DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and CACNA1G

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_061496.2 Gene:CACNA1G / 8913 HGNCID:1394 Length:2377 Species:Homo sapiens


Alignment Length:2396 Identity:574/2396 - (23%)
Similarity:961/2396 - (40%) Gaps:642/2396 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 DEDED-----EGPQP-------DPTLEQGVPIPVRLQ---GSFPPELASTPLEDIDPYYSNVLTF 115
            ||:||     |..||       |.:...|.|.|...:   ||...|....|...:.|     :.|
Human     2 DEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAP-----VVF 61

  Fly   116 VVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTP-- 176
            ..:|:       .:....|.|      |.|.     :|.|....:..||:||:.  |..|...  
Human    62 FYLSQ-------DSRPRSWCL------RTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIA 108

  Fly   177 -------TVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG 234
                   .:::.:......:..|..||::|.| |.....||.|.||.|||.::....:...:||.
Human   109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQ 172

  Fly   235 NL--AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 297
            |:  :|:||.||||.|:.:..||.::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|
Human   173 NVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237

  Fly   298 TQKCI--KKFPLDGSWGNLTDENWDYHNRNSSNWYSEDE-----------GI----SFP-LCGNI 344
            ..:|.  :.|.|..|    .|....|...|      |||           |:    |.| |.|:.
Human   238 RNRCFLPENFSLPLS----VDLERYYQTEN------EDESPFICSQPRENGMRSCRSVPTLRGDG 292

  Fly   345 SGAGQCDDDYV-------------------CLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFW 390
            .|...|..||.                   |..| ..||..|..:||:.|:|:::.|:::|.:.|
Human   293 GGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAG-EHNPFKGAINFDNIGYAWIAIFQVITLEGW 356

  Fly   391 EDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEE 455
            .|:...|:.|...::.::||::|.:|||:::||.|.::|..:.|.:::       |.:.:|    
Human   357 VDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-------ESQLMR---- 410

  Fly   456 AAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMS 520
                     |:|....:.|:..|:.:|..:.:.|:.|        |.:::          ..|.:
Human   411 ---------EQRVRFLSNASTLASFSEPGSCYEELLK--------YLVYI----------LRKAA 448

  Fly   521 IRSVEVESESVSV---IQRQPAPTTAHQ-------ATKVRKVSTTSLSLPGSPFNIRRGSRSSHK 575
            .|..:| |.:..|   :...|||....:       :...|::|...|        :.......|.
Human   449 RRLAQV-SRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHL--------VHHHHHHHHH 504

  Fly   576 YTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGA--IIVP--------- 629
            |.:.||..|                  |.:..|...|.:|       ||:  :::|         
Human   505 YHLGNGTLR------------------APRASPEIQDRDA-------NGSRRLMLPPPSTPALSG 544

  Fly   630 VYYGNLGSRHSSY-----------TSHQSRISYTSHGDLLG-GMAVMGVSTMTKESKLRNRNTRN 682
            ...|...|.||.|           .:...|....:.|..:| |.....|.|......|:.:..  
Human   545 APPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEKAL-- 607

  Fly   683 QSVGATNGGTTCLDTN---------HKL--------DHRDYEIGLECTD-EAGKIKHHDNPFIEP 729
            ..|.|::|..|....|         |||        .....:|...|.. ::|.......|:...
Human   608 VEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPYCAR 672

  Fly   730 VQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTED----DDEDGPTFKDKALEVILK 790
            .....|              :.|.|....|| ..:||.| |:|    |..|..:.:.::|....:
Human   673 AGAGEV--------------ELADREMPDSD-SEAVYEF-TQDAQHSDLRDPHSRRQRSLGPDAE 721

  Fly   791 GIDVFCVWD-CCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGN 854
            ...|...|. .|..:.|       ||...:....|.:.|:|||:.|.:::|:..:|:...|:..|
Human   722 PSSVLAFWRLICDTFRK-------IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISN 779

  Fly   855 YFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLEL-GLEGVQGLSVLRSFRLLRVFK 918
            ..||:.||:|..:||:...|..|.:..:||||.:||.:|:.|: |.:| .||||||:|||:||.|
Human   780 IVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQG-GGLSVLRTFRLMRVLK 843

  Fly   919 LAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGD-LP-RW 981
            |.:..|.|...:.::.:||..:.....:|.:.||||:::||.|||..:...:    ||| || |.
Human   844 LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER----DGDTLPDRK 904

  Fly   982 NFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGS 1045
            ||...:.:.:.||::|..| |.:.:::.|.........:|:|.:..||.|:.||.:|:|:..|.:
Human   905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQA 969

  Fly  1046 SSLS---------------------------------APTADNDTNK------------------ 1059
            ..:|                                 :|:.|.|.::                  
Human   970 EEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKS 1034

  Fly  1060 -----------------------IAEAFNRIGR-------------------------------- 1069
                                   :.||.....|                                
Human  1035 LLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA 1099

  Fly  1070 FKSWVKRNIADCFKLIRNKLTNQIS---DQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELG 1131
            ..||..|..:      ||.|....|   ..|||||.:.:|     |:|      .|..|.|    
Human  1100 ASSWTSRRSS------RNSLGRAPSLKRRSPSGERRSLLS-----GEG------QESQDEE---- 1143

  Fly  1132 HDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHK 1196
                           |.::.|.|...|.:....|.::  :..||.:      |...::...|.|:
Human  1144 ---------------ESSEEERASPAGSDHRHRGSLE--REAKSSF------DLPDTLQVPGLHR 1185

  Fly  1197 NRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDE--- 1258
            .     .|.:|||...:....:.||       ..|......::.|||||   .|.||..|.:   
Human  1186 T-----ASGRGSASEHQDCNGKSAS-------GRLARALRPDDPPLDGD---DADDEGNLSKGER 1235

  Fly  1259 --------YPADCCPDSYYKKFPILAGDDDSPFWQGW-----GNLRLKTFQLIENKYFETAVITM 1310
                    .|| ||.:.            ||  |..:     ...||...::|.:|.|:..|:.:
Human  1236 VRAWIRARLPA-CCLER------------DS--WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1285

  Fly  1311 ILMSSLALALE----DVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAW 1367
            |.::.:.:|:|    |.|..:|..|....|    |||.:|..||.:|.:|||:    :.|..::|
Human  1286 IFLNCITIAMERPKIDPHSAERIFLTLSNY----IFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1346

  Fly  1368 CWLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPS 1429
            ..||.::|::|:|:.:.|:|...|   :...:.:|.||.|||||.:||.||:::||..|:.::..
Human  1347 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411

  Fly  1430 IFNVLLVCLIFWLIFAIMGVQLFAGKYFKC--EDMNGTKLSHEIIPNRNACESENYTWVNSAMNF 1492
            |.|::::|..|::||.|:|||||.||:|.|  ||...       |.|::.|...:|.||....||
Human  1412 IGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRN-------ITNKSDCAEASYRWVRHKYNF 1469

  Fly  1493 DHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIG 1557
            |::|.|.:.||.:|:..||:.||.|.:|:..||:|||...|.:|.|||:.|::..:||.||:|:|
Human  1470 DNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVG 1534

  Fly  1558 VIIDNF-----NEQKKKAGGSLEMFMTEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP------- 1608
            |:::||     ::::::|....|..:...:||..|.|  ..:.|.....|....:.:|       
Human  1535 VVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSR 1599

  Fly  1609 -QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFA 1672
             :.:|..:.|....|:.|...||||:.||.::.|......:..|...|.||.|||..|.:.|:.|
Human  1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1664

  Fly  1673 LRY-HYFIEPWNLFDVVVVILSILGLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1734
            ..: .:|.:.||..|:.:|:|||:|:.|.:|  .....::||::|::||.::.|||:|:|.|.|:
Human  1665 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729

  Fly  1735 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-------MHVKEKSGINDVYNFKTFGQSM 1792
            |.||..:..:||.:.|:.||..|:.||||..|:..|       .|..|  |:.....|:.||.:.
Human  1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCE--GLGRHATFRNFGMAF 1792

  Fly  1793 ILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIA 1857
            :.||::||...|:|::...:.:  ||       ....|.:..:...:.:|:::.:..:::|:.||
Human  1793 LTLFRVSTGDNWNGIMKDTLRD--CD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1848

  Fly  1858 VILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYK 1922
            |::::..::.::.:|..         |:..:.:.|             :..|.|  |.|.|    
Human  1849 VLMKHLEESNKEAKEEA---------ELEAELELE-------------MKTLSP--QPHSP---- 1885

  Fly  1923 IISMDIPICRGDLMYCVDILDALTKDFF--ARKGNPIEETGEIGEI--AARPDTEGYEPVSSTLW 1983
                                  |...|.  ..:|....::.:.|.:  ||...:..:..:.....
Human  1886 ----------------------LGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTD 1928

  Fly  1984 RQREEYCARLIQHAWRKHKARGEGGGSFE-----PDTDHGDGGDPDAGDPAPD-EATDGDAPAGG 2042
            ||..:..:.|||             ||.|     .|...|.||.|.|...||. ..:|...|...
Human  1929 RQLFDTISLLIQ-------------GSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAE 1980

  Fly  2043 DGSVNGTAEGAAD----------------------ADESNVNS-----PGEDAAAAAAAAAAAAA 2080
            ..:::.|:|..::                      |.|||:..     ||.|......:..:...
Human  1981 MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTH 2045

  Fly  2081 A----------GTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITS 2126
            :          |:|..|..|....|...|          ::|..:.:||: |:.||
Human  2046 SLPNDSYMCRHGSTAEGPLGHRGWGLPKA----------QSGSVLSVHSQ-PADTS 2090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 86/320 (27%)
Na_trans_cytopl 515..648 CDD:288761 28/164 (17%)
Ion_trans 835..1028 CDD:278921 67/196 (34%)
Na_trans_assoc 1054..1296 CDD:284034 58/333 (17%)
Ion_trans 1318..1571 CDD:278921 100/270 (37%)
Na_channel_gate 1561..1613 CDD:240441 11/66 (17%)
Ion_trans 1636..1871 CDD:278921 70/244 (29%)
GPHH 1880..1930 CDD:293510 7/49 (14%)
CACNA1GNP_061496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 13/45 (29%)
I 68..398 93/352 (26%)
Ion_trans 130..406 CDD:278921 82/294 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..600 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..720 4/20 (20%)
II 729..967 84/249 (34%)
Ion_trans 760..968 CDD:278921 74/212 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1012 1/20 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1230 46/241 (19%)
III 1263..1540 105/287 (37%)
Ion_trans 1293..1547 CDD:278921 100/264 (38%)
IV 1596..1854 79/268 (29%)
Ion_trans 1628..1851 CDD:278921 70/233 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1878..1917 11/66 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2171..2244
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2272..2377
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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