Protein Alignment para and scn4ab

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_073798670.1
• Gene: scn4ab / 564977
• ZFINID: ZDB-GENE-051201-1
• Length: 1836
• Species: Danio rerio
• Alignment Length: 2128
• Identity: 904/2128 - (42%)
• Similarity: 1212/2128 - (56%)
• Gaps: 433/2128 - (20%)

  Fly    15 LFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTL 79
            :|||.|.|||.:|::|:|.|..:|:.:                |::.::..:||.   |:|...|
Zfish    64 VFRPLTLESLAEIDRRMAEEAAEQERM----------------KEQNVKVAEEDL---PKPTSDL 109

  Fly    80 EQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRR 144
            |.|..:|. :.|..||.|.:.|:|::||||....||:|:.|...|:||:...|.:.|.||||:||
Zfish   110 EAGKVLPF-IYGDPPPNLLNVPIEELDPYYKAQKTFIVIDKKNTIYRFNTEPACYCLSPFNPVRR 173

  Fly   145 VAIYILVH--PLFSLFIITTILVNCILMIMPTTP-TVESTEVIFTGIYTFESAVKVMARGFILCP 206
            .||.||:|  |: .|.|:.|||.||:.|.|...| ..:..|.:||||||||:.|||::|||.:..
Zfish   174 AAIRILIHSYPI-HLVIMLTILTNCVFMAMSDPPGWSKILEYVFTGIYTFEAMVKVLSRGFCIGD 237

  Fly   207 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNL 271
            ||:|||.||||||:||::||:|..:||||::|||||||||||||:.::|||||||||:|:|||.|
Zfish   238 FTFLRDPWNWLDFMVISMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKL 302

  Fly   272 RDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW--------GNLTDEN--------WD 320
            .||:|||:|.||||||:|||::||.|.|||:...|:  .|        .|.||.|        :|
Zfish   303 ADVMILTVFCLSVFALIGLQLFMGNLRQKCVLWPPV--GWYSDNLTVLSNYTDINGNGTANSTFD 365

  Fly   321 YHNR-NSSNWYSEDEGISFPL-CGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            |... ||...|....|...|| |||.|.||.|.:.|:||:. |.||||||||:|:||||||:.||
Zfish   366 YQKYINSEENYYYVPGQMDPLVCGNSSDAGLCPEGYICLKA-GRNPNYGYTSYDNFGWAFLALFR 429

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            ||||||||:|:||.|||||..:|:||:||||||||||:|||||:|||:|      ||:.||...|
Zfish   430 LMTQDFWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAY------AEQNEATAAE 488

  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDD 513
            | :|.||    :.||:.|:...||:.........:.:|..:                  :||::|
Zfish   489 A-KEKEE----EYAKIMEQLKKQAEQKNGMVNGSKTSLSSK------------------KKGDND 530

  Fly   514 NNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTI 578
                     .::.:.:.:::                            .|.:...||:.:..|
Zfish   531 ---------QMQSDYDGIAL----------------------------KPLSKSNGSKGNINY-- 556

  Fly   579 RNGRGRFGIPGSD-RKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSY 642
                  ..:|.|. |||.|:|..:.|   |...:|.....|          |.:|
Zfish   557 ------LEVPDSQIRKPSVVSAVESA---LDAQEDIERPCP----------PGWY---------- 592

  Fly   643 TSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYE 707
                                                                             
Zfish   593 ----------------------------------------------------------------- 592

  Fly   708 IGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTED 772
                                                                             
Zfish   593 ----------------------------------------------------------------- 592

  Fly   773 DDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAM 837
                             |..|:|..||||..|:||:..|.|.|.||||:|.||||||:||:||||
Zfish   593 -----------------KFADIFLKWDCCIPWVKFKRIVYLFVMDPFVDLGITLCIVLNTVFMAM 640

  Fly   838 DHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGV 902
            :|:.|:..:|.||..||..||..||.|..:||:|:.|.||||.||||||.|||.:||:||.|..|
Zfish   641 EHYPMSVHVEEVLAIGNLVFTGIFAAEMVLKLIALDPYYYFQVGWNIFDSIIVTMSLVELMLADV 705

  Fly   903 QGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYH 967
            :||||||||||:|||||||||||||:||.|:|.::|||||||.||.||:|||||:|||||||:|.
Zfish   706 EGLSVLRSFRLMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYT 770

  Fly   968 DHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLV 1030
            |...:. .|.:||||:..||.|:|:|:||||||||||:|||||.| |...||..|:..:||||||
Zfish   771 DSVCKISSDCELPRWHMADFFHAFLIIFRVLCGEWIETMWDCMEVAGQGMCIIVFMMVMVIGNLV 835

  Fly  1031 VLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVK----RNIADCFKLIRNKLTN 1091
            |||||||||||:|...:||| :.|:..|.:..|.:||.|...|:|    :::..|..|
Zfish   836 VLNLFLALLLSSFSGDNLSA-SDDDGENNLQIAISRITRGIDWIKAFANKHVRQCLNL------- 892

  Fly  1092 QISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIG 1156
              ..:..|.:.|                    |:.:.::        ..|........::.:|
Zfish   893 --KPKEEGAKVN--------------------GEGDAKM--------NAIMNSSSSMVKVPIA-- 925

  Fly  1157 DGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDAS 1221
                                  |..:|||..:.:|         :||..:|....|   :|::.
Zfish   926 ----------------------NGESDDDDGNGSS---------EDEDDEGGDINM---KKKNG- 955

  Fly  1222 KEDLGLDEELDEEGECE--EGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFW 1284
                      ||...|.  :.|.:.:.::...:||:..  |.||..::..::.|.|..|......
Zfish   956 ----------DESSTCSTVDKPPEVEDLVEEEEEDLTS--PEDCYTENCIRRCPCLDLDVSQGKG 1008

  Fly  1285 QGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLE 1349
            :.|.|.|...|.::|:.||||.:|.|||:||.|||.||:::.||.:::.||.|.|::||.:|.:|
Zfish  1009 KAWWNFRKTCFAIVEHSYFETFIIFMILLSSGALAFEDIYIEQRRMIKIILEYADQVFTYVFVVE 1073

  Fly  1350 MLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQ 1414
            ||:||:|.|||||||||||||||:||.||||:..|:::|...:.|.|::|||||||||||:||.:
Zfish  1074 MLLKWVAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGYSELGAIKSLRTLRALRPLRALSRFE 1138

  Fly  1415 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTK---LSHEIIPNRN 1476
            ||||||||||.|||||||||||||||||||:||||.|||||::.|  .|.|.   ..|..:.|:.
Zfish  1139 GMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYYC--FNETSEEVFDHNEVNNKT 1201

  Fly  1477 ACES-----ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYM 1536
            .|..     ....|:|..:|||:||..||.|.||||||||:.||..|:|||.::.||:.|.|:||
Zfish  1202 DCYELMEFHPEVRWMNGKINFDNVGMGYLALLQVATFKGWMDIMYSAVDSRAIESQPVYEANLYM 1266

  Fly  1537 YLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAI 1601
            |:|||.||||||||||||||||||||||:||.|..|: ::||||:||||||||||:|||||.|.|
Zfish  1267 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKAKIRGT-DIFMTEEQKKYYNAMKKLGSKKPQKPI 1330

  Fly  1602 PRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSEC 1666
            |||....|.:||:.||.:.|||.||:.|.|||.||.::..|.|.....:|.|:|..|:::|:.||
Zfish  1331 PRPTNCCQGLVFDFVTQQFFDIFIMVMICLNMVTMMVETDDQSPEIEEILFYINFAFIILFTGEC 1395

  Fly  1667 LLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1731
            :|||.|||||||...||:||.|||||||||:.|:|:||||||||||.||:|:|::||||||::||
Zfish  1396 VLKITALRYHYFSIGWNIFDFVVVILSILGIGLADLIEKYFVSPTLFRVIRLARIGRVLRLIRGA 1460

  Fly  1732 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLF 1796
            ||||||||||.|||||||||.|||||:||||:|||||.|.:||::.||:|:.||:|||.|:|.:|
Zfish  1461 KGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEVGIDDMMNFETFGNSIICMF 1525

  Fly  1797 QMSTSAGWDGVLDAIINEEA-CDPPDNDKGYP--GNCGSATVGITFLLSYLVISFLIVINMYIAV 1858
            .::|||||||:|..|:|... |||..::.|..  ||||:|.|||.|..||:|:|||:|:|||||:
Zfish  1526 MITTSAGWDGLLAPILNSPPDCDPDVDNPGSTTRGNCGNAAVGIVFFCSYIVMSFLVVVNMYIAI 1590

  Fly  1859 ILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKI 1923
            ||||::.|||:..:.|.:||::|:||.|::|||..:|:|.|::||||.|.|:.||:|.|||..|:
Zfish  1591 ILENFNVATEESSDPLCEDDFEMFYETWEKFDPTASQFIDYNRLSEFCDTLKDPLRIPKPNTLKL 1655

  Fly  1924 ISMDIPICRGDLMYCVDILDALTKDFF--ARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQR 1986
            |:||||:..||.::|:|:|.|||.:..  :.:.:.::.|.|...:|..|....|||::|||.|::
Zfish  1656 ITMDIPMVTGDKIHCLDLLLALTGEVLGGSDQMDGMKATMEEKFMANNPSKASYEPITSTLKRKQ 1720

  Fly  1987 EEYCARLIQHAWRKH---KARGEGGGSFEPDTDHGDGGDPDAGDPAP---------------DEA 2033
            ||..|..||.|:|.|   :...:....:...|    |.....|| ||               |:|
Zfish  1721 EEVAASTIQRAYRSHILKRCVKQASYMYRDKT----GSKKPTGD-APEKVGMIAENMRNLYGDQA 1780

  Fly  2034 TDGDAPAGGDGSVNGTAEGAADADESNVNS---------PGEDAAAAA 2072
            .:.|.|.|...|.:|..:..|......|.|         |..:::.||
Zfish  1781 VEDDQPVGCSFSQHGKTQFGAKRPPVKVQSDVVLHSAPFPVPESSTAA 1828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	175/304 (58%)
		Na_trans_cytopl	555..740	CDD:463401	17/185 (9%)
		Ion_trans	817..1028	CDD:459842	136/212 (64%)
		Na_trans_assoc	1054..1296	CDD:461936	40/247 (16%)
		Ion_trans	1300..1571	CDD:459842	171/278 (62%)
		Na_channel_gate	1561..1613	CDD:240441	33/51 (65%)
		Ion_trans	1621..1871	CDD:459842	156/252 (62%)
		GPHH	1882..1929	CDD:465306	25/46 (54%)
scn4ab	XP_073798670.1	None