Protein Alignment Cnx14D and CLGN

DIOPT Version :9

• Sequence 1: NP_573131.1
• Gene: Cnx14D / 32620
• FlyBaseID: FBgn0264077
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_001124147.1
• Gene: CLGN / 1047
• HGNCID: 2060
• Length: 610
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 275/619 - (44%)
• Similarity: 372/619 - (60%)
• Gaps: 46/619 - (7%)

  Fly    26 ENSVEDVQIEPGAIYGDEKFAYKSPVIDAEKFYFADHFDDVEASRKRWVLSQAKKNDIADEIAKY 90
            ||| |::.:....:..:.|:....|:   .:.|||:.||....:  .||||:|||:|:.:||:.|
Human    33 ENS-EEIDVNESELSSEIKYKTPQPI---GEVYFAETFDSGRLA--GWVLSKAKKDDMDEEISIY 91

  Fly    91 DGIWNWESPQRIFWANDLGLVLKSKAKHAAIAAPFRQPFDFKSNKPLVVQYELTLQEGQDCGGSY 155
            ||.|..|..:......|.||||||:|||.||:|...:||.| ::|||:||||:..|:|.||||:|
Human    92 DGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIF-ADKPLIVQYEVNFQDGIDCGGAY 155

  Fly   156 LKLLSAGKGTEQ--LNRFNDKTPYTIMFGPDKCGNNLKMHFIFRHVNPLNGNITEKHCKKPNARL 218
            :|||:   .|:.  |..|.|||.|.|||||||||.:.|:||||||.:|..|...|||.|.|:..|
Human   156 IKLLA---DTDDLILENFYDKTSYIIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDL 217

  Fly   219 GVPFTDKLPHLYQLVVRPDNSFEIRLDHKIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERK 283
            ...|||:..|||.||:.||::||:.:|..::.:||||.|.|||:.||.||:||||.|||.||||.
Human   218 KKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERA 282

  Fly   284 KIPDPNAHKPEDWDEDAPPHLPDTDAVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVE 348
            |||||:|.|||||||..|..:.|:..|.|.|||:|||..|.||.|.:|:|||.:.|||||||.:.
Human   283 KIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQIL 347

  Fly   349 NPVCKKAPGCGKWKAPLIPNPNYKGKWSAPMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINA 413
            ||.|:  .|||:||.|:|.||.|||.|..|:::|||.||.|:||||.|||:|||..||.:|..:|
Human   348 NPACR--IGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSA 410

  Fly   414 VGLELWSMSSDILFDNLIITDDVELARDFAANSFDIKRLYIDRESFG--NKVVELARANRAIWGI 476
            :|||||||:|||.|||.||..:.|:|..:||:.:..|.:..:....|  .:::..|..:..:|.|
Human   411 LGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLI 475

  Fly   477 VIVAIAVPVA-ITIFCKFGLGPSRVAAAKKAAAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEK 540
            .:|...||:| ||.||    .|.:|  .||......||||...|......|:|||.||...|
Human   476 YLVTAGVPIALITSFC----WPRKV--KKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALE--- 531

  Fly   541 KEEEEEEEKEENKEEKKEEEKDDEKEMKDCEEEEDDEEKDDEEKTDERAAGDTNKESTPLSASPK 605
            |..:.||||::|..|..|:|::.|.|.|..||.|..|.:::..::::..:.|..||:
Human   532 KPMDLEEEKKQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQSNKSGSEDEMKEA-------- 588

  Fly   606 KNQKSYLDNNEDEEDTLKNKEPTPKKRKRKALKE 639
                        :|.|.....|....|||:..|:
Human   589 ------------DESTGSGDGPIKSVRKRRVRKD 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx14D	NP_573131.1	Calreticulin	59..432	CDD:278680	207/374 (55%)
CLGN	NP_001124147.1	Calreticulin	62..429	CDD:306718	207/374 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..338		49/79 (62%)
		Interaction with PPIB. /evidence=ECO:0000250	317..350		19/32 (59%)
		2-1	339..352		8/12 (67%)
		2-2	356..369		7/12 (58%)
		2-3	370..383		6/12 (50%)
		2-4	384..397		9/12 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..610		31/111 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	501	1.000	Domainoid score	I346
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1071
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm8615
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840