Protein Alignment Ndfip and NDFIP1

DIOPT Version :10

• Sequence 1: NP_730291.1
• Gene: Ndfip / 326197
• FlyBaseID: FBgn0052177
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_085048.1
• Gene: NDFIP1 / 80762
• HGNCID: 17592
• Length: 221
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 75/267 - (28%)
• Similarity: 109/267 - (40%)
• Gaps: 73/267 - (27%)

  Fly     5 NQPSPGDDQLGPPKADFSAPPPYEANVGHGQQVALPAQMPPLALATPDPSQIPIQMQVQLPSQAD 69
            |:...|:    |.:|...|||||.                  :::....:....:.:...|.
Human    24 NEEESGE----PEQAAGDAPPPYS------------------SISAESAAYFDYKDESGFPK--- 63

  Fly    70 LMNAQLPP--EIHGKLPTYEEVQMEKSLNGELPPAFLTLPSSQQLPPPPNPLLPPNPLRDGAAAV 132
                  ||  .:...||:|:|.:..|        |..|:|            |.|....|
Human    64 ------PPSYNVATTLPSYDEAERTK--------AEATIP------------LVPGRDED----- 97

  Fly   133 RSAQPALTFIAIDASDPENSLSTTDNLLGTDIMFITAFIVAFLFNWIGFLMLTCFCHTIAARYGA 197
                    |:..|..|..:.|.     :|.|.:|:..|.:|||||||||.:..|...:.|.||||
Human    98 --------FVGRDDFDDADQLR-----IGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGA 149

  Fly   198 LSGFGLSLAKWTLIVKHSTDLASHENS--WLWWLICAFGFLISIRALIQYVSIKRSWRLLSASAQ 260
            :|||||||.||.|||:.||....:.:.  ||||:....|||:.:|..|.|..:::.....|...:
Human   150 ISGFGLSLIKWILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPR 214

  Fly   261 ERLLFFY 267
            .|:||.|
Human   215 TRVLFIY 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndfip	NP_730291.1	NDFIP-like	23..253	CDD:412068	66/233 (28%)
NDFIP1	NP_085048.1	Interaction with UBE2L3. /evidence=ECO:0000250|UniProtKB:Q8R0W6	2..41		6/20 (30%)
		NDFIP1	16..221	CDD:412069	74/265 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..45		9/42 (21%)
		PPxY motif 1	39..42		2/2 (100%)
		Interaction with ITCH. /evidence=ECO:0000250|UniProtKB:Q8R0W6	42..76		6/60 (10%)
		PPxY motif 2	64..67		2/2 (100%)
		PPxY motif 3	74..76		1/1 (100%)