DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32086 and Efhb

DIOPT Version :9

Sequence 1:	NP_729720.1	Gene:	CG32086 / 326195	FlyBaseID:	FBgn0052086	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001100349.1	Gene:	Efhb / 301168	RGDID:	1566407	Length:	852	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	142/620 - (22%)
Similarity:	225/620 - (36%)	Gaps:	189/620 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GHFIDRNANIPTAG-LSTSGLDGAEGVKVCLS-----ISNPEEL------------AESLVRRNY 51
            |.|.||..:.|||| :...|...|.    ||:     :..|.|.            ||.:.   |
  Rat   271 GKFFDRAPSWPTAGKVKPVGYRVAN----CLTEKLPRLMTPPEAKKYFNFRYPPPGAERIF---Y 328

  Fly    52 GQINKKS-------QKFPAGSVQPSSSIR-DLLTSELQKSRFMSFKEKFYEEMYF--KKATLG-G 105
            |:.|...       ...|.|.|..||.|. ..:|:..||     .|:| .|.:||  ::|.|| .
  Rat   329 GRANDPQIAPYLTHGMRPKGLVTMSSLINPQPITTFQQK-----VKDK-KESIYFSHQRAPLGKS 387

  Fly   106 VKKTYSKPEDVTNISQTFGSPSSQSQNECLYDVILPAKSAEQVNKEYEAFHDKYIISHNHYFPSE 170
            ..:|...|:.:..|:.|.|:|:.:..:  :.||:.|:||.|.|.||.:..||.|.||||.||..|
  Rat   388 HDQTPGLPKGMDVINTTLGTPTIRELS--VRDVVNPSKSFEDVFKEGQEGHDLYTISHNDYFAGE 450

  Fly   171 QVNRRYAQPFDRKSPCGDIHTHGDFGLKVKRCLE--------------EGENHLKVIGKAQVDFM 221
            ..||:|       :| ...|....:|:....|.:              :.|...|::.|...||.
  Rat   451 AKNRKY-------NP-ASFHRFNLYGVPTPHCNDGRTMAKTLHWLHELQMERGAKIVSKRADDFE 507

  Fly   222 DRNEAPLG--MRNKKYTFAV-PDITFGVPLRSN----GDVKMLLNNIEPCYKTNRLLDAIRYLNK 279
            ::.:..||  :.....|..| |..|||..|:..    ||   |::...|          ..||..
  Rat   508 EKFQHRLGRVLDPIAETMNVPPGHTFGACLQPEEYGAGD---LIHYRGP----------DEYLRG 559

  Fly   280 K----------RHSLRNQLEFHKYALNSVLERSDTDGTGHLPLARILEIFRSFHIRLDAQKIRLA 334
            |          ||.|:.....|...|.......|..|.|.:..|.:.|.....::.||
  Rat   560 KDRQRALVAAARHHLKKFNHQHFDTLLMAFRHYDKKGDGVIDRAELHEACVQANLHLD------- 617

  Fly   335 LSNFRLIVD---EGCATER---VNYVDFFRLLSIQNSLPKT---------GNLT---NVSDVSCL 381
                ::::|   :.|..::   :||::|...|:.::.:|.|         |..|   ||::.|.:
  Rat   618 ----KMLLDHLFDYCDVDQDGLINYLEFANFLTWKDRIPLTEYEKRVVIKGKKTDCENVTETSIV 678

  Fly   382 DTTYRLLCADLQ---------------------NKSKDN-----------TGAI----------- 403
            ..|...|..:.:                     :|..|.           .||:
  Rat   679 GETDPSLLVNPEDIVPKEPGSSEEIVRTILRPGDKVSDQYKTTSSEINAVVGAVPSICYPIYGVP 743

  Fly   404 ---------------SQNLEGNKTTAKDLITPDLAILRGLTHSDFTCLRPKAEIERIFRSL---V 450
                           ..|..|.:..|..|:.|.:...:|:...||...|.|.||..|..::   :
  Rat   744 TIRSDIPAPRIRRVSDMNNYGEEGNAYALLHPSIFSQKGVFERDFFKTRSKEEISDILTNIGVKL 808

  Fly   451 TTDKFEAIWQSLMTKFKDQNEMA--SVTQFRTEMH 483
            |.::||.:| :|.::...|.|:.  ::.....|:|
  Rat   809 TEEEFENVW-NLASQKHQQGEVCVETIRNVLDELH 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32086	NP_729720.1	None
Efhb	NP_001100349.1	EFh	585..646	CDD:238008	13/71 (18%)
Efhb	NP_001100349.1	EF-hand_7	585..645	CDD:290234	13/70 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJU2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	78	1.000	Inparanoid score	I5140
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016066at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104929
Panther	1	1.100	-	-	LDO	PTHR12086
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830