DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and SCN1A

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001159435.1	Gene:	SCN1A / 6323	HGNCID:	10585	Length:	2009	Species:	Homo sapiens

Alignment Length:	2089	Identity:	938/2089 - (44%)
Similarity:	1289/2089 - (61%)	Gaps:	276/2089 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            |..||||||..||:|||.|..|..:.::|                      :|::.||:|:..||
Human    14 FNFFTRESLAAIERRIAEEKAKNPKPDKK----------------------DDDENGPKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.||||||:.|:::|.||||:|::
Human    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
Human   121 AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||..||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
Human   186 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW--------------GNLTDE-----NWD 320
            :|||:|.||||||:|||::||.|..|||:..|.:.|.              |.|.:|     :|.
Human   251 MILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWK 315

  Fly   321 YHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLM 385
            .:.::|...|..:..:...||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||||
Human   316 SYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYGYTSFDTFSWAFLSLFRLM 379

  Fly   386 TQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEA- 449
            ||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.::||
Human   380 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKEAE 443

  Fly   450 -------IREAEEAA--AAKAAKLEERANAQAQAAADAAAAEEAALHPEMA----------KSPT 495
                   :::.:|||  ||.|...|......|......:::|.:.|..:.|          |...
Human   444 FQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKE 508

  Fly   496 YSCISYELFVGGEKGNDDNNKEKMSIRSV-------EVESESVSVIQRQPAPTTAHQATKVRKVS 553
            .|        |||:.::|..::..|..|:       .:|...::..:|..:|   ||:.
Human   509 QS--------GGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSP---HQSL------ 556

  Fly   554 TTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTP 618
               ||:.||.|:.||.||:|    :.:.|||....||:.               .:|||.::...
Human   557 ---LSIRGSLFSPRRNSRTS----LFSFRGRAKDVGSEN---------------DFADDEHSTFE 599

  Fly   619 MSE-ENGAIIVPVYYGNLGSRHSSYTSHQSRI--SYTSHGDLLGGMAVMGVSTMTKESKLRNRNT 680
            .:| ...::.||..:|...:.:.|.||..||:  .:.::|.:...:...||.::.
Human   600 DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLV---------- 654

  Fly   681 RNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHH---DNPFIEPVQTQTVVDMK--- 739
                     ||.:.                 .|...|::...   |.|..:...|.|..:|:
Human   655 ---------GGPSV-----------------PTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRR 693

  Fly   740 --DVMVLNDIIEQAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWD 799
              ...|..|.:|..:.|     .|.:|:....|   |:.:|.    :.|......|..::|.:||
Human   694 SSSFHVSMDFLEDPSQR-----QRAMSIASILTNTVEELEES----RQKCPPCWYKFSNIFLIWD 749

  Fly   800 CCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIE 864
            |...|||.:..|:|:|.||||:|.||:|||:||:||||:|:.|......||..||..||..|..|
Human   750 CSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAE 814

  Fly   865 ATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLL 929
            ..:|::||.|.|||||||||||..||.|||:||||..|:||||||||||||||||||||||||:|
Human   815 MFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNML 879

  Fly   930 ISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIV 993
            |.|:|.::|||||||.||.||:|||||:|||||||:|.|...:. .|..||||:..||.|||:||
Human   880 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIV 944

  Fly   994 FRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDT 1057
            ||||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.:.:|:|...||:.
Human   945 FRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEM 1009

  Fly  1058 NKIAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCI 1119
            |.:..|.:|:.:..::|||.|.:..:   :.:.|:.::|  :|..:..|:        |..|.
Human  1010 NNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEI--KPLDDLNNK--------KDSCM-- 1062

  Fly  1120 SAEHGDNELELGHD-EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATD 1183
                .::..|:|.| :.|.|       ...|...:..|..:|               ||:.:.:|
Human  1063 ----SNHTAEIGKDLDYLKD-------VNGTTSGIGTGSSVE---------------KYIIDESD 1101

  Fly  1184 DDTASINSYGSHKNRPF----------KDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECE 1238
                    |.|..|.|.          :.:....:.|....|...:.||      |:|:|.....
Human  1102 --------YMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESK------EKLNESSSSS 1152

  Fly  1239 EG-------PLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQ 1296
            ||       |::...::  ..|:.|:  |..|..:...::|.....:.:....:.|.|||...|:
Human  1153 EGSTVDIGAPVEEQPVV--EPEETLE--PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1213

  Fly  1297 LIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV 1361
            ::|:.:|||.::.|||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.|::.
Human  1214 IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQT 1278

  Fly  1362 YFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQA 1426
            |||||||||||:||.|||::..|:.:|...:.|.|::|||||||||||:||.:|||||||||:.|
Human  1279 YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1343

  Fly  1427 IPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC-EDMNGTKLSHEIIPNRNAC-----ESENYTW 1485
            ||||.|||||||||||||:||||.|||||::.| ....|.:...|.:.|...|     .:|...|
Human  1344 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARW 1408

  Fly  1486 VNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFF 1550
            .|..:|||:||..||.|.||||||||:.||..|:|||.|:.||..|.::|||||||.||||||||
Human  1409 KNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFF 1473

  Fly  1551 TLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEI 1615
            ||||||||||||||:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.
Human  1474 TLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDF 1537

  Fly  1616 VTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIE 1680
            ||.:.|||.||:.|.|||.||.::..|.|:....:|..:|.:|:|:|:.||:||:.:||::||..
Human  1538 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602

  Fly  1681 PWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1745
            .||:||.|||||||:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||
Human  1603 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1667

  Fly  1746 PALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDA 1810
            ||||||.|||||||||:||||||.|.:||.:.||:|::||:|||.|||.|||::|||||||:|..
Human  1668 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732

  Fly  1811 IINEEA--CDPPDNDKG--YPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQ 1871
            |:|.:.  |||...:.|  ..|:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..
Human  1733 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1797

  Fly  1872 EGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLM 1936
            |.|::||::|:||:|::|||:.||::.:::||:|...|||||.:.:|||.::|:||:|:..||.:
Human  1798 EPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRI 1862

  Fly  1937 YCVDILDALTKDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCAR 1992
            :|:|||.|.||       ..:.|:||:..:         |:.|....|:|:::||.|::||..|.
Human  1863 HCLDILFAFTK-------RVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1920

  Fly  1993 LIQHAWRKH 2001
            :||.|:|:|
Human  1921 IIQRAYRRH 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	166/290 (57%)
		Na_trans_cytopl	515..648	CDD:288761	32/140 (23%)
		Ion_trans	835..1028	CDD:278921	124/194 (64%)
		Na_trans_assoc	1054..1296	CDD:284034	49/262 (19%)
		Ion_trans	1318..1571	CDD:278921	157/258 (61%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	144/238 (61%)
		GPHH	1880..1930	CDD:293510	23/49 (47%)
SCN1A	NP_001159435.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60		13/53 (25%)
		I. /evidence=ECO:0000305	110..454		192/345 (56%)
		Ion_trans	127..433	CDD:306908	175/307 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..529		18/81 (22%)
		Na_trans_cytopl	510..705	CDD:314757	53/269 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..627		11/57 (19%)
		II. /evidence=ECO:0000305	750..1022		167/271 (62%)
		Ion_trans	767..980	CDD:306908	137/212 (65%)
		Na_trans_assoc	1006..1213	CDD:310839	49/262 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1163		9/39 (23%)
		III. /evidence=ECO:0000305	1200..1514		187/314 (60%)
		Ion_trans	1217..1492	CDD:306908	164/274 (60%)
		Na_channel_gate	1484..1536	CDD:240441	36/52 (69%)
		IV. /evidence=ECO:0000305	1523..1821		174/297 (59%)
		Ion_trans	1540..1796	CDD:306908	154/255 (60%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1561..1571		2/9 (22%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1619..1636		11/16 (69%)
		GPHH	1800..1863	CDD:318993	29/62 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1986..2009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1621	1.000	Inparanoid score	I82
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm41716
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980