DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and SCN7A

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens


Alignment Length:2119 Identity:697/2119 - (32%)
Similarity:1039/2119 - (49%) Gaps:508/2119 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGP 73
            |.|.:.|. |||:||...|:|.||..|.:                           |.|:||..|
Human     4 SPEPKGLV-PFTKESFELIKQHIAKTHNE---------------------------DHEEEDLKP 40

  Fly    74 QPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDP-YYSNVLTFVVVSKGKDIFRFSASKAMWMLD 137
            .||  ||.|..:|. :.|:....:.|.||||:|| ||....||:|::|.:.||||:|:..:..|.
Human    41 TPD--LEVGKKLPF-IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLS 102

  Fly   138 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT----TPTVESTEVIFTGIYTFESAVKVM 198
            |||.|||..|.:||||.|.|||:.::|::|:.|.:..    .|.:|:|   ..||||||..||:.
Human   103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENT---LLGIYTFEILVKLF 164

  Fly   199 ARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGA 263
            |||.....|::|.|.||||||.|.....:.....|..:..|:|.|.||.||.:.:..|||::||.
Human   165 ARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGV 229

  Fly   264 VIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSN 328
            :|..:|.|..|||||:|.||:|:|:|:.::||.|..||.:       |.. .:||...|||..:.
Human   230 LIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFR-------WPQ-ENENETLHNRTGNP 286

  Fly   329 WYSED-------EGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLM 385
            :|..:       ||..:. ||||.:.||||.:.|||::. |.||:.|:|:|||||||..:.||||
Human   287 YYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKA-GINPDQGFTNFDSFGWALFALFRLM 350

  Fly   386 TQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAI 450
            .||:.|.||..:|.|:|..:|:||:|:.||.|||:.:|.|.|:||:|:|           |::.:
Human   351 AQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEE-----------EKQRV 404

  Fly   451 REAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNN 515
            .|..:       |:|                            |.:.....||    ::||:.: 
Human   405 GEISK-------KIE----------------------------PKFQQTGKEL----QEGNETD- 429

  Fly   516 KEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRN 580
                ..:::::|                                                     
Human   430 ----EAKTIQIE----------------------------------------------------- 437

  Fly   581 GRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSH 645
                                                                             
Human   438 ----------------------------------------------------------------- 437

  Fly   646 QSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGL 710
                                   |.|.|                                     
Human   438 -----------------------MKKRS------------------------------------- 442

  Fly   711 ECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSV---YYFPTED 772
                              |:.|.|.:         |::|.|..||....::...:   |::    
Human   443 ------------------PISTDTSL---------DVLEDATLRHKEELEKSKKICPLYWY---- 476

  Fly   773 DDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAM 837
                             |....|.:|:|...|||.:|:|..|:..||.:||:.:||::|..|:.:
Human   477 -----------------KFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTL 524

  Fly   838 DHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGV 902
            :|:.|:|:...:|..||..|...|..|...|::||.|..|||.||||||.:||...|:||.|..|
Human   525 EHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV 589

  Fly   903 QGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYH 967
            .|:::||.||:||:|||.|.|||..:|:..:..:..||.:|..:|...||..|..||:||||||.
Human   590 AGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYE 654

  Fly   968 D---HKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGN 1028
            :   |.|:  |..||||:..||.|||:.|||:|||||:|::||||.| |...||||:|..::|||
Human   655 EFVCHIDK--DCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGN 717

  Fly  1029 LVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQI 1093
            |:||.|||| |:|:|.|........:|:...:..|..||.:..::|         |::.....|.
Human   718 LLVLYLFLA-LVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYV---------LLKILCKTQN 772

  Fly  1094 SDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDG 1158
            ..:.:.:..|::                                  .:|:.|.:.|..|::... 
Human   773 VPKDTMDHVNEV----------------------------------YVKEDISDHTLSELSNTQ- 802

  Fly  1159 MEFTIHGDMKNNKPKKSKYLNNATDDDTASI----------------NSYGSHKNRPFKDES-HK 1206
                   |...:|.|.|....|||::::.|:                :...:..|:..:.:| ..
Human   803 -------DFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDG 860

  Fly  1207 GSAETMEGEEKRDASKEDLGLDEELDEE----GE--------CEEGPLDGDIIIHAHDEDILDEY 1259
            ||.|.::.....:.|..|:.:.||  ||    ||        |..|...|.|             
Human   861 GSKEKIKQSSSSECSTVDIAISEE--EEMFYGGERSKHLKNGCRRGSSLGQI------------- 910

  Fly  1260 PADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVH 1324
                  ....||..|            |.|:|....:::||.:|:..:..:.|:|:..||.||::
Human   911 ------SGASKKGKI------------WQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIY 957

  Fly  1325 LPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGA 1389
            :.||..::.:|.|.|.|||.||.||||:||:|.|||.||:|.|..||||:|:|    |..||:|.
Human   958 MDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIV----FCLSLIGK 1018

  Fly  1390 GGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1454
            .. :..|.:.:::.|||||.:|:.:.|:|||.||::......||.||||:.||||:||||.||||
Human  1019 TR-EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082

  Fly  1455 KYFKCED-MNGTKLSHEIIPNRNACES----ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQI 1514
            ::::|.| .:|.:.....:.|::.|||    |:..|.|:.||||:|||.:|.|.|||||.|||.|
Human  1083 RFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITI 1147

  Fly  1515 MNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1579
            ||.||||..|:.||..|.|||||.||:.|||||.|..|::.|.|||||||:.|.|.||| .:|:|
Human  1148 MNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGS-NIFIT 1211

  Fly  1580 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDAS 1644
            ..|:|.|..:||:..:...:.:|||..:.|..:|::||.:.|::|:|:.|......|.:|....|
Human  1212 VKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQS 1276

  Fly  1645 DTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVS 1709
            ...:..|.::|:|||::::.||:||:.|.|..||...||:||.:|||.||.||.|...:..|.|.
Human  1277 LQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVP 1341

  Fly  1710 PTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK 1774
            |:|::::.::::..:|||.||.|....|:..|.:|||||.||.||:||||||:|:|||..|.:||
Human  1342 PSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK 1406

  Fly  1775 EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEE--ACDPPDNDKGYP-----GNCGS 1832
            :::|||||.||:|||.||:.|||::..|||||:||||.|.:  .|||   ||..|     |:||:
Human  1407 KEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDP---DKINPGTQVRGDCGN 1468

  Fly  1833 ATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYI 1897
            .:|||.:.:||::||:||::||||.|::|..:.|::...:.|::||:..::::|::|||:.||||
Human  1469 PSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYI 1533

  Fly  1898 RYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGE 1962
            ...:||:|...|:|||.:.||||.::|::|:|:..||.::|:|||.|.||....:.....:...|
Human  1534 DSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSE 1598

  Fly  1963 I--GEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDA 2025
            |  |.:.|.|.....||:::||.|::|...|.:||.|::.::.|..                   
Human  1599 IESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRN------------------- 1644

  Fly  2026 GDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSP 2064
                 |:.|.......||..|:.|.|||. .|::...||
Human  1645 -----DKNTSDIHMIDGDRDVHATKEGAY-FDKAKEKSP 1677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 118/282 (42%)
Na_trans_cytopl 515..648 CDD:288761 1/132 (1%)
Ion_trans 835..1028 CDD:278921 92/196 (47%)
Na_trans_assoc 1054..1296 CDD:284034 43/270 (16%)
Ion_trans 1318..1571 CDD:278921 131/257 (51%)
Na_channel_gate 1561..1613 CDD:240441 20/51 (39%)
Ion_trans 1636..1871 CDD:278921 112/241 (46%)
GPHH 1880..1930 CDD:293510 21/49 (43%)
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 135/323 (42%)
Ion_trans 146..403 CDD:278921 116/279 (42%)
II. /evidence=ECO:0000305 487..758 124/273 (45%)
Ion_trans 522..717 CDD:278921 92/196 (47%)
Na_trans_assoc 743..927 CDD:284034 43/267 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 13/77 (17%)
III. /evidence=ECO:0000305 916..1224 150/325 (46%)
Ion_trans 951..1198 CDD:278921 128/251 (51%)
Na_channel_gate 1194..1246 CDD:240441 20/52 (38%)
IV. /evidence=ECO:0000305 1233..1531 130/300 (43%)
Ion_trans 1268..1497 CDD:278921 110/231 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 136 1.000 Domainoid score I4918
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1621 1.000 Inparanoid score I82
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.980

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