DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cnx14D and Canx

DIOPT Version :9

Sequence 1:NP_573131.1 Gene:Cnx14D / 32620 FlyBaseID:FBgn0264077 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_001103969.1 Gene:Canx / 12330 MGIID:88261 Length:591 Species:Mus musculus


Alignment Length:653 Identity:304/653 - (46%)
Similarity:395/653 - (60%) Gaps:80/653 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAWKMLFAILLLLSAAKT----GY--LAPESENSVEDV--QIEPGAIYGD------EKFAYKSPV 51
            |..|.|..:||:|..|..    |:  .|.:.|:.::||  ::|......|      .|..||:||
Mouse     1 MEGKWLLCLLLVLGTAAVEAHDGHDDDAIDIEDDLDDVIEEVEDSKSKSDASTPPSPKVTYKAPV 65

  Fly    52 IDAEKFYFADHFDDVEASRKRWVLSQAKKNDIADEIAKYDGIWNWESPQRIFWANDLGLVLKSKA 116
            ...| .||||.||  ..|...|:||:|||:|..||||||||.|..:..:......|.||||.|:|
Mouse    66 PTGE-VYFADSFD--RGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPGDKGLVLMSRA 127

  Fly   117 KHAAIAAPFRQPFDFKSNKPLVVQYELTLQEGQDCGGSYLKLLSAGKGTE-QLNRFNDKTPYTIM 180
            ||.||:|...:||.| ..|||:||||:..|.|.:|||:|:||||  |..| .|::|:||||||||
Mouse   128 KHHAISAKLNKPFLF-DTKPLIVQYEVNFQNGIECGGAYVKLLS--KTAELSLDQFHDKTPYTIM 189

  Fly   181 FGPDKCGNNLKMHFIFRHVNPLNGNITEKHCKKPNARLGVPFTDKLPHLYQLVVRPDNSFEIRLD 245
            |||||||.:.|:||||||.||..|...|||.|:|:|.|...||||..|||.|::.|||||||.:|
Mouse   190 FGPDKCGEDYKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVD 254

  Fly   246 HKIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDEDAPPHLPDTDAV 310
            ..::..|:||.|..|||||..||:||.|.|||.||||.||.||:|.||:|||||||..:||.:|.
Mouse   255 QSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEAT 319

  Fly   311 MPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPNYKGKW 375
            .|.|||:|||:.|.||.|.:||||:.::|||||||.:.||.|:.|||||.|:.|:|.||||||||
Mouse   320 KPEGWLDDEPEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKW 384

  Fly   376 SAPMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINAVGLELWSMSSDILFDNLIITDDVELAR 440
            ..|||:|||.||.|.||||.||||||||:||:|||.:|:|||||||:|||.|||.||:.|..:..
Mouse   385 KPPMIDNPNYQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVD 449

  Fly   441 DFAANSFDIKRLYIDRESFG--NKVVELARANRAIWGIVIVAIAVPVAITI-FCKFGLGPSRVAA 502
            |:|.:.:.:|:........|  .:::|.|.....:|.:.|:.:|:||.:.| ||..|        
Mouse   450 DWANDGWGLKKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSG-------- 506

  Fly   503 AKKAAAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEKKEEEEEEEKEENKEEKKEEEKDDEKEM 567
            .|::.|...||||.||||        .|.|:||:||:.|.:|||           ||||.:||:.
Mouse   507 KKQSNAMEYKKTDAPQPD--------VKDEEGKEEEKNKRDEEE-----------EEEKLEEKQK 552

  Fly   568 KDCEEEEDDEEKDDEEKTDERAAGDTNKESTPLSASPKKNQKSYLDNNEDEEDTLKNKEPTPKKR 632
            .|.||:.....:|:|:                  :.||.           |||.:.|:.|..:|.
Mouse   553 SDAEEDGVTGSQDEED------------------SKPKA-----------EEDEILNRSPRNRKP 588

  Fly   633 KRK 635
            :|:
Mouse   589 RRE 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cnx14DNP_573131.1 Calreticulin 59..432 CDD:278680 225/373 (60%)
CanxNP_001103969.1 Calreticulin 72..441 CDD:278680 225/373 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..347 53/85 (62%)
P domain (Extended arm). /evidence=ECO:0000250 277..410 86/132 (65%)
4 X approximate repeats 279..346 42/66 (64%)
Interaction with PPIB. /evidence=ECO:0000250 327..360 19/32 (59%)
4 X approximate repeats 349..406 38/56 (68%)
Sufficient to mediate interaction with SGIP1. /evidence=ECO:0000269|PubMed:21747946 504..591 40/142 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..591 37/124 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 502 1.000 Domainoid score I343
eggNOG 1 0.900 - - E1_KOG0675
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1324
Inparanoid 1 1.050 561 1.000 Inparanoid score I1087
Isobase 1 0.950 - 0 Normalized mean entropy S1544
OMA 1 1.010 - - QHG48587
OrthoDB 1 1.010 - - D230478at33208
OrthoFinder 1 1.000 - - FOG0001260
OrthoInspector 1 1.000 - - mtm8849
orthoMCL 1 0.900 - - OOG6_102144
Panther 1 1.100 - - O PTHR11073
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R163
SonicParanoid 1 1.000 - - X875
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.820

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