DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and CACNA1F

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_005174.2 Gene:CACNA1F / 778 HGNCID:1393 Length:1977 Species:Homo sapiens


Alignment Length:2194 Identity:515/2194 - (23%)
Similarity:871/2194 - (39%) Gaps:648/2194 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 EDEGPQPDPTLEQG-------VPIPVRLQG-SFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIF 125
            :|..|:|.|....|       .|.|..::| |.......||..  ...:|...|..|.|..:   
Human     8 KDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKR--RNQHSKHKTVAVASAQR--- 67

  Fly   126 RFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVES 180
               :.:|::.|...||:||..|.|:....|.:.|:.||..||:.:  .:|        ....:|.
Human    68 ---SPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQ 129

  Fly   181 TEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG----------- 234
            .|.:|..|:|.|:.:|::|.|.:|.|..|:|:.||.|||:::.:...::.::.|           
Human   130 VEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTG 194

  Fly   235 ------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 293
                  ::.|||.|||||.|:.|:.||.|..::.::::::..|..:.:|.:|.:.::|::||:::
Human   195 GKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELF 259

  Fly   294 MGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CDDDYVCL 357
            :|.:.:.|                    :...|.....||..   | |.: ||:|: |..:....
Human   260 LGRMHKTC--------------------YFLGSDMEAEEDPS---P-CAS-SGSGRACTLNQTEC 299

  Fly   358 QGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFY 419
            :|..|.||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||:
Human   300 RGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFF 362

  Fly   420 LVNLILAIVAMSYDELQKKAE---------EEEAAEEEA------IREAEEAAAAKAAKLEERAN 469
            ::||:|.:::..:.:.::||:         |::..||:.      |.:|||.         :..:
Human   363 VLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEEL---------DMED 418

  Fly   470 AQAQAAADAAAAEEAALH-PEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSV 533
            ..|.....:.|.|..|.| |::|          ||          .|:                 
Human   419 PSADDNLGSMAEEGRAGHRPQLA----------EL----------TNR----------------- 446

  Fly   534 IQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLS 598
                                                         |.||.|:             
Human   447 ---------------------------------------------RRGRLRW------------- 453

  Fly   599 TYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAV 663
                                                  ..||:.::|    |.:||..|    ..
Human   454 --------------------------------------FSHSTRSTH----STSSHASL----PA 472

  Fly   664 MGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIE 728
            ....:||:     .:...::..||....|.|                                  
Human   473 SDTGSMTE-----TQGDEDEEEGALASCTRC---------------------------------- 498

  Fly   729 PVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGID 793
                           ||.|::....|..|.::|                 ..:.:....:.... 
Human   499 ---------------LNKIMKTRVCRRLRRANR-----------------VLRARCRRAVKSNA- 530

  Fly   794 VFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFT 858
                  |.|.       |.|:||             :||:.:|.:||.....:.::.:..|....
Human   531 ------CYWA-------VLLLVF-------------LNTLTIASEHHGQPVWLTQIQEYANKVLL 569

  Fly   859 ATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFK 918
            ..|.:|..:||..:.|..|....:|.||..:|.     .:|:|:|.....|:||||..||||:||
Human   570 CLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFK 634

  Fly   919 LAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNF 983
            :.:.|.:|:.|::.:..:|.::.:|..:|.:.|.||:::||||||..::     |......|..|
Human   635 VTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDQTHTKRSTF 694

  Fly   984 TDFMHSFMIVFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLL 1040
            ..|..:.:.||::|.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:
Human   695 DTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCI-YFIILFICGNYILLNVFLAIAV 758

  Fly  1041 SNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQI 1105
            .|..|       .|..|.|                                    ...||::|: 
Human   759 DNLAS-------GDAGTAK------------------------------------DKGGEKSNE- 779

  Fly  1106 SWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNN 1170
                                                    |:..|....:..|:|          
Human   780 ----------------------------------------KDLPQENEGLVPGVE---------- 794

  Fly  1171 KPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEG 1235
                                          |:|.        ||..:..|..|:...:||.:||.
Human   795 ------------------------------KEEE--------EGARREGADMEEEEEEEEEEEEE 821

  Fly  1236 ECEEGPLDGDIIIHAHDEDILDE-YPADCCPDSYYKKFPILAGDDDSPFW--QGWGNLRLKTFQL 1297
            |.|||         |...::|.| .|.:       |..||..|   |.|:  .....||.....|
Human   822 EEEEG---------AGGVELLQEVVPKE-------KVVPIPEG---SAFFCLSQTNPLRKGCHTL 867

  Fly  1298 IENKYFETAVITMILMSSLALALEDVHLPQR--PILQDILYYMDRIFTVIFFLEMLIKWLALGFK 1360
            |.:..|...::..|::||::||.||   |.|  .....||.|.|..||.||.:|:|:|....|..
Human   868 IHHHVFTNLILVFIILSSVSLAAED---PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAF 929

  Fly  1361 VY---FTNAWC-WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVN 1421
            ::   |..:|. .||.::|.||||:|.   :.:..|...|.:|.||.||||||::|.:|::.||.
Human   930 LHRGSFCRSWFNMLDLLVVSVSLISFG---IHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQ 991

  Fly  1422 ALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCED-----MNGTKLSHEIIPNRNACES- 1480
            .:..||.:|.|:::|..:...:||.:|||||.||::.|.|     ....|.|..:.|:.:.... 
Human   992 CVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPL 1056

  Fly  1481 -ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFI 1544
             ....||||..|||:|.:|.:.||.|:||:||..::..|||:...|..||....:.:.::|:.:|
Human  1057 VRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYI 1121

  Fly  1545 IFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP- 1608
            |..:||.:|:|:|.:|..|..|.::...:.|:...:.|...|          .|||.|..|:.| 
Human  1122 IIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEY----------ALKAQPLRRYIPK 1176

  Fly  1609 ---QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI 1670
               |..|:..|....|:.::.|.|.||...:.:..|:.:..:|..:|.||.:|..:|:.|.:|||
Human  1177 NPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKI 1241

  Fly  1671 FALR-YHYFIEPWNLFDVVVVILSILGLVLSDI----------IEKYFVSPTLLRVVRVAKVGRV 1724
            .|.: .|||.:.||.||.::|:.||:.:.::::          .:...:|.|..|:.||.   |:
Human  1242 IAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVM---RL 1303

  Fly  1725 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKT 1787
            ::|:...:||||||:....|..||..:.||:.::.||:|:.||..|..|..:.|  ||...||:|
Human  1304 VKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQT 1368

  Fly  1788 FGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG---NCGSATVGITFLLSYLVISFL 1849
            |.|:::|||:.:|...|..::.|.:....|| |::|.| ||   .||| ...|.:.:|:.::...
Human  1369 FPQAVLLLFRCATGEAWQEIMLASLPGNRCD-PESDFG-PGEEFTCGS-NFAIAYFISFFMLCAF 1430

  Fly  1850 IVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQ 1914
            ::||:::|||::|:...|.| ...|.....|.:..||.::||.....|::..:...|..::|||.
Human  1431 LIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLG 1494

  Fly  1915 IHK--PNKY---KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGE---------- 1962
            ..|  |::.   ::::|::|:.....:.....|.||.:.....|  || :|:..:          
Human  1495 FGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGN-LEQANQELRIVIKKIW 1558

  Fly  1963 -------IGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGG--GS-------- 2010
                   :.|:...||.|     ..|:.:   .|...|||..:||.:.|.|.|  |:        
Human  1559 KRMKQKLLDEVIPPPDEE-----EVTVGK---FYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSS 1615

  Fly  2011 -----------------------FEPDTDHGDGG--DPDAGDPAPDEATDGDAPAGGDGSVNGTA 2050
                                   .|.:.:.|..|  :.|..|...::||....|:...||....:
Human  1616 ALQAGLRSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVS 1680

  Fly  2051 EGAADADESNVN-SPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQT 2098
            ....|....::: .|.:|            ..||.|:..|....||..|
Human  1681 LPVGDRLPDSLSFGPSDD------------DRGTPTSSQPSVPQAGSNT 1717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 78/301 (26%)
Na_trans_cytopl 515..648 CDD:288761 8/132 (6%)
Ion_trans 835..1028 CDD:278921 59/205 (29%)
Na_trans_assoc 1054..1296 CDD:284034 36/244 (15%)
Ion_trans 1318..1571 CDD:278921 95/265 (36%)
Na_channel_gate 1561..1613 CDD:240441 12/55 (22%)
Ion_trans 1636..1871 CDD:278921 81/250 (32%)
GPHH 1880..1930 CDD:293510 13/54 (24%)
CACNA1FNP_005174.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60 12/53 (23%)
I 79..375 88/322 (27%)
Ion_trans 109..383 CDD:278921 77/300 (26%)
Binding to the beta subunit. /evidence=ECO:0000250 395..412 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..441 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..488 9/45 (20%)
II 515..761 75/295 (25%)
Ion_trans 546..763 CDD:278921 67/222 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..830 24/196 (12%)
III 858..1140 101/287 (35%)
Ion_trans 888..1107 CDD:278921 83/224 (37%)
Dihydropyridine binding. /evidence=ECO:0000250 1060..1150 33/89 (37%)
IV 1177..1444 86/272 (32%)
Ion_trans 1207..1452 CDD:278921 81/251 (32%)
Dihydropyridine binding. /evidence=ECO:0000250 1397..1463 22/69 (32%)
Phenylalkylamine binding. /evidence=ECO:0000250 1409..1452 13/44 (30%)
GPHH 1460..1523 CDD:293510 14/62 (23%)
Ca_chan_IQ 1525..1596 CDD:285917 17/79 (22%)
CAC1F_C 1620..1974 CDD:293490 20/110 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1637..1754 20/93 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1816..1841
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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