DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32075 and LAS1L

DIOPT Version :9

Sequence 1:	NP_001246712.1	Gene:	CG32075 / 326192	FlyBaseID:	FBgn0052075	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_112483.1	Gene:	LAS1L / 81887	HGNCID:	25726	Length:	734	Species:	Homo sapiens

Alignment Length:	531	Identity:	110/531 - (20%)
Similarity:	198/531 - (37%)	Gaps:	125/531 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VVTPWRDTLEFNTTYKWLFGKSNTPATWRQALSKIRIWCLRRGSLCPAAVLATSVLVQAHLEDQE 104
            :|..|....|::....:||  .:.....|.||::|.:|..|.|:..|.||.:|:.|::..|.|..
Human    41 IVVAWLSRAEWDQVTVYLF--CDDHKLQRYALNRITVWRSRSGNELPLAVASTADLIRCKLLDVT 103

  Fly   105 ---GSAKIQDTYASAFTRFYNFMSSIIQGHNMSSMYETAKELGLQSFIVDLRHLCAHGQELPPVE 166
               |:.:::..|..|..||.|.:|..........:...|:|:.:..:||||||...| :::|.:.
Human   104 GGLGTDELRLLYGMALVRFVNLISERKTKFAKVPLKCLAQEVNIPDWIVDLRHELTH-KKMPHIN 167

  Fly   167 VLRNTSNHCLEWLRTYYWLPHMET-------MSNLDAGKLHRKDKLKFEKAVTDLLEIYDLTLEC 224
            ..|......|:||:..||...:|.       :.....| :..:|:.:.:..|.|     |:|.:.
Human   168 DCRRGCYFVLDWLQKTYWCRQLENSLRETWELEEFREG-IEEEDQEEDKNIVVD-----DITEQK 226

  Fly   225 HIKGAEKLKAISKLKSSGEFNKIRVYSSSKKAKTSKEILSAVLGDLSALVKKESSSMKDLLDIYT 289
            .....:.....|.:|:.|:            :|.|:|:.|..         |::.|.|:|   |.
Human   227 PEPQDDGKSTESDVKADGD------------SKGSEEVDSHC---------KKALSHKEL---YE 267

  Fly   290 KCLLKMKYFLGVGLEIDDNEDVIIAATQGLFRLLAVQGYIEKVFLA-----------LVQLSENQ 343
            :.                 .:::::..:..|.:|....|:.|...|           |.:|....
Human   268 RA-----------------RELLVSYEEEQFTVLEKFRYLPKAIKAWNNPSPRVECVLAELKGVT 315

  Fly   344 NESEQRRLGASYWAKKMLETFGMLFRMKRMYKAELDLNDKLKPADFATLNTDKISKTMRSLLVHS 408
            .|:.:..|.|......::.||..|..::..|:   |...:::..:    .||..|        |.
Human   316 CENREAVLDAFLDDGFLVPTFEQLAALQIEYE---DGQTEVQRGE----GTDPKS--------HK 365

  Fly   409 NADLSVTLIFGDNPKKSRSLIFDRDFIMQRVDAFSNYSAPILKGLLPLADPPYTKTQIE----DL 469
            |.||:..|:    ||                 .||.:..|:|:|   |....:|:..:|    :|
Human   366 NVDLNDVLV----PK-----------------PFSQFWQPLLRG---LHSQNFTQALLERMLSEL 406

  Fly   470 TKLCDAQLEEFYEEEAMEE--DSSSEESNNLDRLERFLEQAAQSKEHTSDWGVWKLDKHTDWPK- 531
            ..|..:.:...|......|  .::::...|..|.      :|...|....|.::......|||:
Human   407 PALGISGIRPTYILRWTVELIVANTKTGRNARRF------SAGQWEARRGWRLFNCSASLDWPRM 465

  Fly   532 --CALGVLPWA 540
              ..||...||
Human   466 VESCLGSPCWA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32075	NP_001246712.1	Las1	42..186	CDD:281960	41/146 (28%)
LAS1L	NP_112483.1	Las1	43..187	CDD:281960	41/146 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..255		12/68 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..619
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158367
Domainoid	1	1.000	59	1.000	Domainoid score	I10740
eggNOG	1	0.900	-	-		E1_KOG2425
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1070386at2759
OrthoFinder	1	1.000	-	-		FOG0005077
OrthoInspector	1	1.000	-	-		oto88971
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15002
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R650
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.970