DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and SCN3A

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_008853.3	Gene:	SCN3A / 6328	HGNCID:	10590	Length:	2000	Species:	Homo sapiens

Alignment Length:	2131	Identity:	970/2131 - (45%)
Similarity:	1314/2131 - (61%)	Gaps:	244/2131 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||:|.|.|..|:.                ||:|      |.|::..|:|:..||
Human    14 FRLFTRESLAAIEKRAAEEKAKKP----------------KKEQ------DNDDENKPKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.||||||:.|:::|.|.||:|::
Human    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.:...|. .::.|..|||||||||.:|::||||.|..||:
Human   121 AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
Human   186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLD------------------GSWGNLTDE--NW 319
            :|||:|.||||||:|||::||.|..||::..|.|                  |::.|:|..  ||
Human   251 MILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNW 315

  Fly   320 DYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            ..:..:.|::|..| |...| ||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
Human   316 KDYIGDDSHFYVLD-GQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 378

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            |||||:||:||||.|||||..:|:||:::||||||||||||||:|||:|:| |.:|..|||.::|
Human   379 LMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKE 442

  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAAL---------HPEMAKSPTYSCISY--- 501
            |  |.::.......:.||   |||.|||.||:.:.:.:         ..|.:|..:.|...:
Human   443 A--EFQQMLEQLKKQQEE---AQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNR 502

  Fly   502 -------ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVST---TS 556
                   |...|..||..|:..:..|..||:..|...|:        ..::.|..:|..:   :.
Human   503 RKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM--------DGNRLTSDKKFCSPHQSL 559

  Fly   557 LSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE 621
            ||:.||.|:.||.|::|    |.:.|||....||:.               .:|||.::....||
Human   560 LSIRGSLFSPRRNSKTS----IFSFRGRAKDVGSEN---------------DFADDEHSTFEDSE 605

  Fly   622 -ENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSV 685
             ...::.||..:|...:.:.|..|..||        ::.|:...|....|.:.         ..|
Human   606 SRRDSLFVPHRHGERRNSNVSQASMSSR--------MVPGLPANGKMHSTVDC---------NGV 653

  Fly   686 GATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVV---DMKDVMVLNDI 747
            .:..||.:.|                 |...|::..      |...|:|.|   .:....:..::
Human   654 VSLVGGPSAL-----------------TSPTGQLPP------EGTTTETEVRKRRLSSYQISMEM 695

  Fly   748 IEQAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809
            :|.::||     .|.||:....|   |:.:|.    :.|......:..:||.:||||..|||.:.
Human   696 LEDSSGR-----QRAVSIASILTNTMEELEES----RQKCPPCWYRFANVFLIWDCCDAWLKVKH 751

  Fly   810 WVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSP 874
            .|:|||.||||:|.||:|||:||:||||:|:.|.::...||..||..||..|..|..:|::||.|
Human   752 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDP 816

  Fly   875 KYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGA 939
            .|||||||||||.|||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::||
Human   817 YYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 881

  Fly   940 LGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIE 1003
            |||||.||.||:|||||:|||||||:|.:...:..|. .||||:..||.|||:||||||||||||
Human   882 LGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIE 946

  Fly  1004 SMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRI 1067
            :|||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...||:.|.:..|..|:
Human   947 TMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 1011

  Fly  1068 GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGH 1132
            .:...:||..:.:||             |.:..|..::..| .||..:..|:|...|   :|:..
Human  1012 QKGIDYVKNKMRECF-------------QKAFFRKPKVIEI-HEGNKIDSCMSNNTG---IEISK 1059

  Fly  1133 D-EILADGL-IKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSH 1195
            : ..|.||. ...|:...:.:|..:.|..::             ..::||.:...|..| :.|..
Human  1060 ELNYLRDGNGTTSGVGTGSSVEKYVIDENDY-------------MSFINNPSLTVTVPI-AVGES 1110

  Fly  1196 KNRPFKDESHKGSAETMEGEEKRDA--SKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDE 1258
            .......|.....:|..|.:||.:|  |.|...:|..|..|||            .|..|...|.
Human  1111 DFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGE------------QAETEPEEDL 1163

  Fly  1259 YPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDV 1323
            .|..|..:...||||......:....:.|.|||...:.::|:.:|||.::.|||:||.|||.||:
Human  1164 KPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDI 1228

  Fly  1324 HLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVG 1388
            ::.||..::.:|.|.|::||.||.||||:||:|.||:.|||||||||||:||.|||::.||:.:|
Human  1229 YIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1293

  Fly  1389 AGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1453
            ...:.|.|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:||||.|||
Human  1294 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1358

  Fly  1454 GKYFKCEDM-NGTKLSHEIIPNRNACES--ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIM 1515
            ||::.|.:| .|.......:.|.:.|::  :...|.|..:|||:||..||.|.||||||||:.||
Human  1359 GKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIM 1423

  Fly  1516 NDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1580
            ..|:|||:|..||:.|.|:|||||||.||||||||||||||||||||||:||||.||. ::||||
Human  1424 YAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTE 1487

  Fly  1581 DQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASD 1645
            :||||||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:.|.|||.||.::..|...
Human  1488 EQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGK 1552

  Fly  1646 TYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSP 1710
            ....||..:|.:|:|:|:.|.:||:.:||::||...||:||.|||||||:|:.|:::||||||||
Human  1553 YMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSP 1617

  Fly  1711 TLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKE 1775
            ||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:||||||.|.:||:
Human  1618 TLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKK 1682

  Fly  1776 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDNDKGYP-----GNCGSA 1833
            ::||:|::||:|||.|||.|||::|||||||:|..|:|...  |||   |..:|     |:||:.
Human  1683 EAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDP---DTIHPGSSVKGDCGNP 1744

  Fly  1834 TVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIR 1898
            :|||.|.:||::||||:|:||||||||||:|.|||:..|.|::||::|:||:|::|||:.||:|.
Human  1745 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIE 1809

  Fly  1899 YDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEI 1963
            :.:||:|...|:|||.|.||||.::|:||:|:..||.::|:|||.|.||       ..:.|:||:
Human  1810 FSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK-------RVLGESGEM 1867

  Fly  1964 GEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH--KARGEG-GGSFEPDTD 2016
            ..:         |:.|....|||:::||.|::||..|.:||..:|.:  |.|.:. ..::..:..
Human  1868 DALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAI 1932

  Fly  2017 HGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGED 2067
            .|....|...|...|:......|...|||.:.|:..:.|    :|..|.::
Human  1933 KGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD----SVTKPDKE 1979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	168/292 (58%)
		Na_trans_cytopl	515..648	CDD:288761	32/136 (24%)
		Ion_trans	835..1028	CDD:278921	124/194 (64%)
		Na_trans_assoc	1054..1296	CDD:284034	55/245 (22%)
		Ion_trans	1318..1571	CDD:278921	160/255 (63%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	144/241 (60%)
		GPHH	1880..1930	CDD:293510	25/49 (51%)
SCN3A	NP_008853.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60		14/53 (26%)
		I. /evidence=ECO:0000305	110..455		194/349 (56%)
		Ion_trans	149..434	CDD:278921	166/287 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..528		6/34 (18%)
		Na_trans_cytopl	510..629	CDD:288761	36/145 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..631		12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..681		6/41 (15%)
		II. /evidence=ECO:0000305	742..1014		170/271 (63%)
		Ion_trans	777..972	CDD:278921	124/194 (64%)
		Na_trans_assoc	998..1200	CDD:284034	55/244 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1162		15/55 (27%)
		III. /evidence=ECO:0000305	1188..1499		189/311 (61%)
		Ion_trans	1223..1477	CDD:278921	158/253 (62%)
		Na_channel_gate	1469..1521	CDD:240441	36/52 (69%)
		IV. /evidence=ECO:0000305	1508..1806		174/300 (58%)
		Ion_trans	1543..1781	CDD:278921	144/240 (60%)
		ChtBD1	1708..>1743	CDD:302575	16/37 (43%)
		GPHH	1793..1848	CDD:293510	27/54 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1949..2000		8/35 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1069
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1621	1.000	Inparanoid score	I82
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm41716
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880