back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and SCN2A

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens

Alignment Length:	2160	Identity:	973/2160 - (45%)
Similarity:	1319/2160 - (61%)	Gaps:	282/2160 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||||||.|..|:.:.|||                     |||::.||:|:..||
Human    14 FRFFTRESLAAIEQRIAEEKAKRPKQERK---------------------DEDDENGPKPNSDLE 57

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.|.||||:.|:::|.||||||::
Human    58 AGKSLPF-IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKL 121

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.||::.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
Human   122 AIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 186

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||..||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
Human   187 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 251

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS---------WGNLTDENWDYHNRNSS--N 328
            :|||:|.||||||:|||::||.|..||: ::|.|.|         :.|..|.|....||..|  |
Human   252 MILTVFCLSVFALIGLQLFMGNLRNKCL-QWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFN 315

  Fly   329 W--YSEDEGISF--------PLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            |  |.||:...:        .||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
Human   316 WDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 379

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            ||||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.::|
Human   380 LMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKE 443

  Fly   449 A---------IREAEEA-AAAKAAKLEER----------ANAQAQAAADAAAAEEAALHPEMAKS 493
            |         .::.||| |||.||..|.|          .:..:..|:..::..|..|.....|.
Human   444 AEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKK 508

  Fly   494 PTYSCISYELFVGGEKGNDDNNKEKMSIRSV-------EVESESVSVIQRQPAPTTAHQATKVRK 551
            .       :....||:..:|..::..|..|:       .:|...::..:|..:|   ||:.
Human   509 K-------QKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSP---HQSL---- 559

  Fly   552 VSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAV 616
                 ||:.||.|:.||.||:|    :.:.|||....||:.               .:|||.::.
Human   560 -----LSIRGSLFSPRRNSRAS----LFSFRGRAKDIGSEN---------------DFADDEHST 600

  Fly   617 TPMSEEN----GAIIVPVYYGNLGSRHS--SYTSHQSRI--------SYTSHGDLLGGMAVM-GV 666
               .|:|    .::.||..:|.  .|||  |..|..||:        ...|..|..|.:::: |.
Human   601 ---FEDNDSRRDSLFVPHRHGE--RRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

  Fly   667 STMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQ 731
            ||:|...:|...            |||......|.....|.:.::..:             :|..
Human   661 STLTSAGQLLPE------------GTTTETEIRKRRSSSYHVSMDLLE-------------DPTS 700

  Fly   732 TQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFC 796
            .|..  |....:|.:.:|:                   .|:..:..|....|...:.|
Human   701 RQRA--MSIASILTNTMEE-------------------LEESRQKCPPCWYKFANMCL------- 737

  Fly   797 VWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATF 861
            :||||..|||.:..|:|:|.||||:|.||:|||:||:||||:|:.|.::...||..||..||..|
Human   738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802

  Fly   862 AIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL 926
            ..|..:|::||.|.|||||||||||..||:|||:||||..|:|||||||||||||||||||||||
Human   803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTL 867

  Fly   927 NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFP-DGDLPRWNFTDFMHSF 990
            |:||.|:|.::|||||||.||.||:|||||:|||||||:|.:...:.. |.:||||:..||.|||
Human   868 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSF 932

  Fly   991 MIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD 1054
            :||||||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...|
Human   933 LIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD 997

  Fly  1055 NDTNKIAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTNQISWIWSEGKGVC 1116
            |:.|.:..|..|:.:...:|||.|.:..:   :.:.|..::|  :|..:..|:..
Human   998 NEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI--KPLEDLNNKKD---------- 1050

  Fly  1117 RCISAEHGDNELELGHD-EILADGLIKKGIKEQTQLEVAIGDGME-FTIHGDMKNNKPKKSKYLN 1179
            .|||   ....:|:|.| ..|.||   .|...      .||..:| :.:      ::.....::|
Human  1051 SCIS---NHTTIEIGKDLNYLKDG---NGTTS------GIGSSVEKYVV------DESDYMSFIN 1097

  Fly  1180 NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDG 1244
            |.:...|..| :.|.........|.....::..|.:||.:|:....|...::....|.|:..::
Human  1098 NPSLTVTVPI-AVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE- 1160

  Fly  1245 DIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVIT 1309
                   .|:.|:  |..|..:...:||.......:....:.|.|||...::::|:.:|||.::.
Human  1161 -------PEESLE--PEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVF 1216

  Fly  1310 MILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVI 1374
            |||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.||:||||||||||||:|
Human  1217 MILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLI 1281

  Fly  1375 VMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1439
            |.|||::..|:.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.||||||||
Human  1282 VDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346

  Fly  1440 FWLIFAIMGVQLFAGKYFKCED-MNGTKLSHEIIPNRNACES---ENYT--WVNSAMNFDHVGNA 1498
            |||||:||||.|||||::.|.: ..|......::.|.:.|::   .|.|  |.|..:|||:||..
Human  1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLG 1411

  Fly  1499 YLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNF 1563
            ||.|.||||||||:.||..|:|||.|:.||..|.|:|||||||.|||||||||||||||||||||
Human  1412 YLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1476

  Fly  1564 NEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLF 1628
            |:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:.
Human  1477 NQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMIL 1540

  Fly  1629 IGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILS 1693
            |.|||.||.::..|.|.....:|.::|.:|:|:|:.||:||:.:|||:||...||:||.||||||
Human  1541 ICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILS 1605

  Fly  1694 ILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1758
            |:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.||||||
Human  1606 IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670

  Fly  1759 MFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE--EACDPPD 1821
            |||:||||||.|.:||.:.||:|::||:|||.|||.|||::|||||||:|..|:|.  ..|||
Human  1671 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDP-- 1733

  Fly  1822 NDKGYP-----GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1881
             ||.:|     |:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|::||::|
Human  1734 -DKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEM 1797

  Fly  1882 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALT 1946
            :||:|::|||:.||:|.:.:||:|.|.|:|||.|.||||.::|:||:|:..||.::|:|||.|.|
Human  1798 FYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFT 1862

  Fly  1947 KDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWR--- 1999
            |       ..:.|:||:..:         |:.|....|||:::||.|::||..|.:||.|:|
Human  1863 K-------RVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920

  Fly  2000 -KHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADA------- 2056
             |.|.: :....::.|......|.|...|...|:..:...|...|.:.:.|:..:.|:
Human  1921 LKQKVK-KVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTKPEKE 1984

  Fly  2057 ----DESNVNSPGED 2067
                |:|.....|:|
Human  1985 KFEKDKSEKEDKGKD 1999

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.