Protein Alignment para and SCN5A

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: NP_932173.1
• Gene: SCN5A / 6331
• HGNCID: 10593
• Length: 2016
• Species: Homo sapiens
• Alignment Length: 2171
• Identity: 943/2171 - (43%)
• Similarity: 1264/2171 - (58%)
• Gaps: 304/2171 - (14%)

  Fly    14 SLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPT 78
            |.||.||||||..||:|:|.:..:.....::..|| :|                 |:|.|:|...
Human    11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG-LP-----------------EEEAPRPQLD 57

  Fly    79 LEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIR 143
            |:....:| .|.|:.|.||...||||:||:||...||:|::|||.||||||:.|:::|.||:|||
Human    58 LQASKKLP-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121

  Fly   144 RVAIYILVHPLFSLFIITTILVNCILMIM----PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 204
            |.|:.||||.||::.|:.|||.||:.|..    |.|..||.|   ||.||||||.||::||||.|
Human   122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYT---FTAIYTFESLVKILARGFCL 183

  Fly   205 CPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 269
            ..||:|||.||||||.||.:||.|..:||||::|||||||||||||::::.||||||||:|:|||
Human   184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVK 248

  Fly   270 NLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKF-PLDGSWGN-----LTDENWDYHNRNSSN 328
            .|.||::||:|.||||||:|||::||.|..||::.| .|:|:.|:     |..|:.|.:..:..|
Human   249 KLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPEN 313

  Fly   329 WYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDL 393
            :..::......||||.|.||.|.:.|.||:. |.||::||||||||.||||:.|||||||.||.|
Human   314 YLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377

  Fly   394 YQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAA 458
            ||..||:||..:|:||:::||||||||||||||:|||:|:| |.:|...|..|:|  :..:||.
Human   378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE-QNQATIAETEEKE--KRFQEAM- 438

  Fly   459 AKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRS 523
                                          ||.|                     ...|.::||.
Human   439 ------------------------------EMLK---------------------KEHEALTIRG 452

  Fly   524 VEVESESVSVIQRQP-APTTAHQATKVRKVSTTSLS-------LPGSPFNIRRGSRSSHKYTIRN 580
            |:..|.  |.::..| ||..:|:....|:...:|.:       ||.|  :...|.|:.:..::..
Human   453 VDTVSR--SSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKS--DSEDGPRAMNHLSLTR 513

  Fly   581 GRGRFGI-PGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSY-- 642
            |..|..: |.|.|..:.....:|......:|||.|:....||               |.|:|.
Human   514 GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESE---------------SHHTSLLV 563

  Fly   643 ------TSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
                  ||.|.:   .|.|....|.|:.|              .:|.:|.. ||..:.|.....
Human   564 PWPLRRTSAQGQ---PSPGTSAPGHALHG--------------KKNSTVDC-NGVVSLLGAGDP- 609

  Fly   702 DHRDYEIGLECTDEAG------KIKHHDN---PFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSR 757
                     |.|....      .::|..:   |..||...|.:......:   |..|:...|...
Human   610 ---------EATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCV---DGFEEPGARQRA 662

  Fly   758 ASDRGVSVYYFPTEDDDED----GPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDP 818
            .|  .|||.....|:.:|.    .|.:...|..        :.:|:||.:|:..::.|.|:|.||
Human   663 LS--AVSVLTSALEELEESRHKCPPCWNRLAQR--------YLIWECCPLWMSIKQGVKLVVMDP 717

  Fly   819 FVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWN 883
            |.:|.||:|||:||:|||::|::|..|.|.:|:.||..||..|..|.|.|::|:.|.||||:|||
Human   718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWN 782

  Fly   884 IFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLC 948
            |||.|||.|||:||||..:..|||||||||||||||||||||||.||.|:|.::|||||||.||.
Human   783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847

  Fly   949 IIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-G 1012
            ||:|||||:|||||||||.:.:|. ..|.||||:..||.|:|:|:||:|||||||:|||||.| |
Human   848 IIVFIFAVVGMQLFGKNYSELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSG 911

  Fly  1013 DVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRN 1077
            ...|:..||..:|||||||||||||||||:|.:.:|:||..|.:.|.:..|..||.|...:|||.
Human   912 QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRT 976

  Fly  1078 IAD-CFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLI 1141
            ..| |..|:|.:.....:....|:..:.|:..:|........:.....:...|.|..    .|..
Human   977 TWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQ----PGQG 1037

  Fly  1142 KKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESH- 1205
            ..|..|...:.:|:.:                     ::..|.:....||.|:.:....:.||.
Human  1038 TPGDPEPVCVPIAVAE---------------------SDTDDQEEDEENSLGTEEESSKQQESQP 1081

  Fly  1206 -KGSAE-------------TMEGEEKRDASKEDL-----------GLDEELDEEGECEEGPL--- 1242
             .|..|             |...|.:..||:.|.           |..|  ..|..|.||..
Human  1082 VSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGE--TPEDSCSEGSTADM 1144

  Fly  1243 --DGDIIIHAHD--EDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYF 1303
              ..:::....|  :|:.|  |.||..:...::.|..|.|......:.|..||...:.::|:.:|
Human  1145 TNTAELLEQIPDLGQDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207

  Fly  1304 ETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC 1368
            ||.:|.|||:||.|||.||::|.:|..::.:|.|.|::||.:|.||||:||:|.|||.|||||||
Human  1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWC 1272

  Fly  1369 WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNV 1433
            ||||:||.|||::.||:.:|...:...|::|||||||||||:||.:||||||||||.|||||.||
Human  1273 WLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV 1337

  Fly  1434 LLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTK----LSHEIIPNRNACESENYT----WVNSAM 1490
            |||||||||||:||||.|||||:.:|  :|.|:    |::.|:.|::.|||.|.|    |....:
Human  1338 LLVCLIFWLIFSIMGVNLFAGKFGRC--INQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKV 1400

  Fly  1491 NFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLF 1555
            |||:||..||.|.||||||||:.||..|:|||..::||..|.|:|||:|||.|||||||||||||
Human  1401 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLF 1465

  Fly  1556 IGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKK 1620
            |||||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|..:|:|||.:.
Human  1466 IGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529

  Fly  1621 FDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLF 1685
            ||:.||..|.|||.||.::..|.|.....:|..:|.:||.||:.||::|:.|||::||...||:|
Human  1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1594

  Fly  1686 DVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1750
            |.|||||||:|.||||||:|||.||||.||:|:|::||:|||::||||||||||||.||||||||
Human  1595 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFN 1659

  Fly  1751 ICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN-- 1813
            |.|||||||||::||||:.|.:||.::||:|::||:||..||:.|||::|||||||:|..|:|
Human  1660 IGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG 1724

  Fly  1814 EEACDPP-DNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDD 1877
            ...|||. .|..|..|:|||..|||.|..:|::||||||:|||||:||||:|.|||:..|.|::|
Human  1725 PPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1789

  Fly  1878 DYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDIL 1942
            |:||:||||::||||.||:|.|..||:|.|.|..||:|.|||:..:|:||:|:..||.::|:|||
Human  1790 DFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDIL 1854

  Fly  1943 DALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAW 1998
            .|.||       ..:.|:||:..:         ||.|....|||:::||.|:.||..|.:||.|:
Human  1855 FAFTK-------RVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAF 1912

  Fly  1999 RKHKARGE------------GGGSFEPDTDHGDG----------GDPDAGDPAPDEATDGDAPAG 2041
            |:|..:..            |.|..|.|....:|          ..| .|.|:....:....|..
Human  1913 RRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP-LGPPSSSSISSTSFPPS 1976

  Fly  2042 GDGSVNGTAEGAADADESNVNSPGED 2067
            .|.....|::        |:...|.|
Human  1977 YDSVTRATSD--------NLQVRGSD 1994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	167/293 (57%)
		Na_trans_cytopl	555..740	CDD:463401	41/209 (20%)
		Ion_trans	817..1028	CDD:459842	133/211 (63%)
		Na_trans_assoc	1054..1296	CDD:461936	53/275 (19%)
		Ion_trans	1300..1571	CDD:459842	172/278 (62%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1621..1871	CDD:459842	152/252 (60%)
		GPHH	1882..1929	CDD:465306	26/46 (57%)
SCN5A	NP_932173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..56		8/45 (18%)
		I. /evidence=ECO:0000305	113..420		178/311 (57%)
		Ion_trans	130..423	CDD:459842	168/297 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..591		34/163 (21%)
		Na_trans_cytopl	507..667	CDD:463401	39/207 (19%)
		II. /evidence=ECO:0000305	699..969		163/270 (60%)
		Ion_trans	716..927	CDD:459842	133/211 (63%)
		Na_trans_assoc	953..1200	CDD:461936	53/275 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1005..1141		27/162 (17%)
		III. /evidence=ECO:0000305	1187..1501		191/316 (60%)
		Ion_trans	1204..1479	CDD:459842	170/276 (62%)
		Na_channel_gate	1471..1523	CDD:240441	35/52 (67%)
		IV. /evidence=ECO:0000305	1510..1807		175/296 (59%)
		Ion_trans	1528..1782	CDD:459842	152/253 (60%)
		Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208	1839..1901		23/68 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1959..2016		9/45 (20%)
		Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568	1974..1977		1/2 (50%)