DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and CACNA1C

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_016875415.1 Gene:CACNA1C / 775 HGNCID:1390 Length:2412 Species:Homo sapiens


Alignment Length:2204 Identity:524/2204 - (23%)
Similarity:902/2204 - (40%) Gaps:609/2204 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIF 185
            :|:..|...|||||..|.|:....|.:.|:.||..||:.:.:          .|...:|..|.:|
Human   158 RALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLF 222

  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGID----------LG------ 234
            ..|:|.|:.:||:|.|.:..|..|||:.||.|||:::.:...:..::          ||      
Human   223 LIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 287

  Fly   235 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 299
            ::.|||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||:::||.:.:
Human   288 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 352

  Fly   300 KCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAG-QCDDDYVCLQGFGPN 363
            .|                   |:....::..:||:...   |...:|.| ||.:..||..|: ..
Human   353 TC-------------------YNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKPGW-DG 394

  Fly   364 PNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYLVNLIL 425
            |.:|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||:::||:|
Human   395 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFFVLNLVL 457

  Fly   426 AIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ----AQAAADAAAAEEAAL 486
            .:::..:.:.::||:..  .:.:.:||.::        |||.....    .||.......|:..:
Human   458 GVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLKGYLDWITQAEDIDPENEDEGM 512

  Fly   487 HPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRK 551
            ..|..::.           |...|..|..|.|.:..|...|:. ||:      ||:..::.....
Human   513 DEEKPRNR-----------GTPAGMLDQKKGKFAWFSHSTETH-VSM------PTSETESVNTEN 559

  Fly   552 VSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAV 616
            |:...:........:.:||||                                          ||
Human   560 VAGGDIEGENCGARLAKGSRS------------------------------------------AV 582

  Fly   617 TPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTR 681
            .|      |:::|                                  .||:|:            
Human   583 EP------AVLLP----------------------------------WGVTTV------------ 595

  Fly   682 NQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPF-IEPVQTQTVVDMKDVMVLN 745
                                                     ::|: :|.:||:.           
Human   596 -----------------------------------------NSPWPLEELQTEA----------- 608

  Fly   746 DIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDC-------CWV 803
              :.|.:..| |.|....|.|:                      :..:.||...|       .:.
Human   609 --LSQTSPSH-RISKSKFSRYW----------------------RRWNRFCRRKCRAAVKSNVFY 648

  Fly   804 WLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMK 868
            ||     |..:||             :||:.:|.:|::....:..|..:.|....|.|..|..:|
Human   649 WL-----VIFLVF-------------LNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLK 695

  Fly   869 LMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTLNL 928
            :.::..:.||...:|.||..:|...:||..|...:     |:||||..||||:||:.:.|.:|:.
Human   696 MYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSN 760

  Fly   929 LISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIV 993
            |::.:..::.::.:|..:|.:.|.||:::||||||..::     |.:....|..|.:|..|.:.|
Human   761 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDEMQTRRSTFDNFPQSLLTV 820

  Fly   994 FRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSLS 1049
            |::|.|| |...|:|.:       :.|.:.|| :|:...:.||.::||:|||:.:.|.. :.||:
Human   821 FQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLT 884

  Fly  1050 APTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKG 1114
            :...:.:..|                                                   |.|.
Human   885 SAQKEEEEEK---------------------------------------------------ERKK 898

  Fly  1115 VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLN 1179
            :.|..|.|.        ..|::....:.:..:|:.:|:....||           ..|..:| :|
Human   899 LARTASPEK--------KQELVEKPAVGESKEEKIELKSITADG-----------ESPPATK-IN 943

  Fly  1180 NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDG 1244
              .||...:.|          :|:|...:.|| .|||           ||   ||.|...||...
Human   944 --MDDLQPNEN----------EDKSPYPNPET-TGEE-----------DE---EEPEMPVGPRPR 981

  Fly  1245 DII-IHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVI 1308
            .:. :|..::.:         |......|.|.:.::         ..||:..:::.:..|...::
Human   982 PLSELHLKEKAV---------PMPEASAFFIFSSNN---------RFRLQCHRIVNDTIFTNLIL 1028

  Fly  1309 TMILMSSLALALED--VHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAW 1367
            ..||:||::||.||  .|...|   ..||:|.|.:||.||.:|:.:|..|.|..:    :..|.:
Human  1029 FFILLSSISLAAEDPVQHTSFR---NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYF 1090

  Fly  1368 CWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1432
            ..||.::|.||||:|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|
Human  1091 NILDLLVVSVSLISFG---IQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1152

  Fly  1433 VLLVCLIFWLIFAIMGVQLFAGKYFKCEDMN---------------GTKLSHEIIPNRNACESEN 1482
            :::|..:...:||.:|||||.||.:.|.|.:               ..::.|.||..|       
Human  1153 IVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPR------- 1210

  Fly  1483 YTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFG 1547
             :|.||..:||:|..|.:.||.|:||:||.:::..:|||...||.||....:.:.::|:.:||..
Human  1211 -SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIII 1274

  Fly  1548 SFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP---- 1608
            :||.:|:|:|.:|..|.||.::...:.|:...:.|...|          .|||.|..|:.|    
Human  1275 AFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY----------ALKARPLRRYIPKNQH 1329

  Fly  1609 QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFAL 1673
            |..|:.:|....|:.::.:.|.||...:.:..|..|..:...::.||.:|..:|:.|.:||:.|.
Human  1330 QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1394

  Fly  1674 R-YHYFIEPWNLFDVVVVILSILGLVLSDIIEKYF------------------------------ 1707
            : ..||.:|||:||.::||.||:.::||: ...||                              
Human  1395 KPKGYFSDPWNVFDFLIVIGSIIDVILSE-TNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHT 1458

  Fly  1708 -VSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIF 1762
             .||::         :...|:.:|.|:::|:...:||||||:....|..||..:.||:.::.||:
Human  1459 QCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1523

  Fly  1763 AIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDP---PDN 1822
            |:.||..|  :.:.:.:.||...||:||.|:::|||:.:|...|..::.|.:..:.|.|   |.|
Human  1524 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSN 1588

  Fly  1823 DKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQ 1887
            .......|||:.....|:..|::.:||| ||:::|||::|:...|.| ...|.....|.:..||.
Human  1589 STEGETPCGSSFAVFYFISFYMLCAFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWA 1651

  Fly  1888 QFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDLMYCVDILDALT 1946
            ::|||....|::..:...|..::|||...|  |::.   :::||::|: ..|.:|:...:. ||.
Human  1652 EYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLF-ALV 1715

  Fly  1947 KDFF---ARKGNPIEETGEIGEIAARP------DTEGYEPVSSTLWRQR---------------- 1986
            :...   ..:|....|..:..|...||      ..|....:...:|::.                
Human  1716 RTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDE 1780

  Fly  1987 ----EEYCARLIQHAWRKHKARGEGGGSFEPDTDHG---DGGDPDAGDPAPD--EATDGDAPAGG 2042
                :.|...|||..:||.|.|.|.|...:|...:.   ..|.....|..|:  .|..||.    
Human  1781 VTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDL---- 1841

  Fly  2043 DGSVNGTAEGAAD-ADESNVNSPGEDAAAAAAAA------------AAAAAAGTTTAGSP----G 2090
                  |||...| |.:..|::..||.....|..            ..:|...|.|...|    .
Human  1842 ------TAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINK 1900

  Fly  2091 AGSAGRQTAVLVESDGFVTKNGHKVVIHSR-SPSITSRTAD-----------VXARPRP 2137
            |||          |.|......|:.::.|. :||..|.|..           :...|||
Human  1901 AGS----------SQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRP 1949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 81/300 (27%)
Na_trans_cytopl 515..648 CDD:288761 18/132 (14%)
Ion_trans 835..1028 CDD:278921 59/205 (29%)
Na_trans_assoc 1054..1296 CDD:284034 37/242 (15%)
Ion_trans 1318..1571 CDD:278921 95/273 (35%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 81/280 (29%)
GPHH 1880..1930 CDD:293510 15/54 (28%)
CACNA1CXP_016875415.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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