DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Scn1a

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_110502.2 Gene:Scn1a / 81574 RGDID:69364 Length:2009 Species:Rattus norvegicus


Alignment Length:2085 Identity:943/2085 - (45%)
Similarity:1291/2085 - (61%) Gaps:268/2085 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            |..||||||..||:|||.|..|..:.::|                      :|::.||:|:..||
  Rat    14 FNFFTRESLAAIERRIAEEKAKNPKPDKK----------------------DDDENGPKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.||||||:.|:::|.||||:|::
  Rat    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
  Rat   121 AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||..||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
  Rat   186 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW--------------GNLTDE-----NWD 320
            :|||:|.||||||:|||::||.|..||::..|.:.|.              |.|.:|     :|.
  Rat   251 MILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNVTTDYNGTLVNETVFEFDWK 315

  Fly   321 YHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLM 385
            .:.::|...|..:..:...||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||||
  Rat   316 SYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYGYTSFDTFSWAFLSLFRLM 379

  Fly   386 TQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEA- 449
            ||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.::|| 
  Rat   380 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKEAE 443

  Fly   450 ----------IREAEEAAAAKAAKLEERANAQAQAAADAA---------AAEEAALHPEMAKSPT 495
                      .:||.:.|||..|....|..:.|...:|::         :|:|.....:..|...
  Rat   444 FQQMLEQLKKQQEAAQQAAAATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKE 508

  Fly   496 YSCISYELFVGGEKGNDD---NNKEKMSIR----SVEVESESVSVIQRQPAPTTAHQATKVRKVS 553
            .|        |||:.:||   .::.:.|||    ...:|...::..:|..:|   ||:.      
  Rat   509 QS--------GGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSP---HQSL------ 556

  Fly   554 TTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTP 618
               ||:.||.|:.||.||:|    :.:.|||....||:.               .:|||.::...
  Rat   557 ---LSIRGSLFSPRRNSRTS----LFSFRGRAKDVGSEN---------------DFADDEHSTFE 599

  Fly   619 MSE-ENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRN 682
            .:| ...::.||..:|...:.:.|.||..||        :|.|:...|        |:.:....|
  Rat   600 DNESRRDSLFVPRRHGERRNSNLSQTSRSSR--------MLAGLPANG--------KMHSTVDCN 648

  Fly   683 QSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHH---DNPFIEPVQTQTVVDMK----- 739
            ..|....|.:.                  .|...|::...   |.|..:...|.|..:|:     
  Rat   649 GVVSLVGGPSV------------------PTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSS 695

  Fly   740 DVMVLNDIIEQAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCC 801
            ...|..|.:|..:.|     .|.:|:....|   |:.:|.    :.|......|..::|.:|||.
  Rat   696 SFHVSMDFLEDPSQR-----QRAMSIASILTNTVEELEES----RQKCPPCWYKFSNIFLIWDCS 751

  Fly   802 WVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEAT 866
            ..|||.:..|:|:|.||||:|.||:|||:||:||||:|:.|.:....||..||..||..|..|..
  Rat   752 PYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMF 816

  Fly   867 MKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLIS 931
            :|::||.|.|||||||||||..||.|||:||||..|:||||||||||||||||||||||||:||.
  Rat   817 LKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIK 881

  Fly   932 IMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFR 995
            |:|.::|||||||.||.||:|||||:|||||||:|.|...:. .|..||||:..||.|||:||||
  Rat   882 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFR 946

  Fly   996 VLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNK 1059
            ||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.:.:|:|...||:.|.
  Rat   947 VLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNN 1011

  Fly  1060 IAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISA 1121
            :..|.:|:.:..::|||.|.:..:   :.:.|:.::|  :|..:..|:        |..|.    
  Rat  1012 LQIAVDRMHKGVAYVKRKIYEFIQQSFVRKQKILDEI--KPLDDLNNR--------KDNCT---- 1062

  Fly  1122 EHGDNELELGHD-EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDD 1185
              .::..|:|.| :.|.|       ...|...:..|..:|               ||:.:.:|  
  Rat  1063 --SNHTTEIGKDLDCLKD-------VNGTTSGIGTGSSVE---------------KYIIDESD-- 1101

  Fly  1186 TASINSYGSHKNRPF----------KDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG 1240
                  |.|..|.|.          :.:....:.|....|...:.||      |:|:|.....||
  Rat  1102 ------YMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESK------EKLNESSSSSEG 1154

  Fly  1241 PLDGDIIIHAHDEDILDE----YPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENK 1301
            . ..||...|.::.:::.    .|..|..:...::|.......:....:.|.|||...|:::|:.
  Rat  1155 S-TVDIGAPAEEQPVMEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHN 1218

  Fly  1302 YFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNA 1366
            :|||.::.|||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.|::.|||||
  Rat  1219 WFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNA 1283

  Fly  1367 WCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1431
            ||||||:||.|||::..|:.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.
  Rat  1284 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIM 1348

  Fly  1432 NVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEI--IPNRNAC-----ESENYTWVNSA 1489
            |||||||||||||:||||.|||||::.|.:.. |..:.||  :.|.:.|     .:|...|.|..
  Rat  1349 NVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTT-TGDTFEITEVNNHSDCLKLIERNETARWKNVK 1412

  Fly  1490 MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNL 1554
            :|||:||..||.|.||||||||:.||..|:|||.|:.||..|.::|||||||.||||||||||||
  Rat  1413 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNL 1477

  Fly  1555 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDK 1619
            ||||||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:
  Rat  1478 FIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQ 1541

  Fly  1620 KFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNL 1684
            .|||.||:.|.|||.||.::..|.||...::|..:|.:|:|:|:.||:||:.:||::||...||:
  Rat  1542 VFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNI 1606

  Fly  1685 FDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALF 1749
            ||.|||||||:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||
  Rat  1607 FDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1671

  Fly  1750 NICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE 1814
            ||.|||||||||:||||||.|.:||.:.||:|::||:|||.|||.|||::|||||||:|..|:|.
  Rat  1672 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 1736

  Fly  1815 EA--CDPPDNDKG--YPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLT 1875
            :.  |||...:.|  ..|:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|:
  Rat  1737 KPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1801

  Fly  1876 DDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVD 1940
            :||::|:||:|::|||:.||::.:::||:|...|||||.:.:|||.::|:||:|:..||.::|:|
  Rat  1802 EDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLD 1866

  Fly  1941 ILDALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQH 1996
            ||.|.||       ..:.|:||:..:         |:.|....|:|:::||.|::||..|.:||.
  Rat  1867 ILFAFTK-------RVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1924

  Fly  1997 AWRKH 2001
            |:|:|
  Rat  1925 AYRRH 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 165/290 (57%)
Na_trans_cytopl 515..648 CDD:288761 33/137 (24%)
Ion_trans 835..1028 CDD:278921 124/194 (64%)
Na_trans_assoc 1054..1296 CDD:284034 49/259 (19%)
Ion_trans 1318..1571 CDD:278921 158/259 (61%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 145/238 (61%)
GPHH 1880..1930 CDD:293510 23/49 (47%)
Scn1aNP_110502.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 13/53 (25%)
I. /evidence=ECO:0000305 110..454 191/345 (55%)
Ion_trans 127..433 CDD:395416 174/307 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..528 16/77 (21%)
Na_trans_cytopl 510..718 CDD:403218 61/285 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..628 12/58 (21%)
II. /evidence=ECO:0000305 750..1022 167/271 (62%)
Ion_trans 767..980 CDD:395416 137/212 (65%)
Na_trans_assoc 1006..1213 CDD:399489 49/259 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 11/40 (28%)
III. /evidence=ECO:0000305 1200..1514 188/315 (60%)
Ion_trans 1217..1492 CDD:395416 165/275 (60%)
Na_channel_gate 1484..1536 CDD:240441 36/52 (69%)
IV. /evidence=ECO:0000305 1523..1821 175/297 (59%)
Ion_trans 1540..1796 CDD:395416 155/255 (61%)
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1561..1571 3/9 (33%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1619..1636 11/16 (69%)
GPHH 1808..1855 CDD:407139 22/46 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1986..2009
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 342 1.000 Domainoid score I1036
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1645 1.000 Inparanoid score I74
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm45846
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X214
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

Return to query results.
Submit another query.