DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1h

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_006524796.1 Gene:Cacna1h / 58226 MGIID:1928842 Length:2367 Species:Mus musculus


Alignment Length:2349 Identity:561/2349 - (23%)
Similarity:987/2349 - (42%) Gaps:573/2349 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTFESAVK 196
            |...:.::.:|.|....:..|::||:.  |..|....         :|:.:......:..|..:|
Mouse    90 RSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVECRSERCSILEAFDDFIFAFFAVEMVIK 154

  Fly   197 VMARGFI--LCPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALKTVAIVPGL 257
            ::|.|..  .|   ||.|.||.|||.::....:...:|..|  |:|:||.||||.|:.:..||.:
Mouse   155 MVALGLFGQKC---YLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSM 216

  Fly   258 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYH 322
            :.:|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.    ||.::         ..
Mouse   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF----LDSAF---------VR 268

  Fly   323 NRNSS---NWYSEDEGISFPL------------CGNIS----------------GAGQCDD---- 352
            |.|.:   .:|..:||...|.            |.:|.                |..|.:|    
Mouse   269 NNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGGAG 333

  Fly   353 --------DY--VCLQG-FGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHM 406
                    .|  ||..| |  ||:.|..:||:.|:|:::.|:::|.:.|.|:...|:.|...::.
Mouse   334 RNACINWNQYYNVCRSGEF--NPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNF 396

  Fly   407 LFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ 471
            ::||::|.:|||:::||.|.::|..:.|.:::       |.:.:|             |:||...
Mouse   397 IYFILLIIVGSFFMINLCLVVIATQFSETKQR-------ENQLMR-------------EQRARYL 441

  Fly   472 AQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQR 536
            :..:..|:.:|..:.:.|:.|           :||       :...|:..||:.:.:...|..::
Mouse   442 SNDSTLASFSEPGSCYEELLK-----------YVG-------HIFRKVKRRSLRLYARWQSRWRK 488

  Fly   537 QPAP-TTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSS--------------HKYTIRNG--RGR 584
            :..| :|.|.....|:..             |.|.|::              |.|...:|  |..
Mouse   489 KVDPSSTLHGQGPRRRPR-------------RAGRRTASVHHLVYHHHHHHHHHYHFSHGGPRRP 540

  Fly   585 FGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRI 649
            ...||:....||.:.       :|.:..|....|...|:   :..:|:.:.   |......::|:
Mouse   541 SPEPGAGDTRLVRAC-------VPPSPPSPGHGPPDSES---VHSIYHADC---HVEGPQERARV 592

  Fly   650 SYT----SHGDLLGGMAVMGVSTMTKESKLRNR-NTRNQSVGATNGGTTCLDTNH---------- 699
            ::|    :...|..|:..|...|:.....:.:: :|.::..|..:.||... |.|          
Mouse   593 AHTIATAASLKLASGLGTMNYPTILPSGAVNSKGSTSSRPKGLRSAGTPGA-TAHSPLSLGSPSP 656

  Fly   700 --KLDHRDYEIGLECTDEAGKIKHHDN------PFIEPVQTQTVVDMKD----VMVLNDIIEQAA 752
              |:.|...|.||      |:...|.:      |...|.......::|.    ...|.|...:.:
Mouse   657 YEKIQHVVGEQGL------GRASSHLSGLSVPCPLPSPQAGTLTCELKSCPYCASALEDPEFEFS 715

  Fly   753 GRHSRASDRGVSVYYF-----------PTEDDDEDG-PTFKDKALEVILK------GIDVFCVWD 799
            |..|..|| ...||.|           |.:...|.| |...::.....|:      |:.      
Mouse   716 GSESGDSD-AHGVYEFTQDVRHGDCRDPVQQPHEGGTPGHGNERWRPPLRTASQPGGLG------ 773

  Fly   800 CCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIE 864
              .:|..|...:..||...:....|...|:|||:.|.:::|:...|:...|:..|..||:.||:|
Mouse   774 --RLWASFSSKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPDELTNALEISNIVFTSMFALE 836

  Fly   865 ATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLL 929
            ..:||:|..|..|.:..:||||.|:|.:|:.|:..:...||||||:||||||.||.:..|.|...
Mouse   837 MLLKLLACGPLGYIRNPYNIFDGIVVIISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQ 901

  Fly   930 ISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYH---DHKDRFPDGDLPRWNFTDFMHSFM 991
            :.::.|||..:.....:|.:.||||:::||.|||..:.   |..|..||    |.||...:.:.:
Mouse   902 LVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPD----RKNFDSLLWAIV 962

  Fly   992 IVFRVLCGE-W---------IESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNF--- 1043
            .||::|..| |         ..|.|..:|         |:|.:..||.|:.||.:|:|:..|   
Mouse   963 TVFQILTQEDWNVVLYNGMASTSSWAALY---------FVALMTFGNYVLFNLLVAILVEGFQAE 1018

  Fly  1044 GSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNI-ADCFKLIRNKLTNQISDQPSGERTNQISW 1107
            |.::.|....|..:..:.|.|:::        |:: |...|:....:|      |:|.       
Mouse  1019 GDATRSDTDEDKTSTHLEEDFDKL--------RDVQATEMKMYSLAVT------PNGH------- 1062

  Fly  1108 IWSEGKG----------VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFT 1162
              .||:|          ....:........|::.|  .|.|...........||           
Mouse  1063 --LEGRGSLPPPLITHTAATPMPTPKSSPHLDMAH--TLLDSRRSSSGSVDPQL----------- 1112

  Fly  1163 IHGDMKNNKPKKSKYL-----NNATDDDTASINSYGSHKNRPFKDESHKGSAETM---EGEEKRD 1219
              ||.|:....:|...     |:|.....:|.||.|  :....|..|..|..|::   ||:...|
Mouse  1113 --GDQKSLASLRSSPCAPWGPNSAGSSRRSSWNSLG--RAPSLKRRSQCGERESLLSGEGKGSTD 1173

  Fly  1220 ASKED-------------------LGLDEEL----------------------DEEGECEEGPLD 1243
            ...||                   |...|.|                      |..|:....|.:
Mouse  1174 DEAEDSRPNSGTHPGASPGPRATPLRRAESLGHRSTMDLCPPRPATLLPTKFRDCNGQMVALPSE 1238

  Fly  1244 GDIIIHAHDEDIL---DEYPADCCPDSYYKKFPILAGDDDSPFW----QGW--------GNLRLK 1293
            ..:.|.:|.||..   |:....||    ::...:|  :..:|.|    :.|        ..||:.
Mouse  1239 FFLRIDSHKEDAAEFDDDIEDSCC----FRLHKVL--EPYAPQWCSSRESWALYLFPPQNRLRVS 1297

  Fly  1294 TFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALG 1358
            ..::|.:|.|:..|:..|.::.:.:|||...:......:..|...:.|||.||.:||::|.:|||
Mouse  1298 CQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALG 1362

  Fly  1359 F----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGM 1416
            .    ..|..::|..||.::|:|||::.:.::..|||   :...:.:|.||.|||||.:||..|:
Mouse  1363 LLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGL 1427

  Fly  1417 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESE 1481
            ::||..|:.::..|.|::|:|..|::||.|:|||||.||::.||   ||...:  |..:..|.:.
Mouse  1428 KLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCE---GTDTRN--ITTKAECHAA 1487

  Fly  1482 NYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIF 1546
            :|.||....|||::|.|.:.||.:::..||:.||.|.:|:..:|:||::..|.:|.|||:.|::.
Mouse  1488 HYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLI 1552

  Fly  1547 GSFFTLNLFIGVIIDNFNE--QKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIP------- 1602
            .|||.||:|:||:::||::  |.::|        .|.:::....::::..::..||:|       
Mouse  1553 VSFFVLNMFVGVVVENFHKCRQHQEA--------EEARRREEKRLRRLERRRRSKAVPEVEEAQR 1609

  Fly  1603 RPRW----RPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFS 1663
            ||.:    ..:..:..:.|....|:.|...|.||:.||:::.|:...:.:..|.|.|.:|.::|.
Mouse  1610 RPYYADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFV 1674

  Fly  1664 SECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLSDIIEKYF--VSPTLLRVVRVAKVGRVL 1725
            .|..||:.|..: .:|.:.||..|:.:|:|||:|:.|.:|.....  ::||::|::||.::.|||
Mouse  1675 FEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLRIARVL 1739

  Fly  1726 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKS---GINDVYNF 1785
            :|:|.|.|:|.||..:..:||.:.|:.||..|:.||:|..|:..|  :...|.:   |::....|
Mouse  1740 KLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATF 1804

  Fly  1786 KTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGIT--FLLSYLVISF 1848
            ..||.:.:.||::||...|:|::...:.|  |...|.      :|.|....::  :.:::::::.
Mouse  1805 TNFGMAFLTLFRVSTGDNWNGIMKDTLRE--CTREDK------HCLSYLPALSPVYFVTFVLVAQ 1861

  Fly  1849 LIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQ---------QFDPEGTQ-------YI 1897
            .:::|:.:||::::..::.::.:|. .:.|.::..||.|         ..:.:||:       .:
Mouse  1862 FVLVNVVVAVLMKHLEESNKEARED-AEMDAEIELEIAQGSTAQPPSTAQESQGTEPDTPNLLVV 1925

  Fly  1898 RYDQLSEFLDV---------LEP-------PLQ-------------IHKPNKYKIISMDIP---- 1929
            |...:|..|.:         :.|       |||             .|.|:.....|..:|    
Mouse  1926 RKVSVSRMLSLPNDSYMFRPVAPAAAPHSHPLQEVEMETYTGPVTSAHSPSLEPRTSFQVPSAAS 1990

  Fly  1930 --------------------------ICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAA 1968
                                      :||.:.|:...:           :|. |::.||    .:
Mouse  1991 SPARVSDPLCALSPRDTPRSLSLSRILCRQEAMHAESL-----------EGQ-IDDAGE----DS 2039

  Fly  1969 RPD-TEGYEPVS---STLWRQREEYCA-RLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDP 2028
            .|| ||..|.:|   :.|...|...|: |......||| ..|:...|..|.|..||  |.:|.||
Mouse  2040 IPDYTEPAENISMSQAPLGTLRSPPCSPRPASVRTRKH-TFGQHCISSRPPTLGGD--DAEAADP 2101

  Fly  2029 APDEATDGDAPAGGDGSVNGTAEGAADADESNVNS-----PGEDAAAAAAAAAAAAAAGTTTAG- 2087
            |.:|.                         |::.|     |..:..:..|:..|:.|.||..:| 
Mouse  2102 ADEEV-------------------------SHITSSAHPWPATEPHSPEASPTASPAKGTVGSGR 2141

  Fly  2088 ---------------SPGAGSAGRQTAV-LVESDGFVTKNGHKVVIHSRSPSITSRTADVXARP- 2135
                           .||...|.|.::| |...||.:.....:.......|::.:|.....:.| 
Mouse  2142 DPHRFCSVDAQSFLDKPGRPDAQRWSSVELDNGDGHLESGEVRARASELEPALGARRKKKMSPPC 2206

  Fly  2136 ---RPPLQD 2141
               .||.:|
Mouse  2207 ISIDPPTED 2215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/331 (25%)
Na_trans_cytopl 515..648 CDD:288761 25/149 (17%)
Ion_trans 835..1028 CDD:278921 69/205 (34%)
Na_trans_assoc 1054..1296 CDD:284034 56/316 (18%)
Ion_trans 1318..1571 CDD:278921 97/261 (37%)
Na_channel_gate 1561..1613 CDD:240441 10/64 (16%)
Ion_trans 1636..1871 CDD:278921 67/244 (27%)
GPHH 1880..1930 CDD:293510 16/124 (13%)
Cacna1hXP_006524796.1 Ion_trans 99..430 CDD:366146 87/355 (25%)
Ion_trans 789..1023 CDD:366146 83/246 (34%)
PHA03307 1058..>1219 CDD:223039 34/192 (18%)
Ion_trans 1304..1576 CDD:366146 101/276 (37%)
Ion_trans 1629..1860 CDD:366146 70/238 (29%)
PHA03247 <1945..2360 CDD:223021 63/315 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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