Protein Alignment Cnx14D and CALR

DIOPT Version :10

• Sequence 1: NP_573131.1
• Gene: Cnx14D / 32620
• FlyBaseID: FBgn0264077
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_004334.1
• Gene: CALR / 811
• HGNCID: 1455
• Length: 417
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 173/538 - (32%)
• Similarity: 251/538 - (46%)
• Gaps: 152/538 - (28%)

  Fly    58 YFADHFDDVEASRKRWVLSQAKKNDIADEIAKYDGIWNWESPQRIFWANDLGLVLKSKAKHAAIA 122
            ||.:.|.|.:....||:.|: .|:|....:......:..|.       .|.||.....|:..|::
Human    22 YFKEQFLDGDGWTSRWIESK-HKSDFGKFVLSSGKFYGDEE-------KDKGLQTSQDARFYALS 78

  Fly   123 APFRQPFDFKSNK--PLVVQYELTLQEGQDCGGSYLKLLSAGKGTEQLNRFNDKTPYTIMFGPDK 185
            |.| :||   |||  .||||:.:..::..||||.|:||..  ...:|.:...| :.|.||||||.
Human    79 ASF-EPF---SNKGQTLVVQFTVKHEQNIDCGGGYVKLFP--NSLDQTDMHGD-SEYNIMFGPDI 136

  Fly   186 CG-NNLKMHFIFRHVNP---LNGNITEKHCKKPNARLGVPFTDKLPHLYQLVVRPDNSFEIRLDH 246
            || ...|:|.||.:...   :|.:|   .||          .|:..|||.|:|||||::|:::|:
Human   137 CGPGTKKVHVIFNYKGKNVLINKDI---RCK----------DDEFTHLYTLIVRPDNTYEVKIDN 188

  Fly   247 KIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDEDAPPHLPDTDAVM 311
            ..::.|||..|:  ...||.:|.||:..|||.||||.||.||...||||||:  |.|:|
Human   189 SQVESGSLEDDW--DFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDK--PEHIP------ 243

  Fly   312 PNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPNYKGKWS 376
                         ||.|.:||||:.|:|||||.|:::||..|     |:||...|.||:|||.|.
Human   244 -------------DPDAKKPEDWDEEMDGEWEPPVIQNPEYK-----GEWKPRQIDNPDYKGTWI 290

  Fly   377 APMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINAVGLELWSMSSDILFDNLIITDDVELARD 441
            .|.|:              ||::..|...:.......:||:||.:.|..:|||.:||:|...|
Human   291 HPEID--------------NPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYA-- 339

  Fly   442 FAANSFDIKRLYIDRESFGNKVVELARANRAIWGIVIVAIAVPVAITIFCKFGLGPSRVAAAKKA 506
                           |.|||:.          ||:.                           ||
Human   340 ---------------EEFGNET----------WGVT---------------------------KA 352

  Fly   507 AAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEKKEEEEEEEKEENKEEKKEEEKDDEKEMKDCE 571
            |                     ||..|.|::||::.:||||:|:..:||:.|:::|||.:.:| |
Human   353 A---------------------EKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDED-E 395

  Fly   572 EEEDDEEKDDEEKTDERA 589
            |:|:|:|:|:||....:|
Human   396 EDEEDKEEDEEEDVPGQA 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx14D	NP_573131.1	Calreticulin	59..432	CDD:459737	132/378 (35%)
CALR	NP_004334.1	N-domain	18..197		66/202 (33%)
		Calreticulin	23..332	CDD:459737	132/378 (35%)
		4 X approximate repeats	191..255		36/86 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..278		49/112 (44%)
		P-domain	198..308		58/151 (38%)
		Interaction with PPIB. /evidence=ECO:0000250	237..270		19/53 (36%)
		3 X approximate repeats	259..297		20/56 (36%)
		C-domain	309..417		48/181 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..417		30/113 (27%)
		Prevents secretion from ER	414..417		173/538 (32%)