DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg10 and Alg10

DIOPT Version :9

Sequence 1:	NP_729680.1	Gene:	Alg10 / 326193	FlyBaseID:	FBgn0052076	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_620801.1	Gene:	Alg10 / 245960	RGDID:	708500	Length:	474	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	152/452 - (33%)
Similarity:	231/452 - (51%)	Gaps:	47/452 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IDEEFHIPQGLAFCRKEFDV--WDPKITTFPGLYLIAL-LLNPLS---------LCTVTGLRMLS 84
            :||.||:||...:|...|.:  |||.|||.|||||::: ::.|.|         :|::..||.::
  Rat    36 MDEIFHLPQAQRYCEGRFSLSQWDPMITTLPGLYLVSVGVVKPASWILGWSEHVVCSIGMLRFVN 100

  Fly    85 LAGAGINILLLYKIRRRILAGSGGNSYAAH--EAITMSVLPPLYFFSHLYYTDTLSLTMVLLFYN 147
            |..:..|..|||.:.|:|...:..:|....  ..:|::|.|.||||:.||||:..|:...|..|.
  Rat   101 LLFSVGNFYLLYLLFRKIQPRNKASSSIQRILSTLTLAVFPTLYFFNFLYYTEAGSVFFTLFAYL 165

  Fly   148 YWQQEAHLPAAVFGAASVLMRQTNIVWVCMATGMTVLDTLVNQCA---RTGRVPKENVRL----- 204
            ......|..:|:.|....:.|||||:|.....|    ..:..:|:   :|....|:..||
  Rat   166 MCLYGNHRTSALLGFCGFMFRQTNIIWAAFCAG----HIIAQKCSEAWKTELQKKKEERLPPAKG 226

  Fly   205 ----MGKELWLQLVSSPQLLCNCILSILAKCCFYASIILPFVGFLFINGSIVVGDKSAHEASLHV 265
                :.:.|...|:.|..|....:|.:|.  ..|..::|.|..|:.:||.|||||:|:|||.||.
  Rat   227 PLSELRRVLQFLLMYSMSLKNLSMLFLLT--WPYMLLLLAFFVFVVVNGGIVVGDRSSHEACLHF 289

  Fly   266 PQLFYFAIFAAGFGISNTI--RQFRPAAELIRRNRVLSLLALLLILVVVHLNTEVHPYLLADNRH 328
            ||||||..|.|.|...:.:  .:.:....|:.:.||...:..|:.:.:|...|.||.||||||||
  Rat   290 PQLFYFFSFTAFFSFPHLLSPTKVKTFLSLVWKRRVQFSVITLVSVFLVWKFTYVHKYLLADNRH 354

  Fly   329 YTFYIWSRLYGRFWWFRYAMAPAYLLSICVLFCGLRHMPESFKLMFPLSLFLVLCFQRLLELRYF 393
            ||||:|.|::.|....:|.:.|||:.:...:...|:.....:.|||.:.|......|:|||.|||
  Rat   355 YTFYVWKRVFQRHEIVKYLLVPAYMFAGWAVADSLKSKSIFWNLMFFVCLVASTVPQKLLEFRYF 419

  Fly   394 LVPYILFRLN------TRHTRKGYAEWLELGAHLLLNVATFYVYFTKEFYWKNYRTPQRIIW 449
            ::|||::|||      :|..       .|||.:.::|..|||::..|.|.|.:....||.:|
  Rat   420 ILPYIIYRLNMPLPPISRLV-------CELGCYAVVNFLTFYIFLNKTFQWSDSHDIQRFMW 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg10	NP_729680.1	DIE2_ALG10	29..402	CDD:282739	135/397 (34%)
Alg10	NP_620801.1	DIE2_ALG10	33..428	CDD:282739	142/425 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346234
Domainoid	1	1.000	210	1.000	Domainoid score	I2731
eggNOG	1	0.900	-	-		E1_KOG2642
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6030
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3338
OMA	1	1.010	-	-		QHG55092
OrthoDB	1	1.010	-	-		D404988at33208
OrthoFinder	1	1.000	-	-		FOG0004262
OrthoInspector	1	1.000	-	-		oto97811
orthoMCL	1	0.900	-	-		OOG6_103728
Panther	1	1.100	-	-	LDO	PTHR12989
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3000
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770