DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Krn and NRG2

DIOPT Version :9

Sequence 1:	NP_524129.1	Gene:	Krn / 326198	FlyBaseID:	FBgn0052179	Length:	217	Species:	Drosophila melanogaster
Sequence 2:	NP_053585.1	Gene:	NRG2 / 9542	HGNCID:	7998	Length:	858	Species:	Homo sapiens

Alignment Length:	107	Identity:	30/107 - (28%)
Similarity:	53/107 - (49%)	Gaps:	31/107 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 YCLNDGTCFTVKIHNEILYNCECALGFMGPRC--------------------EYKEIDGSYLPTR 114
            ||:|.|.|:.::..|::  :|:|..||.|.||                    |.||.:..|   :
Human   352 YCVNGGVCYYIEGINQL--SCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELY---Q 411

  Fly   115 NRVMLEKASIVSGATLALLFMAMCCVVLYLRHEKLQKQKLHD 156
            .||:     .::|..:|||.:.:.|||.|.:.:| |::::|:
Human   412 KRVL-----TITGICVALLVVGIVCVVAYCKTKK-QRKQMHN 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Krn	NP_524129.1	None
NRG2	NP_053585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		I-set	239..328	CDD:254352
		Ig_Pro_neuregulin	253..326	CDD:143227
		PHA02887	<343..383	CDD:165214	13/32 (41%)
		Neuregulin	406..845	CDD:280343	14/51 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..543
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40711
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910