLVVQYEIKLDNSLTCGGAFIKLMSGFMNVEALKHYAPDTEGVELVFGPD 159

  Fly   185 KCGNNLK-MHFIFRHVNPLNGNITEKHCKK-PNARLGVPFTD-KLPHLYQLVV-RPDNSFEIRLD 245
            .|...:. :.|....|:.:......::.:: |.::|    || ...|||.|:: ....||:|.:|
Yeast   160 YCAPEINGVQFAINKVDKITHESKLRYLQEMPLSKL----TDTSQSHLYTLIIDESAQSFQILID 220

  Fly   246 HKIIK-----EGSLLTDFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDEDAPPHLP 305
            .|.:.     |.....:|.||:.||..|.|.:..||..||:|.:||||.|.|..|.||..|..:|
Yeast   221 GKTVMVREHIEDKKKVNFEPPITPPLMIPDVSVAKPHDWDDRIRIPDPEAVKLSDRDERDPLMIP 285

  Fly   306 DTDAVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPN 370
            ..|...|..|....|:.|.||.|.:|..|.....|||..|:::||:|....|||:....||.|..
Yeast   286 HPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEWIPPMIKNPLCTAERGCGQQIPGLINNAK 350

  Fly   371 YKGKWSAPMIENPNNQGKWAPRKIANPDFFEDLKPFQM-TPINAVGLELWSMSSDILFDNL---- 430
            |||......|.|||..|:|.|.:|.||.::|:..|.:: ..|:.|.||.||.|.::|..|:
Yeast   351 YKGPGELNEIINPNYMGEWHPPEIENPLYYEEQHPLRIENVISGVILEFWSGSPNMLISNIYVGK 415

  Fly   431 ------IITDDVELARDFAANSFD 448
                  ||.:...|.||.|....|
Yeast   416 NVTEAQIIGNKTWLMRDRAFRGSD 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx14D	NP_573131.1	Calreticulin	59..432	CDD:278680	123/396 (31%)
CNE1	NP_009343.1	Calreticulin	33..413	CDD:395201	123/386 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I558
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I842
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		otm46798
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	1	1.000	-	-		X875
TreeFam	1	0.960	-	-
	12	11.850