DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and scn8aa

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_005162325.1	Gene:	scn8aa / 58152	ZFINID:	ZDB-GENE-000828-1	Length:	1960	Species:	Danio rerio

Alignment Length:	2099	Identity:	958/2099 - (45%)
Similarity:	1289/2099 - (61%)	Gaps:	260/2099 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ::.||||||.:||:||  |.||.|                ...:.:..|.|:|::..|:|:..||
Zfish    14 YKYFTRESLREIEKRI--EEEKAK----------------PPPKPDNSYRDDDDENKPKPNGDLE 60

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..||.:.:|||||.||:|.|..||||::|||.||||||:.|::|:.|||..||:
Zfish    61 AGKSLPF-IYGDIPPGMVATPLEDFDPFYINQKTFVVLNKGKTIFRFSATPALYMISPFNLARRI 124

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||:|.:||:||:.|||.||:.|.....|. .:..|..||||||||||||::||||.:..||:
Zfish   125 AIKILIHSVFSMFIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESAVKIIARGFCIDGFTF 189

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||:||::||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
Zfish   190 LRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 254

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCI-------KKFP-LDGSWGNLTDENWDYHNRNSSNWYS 331
            :|||:|.||||||:|||::||.|.|||:       :.|| ::||    ...|||.:..|.:|:|.
Zfish   255 MILTVFCLSVFALIGLQLFMGNLRQKCVIWPINITEMFPDVNGS----RAFNWDEYILNETNFYF 315

  Fly   332 EDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQL 396
            ..:.:...||||.|.:|:|.:.|.|::. |.|||||||||||||||||:.||||||||||:||||
Zfish   316 LPDQLDALLCGNSSDSGRCPEGYTCMKA-GRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQL 379

  Fly   397 VLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKA 461
            .|||||..:|:||:::||:|||||||||||:|||:|:| |.:|..|||..    :|||..|..:.
Zfish   380 TLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE-QNQATMEEAER----KEAEFKAMLEQ 439

  Fly   462 AKLEERANAQAQA-AADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVE 525
            .| :::.:|||.| |..|....|..:..:.......||.|.|:.....|...:....|...|..|
Zfish   440 LK-KQQEDAQANAMATSAGTVSEDVVEDDGDGEGNLSCSSSEMSKLSSKSAKERRNRKKKWRQKE 503

  Fly   526 -----------VESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIR 579
                       |:|||....:|:..........:...::.:.||:|||||..||.|:||
Zfish   504 QDKEKGDSEKFVKSESDDGSRRRFRFPDNRLGRRSSIMNQSLLSIPGSPFPSRRNSKSS------ 562

  Fly   580 NGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTS 644
                            :.|..:|......:|||.::.....:|               |..|:.|
Zfish   563 ----------------IFSRCKDGGSENEFADDEHSTVEEYDE---------------RRDSFLS 596

  Fly   645 HQSRISYTS-HGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEI 708
            .|.|.|||. :|.....:...||.::               :|...||...         .:..|
Zfish   597 PQRRSSYTGFYGKRNSTVDCNGVVSL---------------IGPGPGGRLL---------PEVII 637

  Fly   709 GLECTDEAGKIKHHDNPFIEPVQTQTVVDMK-----DVMVLNDIIEQAAGRHSRASDRGVSVYYF 768
            ....||        |:|       .|.:::|     .:||..:.:..:.||..||:    ||...
Zfish   638 DKAATD--------DSP-------TTDLEIKKKLSGSLMVSVEQLNTSFGRKERAN----SVMSA 683

  Fly   769 PTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTM 833
            .|....|:....:.|......|..:.|.:|:|..:|:..:|.|:|||.||||:|.||:|||:||:
Zfish   684 LTNTLVEELEESQRKCPPCWYKFANTFLIWECGPLWMSIKEIVNLIVMDPFVDLAITICIVLNTL 748

  Fly   834 FMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELG 898
            ||||:|:.|..:.|.||..||..||..|..|...||:||.|.|||||||||||..||:|||:|||
Zfish   749 FMAMEHYPMTPQFEHVLSVGNLVFTGIFTAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMELG 813

  Fly   899 LEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFG 963
            |..|:||||||||||||||||||||||||:||.|:|.::|||||||.||.||:|||||:||||||
Zfish   814 LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 878

  Fly   964 KNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVI 1026
            |:|.|...:. .|.:||||:..||.|||:||||||||||||:|||||.| |...|:..|:..:||
Zfish   879 KSYKDCVCKIAQDCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVI 943

  Fly  1027 GNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLI-RNKLT 1090
            |||||||||||||||:|.:.:|:|...|.:.|.:..|..||.:..:|||..:.:...:| ..|:|
Zfish   944 GNLVVLNLFLALLLSSFSADNLAASDDDGEMNNLQIAVIRIKKGIAWVKAKVRELVNIILGRKVT 1008

  Fly  1091 NQIS--DQPSGERTNQISWIWSEGKGVCRCISAEHG-DNELELGHDEILADGLIKKGIKEQTQLE 1152
            ::..  |.....:.|              ||:...| |...:|.:.        |.|....:.:.
Zfish  1009 DEAKPLDDMYDRKLN--------------CIANHTGVDISRDLDYQ--------KNGNGTTSGIG 1051

  Fly  1153 VAIG------DGMEFTIHGDMKNNKPKKSKYLNNAT-DDDTASINSYGSHKNRPFKDESHKGSAE 1210
            .::|      |.|.| ||      .|..:..:..|. :.|..::|:                  |
Zfish  1052 SSVGKYMIDDDHMSF-IH------NPNLTVCVPIAVGESDFENLNT------------------E 1091

  Fly  1211 TMEGEEKRDASKEDLGLDEELDEEG-------ECEEGPLDGDIIIHAHDEDILDEY--PADCCPD 1266
            ....|.:.:.|||   ||:....||       |.||.     :::     :.::||  |..|..:
Zfish  1092 DFSSESEAEGSKE---LDDISSSEGSTIDIKPEVEEA-----VVV-----ETVEEYVDPEACWTE 1143

  Fly  1267 SYYKKFPILAGDDDSPFWQGWGN----LRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQ 1327
            :...::...    |.|..:|||.    ||...:.::|:.:|||.:|.|||:||.|||.|||::.|
Zfish  1144 ACIARYKCC----DVPITEGWGKNWWFLRKTCYLIVEHNWFETLIIFMILLSSGALAFEDVYIEQ 1204

  Fly  1328 RPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGI 1392
            |..::.||.|.|.:||.||.||||:||:|.||..|||||||||||.||.||:::.:|:.:|...:
Zfish  1205 RKTIRIILEYADMVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGYSDL 1269

  Fly  1393 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF 1457
            ...|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:||||.:|||||:
Zfish  1270 GPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFAGKYY 1334

  Fly  1458 KCEDMNGTKLSH---EIIPNRNACES---ENYT---WVNSAMNFDHVGNAYLCLFQVATFKGWIQ 1513
            .|  .|.|:.::   :::.|::.|.:   :|||   |.|..:|||:||..||.|.||||||||:.
Zfish  1335 YC--YNETEKAYFELDVVNNKSECFALIEQNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMD 1397

  Fly  1514 IMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1578
            ||..|:|||.|:.||..|.|||||:|||.||||||||||||||||||||||:||||.||. ::||
Zfish  1398 IMYAAVDSRRVEDQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFM 1461

  Fly  1579 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDA 1643
            ||:||||||||||:|||||.|.||||:.:.|.:||:.||.:.|||.||:.|.|||.||.::..|.
Zfish  1462 TEEQKKYYNAMKKLGSKKPQKPIPRPQNKLQGMVFDFVTQQVFDISIMILICLNMVTMMVETDDQ 1526

  Fly  1644 SDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFV 1708
            |.....:|.::|.||:|.|:||.:||:||||::||...||:||.|||||||:|:.|:|:||||||
Zfish  1527 SQETENILYWINFIFIVAFTSEFVLKLFALRHYYFTNGWNIFDCVVVILSIVGMFLADLIEKYFV 1591

  Fly  1709 SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV 1773
            ||||.||:|:|::||:|||:|||||||||||||.|||||||||.||||||||||:|||||.|.:|
Zfish  1592 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV 1656

  Fly  1774 KEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIN-EEACDPPDNDKG--YPGNCGSATV 1835
            |.:|||:|:|||:|||.|||.||.::|||||||:|..|:| ...|:|...:.|  ..||||:.:|
Zfish  1657 KRESGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCEPTKENPGTSVKGNCGNPSV 1721

  Fly  1836 GITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYD 1900
            ||.|.:.|:::|||||:|||||:||||:|.|||:..:.|.:||::.:||||::|||..:|:|.:.
Zfish  1722 GIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESADPLCEDDFESFYEIWEKFDPTASQFITFA 1786

  Fly  1901 QLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG--NPIEETGEI 1963
            :|.:|.|.||.||::.|||..::|:||:|:..||.::|:|||.|.||......|  :.:.:..|.
Zfish  1787 KLGDFADTLEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGDLDMMRQQMEE 1851

  Fly  1964 GEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH-------------KARGEGGGSFEPDT 2015
            ..|||.|....:||:::||.|::|...|.:||.|:|.|             .:|.|.||:   :.
Zfish  1852 RFIAANPSKVSFEPITTTLRRKQEHMSAGVIQRAFRAHLIRKGFICKRLLSSSRLENGGT---NQ 1913

  Fly  2016 DHGDGGDPDAGDPAPDEAT 2034
            |..:|....|..|:.|..|
Zfish  1914 DKKEGTPSTASLPSYDSVT 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	167/279 (60%)
		Na_trans_cytopl	515..648	CDD:288761	30/143 (21%)
		Ion_trans	835..1028	CDD:278921	126/194 (65%)
		Na_trans_assoc	1054..1296	CDD:284034	53/265 (20%)
		Ion_trans	1318..1571	CDD:278921	162/261 (62%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	147/237 (62%)
		GPHH	1880..1930	CDD:293510	22/49 (45%)
scn8aa	XP_005162325.1	Ion_trans	151..423	CDD:278921	166/277 (60%)
		ATP-synt_B	363..>456	CDD:304375	55/98 (56%)
		Na_trans_cytopl	498..604	CDD:288761	31/142 (22%)
		Ion_trans	750..945	CDD:278921	126/194 (65%)
		Na_trans_assoc	971..1172	CDD:284034	53/264 (20%)
		Ion_trans	1195..1453	CDD:278921	160/259 (62%)
		Na_channel_gate	1445..1497	CDD:240441	36/52 (69%)
		Ion_trans	1519..1756	CDD:278921	147/236 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I972
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1619	1.000	Inparanoid score	I77
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm24873
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880