DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and SCN4A

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_000325.4 Gene:SCN4A / 6329 HGNCID:10591 Length:1836 Species:Homo sapiens


Alignment Length:2136 Identity:921/2136 - (43%)
Similarity:1229/2136 - (57%) Gaps:429/2136 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 RPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQ 81
            ||||||||..||||..   |::..|:|             .||.||    |:.:..|:.|  ||.
Human    18 RPFTRESLAAIEQRAV---EEEARLQR-------------NKQMEI----EEPERKPRSD--LEA 60

  Fly    82 GVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVA 146
            |..:|: :.|..|||:...||||:||||||..||:|::|||.||||||:.|:::|.||:.:||.|
Human    61 GKNLPM-IYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124

  Fly   147 IYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTYL 210
            |.:|:|.|||:||:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.:..||:|
Human   125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFL 189

  Fly   211 RDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275
            ||.||||||.||.:||:|..:||||::|||||||||||||:.::|||||||||:|:|||.|.||:
Human   190 RDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVM 254

  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFP----------LDGSW-GNLT-------------- 315
            |||:|.||||||:|||::||.|.|||::..|          .:.:| ||.|              
Human   255 ILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWY 319

  Fly   316 -DENWDYH----NRNSSNW--YSEDEGISF--------PLCGNISGAGQCDDDYVCLQGFGPNPN 365
             ::.|:.|    ..::.:|  |..|||..:        .||||.|.||.|.:.|.|:: .|.|||
Human   320 ANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIK-TGRNPN 383

  Fly   366 YGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAM 430
            |||||:|:|.||||:.|||||||:||:|:||.|||||..:|:||:||||||||||:|||||:|||
Human   384 YGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAM 448

  Fly   431 SYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPT 495
            :|.|..:....|:..:||..::..|.......:||:...|||                       
Human   449 AYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQA----------------------- 490

  Fly   496 YSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLP 560
                    ..|||...|                         ||                     
Human   491 --------LEGGEADGD-------------------------PA--------------------- 501

  Fly   561 GSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGA 625
                                                                             
Human   502 ----------------------------------------------------------------- 501

  Fly   626 IIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNG 690
                                        ||.                                  
Human   502 ----------------------------HGK---------------------------------- 504

  Fly   691 GTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRH 755
                 |.|..||          |.:.                                |:.|.|.
Human   505 -----DCNGSLD----------TSQG--------------------------------EKGAPRQ 522

  Fly   756 SRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFV 820
            |.:.|.|:|......|:..:..|.:..|....:|       :|:||..||||:..:.|||.||||
Human   523 SSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVL-------IWNCCAPWLKFKNIIHLIVMDPFV 580

  Fly   821 ELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIF 885
            :|.||:|||:||:||||:|:.|.:..:.||..||..||..|..|..:||:||.|..|||:|||||
Human   581 DLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIF 645

  Fly   886 DFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCII 950
            |.|||.|||:||||..||||||||||||||||||||||||||:||.|:|.::|||||||.||.||
Human   646 DSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII 710

  Fly   951 IFIFAVMGMQLFGKNYHDHKDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GD 1013
            :|||||:|||||||:|.:...:.. |.:||||:..||.|||:||||:|||||||:|||||.| |.
Human   711 VFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQ 775

  Fly  1014 VSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNI 1078
            ..|:..||..:|||||||||||||||||:|.:.||:|...|.:.|.:..|   |||.|..:....
Human   776 AMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIA---IGRIKLGIGFAK 837

  Fly  1079 ADCFKLIRNKLTNQISDQPS-GERTNQISWIWSEGKGVCRCISAEHG-----DNELELGHDEILA 1137
            |....|:..|:.:......| ||         ::|.|.    :.|.|     |.:.|...:::..
Human   838 AFLLGLLHGKILSPKDIMLSLGE---------ADGAGE----AGEAGETAPEDEKKEPPEEDLKK 889

  Fly  1138 DGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKD 1202
            |..|..        .:.:.||...::..|..|       ::||........|.|..|....|.::
Human   890 DNHILN--------HMGLADGPPSSLELDHLN-------FINNPYLTIQVPIASEESDLEMPTEE 939

  Fly  1203 ESHKGSAETMEGEEKRDASKEDLGLDE--------------ELDEEGECEEGPLDGDIIIHAHDE 1253
            |:...|       |..|:.|....|.:              |.|.|.:.||.| :|         
Human   940 ETDTFS-------EPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENP-EG--------- 987

  Fly  1254 DILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLAL 1318
                |.|.:|..::..:::|.|..|......:.|..||...|:::|:.:|||.::.|||:||.||
Human   988 ----EQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGAL 1048

  Fly  1319 ALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFV 1383
            |.||:::.||.:::.||.|.|::||.||.:|||:||:|.|||||||||||||||:||.||:|:.|
Human  1049 AFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLV 1113

  Fly  1384 ASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMG 1448
            |:.:|...:...|::|||||||||||:||.:|||||||||:.|||||.|||||||||||||:|||
Human  1114 ANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1178

  Fly  1449 VQLFAGKYFKCEDMNGT---KLSHEIIPNRNACESENYT----WVNSAMNFDHVGNAYLCLFQVA 1506
            |.|||||::.|  :|.|   :.....:.|::.|||..:|    |:|..:|:|:||..||.|.|||
Human  1179 VNLFAGKFYYC--INTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVA 1241

  Fly  1507 TFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1571
            |||||:.||..|:||||.::||..|.|:|||||||.||||||||||||||||||||||:||||.|
Human  1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1306

  Fly  1572 GSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTM 1636
            |. ::||||:||||||||||:|||||.|.||||:.:.|.:|:::||.:.|||.||:.|.|||.||
Human  1307 GK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTM 1370

  Fly  1637 TLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSD 1701
            .::..:.|.....:|..:|.||::||:.||:||:.|||.:||...||:||.|||||||:||.|||
Human  1371 MVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSD 1435

  Fly  1702 IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFG 1766
            :|:||||||||.||:|:|::||||||::||||||||||||.|||||||||.|||||||||::|||
Human  1436 LIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG 1500

  Fly  1767 MSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE--EACDPPDNDKG--YP 1827
            ||.|.:||::|||:|::||:|||.|:|.||:::|||||||:|:.|:|.  ..|||...:.|  ..
Human  1501 MSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVK 1565

  Fly  1828 GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPE 1892
            |:||:.::||.|..||::||||||:|||||:||||::.|||:..|.|.:||::|:||.|::|||:
Human  1566 GDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPD 1630

  Fly  1893 GTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG--N 1955
            .||:|.|.:||:|:|.|:.||:|.||||.|:|::|:|:..||.::|:|||.||||:.....|  :
Human  1631 ATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMD 1695

  Fly  1956 PIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH-KARGEGGGSFEPDTDHGD 2019
            .:::|.|...:||.|....|||:::||.|:.||.||..||.|:|:| ..|.....|:.....| |
Human  1696 ALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSH-D 1759

  Fly  2020 GGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAA 2075
            |    :||.||::          :|.:..|.......:..|.:||..:....|..|
Human  1760 G----SGDDAPEK----------EGLLANTMSKMYGHENGNSSSPSPEEKGEAGDA 1801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 165/311 (53%)
Na_trans_cytopl 515..648 CDD:288761 2/132 (2%)
Ion_trans 835..1028 CDD:278921 124/194 (64%)
Na_trans_assoc 1054..1296 CDD:284034 53/261 (20%)
Ion_trans 1318..1571 CDD:278921 162/259 (63%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 143/238 (60%)
GPHH 1880..1930 CDD:293510 26/49 (53%)
SCN4ANP_000325.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..63 12/42 (29%)
I. /evidence=ECO:0000305 113..454 182/341 (53%)
Ion_trans 152..457 CDD:278921 161/305 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..530 18/256 (7%)
II. /evidence=ECO:0000305 560..832 172/274 (63%)
Ion_trans 595..790 CDD:278921 124/194 (64%)
Na_trans_assoc 816..1026 CDD:284034 53/261 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..886 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..992 17/82 (21%)
III. /evidence=ECO:0000305 1013..1326 191/315 (61%)
Ion_trans 1048..1304 CDD:278921 160/257 (62%)
Na_channel_gate 1296..1348 CDD:240441 36/52 (69%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1310..1312 0/1 (0%)
IV. /evidence=ECO:0000305 1335..1633 172/297 (58%)
Ion_trans 1370..1609 CDD:278921 143/238 (60%)
GPHH 1620..1675 CDD:293510 28/54 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1836 5/24 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 342 1.000 Domainoid score I1069
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1621 1.000 Inparanoid score I82
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm41716
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.880

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