DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and CACNA1I

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_066919.2 Gene:CACNA1I / 8911 HGNCID:1396 Length:2223 Species:Homo sapiens


Alignment Length:2392 Identity:558/2392 - (23%)
Similarity:941/2392 - (39%) Gaps:651/2392 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 QPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDP 138
            :|..|.||..|   |...|.||.| ..||:..||:..:          .|:    |..|.:.|..
Human    18 EPGVTTEQPGP---RSPPSSPPGL-EEPLDGADPHVPH----------PDL----APIAFFCLRQ 64

  Fly   139 FNPIRRVAIYILVHPLFSLFIITTILVNCIL--MIMP------TTPTVESTEVIFTGIYTF---E 192
            ....|...|.::.:|.|....:..||:||:.  |..|      .:...:..:|....|:.|   |
Human    65 TTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAME 129

  Fly   193 SAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG--NLAALRTFRVLRALKTVAIVP 255
            ..:|::|.| |.....||.|.||.|||.::....|...:||.  ||:|:||.||||.||.:..||
Human   130 MVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVP 193

  Fly   256 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCI--KKFPLDGSWGNLTDEN 318
            .::.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.  :.|.:.|...      
Human   194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVA------ 252

  Fly   319 WDYHNRNSSNWYSEDEGISFPLCGNISG----------------AGQC----DDDY--------- 354
                   ...:|..:|....|...::||                ..:|    ||.|         
Human   253 -------LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDL 310

  Fly   355 --------------VCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWH 405
                          ||..| ..||:.|..:||:.|:|::..|:::|.:.|.::...|:.|...::
Human   311 NASGLCVNWNRYYNVCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYN 374

  Fly   406 MLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAK----LEE 466
            .::||::|.:|||:::||.|.::|..:.|  .|..|.....|:..|....:..|..|:    .||
Human   375 FIYFILLIIVGSFFMINLCLVVIATQFSE--TKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEE 437

  Fly   467 ----------RANAQAQAAADAAAAEEAALHPEM---------AKSPTYSCISYELFVGGEKGND 512
                      :|..:|.....|..:...||.||.         ||.|.:       :.|..||..
Human   438 IFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRH-------YHGKTKGQG 495

  Fly   513 DNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYT 577
            |..:                                                  ..|||  |..|
Human   496 DEGR--------------------------------------------------HLGSR--HCQT 508

  Fly   578 IRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSY 642
            :.....    ||:|.     |..:...||          :|:......::.|:        .::.
Human   509 LHGPAS----PGNDH-----SGRELCPQH----------SPLDATPHTLVQPI--------PATL 546

  Fly   643 TSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYE 707
            .|..:......|.|                      ..|...:|:|:.|               :
Human   547 ASDPASCPCCQHED----------------------GRRPSGLGSTDSG---------------Q 574

  Fly   708 IGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTED 772
            .|......||.                             .::|.|..:|:|:.|.|......|:
Human   575 EGSGSGSSAGG-----------------------------EDEADGDGARSSEDGASSELGKEEE 610

  Fly   773 DDE--DGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFM 835
            ::|  ||                  .||.|..||.:.:..:..||...:....|.:.|:|||:.|
Human   611 EEEQADG------------------AVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSM 657

  Fly   836 AMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLE 900
            .::||:..:|:..:|:..|..||:.||:|..:||.|.....|.:..:||||.|||.:|:.|:..:
Human   658 GIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ 722

  Fly   901 GVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKN 965
            ...||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||||:::||.:||..
Human   723 ADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787

  Fly   966 YH---DHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVGDVSCIP----FFLA 1022
            :.   |..|..||    |.||...:.:.:.||::|..|    .|: .:|.|..|..|    :|:|
Human   788 FSLRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE----DWNVVLYNGMASTSPWASLYFVA 844

  Fly  1023 TVVIGNLVVLNLFLALLLSNF---GSSSLSAPTADNDTNKIAEAFNRI----------------- 1067
            .:..||.|:.||.:|:|:..|   |.::.|....|..::.| |.|:::                 
Human   845 LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNI-EEFDKLQEGLDSSGDPKLCPIPM 908

  Fly  1068 ----------------------------------------------------------------- 1067
                                                                             
Human   909 TPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSS 973

  Fly  1068 -----GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNE 1127
                 ||..:|..|.  ..:..:::|       .||.|..:.:|.....|..||           
Human   974 YYGPWGRSAAWASRR--SSWNSLKHK-------PPSAEHESLLSAERGGGARVC----------- 1018

  Fly  1128 LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTAS-INS 1191
                  |:.||    :|......|.......:....|...::...:::..|:|....|.|. :.:
Human  1019 ------EVAAD----EGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPA 1073

  Fly  1192 YGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLD--EELDEEGECEEGPLDGDIIIHAHDED 1254
            .|:|....::      :|....|.|..:.....:..|  .::.:.|:..|...:.|..:......
Human  1074 VGAHPRAAWR------AAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRK 1132

  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPF-WQGWGNLRLKTFQLIENKYFETAVITMILMSSLAL 1318
            ::|.|..|.|.          ..:|.|.: :......|:....:|.:|.|:..|:..|.::.:.:
Human  1133 MIDVYKPDWCE----------VREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITI 1187

  Fly  1319 ALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSL 1379
            |||...:......:..|...:.|||.||..||.:|.::||.    :.|..::|..||..:|.||:
Human  1188 ALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSI 1252

  Fly  1380 INFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1441
            |:.|.||..|||   :...:.:|.||.|||||.:||..|:::||..|:.::..|.|::|:|..|:
Human  1253 IDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFF 1317

  Fly  1442 LIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVA 1506
            :||.|:|||||.||::.|..::...     |.||:.|.:.||.||:...|||::|.|.:.||.:|
Human  1318 IIFGILGVQLFKGKFYHCLGVDTRN-----ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377

  Fly  1507 TFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNE--QKKK 1569
            :..||:.||.:.:|:..||:||:...|.:|.|||:.|::..|||.||:|:||:::||::  |.::
Human  1378 SKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQE 1442

  Fly  1570 AGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW----RPQAIVFEIVTDKKFDIIIMLFIG 1630
            |        .|.:::....:::: .||..||...|.:    ..:.::..:.|....||.|...|.
Human  1443 A--------EEARRREEKRLRRL-EKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1498

  Fly  1631 LNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI--FALRYHYFIEPWNLFDVVVVILS 1693
            ||:.||:|:.|:...:....|.|.|.:|..:|..|.:||:  |.|| .:|.:.||..|:.:|:||
Human  1499 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLS 1562

  Fly  1694 ILGLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1756
            ::|:.|.:| |.... ::||::|::||.::.|||:|:|.|.|:|.||..:..:||.:.|:.||..
Human  1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFM 1627

  Fly  1757 LVMFIFAIFGMSFFMHV-----KEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA 1816
            |:.||:|..|:..|..:     ....|::....|:.||.:.:.|||:||...|:|::...:.:  
Human  1628 LLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD-- 1690

  Fly  1817 CDPPDNDKGYPGNCGSAT--VGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1879
            |...:.      :|.|:.  |...:.:|:::.:..::||:.:||::::...:.::.||   |.:.
Human  1691 CTHDER------SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE---DAEM 1746

  Fly  1880 DMYYEIWQQF---------------------------DPEG----------TQYIRYDQLSEFL- 1906
            |...|:....                           |.||          .:.:..|.:|..: 
Human  1747 DAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIK 1811

  Fly  1907 DVLEPPLQI----------------------HKPNKYKIISMDIPICRGDLMYCVDILDALT--- 1946
            |.||..|.|                      |...:.::...:......|....:.:.|.|:   
Human  1812 DSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLED 1876

  Fly  1947 --------KDFFARKG--NPIE--ETGEIGE-------IAARPDTEG---------YEPVSSTLW 1983
                    ||   .||  :|.|  ..|::||       .|..||.|.         :.||.|   
Human  1877 PTACPPGRKD---SKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRS--- 1935

  Fly  1984 RQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNG 2048
                          |.||.:.......|.|     |...|..  |.|.|.......|...|...|
Human  1936 --------------WLKHDSSQAPPSPFSP-----DASSPLL--PMPAEFFHPAVSASQKGPEKG 1979

  Fly  2049 TAEG-----AADADESNVNSP-----------GEDAAAAAAAAAAAAAAGTT------------- 2084
            |..|     |.....:::.||           |.|.:..|:.:::|.:..||             
Human  1980 TGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRR 2044

  Fly  2085 ------TAGSPGAG-SAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTA 2129
                  .|..|.|| |...:..:.:...|..:..|.:.  |.||.|....|:
Human  2045 ALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRA--HQRSHSSGGSTS 2094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/328 (26%)
Na_trans_cytopl 515..648 CDD:288761 14/132 (11%)
Ion_trans 835..1028 CDD:278921 69/200 (35%)
Na_trans_assoc 1054..1296 CDD:284034 42/332 (13%)
Ion_trans 1318..1571 CDD:278921 100/261 (38%)
Na_channel_gate 1561..1613 CDD:240441 10/57 (18%)
Ion_trans 1636..1871 CDD:278921 71/245 (29%)
GPHH 1880..1930 CDD:293510 13/109 (12%)
CACNA1INP_066919.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46 12/31 (39%)
I 66..401 89/349 (26%)
Ion_trans 127..409 CDD:278921 78/298 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..536 22/146 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 17/126 (13%)
II 626..865 84/246 (34%)
Ion_trans 657..866 CDD:278921 76/216 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..936 0/36 (0%)
III 1157..1434 103/281 (37%)
Ion_trans 1202..1441 CDD:278921 97/243 (40%)
IV 1472..1733 79/269 (29%)
Ion_trans 1504..1741 CDD:278921 71/245 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1758..1784 0/25 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1897 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1937..1960 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2062 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2076..2223 6/21 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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