Protein Alignment CG32086 and EFHB

DIOPT Version :9

• Sequence 1: NP_729720.1
• Gene: CG32086 / 326195
• FlyBaseID: FBgn0052086
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_653316.3
• Gene: EFHB / 151651
• HGNCID: 26330
• Length: 833
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 132/587 - (22%)
• Similarity: 221/587 - (37%)
• Gaps: 148/587 - (25%)

  Fly     5 GHFIDRNANIPTAGLSTSGLDGAEGVKVCLS------ISNPEEL--------AESLVRRNYGQIN 55
            |.|.||....|:||   ..:.....|..||:      |:.||..        ...:.|..||:.|
Human   252 GKFFDRTPCWPSAG---KVIPVGYRVATCLTEKLPRLITPPEAKKYFNFRYPPAGVERVFYGRAN 313

  Fly    56 KKSQKFPAGSVQPSSSIRDLLTSELQKSRFMSFKEKF---YEEMYF--KKATLGGVKKTYSK--- 112
             ..|..|..:....|.|..|..:.:......:|::|.   .|.:|.  ::|.||   |::.:
Human   314 -DPQIAPYLTHGIRSKISVLANTLINPQPITTFQQKIKDKKESIYLSNRRAPLG---KSHDQAPG 374

  Fly   113 -PEDVTNISQTFGSPSSQSQNECLYDVILPAKSAEQVNKEYEAFHDKYIISHNHYFPSEQVNRRY 176
             |:.:...:.|||:...:..:  ..||:.|.||.|:|.||....||.|::|||.|:..|..||:|
Human   375 LPKGMDTTNTTFGTAVIKEYS--AKDVVNPPKSYEEVFKEGNEGHDLYVVSHNDYYAGEAKNRKY 437

  Fly   177 -AQPFDRKSPCGDIHTHGDFGLKVKRCLE-----EGENHLKVIGKAQVDFMDRNEAPLG--MRNK 233
             ...|.|.|..|....|.:.|..:.:.|.     :.:...|.:.|...||.::.:..||  :...
Human   438 NPSSFHRCSVYGVPTPHFNDGRAMAKSLYWLHELQMKRGAKFVSKRADDFKEKFQHKLGRVLDPI 502

  Fly   234 KYTFAV-PDITFGVPLRSN----GDVKMLLNNIEPCYKTNRLLDAIRYLNKK----------RHS 283
            ..|..| ||.|||..||..    ||   |::        |||.|  .||..|          ||.
Human   503 AETMNVPPDCTFGACLRPEEYGVGD---LIH--------NRLPD--EYLRGKDRQRALIAAVRHH 554

  Fly   284 LRNQLEFHKY-ALNSVLERSDTDGTGHLPLARILEIFRSFHIRLDAQKIRLALSNFRLIVDEGCA 347
            |: ::.:.|: .|.:.....|..|.|.:....:.|.....::.|| .|:...|.::..:.::|.
Human   555 LK-KVNYQKFDTLLAAFRHYDKKGDGMIDKDELQEACDQANLSLD-DKLLDQLFDYCDVDNDGF- 616

  Fly   348 TERVNYVDFFRLLSIQNSL--------------------PKTGNLTN-------------VSDVS 379
               :||::|...|:.::.:                    |...|:..             :.:..
Human   617 ---INYLEFANFLNWKDKMLLKEYEERVIIKGRKPDCVNPTEANVEEPEQTLLIKPEDIVLKEAG 678

  Fly   380 CLDTTYRLLCA---DLQNKSKDNT-------GAI--------------------------SQNLE 408
            ..:.|.|.|..   .:.|..|..:       |||                          .:...
Human   679 STEKTLRTLLRPSDKVSNYYKTTSSEINAIVGAIPSTCYPICGVPTIRSDIPAPRIRRISDRTNY 743

  Fly   409 GNKTTAKDLITPDLAILRGLTHSDFTCLRPKAEIERIFRSL---VTTDKFEAIWQSLMTKFKDQN 470
            |.:.:|..|:.|.:...:|:...||...|.|.||..|..::   ::.::||.:| :|.:|...:.
Human   744 GEEGSAYSLLYPTIFARKGVFERDFFKTRSKEEIAEILCNIGVKLSDEEFENVW-NLASKKHHRG 807

  Fly   471 EM 472
            |:
Human   808 EV 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32086	NP_729720.1	None
EFHB	NP_653316.3	EF-hand_7	566..626	CDD:290234	13/64 (20%)
		EFh	566..626	CDD:238008	13/64 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	94	1.000	Inparanoid score	I5070
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016066at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104929
Panther	1	1.100	-	-	LDO	PTHR12086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5195
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.960