DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and CACNA1D

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_011532396.1 Gene:CACNA1D / 776 HGNCID:1391 Length:2246 Species:Homo sapiens


Alignment Length:2114 Identity:503/2114 - (23%)
Similarity:847/2114 - (40%) Gaps:652/2114 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 EGPQPDP------TLEQGVPIPVRLQG--------SFPPELASTPLEDIDPYYSNVLTFVVVSKG 121
            |||...|      .|.....|....|.        |.||.:.|........|          :|.
Human    74 EGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQY----------AKS 128

  Fly   122 KDIFRFSAS---KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------P 173
            |.....|.|   :|::.|...|||||..|.|:....|.:||:..|..||:.:.:          .
Human   129 KKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNS 193

  Fly   174 TTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVV-------IALAYVTMGI 231
            |...:|..|..|..|:|.|:.:|::|.|.:|.|..|:|:.||.||||:       :.|..:|...
Human   194 TNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 258

  Fly   232 DLGN----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFA 286
            :.||          :.|||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|
Human   259 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 323

  Fly   287 LMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCD 351
            ::||::::|.:.:.|   |..|                  |:..:|::.......||   ..||.
Human   324 IIGLELFIGKMHKTC---FFAD------------------SDIVAEEDPAPCAFSGN---GRQCT 364

  Fly   352 -DDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVI 412
             :...|..|: ..||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.:
Human   365 ANGTECRSGW-VGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPW--VYFVSL 426

  Fly   413 IFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAAD 477
            :..|||:::||:|.:::..:.:.::||:..  .:.:.:||.::        |||...........
Human   427 VIFGSFFVLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQ 481

  Fly   478 AAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTT 542
               ||:  :.||..:.            |||:|     |...|:.:.|.||              
Human   482 ---AED--IDPENEEE------------GGEEG-----KRNTSMPTSETES-------------- 510

  Fly   543 AHQATKVRKVSTTSLSLPGSPFNIRRGSRSS-HKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQH 606
                     |:|.::|..|.    .||...| ..:..|.|..:.|..|..|              
Human   511 ---------VNTENVSGEGE----NRGCCGSLWCWWRRRGAAKAGPSGCRR-------------- 548

  Fly   607 LPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTK 671
                                                                .|.|:       .
Human   549 ----------------------------------------------------WGQAI-------S 554

  Fly   672 ESKLRNR----NTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQT 732
            :|||..|    |..|:                                                 
Human   555 KSKLSRRWRRWNRFNR------------------------------------------------- 570

  Fly   733 QTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCV 797
                                 |..||:.:.|:.|                               
Human   571 ---------------------RRCRAAVKSVTFY------------------------------- 583

  Fly   798 WDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFA 862
                  ||     |.::||             :||:.::.:|::....:.::....|....|.|.
Human   584 ------WL-----VIVLVF-------------LNTLTISSEHYNQPDWLTQIQDIANKVLLALFT 624

  Fly   863 IEATMKLMAMSPKYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKS 922
            .|..:|:.::..:.||...:|.||..:|.     ..|:||.:....|:||.|..||||:||:.:.
Human   625 CEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRH 689

  Fly   923 WPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFM 987
            |.:|:.|::.:..:|.::.:|..:|.:.|.||:::||||||..::     |.:....|..|.:|.
Human   690 WTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDETQTKRSTFDNFP 749

  Fly   988 HSFMIVFRVLCGE-WIESMWDCMYV-------GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG 1044
            .:.:.||::|.|| |...|:|.:..       |.:.|| :|:...:.||.::||:|||:.:.|. 
Human   750 QALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNL- 812

  Fly  1045 SSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIW 1109
                    ||      ||:.|                                    |.|     
Human   813 --------AD------AESLN------------------------------------TAQ----- 822

  Fly  1110 SEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKK 1174
                                            |:..:|:.:.::|..:.:|     :.|||||:.
Human   823 --------------------------------KEEAEEKERKKIARKESLE-----NKKNNKPEV 850

  Fly  1175 SKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEE 1239
            ::..|:   |:..:|:.|..                  |.|:|......|:.:.||.:||.|.| 
Human   851 NQIANS---DNKVTIDDYRE------------------EDEDKDPYPPCDVPVGEEEEEEEEDE- 893

  Fly  1240 GPLDGDIIIHAHDEDILDEYPADCCP------DSYYKKFPILAGDDDSPFW--QGWGNLRLKTFQ 1296
                             .|.||...|      :...|..||..|   |.|:  .....:|:...:
Human   894 -----------------PEVPAGPRPRRISELNMKEKIAPIPEG---SAFFILSKTNPIRVGCHK 938

  Fly  1297 LIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV 1361
            ||.:..|...::..|::||.|||.|| .:........||.|.|..||.||.:|:|:|....|..:
Human   939 LINHHIFTNLILVFIMLSSAALAAED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFL 1002

  Fly  1362 YFTNAWC-----WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVN 1421
            : ..|:|     .||.::|.|||::|.   :.:..|...|.:|.||.||||||::|.:|::.||.
Human  1003 H-KGAFCRNYFNLLDMLVVGVSLVSFG---IQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQ 1063

  Fly  1422 ALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACES------ 1480
            .:..||.:|.|:::|..:...:||.:|||||.||:::|.|        |...|...|..      
Human  1064 CVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD--------EAKSNPEECRGLFILYK 1120

  Fly  1481 ---------ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYM 1536
                     ....|.||..|||:|.:|.:.||.|:||:||..::..||||...:..||....:.:
Human  1121 DGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEI 1185

  Fly  1537 YLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAI 1601
            .::|:.:||..:||.:|:|:|.:|..|.||.:|...:.|:...:.|...|          .|||.
Human  1186 SIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY----------ALKAR 1240

  Fly  1602 PRPRWRP----QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIF 1662
            |..|:.|    |...:.:|....|:.::.:.|.||...:.:..|:.|..:|..:|.||.:|..:|
Human  1241 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVF 1305

  Fly  1663 SSECLLKIFALR---Y--------------------------HYFIEPWNLFDVVVVILSILGLV 1698
            :.|.:||:.|.:   |                          |||.:.||.||.::|:.|::.:.
Human  1306 TVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIA 1370

  Fly  1699 LSDI------------------IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1745
            ::::                  .|...:|.|..|:.||.   |:::|:...:||||||:....|.
Human  1371 ITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVM---RLVKLLSRGEGIRTLLWTFIKSF 1432

  Fly  1746 PALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVL 1808
            .||..:.||:.::.||:|:.||..|  :.:::.:.||...||:||.|:::|||:.:|...|..::
Human  1433 QALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1497

  Fly  1809 DAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1872
            .|.:..:.||| .|.:.|....|||....:.|:..|::.:||| ||:::|||::|:...|.| ..
Human  1498 LACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLI-INLFVAVIMDNFDYLTRD-WS 1560

  Fly  1873 GLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPI-C 1931
            .|.....|.:..||.::|||....|::..:...|..::|||...|  |::.   ::::|::|: .
Human  1561 ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1625

  Fly  1932 RGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEGYEPVSSTLWRQR-------- 1986
            .|.:|:...:. ||.:.....|  || :|:..|  |:.|         |...:|::.        
Human  1626 DGTVMFNATLF-ALVRTALKIKTEGN-LEQANE--ELRA---------VIKKIWKKTSMKLLDQV 1677

  Fly  1987 ------------EEYCARLIQHAWRKHKARGEGG 2008
                        :.|...|||..:||.|.|.|.|
Human  1678 VPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQG 1711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 82/301 (27%)
Na_trans_cytopl 515..648 CDD:288761 17/133 (13%)
Ion_trans 835..1028 CDD:278921 56/205 (27%)
Na_trans_assoc 1054..1296 CDD:284034 40/249 (16%)
Ion_trans 1318..1571 CDD:278921 93/272 (34%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 81/284 (29%)
GPHH 1880..1930 CDD:293510 14/54 (26%)
CACNA1DXP_011532396.1 Ion_trans 180..454 CDD:278921 81/300 (27%)
Ion_trans 600..817 CDD:278921 67/237 (28%)
Ion_trans 960..1219 CDD:278921 92/271 (34%)
Ion_trans 1279..1560 CDD:278921 81/285 (28%)
GPHH 1568..1631 CDD:293510 16/62 (26%)
Ca_chan_IQ 1633..1704 CDD:285917 16/83 (19%)
CAC1F_C 1728..2243 CDD:293490
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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