Protein Alignment para and Scn1a

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: NP_110502.2
• Gene: Scn1a / 81574
• RGDID: 69364
• Length: 2009
• Species: Rattus norvegicus
• Alignment Length: 2085
• Identity: 943/2085 - (45%)
• Similarity: 1291/2085 - (61%)
• Gaps: 268/2085 - (12%)

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            |..||||||..||:|||.|..|..:.::|                      :|::.||:|:..||
  Rat    14 FNFFTRESLAAIERRIAEEKAKNPKPDKK----------------------DDDENGPKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.||||||:.|:::|.||||:|::
  Rat    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
  Rat   121 AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||..||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
  Rat   186 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW--------------GNLTDE-----NWD 320
            :|||:|.||||||:|||::||.|..||::..|.:.|.              |.|.:|     :|.
  Rat   251 MILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNVTTDYNGTLVNETVFEFDWK 315

  Fly   321 YHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLM 385
            .:.::|...|..:..:...||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||||
  Rat   316 SYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYGYTSFDTFSWAFLSLFRLM 379

  Fly   386 TQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEA- 449
            ||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.::||
  Rat   380 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKEAE 443

  Fly   450 ----------IREAEEAAAAKAAKLEERANAQAQAAADAA---------AAEEAALHPEMAKSPT 495
                      .:||.:.|||..|....|..:.|...:|::         :|:|.....:..|...
  Rat   444 FQQMLEQLKKQQEAAQQAAAATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKE 508

  Fly   496 YSCISYELFVGGEKGNDD---NNKEKMSIR----SVEVESESVSVIQRQPAPTTAHQATKVRKVS 553
            .|        |||:.:||   .::.:.|||    ...:|...::..:|..:|   ||:.
  Rat   509 QS--------GGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSP---HQSL------ 556

  Fly   554 TTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTP 618
               ||:.||.|:.||.||:|    :.:.|||....||:.               .:|||.::...
  Rat   557 ---LSIRGSLFSPRRNSRTS----LFSFRGRAKDVGSEN---------------DFADDEHSTFE 599

  Fly   619 MSE-ENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRN 682
            .:| ...::.||..:|...:.:.|.||..||        :|.|:...|        |:.:....|
  Rat   600 DNESRRDSLFVPRRHGERRNSNLSQTSRSSR--------MLAGLPANG--------KMHSTVDCN 648

  Fly   683 QSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHH---DNPFIEPVQTQTVVDMK----- 739
            ..|....|.:.                  .|...|::...   |.|..:...|.|..:|:
  Rat   649 GVVSLVGGPSV------------------PTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSS 695

  Fly   740 DVMVLNDIIEQAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCC 801
            ...|..|.:|..:.|     .|.:|:....|   |:.:|.    :.|......|..::|.:|||.
  Rat   696 SFHVSMDFLEDPSQR-----QRAMSIASILTNTVEELEES----RQKCPPCWYKFSNIFLIWDCS 751

  Fly   802 WVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEAT 866
            ..|||.:..|:|:|.||||:|.||:|||:||:||||:|:.|.:....||..||..||..|..|..
  Rat   752 PYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMF 816

  Fly   867 MKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLIS 931
            :|::||.|.|||||||||||..||.|||:||||..|:||||||||||||||||||||||||:||.
  Rat   817 LKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIK 881

  Fly   932 IMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFR 995
            |:|.::|||||||.||.||:|||||:|||||||:|.|...:. .|..||||:..||.|||:||||
  Rat   882 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFR 946

  Fly   996 VLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNK 1059
            ||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.:.:|:|...||:.|.
  Rat   947 VLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNN 1011

  Fly  1060 IAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISA 1121
            :..|.:|:.:..::|||.|.:..:   :.:.|:.::|  :|..:..|:        |..|.
  Rat  1012 LQIAVDRMHKGVAYVKRKIYEFIQQSFVRKQKILDEI--KPLDDLNNR--------KDNCT---- 1062

  Fly  1122 EHGDNELELGHD-EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDD 1185
              .::..|:|.| :.|.|       ...|...:..|..:|               ||:.:.:|
  Rat  1063 --SNHTTEIGKDLDCLKD-------VNGTTSGIGTGSSVE---------------KYIIDESD-- 1101

  Fly  1186 TASINSYGSHKNRPF----------KDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG 1240
                  |.|..|.|.          :.:....:.|....|...:.||      |:|:|.....||
  Rat  1102 ------YMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESK------EKLNESSSSSEG 1154

  Fly  1241 PLDGDIIIHAHDEDILDE----YPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENK 1301
            . ..||...|.::.:::.    .|..|..:...::|.......:....:.|.|||...|:::|:.
  Rat  1155 S-TVDIGAPAEEQPVMEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHN 1218

  Fly  1302 YFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNA 1366
            :|||.::.|||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.|::.|||||
  Rat  1219 WFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNA 1283

  Fly  1367 WCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1431
            ||||||:||.|||::..|:.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.
  Rat  1284 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIM 1348

  Fly  1432 NVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEI--IPNRNAC-----ESENYTWVNSA 1489
            |||||||||||||:||||.|||||::.|.:.. |..:.||  :.|.:.|     .:|...|.|..
  Rat  1349 NVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTT-TGDTFEITEVNNHSDCLKLIERNETARWKNVK 1412

  Fly  1490 MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNL 1554
            :|||:||..||.|.||||||||:.||..|:|||.|:.||..|.::|||||||.||||||||||||
  Rat  1413 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNL 1477

  Fly  1555 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDK 1619
            ||||||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:
  Rat  1478 FIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQ 1541

  Fly  1620 KFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNL 1684
            .|||.||:.|.|||.||.::..|.||...::|..:|.:|:|:|:.||:||:.:||::||...||:
  Rat  1542 VFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNI 1606

  Fly  1685 FDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALF 1749
            ||.|||||||:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||
  Rat  1607 FDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1671

  Fly  1750 NICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE 1814
            ||.|||||||||:||||||.|.:||.:.||:|::||:|||.|||.|||::|||||||:|..|:|.
  Rat  1672 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 1736

  Fly  1815 EA--CDPPDNDKG--YPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLT 1875
            :.  |||...:.|  ..|:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|:
  Rat  1737 KPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1801

  Fly  1876 DDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVD 1940
            :||::|:||:|::|||:.||::.:::||:|...|||||.:.:|||.::|:||:|:..||.::|:|
  Rat  1802 EDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLD 1866

  Fly  1941 ILDALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQH 1996
            ||.|.||       ..:.|:||:..:         |:.|....|:|:::||.|::||..|.:||.
  Rat  1867 ILFAFTK-------RVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1924

  Fly  1997 AWRKH 2001
            |:|:|
  Rat  1925 AYRRH 1929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	173/303 (57%)
		Na_trans_cytopl	555..740	CDD:463401	41/193 (21%)
		Ion_trans	817..1028	CDD:459842	137/212 (65%)
		Na_trans_assoc	1054..1296	CDD:461936	49/259 (19%)
		Ion_trans	1300..1571	CDD:459842	167/277 (60%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1621..1871	CDD:459842	155/253 (61%)
		GPHH	1882..1929	CDD:465306	22/46 (48%)
Scn1a	NP_110502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..60		13/53 (25%)
		I. /evidence=ECO:0000305	110..454		191/345 (55%)
		Ion_trans	127..433	CDD:459842	174/307 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..528		16/77 (21%)
		Na_trans_cytopl	555..718	CDD:463401	47/229 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..628		12/58 (21%)
		II. /evidence=ECO:0000305	750..1022		167/271 (62%)
		Ion_trans	767..980	CDD:459842	137/212 (65%)
		Na_trans_assoc	1006..1213	CDD:461936	49/259 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1163		11/40 (28%)
		III. /evidence=ECO:0000305	1200..1514		188/315 (60%)
		Ion_trans	1217..1492	CDD:459842	165/275 (60%)
		Na_channel_gate	1484..1536	CDD:240441	36/52 (69%)
		IV. /evidence=ECO:0000305	1523..1821		175/297 (59%)
		Ion_trans	1540..1796	CDD:459842	155/255 (61%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8	1561..1571		3/9 (33%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8	1619..1636		11/16 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1986..2009