DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and scn4ab

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_005171642.1 Gene:scn4ab / 564977 ZFINID:ZDB-GENE-051201-1 Length:1835 Species:Danio rerio


Alignment Length:2128 Identity:914/2128 - (42%)
Similarity:1216/2128 - (57%) Gaps:434/2128 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTL 79
            :|||.|.|||.:|::|:|.|..:|:.:                |::.::..:||.   |:|...|
Zfish    64 VFRPLTLESLAEIDRRMAEEAAEQERM----------------KEQNVKVAEEDL---PKPTSDL 109

  Fly    80 EQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRR 144
            |.|..:|. :.|..||.|.:.|:|::||||....||:|:.|...|:||:...|.:.|.||||:||
Zfish   110 EAGKVLPF-IYGDPPPNLLNVPIEELDPYYKAQKTFIVIDKKNTIYRFNTEPACYCLSPFNPVRR 173

  Fly   145 VAIYILVHPLFSLFIITTILVNCILMIMPTTP-TVESTEVIFTGIYTFESAVKVMARGFILCPFT 208
            .||.||:|.||||.|:.|||.||:.|.|...| ..:..|.:||||||||:.|||::|||.:..||
Zfish   174 AAIRILIHSLFSLVIMLTILTNCVFMAMSDPPGWSKILEYVFTGIYTFEAMVKVLSRGFCIGDFT 238

  Fly   209 YLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRD 273
            :|||.||||||:||::||:|..:||||::|||||||||||||:.::|||||||||:|:|||.|.|
Zfish   239 FLRDPWNWLDFMVISMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLAD 303

  Fly   274 VIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW--------GNLTDEN--------WDYH 322
            |:|||:|.||||||:|||::||.|.|||:...|:  .|        .|.||.|        :||.
Zfish   304 VMILTVFCLSVFALIGLQLFMGNLRQKCVLWPPV--GWYSDNLTVLSNYTDINGNGTANSTFDYQ 366

  Fly   323 NR-NSSNWYSEDEGISFPL-CGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLM 385
            .. ||...|....|...|| |||.|.||.|.:.|:||:. |.||||||||:|:||||||:.||||
Zfish   367 KYINSEENYYYVPGQMDPLVCGNSSDAGLCPEGYICLKA-GRNPNYGYTSYDNFGWAFLALFRLM 430

  Fly   386 TQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAI 450
            ||||||:|:||.|||||..:|:||:||||||||||:|||||:|||:|      ||:.||...|| 
Zfish   431 TQDFWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAY------AEQNEATAAEA- 488

  Fly   451 REAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNN 515
            :|.||    :.||:.|:...||:.........:.:|..:                  :||::|  
Zfish   489 KEKEE----EYAKIMEQLKKQAEQKNGMVNGSKTSLSSK------------------KKGDND-- 529

  Fly   516 KEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRN 580
                   .::.:.:.:::                            .|.:...||:.:..|    
Zfish   530 -------QMQSDYDGIAL----------------------------KPLSKSNGSKGNINY---- 555

  Fly   581 GRGRFGIPGSD-RKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTS 644
                ..:|.|. |||.|:|..:.|   |...:|.....|          |.:|            
Zfish   556 ----LEVPDSQIRKPSVVSAVESA---LDAQEDIERPCP----------PGWY------------ 591

  Fly   645 HQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIG 709
                                                                             
Zfish   592 ----------------------------------------------------------------- 591

  Fly   710 LECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDD 774
                                                                             
Zfish   592 ----------------------------------------------------------------- 591

  Fly   775 EDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDH 839
                           |..|:|..||||..|:||:..|.|.|.||||:|.||||||:||:||||:|
Zfish   592 ---------------KFADIFLKWDCCIPWVKFKRIVYLFVMDPFVDLGITLCIVLNTVFMAMEH 641

  Fly   840 HDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQG 904
            :.|:..:|.||..||..||..||.|..:||:|:.|.||||.||||||.|||.:||:||.|..|:|
Zfish   642 YPMSVHVEEVLAIGNLVFTGIFAAEMVLKLIALDPYYYFQVGWNIFDSIIVTMSLVELMLADVEG 706

  Fly   905 LSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDH 969
            |||||||||:|||||||||||||:||.|:|.::|||||||.||.||:|||||:|||||||:|.|.
Zfish   707 LSVLRSFRLMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYTDS 771

  Fly   970 KDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVL 1032
            ..:. .|.:||||:..||.|:|:|:||||||||||:|||||.| |...||..|:..:||||||||
Zfish   772 VCKISSDCELPRWHMADFFHAFLIIFRVLCGEWIETMWDCMEVAGQGMCIIVFMMVMVIGNLVVL 836

  Fly  1033 NLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQP 1097
            |||||||||:|...:||| :.|:..|.:..|.:||.|...|:|..:                   
Zfish   837 NLFLALLLSSFSGDNLSA-SDDDGENNLQIAISRITRGIDWIKAFV------------------- 881

  Fly  1098 SGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFT 1162
                          .|.|.:|::.:.                      ||         :|.:..
Zfish   882 --------------NKHVRQCLNLKP----------------------KE---------EGAKVN 901

  Fly  1163 IHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPF-----KDESHKGSAETMEGEEKRDAS- 1221
            ..||.|.|                |.:||..|....|.     .|:...||:|. |.:|.||.: 
Zfish   902 GEGDAKMN----------------AIMNSSSSMVKVPIANGESDDDDGNGSSED-EDDEGRDINM 949

  Fly  1222 KEDLGLDEELDEEGECE--EGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFW 1284
            |:..|     ||...|.  :.|.:.:.::...:||:..  |.||..::..::.|.|..|......
Zfish   950 KKKNG-----DESSTCSTVDKPPEVEDLVEEEEEDLTS--PEDCYTENCIRRCPCLDLDVSQGKG 1007

  Fly  1285 QGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLE 1349
            :.|.|.|...|.::|:.||||.:|.|||:||.|||.||:::.||.:::.||.|.|::||.:|.:|
Zfish  1008 KAWWNFRKTCFAIVEHSYFETFIIFMILLSSGALAFEDIYIEQRRMIKIILEYADQVFTYVFVVE 1072

  Fly  1350 MLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQ 1414
            ||:||:|.|||||||||||||||:||.||||:..|:::|...:.|.|::|||||||||||:||.:
Zfish  1073 MLLKWVAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGYSELGAIKSLRTLRALRPLRALSRFE 1137

  Fly  1415 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTK---LSHEIIPNRN 1476
            ||||||||||.|||||||||||||||||||:||||.|||||::.|  .|.|.   ..|.::.|:.
Zfish  1138 GMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYYC--FNETSEEVFDHNVVNNKT 1200

  Fly  1477 ACES-----ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYM 1536
            .|..     ....|:|..:|||:||..||.|.||||||||:.||..|:|||.::.||:.|.|:||
Zfish  1201 DCYELMEFHPEVRWMNGKINFDNVGMGYLALLQVATFKGWMDIMYSAVDSRAIESQPVYEANLYM 1265

  Fly  1537 YLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAI 1601
            |:|||.||||||||||||||||||||||:||.|.||: ::||||:||||||||||:|||||.|.|
Zfish  1266 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKAKLGGT-DIFMTEEQKKYYNAMKKLGSKKPQKPI 1329

  Fly  1602 PRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSEC 1666
            |||....|.:||:.||.:.|||.||:.|.|||.||.::..|.|.....:|.|:|..|:::|:.||
Zfish  1330 PRPTNCCQGLVFDFVTQQFFDIFIMVMICLNMVTMMVETDDQSAEIEEILFYINFAFIILFTGEC 1394

  Fly  1667 LLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1731
            :|||.|||||||...||:||.|||||||||:.|:|:||||||||||.||:|:|::||||||::||
Zfish  1395 VLKITALRYHYFSIGWNIFDFVVVILSILGIGLADLIEKYFVSPTLFRVIRLARIGRVLRLIRGA 1459

  Fly  1732 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLF 1796
            ||||||||||.|||||||||.|||||:||||:|||||.|.:||::.||:|:.||:|||.|:|.:|
Zfish  1460 KGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEVGIDDMMNFETFGNSIICMF 1524

  Fly  1797 QMSTSAGWDGVLDAIINEEA-CDPPDNDKGYP--GNCGSATVGITFLLSYLVISFLIVINMYIAV 1858
            .::|||||||:|..|:|... |||..::.|..  ||||:|.|||.|..||:|:|||:|:|||||:
Zfish  1525 MITTSAGWDGLLAPILNSPPDCDPDVDNPGSTTRGNCGNAAVGIVFFCSYIVMSFLVVVNMYIAI 1589

  Fly  1859 ILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKI 1923
            ||||::.|||:..:.|.:||::|:||.|::|||..:|:|.|::||||.|.|:.||:|.|||..|:
Zfish  1590 ILENFNVATEESSDPLCEDDFEMFYETWEKFDPTASQFIDYNRLSEFCDTLKDPLRIPKPNTLKL 1654

  Fly  1924 ISMDIPICRGDLMYCVDILDALTKDFF--ARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQR 1986
            |:||||:..||.::|:|:|.|||.:..  :.:.:.::.|.|...:|..|....|||::|||.|::
Zfish  1655 ITMDIPMVTGDKIHCLDLLLALTGEVLGGSDQMDGMKATMEEKFMANNPSKASYEPITSTLKRKQ 1719

  Fly  1987 EEYCARLIQHAWRKH---KARGEGGGSFEPDTDHGDGGDPDAGDPAP---------------DEA 2033
            ||..|..||.|:|.|   :...:....:...|    |.....|: ||               |:|
Zfish  1720 EEVAASTIQRAYRSHILKRCVKQASYMYRDKT----GSKKPTGE-APEKVGMIAENMRSLYGDQA 1779

  Fly  2034 TDGDAPAGGDGSVNGTAEGAADADESNVNS---------PGEDAAAAA 2072
            .:.|.|.|...|.:|..:..|......|.|         |..:::.||
Zfish  1780 VEDDHPVGCSFSQHGKTQFGAKRPPVKVQSDVVLHSAPFPVPESSTAA 1827

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 168/289 (58%)
Na_trans_cytopl 515..648 CDD:288761 17/133 (13%)
Ion_trans 835..1028 CDD:278921 122/194 (63%)
Na_trans_assoc 1054..1296 CDD:284034 48/249 (19%)
Ion_trans 1318..1571 CDD:278921 160/260 (62%)
Na_channel_gate 1561..1613 CDD:240441 34/51 (67%)
Ion_trans 1636..1871 CDD:278921 146/237 (62%)
GPHH 1880..1930 CDD:293510 27/49 (55%)
scn4abXP_005171642.1 Ion_trans 199..481 CDD:278921 168/290 (58%)
Ion_trans 637..832 CDD:278921 122/194 (63%)
Na_trans_assoc 858..1018 CDD:284034 47/247 (19%)
Ion_trans 1041..1298 CDD:278921 159/258 (62%)
Na_channel_gate 1290..1342 CDD:240441 35/52 (67%)
Ion_trans 1364..1602 CDD:278921 146/237 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 351 1.000 Domainoid score I972
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1619 1.000 Inparanoid score I77
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm24873
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.980

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