DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnx14D and Clgn

DIOPT Version :9

Sequence 1:	NP_573131.1	Gene:	Cnx14D / 32620	FlyBaseID:	FBgn0264077	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_011246598.1	Gene:	Clgn / 12745	MGIID:	107472	Length:	615	Species:	Mus musculus

Alignment Length:	619	Identity:	273/619 - (44%)
Similarity:	375/619 - (60%)	Gaps:	43/619 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SENSVE-DVQIEPGAIYGDEKFAYKSPVIDAEKFYFADHFDDVEASRKRWVLSQAKKNDIADEIA 88
            ||||.| :::.||.:    ..|.||:|....| .||.:.||  ..:...||||:|||:|:..|||
Mouse    36 SENSDESNIKDEPSS----GTFKYKTPQPIGE-VYFTETFD--SGNLAGWVLSKAKKDDMDSEIA 93

  Fly    89 KYDGIWNWESPQRIFWANDLGLVLKSKAKHAAIAAPFRQPFDFKSNKPLVVQYELTLQEGQDCGG 153
            .|||.|..|..:......|.||||||||||.||||...:||.| ::|||:||||:..|:|.||||
Mouse    94 IYDGRWEIEELKENQVPGDRGLVLKSKAKHHAIAAVLEKPFIF-ADKPLIVQYEVNFQDGIDCGG 157

  Fly   154 SYLKLLSAGKGTEQLNRFNDKTPYTIMFGPDKCGNNLKMHFIFRHVNPLNGNITEKHCKKPNARL 218
            :|:||| |..|...|..|.|||.|||||||||||.:.|:|.||||.:|..|...|||.|.|:..|
Mouse   158 AYIKLL-ADTGDLILENFYDKTSYTIMFGPDKCGEDYKLHLIFRHKHPKTGVFEEKHAKPPDVDL 221

  Fly   219 GVPFTDKLPHLYQLVVRPDNSFEIRLDHKIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERK 283
            ...|||:..|||.||:.||::||:.:|.|::.:|:||.|.|||:|||.|||||:|.|||.||:|.
Mouse   222 KEFFTDRKTHLYTLVMNPDDTFEVLIDQKVVNQGTLLDDVVPPINPPREIDDPSDKKPEEWDDRA 286

  Fly   284 KIPDPNAHKPEDWDEDAPPHLPDTDAVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVE 348
            |||||.|.:||||||:.|..:.|:.||.|:|||:|||..|.:|.|.:||||:.::|||||||.:.
Mouse   287 KIPDPTAVRPEDWDENEPAQIEDSSAVKPDGWLDDEPKFIPNPKAEKPEDWSDDMDGEWEAPHIP 351

  Fly   349 NPVCKKAPGCGKWKAPLIPNPNYKGKWSAPMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINA 413
            ||.|:  .|||:||.|:|.||.|||.|..|||.|||.||.|:|:||.|||:|||..||.:|..:|
Mouse   352 NPACQ--IGCGEWKPPMIDNPKYKGIWRPPMINNPNYQGLWSPQKIPNPDYFEDDHPFLLTSFSA 414

  Fly   414 VGLELWSMSSDILFDNLIITDDVELARDFAANSFDIKRLYIDRESFG--NKVVELARANRAIWGI 476
            :|||||||:.||.|||.||..:.|:|..:|.:.:::|.:..:....|  .::|..|.....:|.:
Mouse   415 LGLELWSMTPDIYFDNFIICSEKEVADQWATDGWELKIMVANANEPGVLRQLVIAAEERPWLWLM 479

  Fly   477 VIVAIAVPVA-ITIFCKFGLGPSRVAAAKKAAAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEK 540
            .:|...:||| :..||    .|.:|          .||.:|..|       ::.:|.|.:.:...
Mouse   480 YLVMAGLPVALVASFC----WPRKV----------KKKYEDTGP-------KKTELCKLQSKAAL 523

  Fly   541 KEEEEEEEKEENKEEKKEEEKDDEKEMKDCEEEEDDEEKDDEEKTDERAAGDTNKESTPLSASPK 605
            ::|.|||:..|..|:.:||:|..|.|:...|:|...|  .:|:..::|...:..:|.:.||.|..
Mouse   524 EQEAEEEKAPEKPEDVQEEKKPGEAEVVTVEKEVIGE--PEEKSKEDRETLEGQEEVSKLSKSGS 586

  Fly   606 KNQKSYLDNNEDEEDTLKNKEPTPKKRKRKALKE 639
            :::....|.:....|.     |....|||:..|:
Mouse   587 EDEMKDADESPGSGDA-----PLKSLRKRRVRKD 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx14D	NP_573131.1	Calreticulin	59..432	CDD:278680	209/372 (56%)
Clgn	XP_011246598.1	Calreticulin	66..433	CDD:365986	209/372 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	502	1.000	Domainoid score	I343
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm8849
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830