DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and SCN5A

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001092874.1 Gene:SCN5A / 6331 HGNCID:10593 Length:2016 Species:Homo sapiens


Alignment Length:2171 Identity:945/2171 - (43%)
Similarity:1265/2171 - (58%) Gaps:304/2171 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 SLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPT 78
            |.||.||||||..||:|:|.:..:.....::..|| :|                 |:|.|:|...
Human    11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG-LP-----------------EEEAPRPQLD 57

  Fly    79 LEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIR 143
            |:....:| .|.|:.|.||...||||:||:||...||:|::|||.||||||:.|:::|.||:|||
Human    58 LQASKKLP-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121

  Fly   144 RVAIYILVHPLFSLFIITTILVNCILMIM----PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 204
            |.|:.||||.||::.|:.|||.||:.|..    |.|..||.|   ||.||||||.||::||||.|
Human   122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYT---FTAIYTFESLVKILARGFCL 183

  Fly   205 CPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 269
            ..||:|||.||||||.||.:|||:..|.||||:|||||||||||||::::|||||||||:|:|||
Human   184 HAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 248

  Fly   270 NLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKF-PLDGSWGN-----LTDENWDYHNRNSSN 328
            .|.||::||:|.||||||:|||::||.|..||::.| .|:|:.|:     |..|:.|.:..:..|
Human   249 KLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPEN 313

  Fly   329 WYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDL 393
            :..::......||||.|.||.|.:.|.||:. |.||::||||||||.||||:.|||||||.||.|
Human   314 YLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377

  Fly   394 YQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAA 458
            ||..||:||..:|:||:::||||||||||||||:|||:|:| |.:|...|..|:|  :..:||. 
Human   378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE-QNQATIAETEEKE--KRFQEAM- 438

  Fly   459 AKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRS 523
                                          ||.|                     ...|.::||.
Human   439 ------------------------------EMLK---------------------KEHEALTIRG 452

  Fly   524 VEVESESVSVIQRQP-APTTAHQATKVRKVSTTSLS-------LPGSPFNIRRGSRSSHKYTIRN 580
            |:..|.  |.::..| ||..:|:....|:...:|.:       ||.|  :...|.|:.:..::..
Human   453 VDTVSR--SSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKS--DSEDGPRAMNHLSLTR 513

  Fly   581 GRGRFGI-PGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSY-- 642
            |..|..: |.|.|..:.....:|......:|||.|:....||               |.|:|.  
Human   514 GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESE---------------SHHTSLLV 563

  Fly   643 ------TSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
                  ||.|.:   .|.|....|.|:.|              .:|.:|.. ||..:.|..... 
Human   564 PWPLRRTSAQGQ---PSPGTSAPGHALHG--------------KKNSTVDC-NGVVSLLGAGDP- 609

  Fly   702 DHRDYEIGLECTDEAG------KIKHHDN---PFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSR 757
                     |.|....      .::|..:   |..||...|.:......:   |..|:...|...
Human   610 ---------EATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCV---DGFEEPGARQRA 662

  Fly   758 ASDRGVSVYYFPTEDDDED----GPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDP 818
            .|  .|||.....|:.:|.    .|.:...|..        :.:|:||.:|:..::.|.|:|.||
Human   663 LS--AVSVLTSALEELEESRHKCPPCWNRLAQR--------YLIWECCPLWMSIKQGVKLVVMDP 717

  Fly   819 FVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWN 883
            |.:|.||:|||:||:|||::|::|..|.|.:|:.||..||..|..|.|.|::|:.|.||||:|||
Human   718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWN 782

  Fly   884 IFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLC 948
            |||.|||.|||:||||..:..|||||||||||||||||||||||.||.|:|.::|||||||.||.
Human   783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847

  Fly   949 IIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-G 1012
            ||:|||||:|||||||||.:.:|. ..|.||||:..||.|:|:|:||:|||||||:|||||.| |
Human   848 IIVFIFAVVGMQLFGKNYSELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSG 911

  Fly  1013 DVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRN 1077
            ...|:..||..:|||||||||||||||||:|.:.:|:||..|.:.|.:..|..||.|...:|||.
Human   912 QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRT 976

  Fly  1078 IAD-CFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLI 1141
            ..| |..|:|.:.....:....|:..:.|:..:|........:.....:...|.|..    .|..
Human   977 TWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQ----PGQG 1037

  Fly  1142 KKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESH- 1205
            ..|..|...:.:|:.:                     ::..|.:....||.|:.:....:.||. 
Human  1038 TPGDPEPVCVPIAVAE---------------------SDTDDQEEDEENSLGTEEESSKQQESQP 1081

  Fly  1206 -KGSAE-------------TMEGEEKRDASKEDL-----------GLDEELDEEGECEEGPL--- 1242
             .|..|             |...|.:..||:.|.           |..|  ..|..|.||..   
Human  1082 VSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGE--TPEDSCSEGSTADM 1144

  Fly  1243 --DGDIIIHAHD--EDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYF 1303
              ..:::....|  :|:.|  |.||..:...::.|..|.|......:.|..||...:.::|:.:|
Human  1145 TNTAELLEQIPDLGQDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207

  Fly  1304 ETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC 1368
            ||.:|.|||:||.|||.||::|.:|..::.:|.|.|::||.:|.||||:||:|.|||.|||||||
Human  1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWC 1272

  Fly  1369 WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNV 1433
            ||||:||.|||::.||:.:|...:...|::|||||||||||:||.:||||||||||.|||||.||
Human  1273 WLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV 1337

  Fly  1434 LLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTK----LSHEIIPNRNACESENYT----WVNSAM 1490
            |||||||||||:||||.|||||:.:|  :|.|:    |::.|:.|::.|||.|.|    |....:
Human  1338 LLVCLIFWLIFSIMGVNLFAGKFGRC--INQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKV 1400

  Fly  1491 NFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLF 1555
            |||:||..||.|.||||||||:.||..|:|||..::||..|.|:|||:|||.|||||||||||||
Human  1401 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLF 1465

  Fly  1556 IGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKK 1620
            |||||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|..:|:|||.:.
Human  1466 IGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529

  Fly  1621 FDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLF 1685
            ||:.||..|.|||.||.::..|.|.....:|..:|.:||.||:.||::|:.|||::||...||:|
Human  1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1594

  Fly  1686 DVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1750
            |.|||||||:|.||||||:|||.||||.||:|:|::||:|||::||||||||||||.||||||||
Human  1595 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFN 1659

  Fly  1751 ICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN-- 1813
            |.|||||||||::||||:.|.:||.::||:|::||:||..||:.|||::|||||||:|..|:|  
Human  1660 IGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG 1724

  Fly  1814 EEACDPP-DNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDD 1877
            ...|||. .|..|..|:|||..|||.|..:|::||||||:|||||:||||:|.|||:..|.|::|
Human  1725 PPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1789

  Fly  1878 DYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDIL 1942
            |:||:||||::||||.||:|.|..||:|.|.|..||:|.|||:..:|:||:|:..||.::|:|||
Human  1790 DFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDIL 1854

  Fly  1943 DALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAW 1998
            .|.||       ..:.|:||:..:         ||.|....|||:::||.|:.||..|.:||.|:
Human  1855 FAFTK-------RVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAF 1912

  Fly  1999 RKHKARGE------------GGGSFEPDTDHGDG----------GDPDAGDPAPDEATDGDAPAG 2041
            |:|..:..            |.|..|.|....:|          ..| .|.|:....:....|..
Human  1913 RRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP-LGPPSSSSISSTSFPPS 1976

  Fly  2042 GDGSVNGTAEGAADADESNVNSPGED 2067
            .|.....|::        |:...|.|
Human  1977 YDSVTRATSD--------NLQVRGSD 1994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 162/280 (58%)
Na_trans_cytopl 515..648 CDD:288761 35/149 (23%)
Ion_trans 835..1028 CDD:278921 121/193 (63%)
Na_trans_assoc 1054..1296 CDD:284034 53/275 (19%)
Ion_trans 1318..1571 CDD:278921 162/260 (62%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 143/237 (60%)
GPHH 1880..1930 CDD:293510 28/49 (57%)
SCN5ANP_001092874.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..56 8/45 (18%)
I. /evidence=ECO:0000305 113..420 180/311 (58%)
Ion_trans 151..423 CDD:278921 160/276 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..591 34/163 (21%)
Na_trans_cytopl 485..578 CDD:288761 23/112 (21%)
II. /evidence=ECO:0000305 699..969 163/270 (60%)
Ion_trans 734..927 CDD:278921 121/193 (63%)
Na_trans_assoc 953..1200 CDD:284034 53/275 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1005..1141 27/162 (17%)
III. /evidence=ECO:0000305 1187..1501 191/316 (60%)
Ion_trans 1222..1479 CDD:278921 160/258 (62%)
Na_channel_gate 1471..1523 CDD:240441 35/52 (67%)
IV. /evidence=ECO:0000305 1510..1807 175/296 (59%)
Ion_trans 1545..1782 CDD:278921 143/236 (61%)
GPHH 1792..1849 CDD:293510 31/56 (55%)
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 1839..1901 23/68 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1959..2016 9/45 (20%)
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 1974..1977 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 342 1.000 Domainoid score I1069
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1621 1.000 Inparanoid score I82
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm41716
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.740

Return to query results.
Submit another query.