Protein Alignment para and SCN8A

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: NP_055006.1
• Gene: SCN8A / 6334
• HGNCID: 10596
• Length: 1980
• Species: Homo sapiens
• Alignment Length: 2095
• Identity: 954/2095 - (45%)
• Similarity: 1288/2095 - (61%)
• Gaps: 233/2095 - (11%)

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            |:|||.|||..||:|||    :.|..:..:|:|.              :.::|||..|:|:..||
Human    14 FKPFTPESLANIERRIA----ESKLKKPPKADGS--------------HREDDEDSKPKPNSDLE 60

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|..|.:.||||.||||....||||:::||.:|||||:.|:::|.|||.|||:
Human    61 AGKSLPF-IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRI 124

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||:|.:||:.|:.|||.||:.|.....|. .::.|..|||||||||.||::||||.:..||:
Human   125 AIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||:|..::|||::|||||||||||||::::|||||||||:|:|||.|.||
Human   190 LRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 254

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDEN------WDYHNRNSSNWYSED 333
            :|||:|.||||||:|||::||.|..||: .:|::.:...|  ||      |:.:..|.:|:|:..
Human   255 MILTVFCLSVFALIGLQLFMGNLRNKCV-VWPINFNESYL--ENGTKGFDWEEYINNKTNFYTVP 316

  Fly   334 EGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVL 398
            ..:...||||.|.||||.:.|.|::. |.||||||||||:|.||||:.|||||||:||:||||.|
Human   317 GMLEPLLCGNSSDAGQCPEGYQCMKA-GRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTL 380

  Fly   399 RAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAK 463
            ||||..:|:||:::||:|||||||||||:|||:|:| |.:|..|||.::||   ..:|...:..|
Human   381 RAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKEA---EFKAMLEQLKK 441

  Fly   464 LEERANAQAQAAADAAAAEEAALH--PEMAKSPTYSC-IS-------------------YELFVG 506
            .:|.|.|.|.|.:....:|:|...  .|...||..|. ||                   .||..|
Human   442 QQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEG 506

  Fly   507 GEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQ-ATKVRKVSTTSLSLPGSPFNIRRGS 570
            .|||    :.||:      .:|||...::|:......:: ..|...::.:.||:|||||..|..|
Human   507 EEKG----DPEKV------FKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNS 561

  Fly   571 RSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE-ENGAIIVPVYYGN 634
            :|| .::.| |.|||..|||:.:               :|||.::....|| ...::.:|:   .
Human   562 KSS-IFSFR-GPGRFRDPGSENE---------------FADDEHSTVEESEGRRDSLFIPI---R 606

  Fly   635 LGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESK----LRNRNTRNQSVGATNGGTTCL 695
            ...|.|||:.:.                  |.|..::.|:    ||....||.:|.. ||..:.:
Human   607 ARERRSSYSGYS------------------GYSQGSRSSRIFPSLRRSVKRNSTVDC-NGVVSLI 652

  Fly   696 DTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA--GRHSRA 758
                                .|...|.....:....|:..:..|....|...::|.|  ||
Human   653 --------------------GGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGR---- 693

  Fly   759 SDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELF 823
            .||..|:....|....|:....:.|......|..:.|.:|:|...|:|.:|.|:|||.||||:|.
Human   694 KDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLA 758

  Fly   824 ITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFI 888
            ||:|||:||:||||:||.|..:.|.||..||..||..|..|..:||:||.|.|||||||||||..
Human   759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823

  Fly   889 IVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 953
            ||:|||:||.|..|:||||||||||||||||||||||||:||.|:|.::|||||||.||.||:||
Human   824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 888

  Fly   954 FAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSC 1016
            |||:|||||||:|.:...:. .|.:||||:..||.|||:||||||||||||:|||||.| |...|
Human   889 FAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 953

  Fly  1017 IPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADC 1081
            :..|:..:|||||||||||||||||:|.:.:|:|...|.:.|.:..:..||.:..:|.|..: ..
Human   954 LIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKV-HA 1017

  Fly  1082 FKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIK 1146
            |.....|       |...:....:..:: |.|..|   .|.|...::....|..........||.
Human  1018 FMQAHFK-------QREADEVKPLDELY-EKKANC---IANHTGADIHRNGDFQKNGNGTTSGIG 1071

  Fly  1147 EQTQLEVAIGDGMEFTIHGDMKNNKP---KKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGS 1208
            ...:..:...|.|.|..:.::....|   .:|.:.|..|:|.::..:..|| |::.....|.:||
Human  1072 SSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGS-KDKLDDTSSSEGS 1135

  Fly  1209 AETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFP 1273
            .                     :|.:.|.||.|::       ..|:.||  |..|..:...::|.
Human  1136 T---------------------IDIKPEVEEVPVE-------QPEEYLD--PDACFTEGCVQRFK 1170

  Fly  1274 ILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYM 1338
            ....:.:....:.|..||...|.::|:.:|||.:|.|||:||.|||.||:::.||..::.||.|.
Human  1171 CCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYA 1235

  Fly  1339 DRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRA 1403
            |::||.||.||||:||.|.||..:||||||||||:||.|||::.:|:.:|...:.|.|::|||||
Human  1236 DKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRA 1300

  Fly  1404 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC-EDMNGTKL 1467
            ||||||:||.:||||||||||.|||||.|||||||||||||:||||.||||||..| .:.:..:.
Human  1301 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRF 1365

  Fly  1468 SHEIIPNRNACE------SENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDK 1526
            ..|.:.|:..||      :....|.|..:|||:||..||.|.||||||||:.||..|:|||:.|:
Human  1366 EIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDE 1430

  Fly  1527 QPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKK 1591
            ||..|.|||||:|||.||||||||||||||||||||||:||||.||. ::||||:||||||||||
Human  1431 QPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKK 1494

  Fly  1592 MGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNA 1656
            :|||||.|.||||..:.|.|||:.||.:.|||:||:.|.|||.||.::....|.....:|.::|.
Human  1495 LGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINL 1559

  Fly  1657 IFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKV 1721
            :||:.|:.||:||:||||::||...||:||.|||||||:|:.|:||||||||||||.||:|:|::
Human  1560 VFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARI 1624

  Fly  1722 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFK 1786
            ||:|||:|||||||||||||.|||||||||.||||||||||:|||||.|.:||.::||:|::||:
Human  1625 GRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFE 1689

  Fly  1787 TFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPD--NDK-----GYPGNCGSATVGITFLLSYL 1844
            |||.|||.|||::|||||||:|..|:|.    |||  .||     |:.|:||:.:|||.|.:||:
Human  1690 TFGNSMICLFQITTSAGWDGLLLPILNR----PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYI 1750

  Fly  1845 VISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVL 1909
            :||||||:|||||:||||:|.|||:..:.|::||::.:||||::|||:.||:|.|.:|::|.|.|
Human  1751 IISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADAL 1815

  Fly  1910 EPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG--NPIEETGEIGEIAARPDT 1972
            |.||::.|||..::|:||:|:..||.::|:|||.|.||......|  :.:.:..|...:|:.|..
Human  1816 EHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSK 1880

  Fly  1973 EGYEPVSSTLWRQREEYCARLIQHAWRKHKARG------------EGGGSFE------PDTDHGD 2019
            ..|||:::||.|::||..|.::|.|:|.|.||.            |.||:..      |.|
Human  1881 VSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPST---- 1941

  Fly  2020 GGDPDAGDPAPDEAT 2034
                 |..|:.|..|
Human  1942 -----ASLPSYDSVT 1951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	167/290 (58%)
		Na_trans_cytopl	555..740	CDD:463401	42/189 (22%)
		Ion_trans	817..1028	CDD:459842	138/212 (65%)
		Na_trans_assoc	1054..1296	CDD:461936	45/244 (18%)
		Ion_trans	1300..1571	CDD:459842	170/277 (61%)
		Na_channel_gate	1561..1613	CDD:240441	36/51 (71%)
		Ion_trans	1621..1871	CDD:459842	159/256 (62%)
		GPHH	1882..1929	CDD:465306	24/46 (52%)
SCN8A	NP_055006.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..62		13/51 (25%)
		I. /evidence=ECO:0000305	114..442		186/335 (56%)
		Ion_trans	131..421	CDD:459842	168/294 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..530		24/93 (26%)
		Na_trans_cytopl	546..702	CDD:463401	51/218 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	568..602		13/49 (27%)
		II. /evidence=ECO:0000305	735..1007		168/271 (62%)
		Ion_trans	752..965	CDD:459842	138/212 (65%)
		Na_trans_assoc	991..1192	CDD:461936	45/243 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1107..1148		13/62 (21%)
		III. /evidence=ECO:0000305	1180..1495		190/315 (60%)
		Ion_trans	1197..1473	CDD:459842	168/275 (61%)
		Na_channel_gate	1465..1517	CDD:240441	37/52 (71%)
		IV. /evidence=ECO:0000305	1504..1801		179/300 (60%)
		Ion_trans	1522..1776	CDD:459842	159/257 (62%)
		IQ	1894..1915	CDD:197470	9/20 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1922..1980		9/39 (23%)