DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and CACNA1I

DIOPT Version :10

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_066919.2 Gene:CACNA1I / 8911 HGNCID:1396 Length:2223 Species:Homo sapiens


Alignment Length:2392 Identity:558/2392 - (23%)
Similarity:941/2392 - (39%) Gaps:651/2392 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 QPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDP 138
            :|..|.||..|   |...|.||.| ..||:..||:..:          .|:    |..|.:.|..
Human    18 EPGVTTEQPGP---RSPPSSPPGL-EEPLDGADPHVPH----------PDL----APIAFFCLRQ 64

  Fly   139 FNPIRRVAIYILVHPLFSLFIITTILVNCIL--MIMP------TTPTVESTEVIFTGIYTF---E 192
            ....|...|.::.:|.|....:..||:||:.  |..|      .:...:..:|....|:.|   |
Human    65 TTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAME 129

  Fly   193 SAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG--NLAALRTFRVLRALKTVAIVP 255
            ..:|::|.| |.....||.|.||.|||.::....|...:||.  ||:|:||.||||.||.:..||
Human   130 MVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVP 193

  Fly   256 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCI--KKFPLDGSWGNLTDEN 318
            .::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.  :.|.:.|...      
Human   194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVA------ 252

  Fly   319 WDYHNRNSSNWYSEDEGISFPLCGNISG----------------AGQC----DDDY--------- 354
                   ...:|..:|....|...::||                ..:|    ||.|         
Human   253 -------LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDL 310

  Fly   355 --------------VCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWH 405
                          ||..| ..||:.|..:||:.|:|::..|:::|.:.|.::...|:.|...::
Human   311 NASGLCVNWNRYYNVCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYN 374

  Fly   406 MLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAK----LEE 466
            .::||::|.:|||:::||.|.::|..:.|  .|..|.....|:..|....:..|..|:    .||
Human   375 FIYFILLIIVGSFFMINLCLVVIATQFSE--TKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEE 437

  Fly   467 ----------RANAQAQAAADAAAAEEAALHPEM---------AKSPTYSCISYELFVGGEKGND 512
                      :|..:|.....|..:...||.||.         ||.|.:       :.|..||..
Human   438 IFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRH-------YHGKTKGQG 495

  Fly   513 DNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYT 577
            |..:                                                  ..|||  |..|
Human   496 DEGR--------------------------------------------------HLGSR--HCQT 508

  Fly   578 IRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSY 642
            :.....    ||:|.     |..:...||          :|:......::.|:        .::.
Human   509 LHGPAS----PGNDH-----SGRELCPQH----------SPLDATPHTLVQPI--------PATL 546

  Fly   643 TSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYE 707
            .|..:......|.|                      ..|...:|:|:.|               :
Human   547 ASDPASCPCCQHED----------------------GRRPSGLGSTDSG---------------Q 574

  Fly   708 IGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTED 772
            .|......||.                             .::|.|..:|:|:.|.|......|:
Human   575 EGSGSGSSAGG-----------------------------EDEADGDGARSSEDGASSELGKEEE 610

  Fly   773 DDE--DGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFM 835
            ::|  ||                  .||.|..||.:.:..:..||...:....|.:.|:|||:.|
Human   611 EEEQADG------------------AVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSM 657

  Fly   836 AMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLE 900
            .::||:..:|:..:|:..|..||:.||:|..:||.|.....|.:..:||||.|||.:|:.|:..:
Human   658 GIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ 722

  Fly   901 GVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKN 965
            ...||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:::||.:||..
Human   723 ADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787

  Fly   966 YH---DHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVGDVSCIP----FFLA 1022
            :.   |..|..||    |.||...:.:.:.||::|..|    .|: .:|.|..|..|    :|:|
Human   788 FSLRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE----DWNVVLYNGMASTSPWASLYFVA 844

  Fly  1023 TVVIGNLVVLNLFLALLLSNF---GSSSLSAPTADNDTNKIAEAFNRI----------------- 1067
            .:..||.|:.||.:|:|:..|   |.::.|....|..::.| |.|:::                 
Human   845 LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNI-EEFDKLQEGLDSSGDPKLCPIPM 908

  Fly  1068 ----------------------------------------------------------------- 1067
                                                                             
Human   909 TPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS 973

  Fly  1068 -----GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNE 1127
                 ||..:|..|.  ..:..:::|       .||.|..:.:|.....|..||           
Human   974 YYGPWGRSAAWASRR--SSWNSLKHK-------PPSAEHESLLSAERGGGARVC----------- 1018

  Fly  1128 LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTAS-INS 1191
                  |:.||    :|......|.......:....|...::...:::..|:|....|.|. :.:
Human  1019 ------EVAAD----EGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPA 1073

  Fly  1192 YGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLD--EELDEEGECEEGPLDGDIIIHAHDED 1254
            .|:|....::      :|....|.|..:.....:..|  .::.:.|:..|...:.|..:......
Human  1074 VGAHPRAAWR------AAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRK 1132

  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPF-WQGWGNLRLKTFQLIENKYFETAVITMILMSSLAL 1318
            ::|.|..|.|.          ..:|.|.: :......|:....:|.:|.|:..|:..|.::.:.:
Human  1133 MIDVYKPDWCE----------VREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITI 1187

  Fly  1319 ALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSL 1379
            |||...:......:..|...:.|||.||..||.:|.::||.    :.|..::|..||..:|.||:
Human  1188 ALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSI 1252

  Fly  1380 INFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1441
            |:.|.||..|||   :...:.:|.||.|||||.:||..|:::||..|:.::..|.|::|:|..|:
Human  1253 IDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFF 1317

  Fly  1442 LIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVA 1506
            :||.|:|||||.||::.|..::...     |.||:.|.:.||.||:...|||::|.|.:.||.:|
Human  1318 IIFGILGVQLFKGKFYHCLGVDTRN-----ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377

  Fly  1507 TFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNE--QKKK 1569
            :..||:.||.:.:|:..||:||:...|.:|.|||:.|::..|||.||:|:||:::||::  |.::
Human  1378 SKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQE 1442

  Fly  1570 AGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW----RPQAIVFEIVTDKKFDIIIMLFIG 1630
            |        .|.:::....:::: .||..||...|.:    ..:.::..:.|....||.|...|.
Human  1443 A--------EEARRREEKRLRRL-EKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1498

  Fly  1631 LNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI--FALRYHYFIEPWNLFDVVVVILS 1693
            ||:.||:|:.|:...:....|.|.|.:|..:|..|.:||:  |.|| .:|.:.||..|:.:|:||
Human  1499 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLS 1562

  Fly  1694 ILGLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1756
            ::|:.|.:| |.... ::||::|::||.::.|||:|:|.|.|:|.||..:..:||.:.|:.||..
Human  1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFM 1627

  Fly  1757 LVMFIFAIFGMSFFMHV-----KEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA 1816
            |:.||:|..|:..|..:     ....|::....|:.||.:.:.|||:||...|:|::...:.:  
Human  1628 LLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD-- 1690

  Fly  1817 CDPPDNDKGYPGNCGSAT--VGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1879
            |...:.      :|.|:.  |...:.:|:::.:..::||:.:||::::...:.::.||   |.:.
Human  1691 CTHDER------SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE---DAEM 1746

  Fly  1880 DMYYEIWQQF---------------------------DPEG----------TQYIRYDQLSEFL- 1906
            |...|:....                           |.||          .:.:..|.:|..: 
Human  1747 DAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIK 1811

  Fly  1907 DVLEPPLQI----------------------HKPNKYKIISMDIPICRGDLMYCVDILDALT--- 1946
            |.||..|.|                      |...:.::...:......|....:.:.|.|:   
Human  1812 DSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLED 1876

  Fly  1947 --------KDFFARKG--NPIE--ETGEIGE-------IAARPDTEG---------YEPVSSTLW 1983
                    ||   .||  :|.|  ..|::||       .|..||.|.         :.||.|   
Human  1877 PTACPPGRKD---SKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRS--- 1935

  Fly  1984 RQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNG 2048
                          |.||.:.......|.|     |...|..  |.|.|.......|...|...|
Human  1936 --------------WLKHDSSQAPPSPFSP-----DASSPLL--PMPAEFFHPAVSASQKGPEKG 1979

  Fly  2049 TAEG-----AADADESNVNSP-----------GEDAAAAAAAAAAAAAAGTT------------- 2084
            |..|     |.....:::.||           |.|.:..|:.:::|.:..||             
Human  1980 TGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRR 2044

  Fly  2085 ------TAGSPGAG-SAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTA 2129
                  .|..|.|| |...:..:.:...|..:..|.:.  |.||.|....|:
Human  2045 ALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRA--HQRSHSSGGSTS 2094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 152..436 CDD:459842 88/341 (26%)
Na_trans_cytopl 555..740 CDD:463401 23/184 (13%)
Ion_trans 817..1028 CDD:459842 74/218 (34%)
Na_trans_assoc 1054..1296 CDD:461936 42/332 (13%)
Ion_trans 1300..1571 CDD:459842 104/279 (37%)
Na_channel_gate 1561..1613 CDD:240441 10/57 (18%)
Ion_trans 1621..1871 CDD:459842 78/260 (30%)
GPHH 1882..1929 CDD:465306 12/106 (11%)
CACNA1INP_066919.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46 12/31 (39%)
I 66..401 89/349 (26%)
Ion_trans 78..409 CDD:459842 89/347 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..536 22/146 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 17/126 (13%)
II 626..865 84/246 (34%)
Ion_trans 639..866 CDD:459842 81/234 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..936 0/36 (0%)
III 1157..1434 103/281 (37%)
Ion_trans 1169..1441 CDD:459842 104/276 (38%)
IV 1472..1733 79/269 (29%)
Ion_trans 1486..1741 CDD:459842 78/263 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1758..1784 0/25 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1897 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1937..1960 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2062 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2076..2223 6/21 (29%)

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