DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and cacna1ia

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_009297749.2 Gene:cacna1ia / 566351 ZFINID:ZDB-GENE-060503-324 Length:2122 Species:Danio rerio


Alignment Length:2298 Identity:533/2298 - (23%)
Similarity:915/2298 - (39%) Gaps:626/2298 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 FSLFIITTILVNCIL--MIMP------TTPTVESTEVIFTGIYTF---ESAVKVMARGFI--LCP 206
            |....|..||:||:.  |..|      |:...:..:.....||.|   |..||::|.|..  .| 
Zfish    13 FERISIMVILLNCVTLGMYQPCENIDCTSERCQVLQAFDAFIYIFFALEMVVKMVALGIFGRRC- 76

  Fly   207 FTYLRDAWNWLDFVVIALAYVTMGIDLGNL--AALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 269
              ||.|.||.|||.::....|...:||.|:  :|:||.||||.||.:..||.::.:|..:::::.
Zfish    77 --YLGDTWNRLDFFIVMAGMVEYSLDLQNINFSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLP 139

  Fly   270 NLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENW----------DYHNR 324
            .|.:|::|..|...:|.::|:|::.|:|..:|   :|         :||:          .|:..
Zfish   140 MLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC---YP---------EENFTLTSGLTLPTPYYQP 192

  Fly   325 NSSN------WYSEDEGISFPLCGNI----SGAGQC---DDDYVCLQGFG--------------- 361
            ...:      ..::|.||.  .|.::    .|..:|   .:|.:..|..|               
Zfish   193 EEDDERPFICSLAQDNGIM--SCSDVPARREGGRECCLDKEDALHRQALGLSAEPLVNGSASAMG 255

  Fly   362 ----------------PNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFI 410
                            .||:.|..:||:.|:|::..|:::|.:.|.::...|:.|...::.::||
Zfish   256 LCVNWNQYYTRCHTGHTNPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFI 320

  Fly   411 VIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAA 475
            .:|.:|||:::||.|.::|..:.|  .|..|.:..:|:..|....:..                 
Zfish   321 FLIIIGSFFMINLCLVVIATQFSE--TKQREHQLMQEQRARYLSSSTL----------------- 366

  Fly   476 ADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAP 540
              |:.||....:.|:     :..:.:.|                  |.....|.::..:.|..||
Zfish   367 --ASLAEPGDCYEEL-----FQLVCHIL------------------RKARRRSAALYYMLRGKAP 406

  Fly   541 TTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQ 605
            .                  ||       |.|         |||:.|                   
Zfish   407 P------------------PG-------GGR---------GRGKGG------------------- 418

  Fly   606 HLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMT 670
                   :.::...:..||           |.:|.   .|.::.|:..|                
Zfish   419 -------AGSIGGGANVNG-----------GEKHH---CHSAQTSHCIH---------------- 446

  Fly   671 KESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTV 735
             |:||.:.:....|:..:.....|......|..::   |.|.|..:...:..:....|..:.:..
Zfish   447 -ETKLDHSSENAVSLSISPNPEECPQCAAALSLKE---GEESTGHSANGEEEEGALEETDRDENR 507

  Fly   736 VDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDC 800
            :|.|                 |:||           .||    |.|.|..          |:..|
Zfish   508 LDKK-----------------RSSD-----------SDD----TLKKKRT----------CLGKC 530

  Fly   801 CWVW--LKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAI 863
            ..||  ::.:.|.  ||...:....|.:.|::||:.|.::||:...|:..||:..|..||:.|.:
Zfish   531 KDVWDEIRVKLWG--IVESKYFNRGIMIAILINTISMGIEHHNQPDELTNVLEICNIVFTSMFTL 593

  Fly   864 EATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNL 928
            |..:||.|.....|.:..:||||.|||.:|:.|:..:...||||||:||||||.||.:..|.|..
Zfish   594 EMILKLTAFGFFEYLRNPYNIFDGIIVIISVCEIIGQSDGGLSVLRTFRLLRVIKLVRFMPALRR 658

  Fly   929 LISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYH---DHKDRFPDGDLPRWNFTDFMHSF 990
            .:.::.:||..:.....:|.:.||||:::||.:||..:.   :..|..||    |.||...:.:.
Zfish   659 QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLKTEAGDTVPD----RKNFDSLLWAI 719

  Fly   991 MIVFRVLCGEWIESMWD-CMYVGDVSCIP----FFLATVVIGNLVVLNLFLALLLSNFGSSSLSA 1050
            :.||::|..|    .|: .:|.|..|..|    :|:|.:..||.|:.||.:|:|:..|       
Zfish   720 VTVFQILTQE----DWNMVLYNGMASTSPLAALYFVALMTFGNYVLFNLLVAILVEGF------- 773

  Fly  1051 PTADNDTNKIAEAFNRIGRFKSWVKRNIADC-FKLIRNKLTNQISD------------------- 1095
             .|:.|.|            :|:...:.:.| .:....|.:.|:||                   
Zfish   774 -QAEGDAN------------RSYSDDDRSSCNLEETEKKDSLQLSDPKISTLTPNGHLDLAPAPN 825

  Fly  1096 ----QPS-------GERTNQIS----------------------W-------IWSE-------GK 1113
                .||       |.|.:.:|                      |       |||.       |:
Zfish   826 ARGFYPSERLSFALGSRKSSVSSLGRASLEQTTLCPGRASLYHNWGRPARPGIWSRRSSWNSLGR 890

  Fly  1114 GVCRCISAEHG-------------DNELELG------HDEILADGLIKKGIKEQTQLEVAIGDGM 1159
            . .||:....|             :.|..|.      |..:|......:  :|:..|.:.:.:.:
Zfish   891 S-SRCLGMGGGGSLRVRSPHCHPAEQESLLSPPPPPLHPPLLPRHFPPR--RERRALSLELPELL 952

  Fly  1160 EF------TIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGE--- 1215
            :.      .:|       |::.|      ...:..:.|.|.|       :...|...:::.:   
Zfish   953 QVPGPPLPPLH-------PRQRK------KSFSGGLGSVGEH-------QDCNGKTPSVQPQIIN 997

  Fly  1216 -------EKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFP 1273
                   .::|  :||  |::|||..             :....:.:::.|..|.|.        
Zfish   998 EVYPQVNTRKD--RED--LEDELDYS-------------LCFRIQKMMEVYRPDWCE-------- 1037

  Fly  1274 ILAGDDDSPF-WQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYY 1337
              ..:|.|.| :......||....:|.:|.|:..|:..|..:.:.:|||...:.|..:.:..|..
Zfish  1038 --TREDWSVFLFSPQNKFRLLCQSIIAHKLFDYVVLAFIFSNCITVALERPKILQGSLERLFLTV 1100

  Fly  1338 MDRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSLINFVASLVGAGGI-QAFKT 1397
            .:.|||.||..||.:|.:::|.    :.|..::|..||..:|.||||:.|.|:.|...| ...:.
Zfish  1101 SNYIFTAIFVGEMTLKVVSMGLYIGEQAYLRSSWNILDGFLVFVSLIDIVVSMAGGAKILGVLRV 1165

  Fly  1398 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDM 1462
            :|.||.|||||.:||..|:::||..|:.::..|.|::|:|..|::||.|:|||||.||::.|   
Zfish  1166 LRLLRTLRPLRVISRAPGLKLVVETLITSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYYC--- 1227

  Fly  1463 NGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQ 1527
              ..|..:.|.|::.|...||.||:...|||::|.|.:.||.:|:..||:.||...:|:..||:|
Zfish  1228 --LGLDVKNITNKSDCLLANYKWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYHGLDAVAVDQQ 1290

  Fly  1528 PIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKM 1592
            ||...|.:|.|||:.|::..|||.||:|:||:::||::.::..       ..|:.|:.....::.
Zfish  1291 PITNNNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ-------EVEEAKRREEKRQRR 1348

  Fly  1593 GSKKPLKAIPRPRW----RPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDY 1653
            ..||..||...|.:    ..:.::..:.|....||.|...|.:|:.||:|:.|....:....|.|
Zfish  1349 MEKKRRKAQKLPYYASYSHVRLMIHTLCTSHYLDIFITFIICVNVVTMSLEHYSQPHSLEIALKY 1413

  Fly  1654 LNAIFVVIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLSDI-IEKYF-VSPTLLRV 1715
            .|..|...|..|.:||:.|..: .:|.:.||..|:.:|:||::|:.|.:| |.... ::||::|:
Zfish  1414 CNYFFTSTFVLEAVLKLIAFGFRRFFKDRWNQLDLAIVLLSVMGITLEEIEISAALPINPTIIRI 1478

  Fly  1716 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEK-- 1776
            :||.::.|||:|:|.|.|:|.||..:..:||.:.|:.||..|:.||:|..|:..|  :...|.  
Zfish  1479 MRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGELVCNEDYP 1543

  Fly  1777 -SGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFL 1840
             .|::....|:.||.:.:.|||:||...|:|::...:.|  |.|.:    |..|.....:...:.
Zfish  1544 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRE--CPPGE----YTCNPSLQFISPLYF 1602

  Fly  1841 LSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQ-----------QFDPEGT 1894
            :|:::.:..::||:.:||::::...:.::.||. .:.|.::..|:.|           ..|..|.
Zfish  1603 VSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEE-AEMDAEIEMELAQGTLCCIGGGVAVADRTGM 1666

  Fly  1895 QYIRYDQLSEFLDVLEPPLQI-----HKPNKYK-----------IISMDIPI---CRGDLMYCVD 1940
            .:    |.:....|:.|...|     |:||..:           :.|:.:.|   ..|:::    
Zfish  1667 GH----QGAASCSVVPPHSPITHPVAHEPNSIRRLYSPAQENLWLDSVSLLIKDSFEGEML---- 1723

  Fly  1941 ILDALTKDFFARKGNP-------------------------IEETGEIGEIAARPD--------- 1971
            ::|.|:...|....:|                         .|:..:.....|.||         
Zfish  1724 MIDNLSGSVFHHYSSPPVCKDCRTHPQEQIHMAELEQASLRSEQLSDKSSSPALPDDLSLDEQSV 1788

  Fly  1972 -----TEGYEPVSSTLWRQREEYCAR---LIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDP 2028
                 .||.|.|.... ...||...|   .::.:.|.|.:..|.||:.:         .|....|
Zfish  1789 YQMAAKEGKERVCDEC-HHSEEPGGRGNSRLRRSSRVHSSGTEDGGTCQ---------SPHHNTP 1843

  Fly  2029 APDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAA---------------A 2078
            |  ..:.|..|.......:....|.:....:.|..|.|....||||..|               .
Zfish  1844 A--RHSIGGVPCSSSSQEHPGVSGGSSRSNTPVCLPAEFFHPAAAALPAPPRGRTGHKPRGLRLT 1906

  Fly  2079 AAAGTTTAGSPGAGSAGRQTAVLVESDGFVT------------KNGHKVVIHSRSPSI------- 2124
            :.|...:..||||.:....|.....||..:.            :.|...::.:..|.:       
Zfish  1907 SPASWASLRSPGANTRLLTTQYPSHSDSSLATGSSEGSLPTTMEEGLSFIVSTPQPLLDTLLDER 1971

  Fly  2125 TSRTADVXARPRPP----LQDAR 2143
            ||.:.:  .||.||    ||..|
Zfish  1972 TSLSTE-TLRPSPPATHILQTTR 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 84/339 (25%)
Na_trans_cytopl 515..648 CDD:288761 18/132 (14%)
Ion_trans 835..1028 CDD:278921 68/200 (34%)
Na_trans_assoc 1054..1296 CDD:284034 49/344 (14%)
Ion_trans 1318..1571 CDD:278921 99/257 (39%)
Na_channel_gate 1561..1613 CDD:240441 9/55 (16%)
Ion_trans 1636..1871 CDD:278921 71/242 (29%)
GPHH 1880..1930 CDD:293510 12/76 (16%)
cacna1iaXP_009297749.2 Ion_trans 12..350 CDD:306908 89/355 (25%)
Ion_trans 547..774 CDD:306908 80/242 (33%)
Ion_trans 1063..1334 CDD:306908 103/282 (37%)
Ion_trans 1378..1633 CDD:306908 77/260 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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