DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and scn8ab

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_005166128.1 Gene:scn8ab / 793996 ZFINID:ZDB-GENE-060906-2 Length:1969 Species:Danio rerio


Alignment Length:2112 Identity:941/2112 - (44%)
Similarity:1283/2112 - (60%) Gaps:280/2112 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            |:.||.|||..||:|| ||.:|:|.:               |.:.:..:.|:|:|..|:|:..||
Zfish    14 FKRFTPESLANIEKRI-AEEKKKKPV---------------KPRSDSSHRDDDDDNKPKPNSDLE 62

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|..:.:.||||:||:|.|..||:|::|||.||||||:.:::::.|||..|::
Zfish    63 AGKGVPF-IYGDVPSNMLAVPLEDLDPFYLNKKTFIVLNKGKTIFRFSATPSLYIISPFNLFRQI 126

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||:|.:||:.|:.|||.||:.|.....|. .:..|..|||||||||..|::||||.:..||:
Zfish   127 AIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESLTKIVARGFCIDDFTF 191

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||:||::||:|..::|||::|||||||||||||||::|||||||||:|:|||.|.||
Zfish   192 LRDPWNWLDFMVISMAYITEFVNLGNVSALRTFRVLRALKTVAVIPGLKTIVGALIQSVKKLSDV 256

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCI-------KKFPLDGSWGNLTDENWDYHN--RNSSNWY 330
            :|||:|.||||||:|||::||.|.|||:       :.:..:||.|      :|::.  .|.:|:|
Zfish   257 MILTVFCLSVFALIGLQLFMGNLRQKCVIWPVNSTETYLANGSKG------FDFNEYIMNDTNFY 315

  Fly   331 SEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQ 395
            .....:...||||.|.:|:|.:.|.|::. |.|||||||||||||||||:.||||||||||:|||
Zfish   316 FLPGMLDALLCGNSSDSGRCPEGYTCMKA-GRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQ 379

  Fly   396 LVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAK 460
            |.|||||..:|:||:::||:|||||||||||:|||:|:| |.:|..|||.::||   ..:|...:
Zfish   380 LTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE-QNQATIEEAEQKEA---EFKAMLEQ 440

  Fly   461 AAKLEERANAQAQAAADAAAAEEAAL-----HPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMS 520
            ..|.:|.|.|.|.|.:....:|:|..     |...:.|....       :..:...:..|::|..
Zfish   441 LKKQQEEAQANAMATSAGTVSEDAVEDDGGGHLSRSSSEVSK-------LSSKSAKERRNRKKKW 498

  Fly   521 IRSVEVESESVSVIQRQPAPTTAHQATKVRK---------VSTTSLSLPGSPFNIRRGSRSSHKY 576
            .:..|.:.:|..|::.:....:.....:.|.         ::.:.||:|||||..||.|..|.| 
Zfish   499 RKEQEEKGDSEKVVKSESDDGSKRSRFRFRDNRLGRKASIMNQSLLSIPGSPFMSRRSSIFSFK- 562

  Fly   577 TIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEE-NGAIIVPVYYGNLGSRHS 640
                        ||:.:               :|||.::....||: .|::.||  |..  |.:|
Zfish   563 ------------GSENE---------------FADDEHSTVEESEDRRGSLFVP--YRR--SSYS 596

  Fly   641 SYTSHQSRIS---------YTSHGDLLGGMAVM--GVSTMTKESKLRNRNTRNQSVGATNGGTTC 694
            .|:...|||:         ..|..|..|.::::  |...:..|.|:        ...|::..|  
Zfish   597 GYSQGSSRINPLAPHPGCKRNSTVDCNGVVSLIGPGPGRLLPEVKI--------DKAASDDST-- 651

  Fly   695 LDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKD------VMVLNDIIEQAAG 753
                              |:..||.||..:..:...|..|....|:      .:|.|.::|:.  
Zfish   652 ------------------TEVEGKRKHSGSLMVSVDQLNTSFSRKERANSAMTVVTNTLVEEL-- 696

  Fly   754 RHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDP 818
               ..|.|.....::                     |..:.|.:|:||.:|:|.:|.|:|||.||
Zfish   697 ---EESQRKCPPCWY---------------------KFANTFLIWECCPIWIKIKEIVNLIVMDP 737

  Fly   819 FVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWN 883
            ||:|.||:|||:||:||||:|:.|....|.||..||..||..|..|...||:||.|.||||||||
Zfish   738 FVDLAITICIVLNTVFMAMEHYPMTPRFEEVLSVGNLVFTGIFTAEMFAKLIAMDPYYYFQEGWN 802

  Fly   884 IFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLC 948
            |||..||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::|||||||.||.
Zfish   803 IFDGFIVSLSLVELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 867

  Fly   949 IIIFIFAVMGMQLFGKNYHDHKDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV- 1011
            ||:|||||:|||||||:|.|...:..:. :||||:..||.|||:||||||||||||:|||||.| 
Zfish   868 IIVFIFAVVGMQLFGKSYKDCVCKIAESCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVA 932

  Fly  1012 GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKR 1076
            |...|:..|:..:|||||||||||||||||:|.:.:|:|...|.:.|.:..:..||.:..:|.|.
Zfish   933 GQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGIAWFKI 997

  Fly  1077 NIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLI 1141
            ::......:..|...:..|:|..:..                      |.:|.|           
Zfish   998 HVRLLVAHVLKKKPLEDEDKPLDDMY----------------------DKKLNL----------- 1029

  Fly  1142 KKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYG---------SHKN 1197
               :...|.:|:..||           .|.||..   |..|....:|:..|.         .:.|
Zfish  1030 ---MGNHTGVEIKCGD-----------LNYPKNG---NGTTSGIGSSVGKYMIDEEPMSFIHNPN 1077

  Fly  1198 RPFKDESHKGSAETMEGEEKRDASKE-DLGLDEELDEEGECEEGPLDGDIIIHAHDE-----DIL 1256
            ...:.....|.:: .|.....|.|.| |:...::||:....|...:|    |...:|     :::
Zfish  1078 LTVRVPIAVGESD-FENLNTEDFSSESDVENSKDLDDTSSSEGSTID----IKPDEEEMAVVEVV 1137

  Fly  1257 DEY--PADCCPDSYYKKFPILAGDDDSPFWQGWGN----LRLKTFQLIENKYFETAVITMILMSS 1315
            :||  |..|..|:...::...    |.|..:|||.    ||...:.::|:.:|||.:|.|||:||
Zfish  1138 EEYLDPEACWTDACVARYKCC----DVPITEGWGKYWWFLRKTCYLIVEHNWFETLIIFMILLSS 1198

  Fly  1316 LALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLI 1380
            .|||.|||::.||..:|.||.|.||:||.||.||||:||:|.||..|||||||||||.||.||::
Zfish  1199 GALAFEDVYIEQRKTIQIILEYADRVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIV 1263

  Fly  1381 NFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFA 1445
            :.:|:.:|...:...|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:
Zfish  1264 SLIANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1328

  Fly  1446 IMGVQLFAGKYFKCEDMNGTKLSH---EIIPNRNAC---ESENYT---WVNSAMNFDHVGNAYLC 1501
            ||||.||||||:.|  .|.|...:   :::.|:..|   .:.|||   |.|..:|||:||..||.
Zfish  1329 IMGVNLFAGKYYYC--FNQTAEEYFQVDVVNNKTECFALINANYTEVRWKNVKINFDNVGAGYLA 1391

  Fly  1502 LFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQ 1566
            |.||||||||:.||..|:|||:|:.||:.|.|||||:|||.||||||||||||||||||||||:|
Zfish  1392 LLQVATFKGWMDIMYAAVDSRKVEDQPLYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1456

  Fly  1567 KKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGL 1631
            |||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:.|.|
Zfish  1457 KKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGMVFDFVTQQAFDISIMMLICL 1520

  Fly  1632 NMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILG 1696
            ||.||.::..|.||....:|.::|.:|:|.|:.|.:||:||||::||...||:||.|||||||:|
Zfish  1521 NMVTMMVETDDQSDETENILYWINFVFIVAFTGEFVLKLFALRHYYFTNGWNVFDCVVVILSIVG 1585

  Fly  1697 LVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFI 1761
            :.|:|:||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||||||
Zfish  1586 MFLADLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1650

  Fly  1762 FAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN-EEACDPPDNDKG 1825
            |:|||||.|.:||.:.||:|:|||:|||.|||.||.::|||||||:|..|:| ...|||...:.|
Zfish  1651 FSIFGMSNFAYVKREIGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCDPNKENPG 1715

  Fly  1826 --YPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQ 1888
              ..||||:.:|||.|.:.|:::|||||:|||||:||||:|.|||:..:.|.:||::.:||||::
Zfish  1716 TTVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESADPLCEDDFESFYEIWEK 1780

  Fly  1889 FDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARK 1953
            |||:.:|:|.:.:|.:|.|.||.||::.|||..::|:||:|:..||.::|:|||.|.||......
Zfish  1781 FDPDASQFITFAKLPDFADTLEHPLRVPKPNIIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDS 1845

  Fly  1954 G--NPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKA-RG---------- 2005
            |  :.:.:..|...:||.|....|||:::||.|::||..|.:||.::|.|.| ||          
Zfish  1846 GDLDMMRQQMEERFVAANPSKVSYEPITTTLRRKQEEVSAIVIQRSYRSHLASRGFICKRRPANN 1910

  Fly  2006 ---EGGGSFEPDTDHGDGGDPDAGDPAPDEAT 2034
               .|||:.|..    :|....|..|:.|..|
Zfish  1911 KLENGGGNQEKK----EGTPSTASLPSYDSVT 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 162/280 (58%)
Na_trans_cytopl 515..648 CDD:288761 32/142 (23%)
Ion_trans 835..1028 CDD:278921 125/194 (64%)
Na_trans_assoc 1054..1296 CDD:284034 48/262 (18%)
Ion_trans 1318..1571 CDD:278921 165/261 (63%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 146/237 (62%)
GPHH 1880..1930 CDD:293510 22/49 (45%)
scn8abXP_005166128.1 Ion_trans 133..423 CDD:306908 170/297 (57%)
ARGLU <418..449 CDD:330370 11/34 (32%)
Na_trans_cytopl 503..672 CDD:314757 47/228 (21%)
Ion_trans 736..949 CDD:306908 138/212 (65%)
Na_trans_assoc 975..1178 CDD:310839 48/261 (18%)
Ion_trans 1183..1459 CDD:306908 173/277 (62%)
Na_channel_gate 1451..1503 CDD:240441 36/52 (69%)
Ion_trans 1508..1762 CDD:306908 156/253 (62%)
GPHH 1766..1829 CDD:318993 28/62 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 351 1.000 Domainoid score I972
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1619 1.000 Inparanoid score I77
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm24873
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1212.010

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