Protein Alignment para and Scn7a

DIOPT Version :9

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: NP_001375437.1
• Gene: Scn7a / 64155
• RGDID: 61922
• Length: 1680
• Species: Rattus norvegicus
• Alignment Length: 2069
• Identity: 662/2069 - (31%)
• Similarity: 1019/2069 - (49%)
• Gaps: 462/2069 - (22%)

  Fly     9 SEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGP 73
            |.|.:.|. |||.|||..|:..||                        ||..|     |.|:|..
  Rat     4 SPEPKGLV-PFTAESLELIKNHIA------------------------KKCNE-----EHEEEDL 38

  Fly    74 QPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYY---SNVLTFVVVSKGKDIFRFSASKAMWM 135
            :|...||.|..:|. ..|:.|....|.||||:||||   .|  ||:|:::.:.||||:|...:..
  Rat    39 KPSWGLEAGKKLPF-AYGTLPQGTVSEPLEDVDPYYYVKRN--TFMVLNRNRVIFRFNAVSILCT 100

  Fly   136 LDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTP----TVESTEVIFTGIYTFESAVK 196
            |.|.:.:||..|.:||||||.|.|:.::|.:.|||.|...|    .||:|   ..||||||..||
  Rat   101 LSPLSSLRRAVIKVLVHPLFRLLILISVLTDSILMCMSNLPEWILAVENT---LLGIYTFEILVK 162

  Fly   197 VMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIV 261
            |:|||.....|::|.|.||||||.|.....:|....|.:|...:|.|.||.||.:.:..||::||
  Rat   163 VIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIV 227

  Fly   262 GAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNS 326
            ..:::.:|.|...|.|.:|.|:|.:|.|:.::||.|..||::....||:..........||....
  Rat   228 VTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVMYNGTGSQYHILER 292

  Fly   327 SNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFW 390
            .|:|.. ||..:. ||||.:.||.|.:.|:|::. |.||:.|:||||:||||.|:.|||||||:.
  Rat   293 ENFYYM-EGARYALLCGNKTDAGLCPEGYMCVKE-GSNPDNGFTSFDNFGWALLAMFRLMTQDYP 355

  Fly   391 EDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEE 455
            |.||..:|.|:|..:|:||::|.|..:||:.:|.|.|:.|:|::.:::|.||
  Rat   356 ELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRASEE------------- 407

  Fly   456 AAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMS 520
                                                                  ..|.::|...:
  Rat   408 ------------------------------------------------------SRDMDSKCHQT 418

  Fly   521 IRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRF 585
            ::..|.|.|...:...|         .:::|.|.||::   :..:|...:...||..
  Rat   419 VKEFEEEHEGAEMETTQ---------IEMKKRSPTSIN---TTLDILEDTALGHKEE-------- 463

  Fly   586 GIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRIS 650
              |.:.||...|..|:
  Rat   464 --PETSRKECPLCWYK------------------------------------------------- 477

  Fly   651 YTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDE 715
                              .||                     ||.
  Rat   478 ------------------FTK---------------------TCF-------------------- 483

  Fly   716 AGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTF 780
                                                                             
  Rat   484 ----------------------------------------------------------------- 483

  Fly   781 KDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKE 845
                            :|.|...|:|..|:...|:..|..:||:.:||::|..|:|::|..|::|
  Rat   484 ----------------IWKCSPCWIKLNEFADRIITHPLFDLFLVICIILNICFLALEHFPMSEE 532

  Fly   846 MERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRS 910
            :..:|..||..|...:.||..:|::||.|..|||..|:|||.|:|.|.|.|:.|..::.::|...
  Rat   533 LMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISWHIFDSILVVLGLTEMLLADIEEITVFIL 597

  Fly   911 FRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHD---HKDR 972
            ..|:.: ||.|..|....|:.|:||.:.||.:|..::.|.|:..||.||:|||::|.|   |.|:
  Rat   598 VPLIFI-KLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQ 661

  Fly   973 FPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFL 1036
              |....||:.:||:|:::.|||:|||||||::|:||.| |:..||||::..::||||::|.||:
  Rat   662 --DCQRQRWHMSDFLHAYVTVFRILCGEWIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFV 724

  Fly  1037 ALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCF--------KLIRNKLTNQ- 1092
            | |:|:|.|.        :.|.::::....:....:|:|. :.:|.        |.:..:.|:|
  Rat   725 A-LVSSFASY--------DATTEVSKEAKNLQLAVAWIKM-VINCVLLKILCKEKTVSTEATDQT 779

  Fly  1093 ----ISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEV 1153
                :.:..||...:::    |..:...|......|..:..:...|  :..||......:|   |
  Rat   780 CDPSVKENISGHTLSEL----SNTQTFLRYKDQSSGTEKTPVTESE--SQSLIASPSVSET---V 835

  Fly  1154 AIGDGMEFTIHGDMKN--NKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEE 1216
            .|..|     ..|::|  ||..:||..|             ||.|             |.|:...
  Rat   836 PIASG-----ESDIENLDNKETRSKSAN-------------GSSK-------------EKMKQSS 869

  Fly  1217 KRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDS 1281
            ..:.|..|:.:.||       ||       :::.|::..|.:       :.|.:|........:|
  Rat   870 SSECSTVDIAISEE-------EE-------MVYEHEKSKLHK-------NGYERKSSAGQVSRES 913

  Fly  1282 PFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIF 1346
            ...:.|.|:|....:::||.:||..:..:.|:.:..|||||:::.||..::..|.|.|.||..||
  Rat   914 RNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTIKIFLEYGDMIFAYIF 978

  Fly  1347 FLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKT------MRTLRALR 1405
            .||||:||:|.|||.||:|.|..|||::|:|..:    ||:|       ||      :.:::.||
  Rat   979 ILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCL----SLIG-------KTREDLNPLASIKFLR 1032

  Fly  1406 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCED-MNGTKLSH 1469
            .||.:|:.:.|:||:.||::......:|.||||:.||:|::|||.|||||:::|.| ..|.:.|.
  Rat  1033 ALRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPTRGERFSV 1097

  Fly  1470 EIIPNRNACE----SENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIR 1530
            ..:.|::.||    :|:..|.|:.:|||:|||.:|.|||||||.|||.|||.||||..|..||..
  Rat  1098 FEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVYMQPSF 1162

  Fly  1531 ETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKM--- 1592
            |.:::||.||:.|::||.|..|.:.|||||.|||:||.|.||| .:|:|..|||.|.|:||:
  Rat  1163 EHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQGGS-NIFITVKQKKQYRALKKLLYA 1226

  Fly  1593 GSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAI 1657
            .|:||   ..|||.:.|..:.::||.:.|::||:|.|.....|:.:...:.|......:.::|::
  Rat  1227 DSQKP---AARPRNKFQGFICDVVTHRVFNVIIILLICFQATTIMIQNDEQSPQIETAVFWMNSL 1288

  Fly  1658 FVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVG 1722
            |.::|:.||:||:.|.|.|||...||:.|.:||:.||.||:|...|.:|||.|:|::::.::::.
  Rat  1289 FTMLFTLECILKLTAFRCHYFTSAWNVHDFMVVVFSITGLLLPLSIGQYFVPPSLVQLLLLSRII 1353

  Fly  1723 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKT 1787
            .|||..||.|....|:..|.:|||||.||.||:||||||:|||||..|.:||:::|||||.||:|
  Rat  1354 HVLRPGKGPKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFET 1418

  Fly  1788 FGQSMILLFQMSTSAGWDGVLDAIINEE--ACDPPDNDKGYP-----GNCGSATVGITFLLSYLV 1845
            ||.||:.|||::|.:||||:||||.|.:  .|||   ||..|     |:|||.:|||.:.:||::
  Rat  1419 FGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDP---DKINPGTQVRGDCGSPSVGIFYFVSYIL 1480

  Fly  1846 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLE 1910
            ||:||::|||:.:|:|..|..::.....|::||:..::::|.:|||:.||||...:||:|...|:
  Rat  1481 ISWLIIVNMYVVLIMEFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDSTKLSDFAAALD 1545

  Fly  1911 PPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEI--GEIAARPDTE 1973
            |||.:.||||.::::||:|:..||.::|:|||.|.||....:.....:...||  |.:.|.|...
  Rat  1546 PPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKI 1610

  Fly  1974 GYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFE--PDTDHGDGGDPDA 2025
            .|||:::||.|::|...|.:||.|::.::.| :.....:  |:.|.| ..||::
  Rat  1611 TYEPITTTLKRKQEAVSATIIQRAYKSYRLR-QSDKKIQDIPEIDDG-REDPNS 1662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	112/275 (41%)
		Na_trans_cytopl	515..648	CDD:288761	17/132 (13%)
		Ion_trans	835..1028	CDD:278921	79/196 (40%)
		Na_trans_assoc	1054..1296	CDD:284034	45/256 (18%)
		Ion_trans	1318..1571	CDD:278921	122/263 (46%)
		Na_channel_gate	1561..1613	CDD:240441	25/54 (46%)
		Ion_trans	1636..1871	CDD:278921	110/241 (46%)
		GPHH	1880..1930	CDD:293510	21/49 (43%)
Scn7a	NP_001375437.1	Ion_trans	117..405	CDD:395416	119/292 (41%)
		Ion_trans	504..738	CDD:395416	98/245 (40%)
		Na_trans_assoc	742..926	CDD:399489	44/245 (18%)
		Ion_trans	932..1203	CDD:395416	126/281 (45%)
		Na_channel_gate	1194..1245	CDD:240441	25/54 (46%)
		Ion_trans	1249..1496	CDD:395416	114/249 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4754
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930