Protein Alignment Cnx14D and Calr

DIOPT Version :9

• Sequence 1: NP_573131.1
• Gene: Cnx14D / 32620
• FlyBaseID: FBgn0264077
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_031617.1
• Gene: Calr / 12317
• MGIID: 88252
• Length: 416
• Species: Mus musculus
• Alignment Length: 541
• Identity: 175/541 - (32%)
• Similarity: 256/541 - (47%)
• Gaps: 159/541 - (29%)

  Fly    58 YFADHFDDVEASRKRWVLSQAKKNDIADEI---AKYDGIWNWESPQRIFWANDLGLVLKSKAKHA 119
            ||.:.|.|.:|...|||.|: .|:|....:   .|:.|...          .|.||.....|:..
Mouse    22 YFKEQFLDGDAWTNRWVESK-HKSDFGKFVLSSGKFYGDLE----------KDKGLQTSQDARFY 75

  Fly   120 AIAAPFRQPFDFKSNK--PLVVQYELTLQEGQDCGGSYLKLLSAGKGTEQLNRFNDKTPYTIMFG 182
            |::|.| :||   |||  .||||:.:..::..||||.|:||..:  |.:|.:...| :.|.||||
Mouse    76 ALSAKF-EPF---SNKGQTLVVQFTVKHEQNIDCGGGYVKLFPS--GLDQKDMHGD-SEYNIMFG 133

  Fly   183 PDKCG-NNLKMHFIFRHVNP---LNGNITEKHCKKPNARLGVPFTDKLPHLYQLVVRPDNSFEIR 243
            ||.|| ...|:|.||.:...   :|.:|   .||          .|:..|||.|:|||||::|::
Mouse   134 PDICGPGTKKVHVIFNYKGKNVLINKDI---RCK----------DDEFTHLYTLIVRPDNTYEVK 185

  Fly   244 LDHKIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDEDAPPHLPDTD 308
            :|:..::.|||..|:  ...||.:|.||:..|||.||||.||.||...||||||:  |.|:|
Mouse   186 IDNSQVESGSLEDDW--DFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDK--PEHIP--- 243

  Fly   309 AVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPNYKG 373
                            ||.|.:||||:.|:|||||.|:::||..|     |:||...|.||:|||
Mouse   244 ----------------DPDAKKPEDWDEEMDGEWEPPVIQNPEYK-----GEWKPRQIDNPDYKG 287

  Fly   374 KWSAPMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINAVGLELWSMSSDILFDNLIITDDVEL 438
            .|..|.|:              ||::..|...:.......:||:||.:.|..:|||.:||:|...
Mouse   288 TWIHPEID--------------NPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAY 338

  Fly   439 ARDFAANSFDIKRLYIDRESFGNKVVELARANRAIWGIVIVAIAVPVAITIFCKFGLGPSRVAAA 503
            |                 |.|||:.          ||:.
Mouse   339 A-----------------EEFGNET----------WGVT-------------------------- 350

  Fly   504 KKAAAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEKKEEEEEEEKEENKEEKKEEEKDDEKEMK 568
             |||                     ||..|.|::||::.:||||:|:..:||:.|:::||:.  :
Mouse   351 -KAA---------------------EKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDDD--R 391

  Fly   569 DCEEEEDDEEKDDEEKTDERA 589
            |.:|:|:||:::|||::..:|
Mouse   392 DEDEDEEDEKEEDEEESPGQA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx14D	NP_573131.1	Calreticulin	59..432	CDD:278680	136/381 (36%)
Calr	NP_031617.1	N-domain	18..197		70/205 (34%)
		Calreticulin	23..332	CDD:278680	136/381 (36%)
		4 X approximate repeats	191..255		36/86 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..278		49/112 (44%)
		P-domain	198..308		58/151 (38%)
		Interaction with PPIB. /evidence=ECO:0000269|PubMed:20801878	237..270		19/53 (36%)
		3 X approximate repeats	259..297		20/56 (36%)
		C-domain	309..416		46/181 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..416		28/113 (25%)
		Prevents secretion from ER	413..416		175/541 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940