DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and CACNA1E

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_016857732.1	Gene:	CACNA1E / 777	HGNCID:	1392	Length:	2458	Species:	Homo sapiens

Alignment Length:	2254	Identity:	532/2254 - (23%)
Similarity:	892/2254 - (39%)	Gaps:	690/2254 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EEERSLFRPFTRESLVQ-----IEQR--IAAE--HEKQKELERKRAEGEVPQYGRKKKQKEIRYD 65
            |...|.|.|.:.|.:.:     ||||  |.|.  |:.|...:.:|.|.|:.::|.....:. ...
Human    97 EAGSSPFLPVSPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVARP-GSG 160

  Fly    66 DEDEDEGPQPDPTLEQGVPIPVRLQGS----FPPELAST-PLEDIDPYYSNVLTFVVVSKGKDIF 125
            |.|.|:...     .||.|:|...|.:    ...:.|.| .|.:..|...|.
Human   161 DGDSDQSRN-----RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNC------------- 207

  Fly   126 RFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVES 180
             |:.::::::....|.:|:.|..::..|.|...|:.||:.|||::.:          |.:..:|.
Human   208 -FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEK 271

  Fly   181 TEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYV-TMGIDLG---NLAALRT 241
            ||..|.||:.||:.:|::|.|||....:|||:.||.:||:|:....: |.|....   :|..||.
Human   272 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRA 336

  Fly   242 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFP 306
            .||||.||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::||:.|.|.|.:.|.
Human   337 VRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACF---- 397

  Fly   307 LDGSWGNLTDENWDYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTS 370
                             .|:|...   ||...| .|| :.|   |...|.|....|||.  |.|.
Human   398 -----------------MNNSGIL---EGFDPPHPCG-VQG---CPAGYECKDWIGPND--GITQ 436

  Fly   371 FDSFGWAFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDE 434
            ||:..:|.|:.|:.:|.:.|.. ||.........|:.|:||.:|.:|||:::||:|.:::..:.:
Human   437 FDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAK 501

  Fly   435 LQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCI 499
            .:::.|...|..:  :|..::        :|...|.. :|..|  .|||..|..|
Human   502 ERERVENRRAFMK--LRRQQQ--------IERELNGY-RAWID--KAEEVMLAEE---------- 543

  Fly   500 SYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPF 564
                           ||                                  ...|::|.:
Human   544 ---------------NK----------------------------------NAGTSALEV----- 554

  Fly   565 NIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVP 629
             :||.       ||:..|..            ..|...:.:|.  .|.|:..||:
Human   555 -LRRA-------TIKRSRTE------------AMTRDSSDEHC--VDISSVGTPL---------- 587

  Fly   630 VYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTC 694
                   :|.|..::....:||..|                ||..||.
Human   588 -------ARASIKSAKVDGVSYFRH----------------KERLLRI----------------- 612

  Fly   695 LDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRAS 759
                                   .|:|       .|::|
Human   613 -----------------------SIRH-------MVKSQ-------------------------- 621

  Fly   760 DRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFI 824
                 |:|                                          |:.|.:
Human   622 -----VFY------------------------------------------WIVLSL--------- 630

  Fly   825 TLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFII 889
               :.:||..:|:.||:..:.:..:|....:.|...|.:|.::|:..|.|:.||...:|.|||.:
Human   631 ---VALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGV 692

  Fly   890 VALSLLE----LGLEGVQ-GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLC 948
            ...|:.|    :...|.. |:||||:.||||:||:.|.|.:| ||::|:|. :|.::.:|.|:|.
Human   693 TVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLF 756

  Fly   949 IIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE--------- 1003
            :.|.:||::||||||..::     |.|| .|..||..|..:.|.||::|.|| |.|
Human   757 LFIVVFALLGMQLFGGRFN-----FNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQ 815

  Fly  1004 -----SMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEA 1063
                 .||..:|         |:...:.||..:||:|||:.:.|..    :|.....|..:..||
Human   816 GGVSSGMWSAIY---------FIVLTLFGNYTLLNVFLAIAVDNLA----NAQELTKDEQEEEEA 867

  Fly  1064 FNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQIS-W-----------------IWS 1110
            ||:        |..:....::......|..|.:....|.:.:| |                 :|.
Human   868 FNQ--------KHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWE 924

  Fly  1111 EGKGVCR---CISAEHGDNELEL-------------------GHDEI---------LADGLIKKG 1144
            :.....|   .:|::...|..|.                   .|..:         ||.||..:.
Human   925 QRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEK 989

  Fly  1145 IKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNN----------------------------- 1180
            .:|:     .|..|      |.:|.:...:|..|:|
Human   990 FEEE-----RISRG------GSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQE 1043

  Fly  1181 -------ATDDD-----------------TASINSYGSHKNRPFKDESHKGSAETMEGEEKRD-- 1219
                   .|.:|                 |....|..:.::|....|.....|...|||:..:
Human  1044 AGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELR 1108

  Fly  1220 ---ASKE---------DL----------------GLDE---------------------ELDEEG 1235
               .:||         ||                ||||                     |.:.||
Human  1109 GNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEG 1173

  Fly  1236 ECEEG-----PLDGDIIIHAHDEDI------LDEYPAD------CCPD----------------- 1266
            ..|:.     .||...:|...:.|:      .|:...:      ..||
Human  1174 SSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTD 1238

  Fly  1267 ---SYYKKFPILAGDDD---------------------SPFWQGWGN-LRLKTFQLIENKYFETA 1306
               |..|:..|...:::                     |.|.....| :|.....::..:|||..
Human  1239 GEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMC 1303

  Fly  1307 VITMILMSSLALALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----Y 1362
            ::.:|..||:|||.||      |:|.:     :|.|.|.:||.:|..||:||.:..|..:    |
Human  1304 ILLVIAASSIALAAED------PVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSY 1362

  Fly  1363 FTNAWCWLDFVIVMVSLINF-VASLVGAG---GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNAL 1423
            |.:.|..||||:|:.:|:.| :|:.:|..   .|:..|::|.||.||||:.:.|:..::.|.:.:
Human  1363 FRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCV 1427

  Fly  1424 VQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN--------GTKLSHEIIPNRNACES 1480
            |.::.::||:|:|..:|..|||::.||||.||:|.|.|.:        |..:.||    :|..|.
Human  1428 VTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHE----KNKMEV 1488

  Fly  1481 ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFII 1545
            :...|.....::|::..|.|.||.|:|.:||.|::..::|..|.|:.|.|...:.|.:::|.:.:
Human  1489 KGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFV 1553

  Fly  1546 FGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRW 1606
            ...||.:|:|:.:||..|.||..|        |.|:   :|.....:....|.||| :.:|:.|.
Human  1554 VFPFFFVNIFVALIIITFQEQGDK--------MMEECSLEKNERACIDFAISAKPLTRYMPQNRH 1610

  Fly  1607 RPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIF 1671
            ..|..|:..|....|:..||..|.||...:.:..|.|..||...|.|||..|.::||.||:||:.
Human  1611 TFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVI 1675

  Fly  1672 ALRY-HYFIEPWNLFDVVVVILSILGLVLSD--IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1733
            |..: :||.:.||:||.:.||.||..::|:|  ::.....:.:.|::.|.|   |:::|::....
Human  1676 AFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAA---RLIKLLRQGYT 1737

  Fly  1734 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK--EKSGINDVYNFKTFGQSMILLF 1796
            ||.||:....|..||..:|||:.::.||:||.||..|.::|  |:|.||...||::|..|::|||
Human  1738 IRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLF 1802

  Fly  1797 QMSTSAGWDGVLDAIINEEACDPP--------DNDKGYPGNCGSATVGITFLLSYLVISFLIVIN 1853
            :.:|...|..::.:.:.|:.|:|.        :|::     ||: .:...:.:|::.....:::|
Human  1803 RSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER-----CGT-DLAYVYFVSFIFFCSFLMLN 1861

  Fly  1854 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK- 1917
            :::|||::|:...|.| ...|.....|.:..:|.::|......|.|.::.|.|.::.|||.:.|
Human  1862 LFVAVIMDNFEYLTRD-SSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKR 1925

  Fly  1918 -PNK--YK-IISMDIPICRGDLMYCVDILDALTK---DFFARKG 1954
             |:|  || ::.|::|:.....::....|.||.:   |....||
Human  1926 CPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKG 1969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	86/286 (30%)
		Na_trans_cytopl	515..648	CDD:288761	17/132 (13%)
		Ion_trans	835..1028	CDD:278921	69/213 (32%)
		Na_trans_assoc	1054..1296	CDD:284034	65/453 (14%)
		Ion_trans	1318..1571	CDD:278921	91/273 (33%)
		Na_channel_gate	1561..1613	CDD:240441	14/55 (25%)
		Ion_trans	1636..1871	CDD:278921	78/247 (32%)
		GPHH	1880..1930	CDD:293510	16/54 (30%)
CACNA1E	XP_016857732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810