Protein Alignment para and scn12aa

DIOPT Version :9

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_009297176.1
• Gene: scn12aa / 795688
• ZFINID: ZDB-GENE-060908-2
• Length: 1940
• Species: Danio rerio
• Alignment Length: 2057
• Identity: 929/2057 - (45%)
• Similarity: 1231/2057 - (59%)
• Gaps: 292/2057 - (14%)

  Fly    17 RPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQ 81
            ||||||||..|||||:.|                    |.:..|:.:.|..|.:| |:|...||.
Zfish    14 RPFTRESLAAIEQRISEE--------------------RARNTKDYKADPGDVEE-PKPRADLEV 57

  Fly    82 GVPIPVRLQGSFPPELASTPLEDIDP-YYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            |..:| |:.|..|..|...||||||| |:.|..||:|::|||.||||||:.|:::..||:.|||:
Zfish    58 GKVLP-RIFGEIPAGLVGVPLEDIDPFYFRNQKTFIVLNKGKAIFRFSATSALYIFSPFHCIRRI 121

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            :|.||||.||||||:.|||.||..|.|...|. .:..|..|||||||||.:|::||||....||:
Zfish   122 SIRILVHSLFSLFIMCTILTNCCFMAMSDPPLWTKYLEYTFTGIYTFESLIKILARGFCTECFTF 186

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
Zfish   187 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADV 251

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKK--------FPLDGSWGNLTDENW----DYHNRNSS 327
            :|||:|.||||||:|||::||:|.|||::.        :|.:||: ...::.|    |:.. |..
Zfish   252 MILTVFCLSVFALIGLQLFMGILRQKCVRSIGHCVNSTYPGNGSF-VCNNKTWLSVKDFLT-NED 314

  Fly   328 NWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWED 392
            |:|..:......:||..|.||:|.|.:.||: ...||||||||||:||||||..|||||||:||.
Zfish   315 NFYKIEGSKDALICGYSSDAGKCPDGFDCLK-TSRNPNYGYTSFDTFGWAFLGLFRLMTQDYWES 378

  Fly   393 LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEA-IREAEEA 456
            ||...||:||..:|:||:::||||||||||||||:|||:|:      |:.:|...|| .:|.|..
Zfish   379 LYHQTLRSAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYE------EQNQATIAEAWAKEREFQ 437

  Fly   457 AAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSI 521
            .|.:..:.|:||.|: |...:|    |.||..:...||.              ...|:.|.:...
Zfish   438 LAMEHLRKEQRALAK-QRRKEA----EMALAADFCPSPF--------------SRKDSIKCRTRT 483

  Fly   522 RSVEVESESV--------SVIQRQPA-PTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSS-HKY 576
            ||....||.:        ..:..:|| |..|              :|...|.:.||||:.| ..:
Zfish   484 RSHRTLSEEIEDSFLPKFEPLDEKPAHPLLA--------------TLSSHPLSTRRGSQMSIFTF 534

  Fly   577 TIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEEN-GAIIVPVYYGNLGSRHS 640
            ..||                 |:..|      :|||.::|....... |::..|.:....|
Zfish   535 RPRN-----------------SSEAD------FADDEHSVADYGRSRAGSMATPWHKHRTG---- 572

  Fly   641 SYTSHQSRISYT---SHGDL-----LGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDT 697
            |..||.|:: :|   ::|.|     ..|:..:|:.|.|...|
Zfish   573 SIRSHSSQV-FTPTLANGRLNISLEQNGITGIGLHTPTTGPK----------------------- 613

  Fly   698 NHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRG 762
                      ..:|      |:|....|..:..|.:..||:::        |....|..|...
Zfish   614 ----------FSME------KVKEGTEPECQNEQVKLTVDVQE--------EVLPPRRKRGLS-- 652

  Fly   763 VSVYYFPTEDDD-EDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITL 826
             ||.:|....|: |:.   :.|......:....:.:|.|...||:.:|.:.::|.|||::|.||:
Zfish   653 -SVSFFSDAMDELEEA---RQKCPPCWYEFAQKYLIWTCSPAWLRVKEGLKVMVMDPFLDLAITI 713

  Fly   827 CIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA 891
            |||:||:|||::|:.|..|...:|..||..||..|..|..:|:.|:.|.||||:||||||.|||.
Zfish   714 CIVLNTLFMALEHYPMTDEFNSMLSIGNLVFTGIFTAEMVLKIFALDPYYYFQQGWNIFDGIIVC 778

  Fly   892 LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAV 956
            |||:||||..|:||||||||||||||||||||||||.||.|:|.::|||||||.||.||:|||||
Zfish   779 LSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAV 843

  Fly   957 MGMQLFGKNYHDHKDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPF 1019
            :|||||||||.|...:.. |..||||:..||.|||:||||||||||||:|||||.| |...||..
Zfish   844 VGMQLFGKNYQDCVCKISYDCTLPRWHMKDFFHSFLIVFRVLCGEWIETMWDCMEVAGQPLCILV 908

  Fly  1020 FLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKL 1084
            |:..:|||||||||||||||||:|.|.:||||..|.:.|.:..|..||....||:...|.|.|
Zfish   909 FMLVMVIGNLVVLNLFLALLLSSFSSDNLSAPDEDGEMNNLQIAIARIHCGFSWLLNGIKDLF-- 971

  Fly  1085 IRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILAD-GLIKKGIKEQ 1148
                         ||..|..               ..:..:.::.|.|.|.... |.::|.:..:
Zfish   972 -------------SGNLTRH---------------RRKSKEAQVTLNHTECNGGLGSLEKYVFPE 1008

  Fly  1149 TQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETME 1213
            |:                        ..|:.|........| :.|.......::|..:...|:.|
Zfish  1009 TE------------------------DSYMTNPNLTICVPI-APGESDVEFLEEEEEEEDTESSE 1048

  Fly  1214 GEEKRDASKEDLGLDE----ELDEEGECEEGPLDGDIIIHAHDE---DILDEYPADCCPDSYYKK 1271
            .||::   :|.:.|.|    :|.:.||.||          .:.|   |.:|  |.:|.|:...::
Zfish  1049 DEEEK---QEVISLSEGSTVDLRKPGEDEE----------EYSEMADDGMD--PEECFPEFCMQR 1098

  Fly  1272 FPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILY 1336
            ......:......|.|..||...:|::|:.:|||.:|.|||:||.|||.||:::.||.:::.:|.
Zfish  1099 CKCCNINTTQGLGQMWWRLRKTCYQIVEHSWFETFIIFMILLSSGALAFEDIYIEQRKVVKVVLE 1163

  Fly  1337 YMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTL 1401
            |.|::|:.||.|||.:||:|.|||.||||.||||||:||.||||:.||:.:|.....|.|::|||
Zfish  1164 YADKVFSYIFVLEMFLKWIAYGFKKYFTNYWCWLDFLIVDVSLISLVANSLGYSDFGAIKSLRTL 1228

  Fly  1402 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTK 1466
            ||||||||:||.:|||||||||:.|||||.|||||||||||||:||||.|||||:.||.:..|..
Zfish  1229 RALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGKCVNRTGFI 1293

  Fly  1467 LSHEIIPNRNACESENYT---WVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQP 1528
            .:..|:.|:..|.|.|.|   |....:|||:||..||.|.||||||||::||..|:|||.|:.||
Zfish  1294 HNASIVNNKTECLSMNDTQFYWTKVKVNFDNVGLGYLSLLQVATFKGWMEIMYAAVDSRGVEDQP 1358

  Fly  1529 IRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMG 1593
            |:|.|:|||||||.||||||||||||||||||||||:||:..||. ::||||:||||||||||:|
Zfish  1359 IKEINLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKRMIGGQ-DIFMTEEQKKYYNAMKKLG 1422

  Fly  1594 SKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIF 1658
            ||||.|.||||....|...|::|:.:.|||.||:.|.|||.||.::..:.|.....:|:.:|..|
Zfish  1423 SKKPQKPIPRPMNILQGFFFDLVSKQAFDITIMMLIILNMITMMVETDEQSARMETILNNINLAF 1487

  Fly  1659 VVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSIL--------GLVLSDIIEKYFVSPTLLRV 1715
            :|||::|||:||||||.::|...||:||.|||||||:        |:||:||||||||||||.||
Zfish  1488 IVIFTTECLIKIFALRCYFFTISWNIFDFVVVILSIVGKCTTFQSGIVLADIIEKYFVSPTLFRV 1552

  Fly  1716 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGIN 1780
            :|:|::||||||::.|||||||||||.|||||||||.|||||||||:|||||:.|.:||::.||:
Zfish  1553 IRLARIGRVLRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMANFAYVKKQGGID 1617

  Fly  1781 DVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE--EACDPPDNDKG--YPGNCGSATVGITFLL 1841
            |::||:|||.|||.|||::|||||:.:||.|:|.  |.|.....:.|  ..||||..:|||||.:
Zfish  1618 DMFNFETFGNSMICLFQITTSAGWNNLLDPILNNSPEECSSSFANTGTNTKGNCGHPSVGITFFV 1682

  Fly  1842 SYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFL 1906
            ||::||||||:|||||:||||:|.|||:..|.|::||::|:||:|::||.|.|.:|.|.:||.|.
Zfish  1683 SYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDVEATHFIEYAKLSNFA 1747

  Fly  1907 DVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEI----- 1966
            |.|..||:|.||||.|:|.||:|:..||.::|:|||.|.||       ..:.||||:..:
Zfish  1748 DSLSEPLRIAKPNKIKLIHMDLPMVNGDRIHCLDILFAFTK-------RVLGETGEMDALKQQME 1805

  Fly  1967 ----AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR 2004
                ...|....:||:::||.|::||..|.|||.|:|.|..|
Zfish  1806 EKFMVTNPSKISHEPITTTLRRKQEEISATLIQRAYRAHLIR 1847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	158/283 (56%)
		Na_trans_cytopl	515..648	CDD:288761	30/143 (21%)
		Ion_trans	835..1028	CDD:278921	124/194 (64%)
		Na_trans_assoc	1054..1296	CDD:284034	46/249 (18%)
		Ion_trans	1318..1571	CDD:278921	160/255 (63%)
		Na_channel_gate	1561..1613	CDD:240441	33/51 (65%)
		Ion_trans	1636..1871	CDD:278921	147/246 (60%)
		GPHH	1880..1930	CDD:293510	26/49 (53%)
scn12aa	XP_009297176.1	Ion_trans	146..425	CDD:278921	157/287 (55%)
		Na_trans_cytopl	<520..579	CDD:288761	20/85 (24%)
		Ion_trans	722..917	CDD:278921	124/194 (64%)
		Na_trans_assoc	943..1123	CDD:284034	46/249 (18%)
		Ion_trans	1145..1398	CDD:278921	159/252 (63%)
		Na_channel_gate	1391..1443	CDD:240441	33/52 (63%)
		Ion_trans	1465..1711	CDD:278921	147/245 (60%)
		GPHH	1723..1775	CDD:293510	26/51 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1619	1.000	Inparanoid score	I77
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm24873
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.880