DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and cacna1e

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_017212914.2 Gene:cacna1e / 564274 -ID:- Length:2444 Species:Danio rerio


Alignment Length:2310 Identity:522/2310 - (22%)
Similarity:895/2310 - (38%) Gaps:728/2310 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 IEQR--IAAE--HEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQGVPIPV 87
            ||||  |.|.  |:.|...:.:|.|.|:.::|..........|...|....:..|.:..|...|.
Zfish   133 IEQRDIIKAHQAHKIQSTPQARRKEWEMARFGDDVPGLLGAGDGGSERSRNRDAPAVSTGGVSPA 197

  Fly    88 RLQGSFPPELAST-PLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILV 151
            ..|..  .:.|.| .|.:..|...|.              |:.::::::....|.:|:.|..|:.
Zfish   198 FKQTK--AQRARTMALYNPIPVRQNC--------------FTVNRSLFIFGEDNIVRKYAKKIIE 246

  Fly   152 HPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCP 206
            .|.|...|:.||:.|||::.:          |....:|.||..|.|::.||:.:|::|.||:...
Zfish   247 WPPFEYMILATIIANCIVLALEQHLPGEDKTPMAKRLEKTEPYFIGMFCFEAGIKIIALGFVFHK 311

  Fly   207 FTYLRDAWNWLDFVVI-----ALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 266
            .:|||:.||.:||:|:     |.|...|.|.| :|..||..||||.||.|:.:|.|:.::.::::
Zfish   312 GSYLRNGWNVMDFIVVSSGILATAGAHMNISL-DLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMK 375

  Fly   267 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC--IKKFPLDGSWGNLTDENWDYHNRNSSNW 329
            ::..|..:.:|..|::.:||::||:.|.|.|.::|  :.|               |....:|   
Zfish   376 AMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHKQCEPVGK---------------DSERADS--- 422

  Fly   330 YSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLY 394
             .|:|   || |    |:..|.|.|.| .|:...||.|.|.||:..::.|:.|:.:|.:.|..:.
Zfish   423 -PENE---FP-C----GSKLCPDHYNC-SGYWTGPNDGITQFDNILFSLLTVFQCITMEGWTTIL 477

  Fly   395 QLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAA 458
            .....|.| .|:.|:||.:|.:|||:::||:|.:::..:.:.:::.|...|..:  :|..::   
Zfish   478 YYTNDALGSTWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK--LRRQQQ--- 537

  Fly   459 AKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRS 523
                 :|...|.. :|..|  .|||..|..|                         ||..     
Zfish   538 -----IERELNGY-RAWID--RAEEVMLAEE-------------------------NKNS----- 564

  Fly   524 VEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIP 588
               ...::.|::|         ||.::                                 |.|:.
Zfish   565 ---GPSALDVLKR---------ATTIK---------------------------------RRGVD 584

  Fly   589 GSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTS 653
            .:.|.|        .:|   |||.|:...|::.           .::.|.....||:..|     
Zfish   585 DARRAP--------EEQ---YADISSLGMPLNR-----------ASIRSAKRGPTSYFRR----- 622

  Fly   654 HGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGK 718
                             ||..||....|                                     
Zfish   623 -----------------KERLLRISVRR------------------------------------- 633

  Fly   719 IKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDK 783
                      .|:|||                               :|                
Zfish   634 ----------MVKTQT-------------------------------FY---------------- 641

  Fly   784 ALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMER 848
                                      |..|.:            :.:||:.:|:.||...:.:..
Zfish   642 --------------------------WTVLGL------------VALNTLCVAIVHHKQPQWLSS 668

  Fly   849 VLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLEL--GL--EGVQ-GLSVL 908
            :|....:.|...|..|..:|:..:.|:.||...:|.||..::..|:.|:  |.  .|.. |:|||
Zfish   669 LLYYAEFLFLGLFLTEMFLKMYGLGPRLYFHSSFNCFDCGVIVGSIFEVFWGFFRPGTSFGISVL 733

  Fly   909 RSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDR 972
            |:.||||:||:.|.|.:| ||::|:| .:|.::.:|.|:|.:.|.:||::||||||       .|
Zfish   734 RALRLLRIFKITKYWASLRNLVVSLM-NSMKSIISLLFLLFLFIVVFALLGMQLFG-------GR 790

  Fly   973 FPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE--------------SMWDCMYVGDVSCIPFFLA 1022
            |...:....||..|..:.|.||::|.|| |.|              .||..:|         |:.
Zfish   791 FIFDEYTPTNFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVKSGMWSSVY---------FIV 846

  Fly  1023 TVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNR---------IGRFKSWV---- 1074
            ..:.||..:||:|||:.:.|..    :|.....|..:..||||:         :|...|::    
Zfish   847 LTLFGNYTLLNVFLAIAVDNLA----NAQELTKDEEEEEEAFNQKHALQKAKEVGPMSSFMSSER 907

  Fly  1075 --------KRNIADCFKLIRNKLTNQISDQPS----------------GERTNQISW-IWSEGKG 1114
                    ||.|.      |::......|..|                .||..:::. :|.:...
Zfish   908 RRRPYLYRKRAIH------RSRAAYSFEDAESLADARPFNASNSFMSRRERRRRLTMSVWEQRTS 966

  Fly  1115 VCRCISAEHGDNELELGHDEIL------------------ADGLIKKGIKEQTQLEVAIGDGMEF 1161
            ..|        ...::...|||                  ..||...|.|.:.....:.....|.
Zfish   967 QLR--------RHRQMSSREILFSSPSEEQDGPPGCPLHRKPGLSPSGSKRRATETTSTTIMPEG 1023

  Fly  1162 TIHGDMKNNKPKKSKYL----------------------------------------NNATDDDT 1186
            |:...|..:.|...:.|                                        :..:.:..
Zfish  1024 TLEPPMPMDMPVDEQALPISIPEPPLAIPIPEPPMPVDACLPEPPVTLNLPLTEPSESKTSPEGA 1088

  Fly  1187 ASINSY-----------------------------GSHKNRPFKDESH---KGSAETM------- 1212
            ..||::                             |....||...|.|   :|. ||:       
Zfish  1089 LDINNHCPRLNGNRRQRAVRKHRPPAMGDMLTPDMGPRPRRPRHRELHTDPRGK-ETLQGDGVDG 1152

  Fly  1213 -------EGEEKRDA--SKEDLGLDEE------------------------LDEE---------- 1234
                   ||:||.|.  |.:..||::.                        ||.|          
Zfish  1153 KEQKPGSEGDEKSDGEISPDGRGLEQRQNKPDNTESSTESKPANSPRKIPPLDSEPATLQLTDNT 1217

  Fly  1235 -----------GECE---EGPLDGD-------IIIHAHD------------------------ED 1254
                       ||.:   .|.|:.|       |:|...|                        |:
Zfish  1218 LQQSSQGTTCAGETDNNNHGSLNQDKSSLNTSIVIEVTDTQPSMELTSITGNSKDVEASKPEKEE 1282

  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALA 1319
            ...:.|....|.|.:...|      ::|       :|.....::..:|||.:::.:|..||:|||
Zfish  1283 ETPDAPKGPPPVSMFIFKP------NNP-------VRRACHYVVNLRYFEMSILLVIAASSIALA 1334

  Fly  1320 LEDVHLPQRPI-----LQDILYYMDRIFTVIFFLEMLIKW----LALGFKVYFTNAWCWLDFVIV 1375
            .||      |:     ...:|.|.|.:||.:|..||:||.    |.|.:..||.:.|..|||::|
Zfish  1335 AED------PVNTNSDRNKVLRYFDYVFTGVFTFEMIIKMIDQGLVLHYGSYFRDPWNILDFIVV 1393

  Fly  1376 MVSLINF-VASLVGAG---GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1436
            :.:|:.| :.:::|:.   .|:..|::|.||.||||:.:.|:..::.|.:.:|.::.::||:|:|
Zfish  1394 VGALVAFALTNVMGSNTGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIV 1458

  Fly  1437 CLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNAC-----------ESENYTWVNSAM 1490
            ..:|..|||::.||||.||::.|.|.:.        ...|.|           :.|...|.....
Zfish  1459 YKLFMFIFAVIAVQLFKGKFYYCTDSSK--------DTENECKGYYIDYDKDKKKEKREWKRRDF 1515

  Fly  1491 NFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLF 1555
            ::|:|..|.|.||.|:|.:||.|::..::|..|.|:.|.:...:.|.:::|.:.:...||.:|:|
Zfish  1516 HYDNVVWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFVNIF 1580

  Fly  1556 IGVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIV 1616
            :.:||..|.||..|        |.|:   :|.....:....|.||| :.:|:.|...|..:::.|
Zfish  1581 VALIIITFQEQGDK--------MMEECSLEKNERACIDFAISAKPLTRYMPQNRQTLQYRLWQFV 1637

  Fly  1617 TDKKFDIIIMLFIGLNMFTMTLDRYDAS-DTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYFI 1679
            ....|:..::..|.||...:.:..:|.. :.|:.||.|||.||.||||.||:|||.|.. .:||.
Zfish  1638 VSPSFEYTVLTMIALNTIVLMMKHHDPRLEGYDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFR 1702

  Fly  1680 EPWNLFDVVVVILSILGLVLSDIIEKYFVSPTL-LRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1743
            :.||:||    .:::||.:...:::|:....|. :..:::.:..|:::|::....||.||:....
Zfish  1703 DTWNIFD----FITVLGSITEILVDKFQTGKTFNMGFLKLFRAARLIKLLRQGYTIRILLWTFVQ 1763

  Fly  1744 SLPALFNICLLLFLVMFIFAIFGMSFFMHVK--EKSGINDVYNFKTFGQSMILLFQMSTSAGWDG 1806
            |..||..:|||:.::.||:||.||..|.::|  ||:.||:..||:||..:::|||:.:|...|..
Zfish  1764 SFKALPYVCLLIAMLFFIYAIIGMQVFGNIKINEKTQINEHNNFRTFFGALMLLFRSATGESWQE 1828

  Fly  1807 VLDAIINEEAC--DPPDND--KGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQAT 1867
            ::.:.:.|:.|  |...|.  |....:||: .....:.:|::..|..:::|:::|||::|:...|
Zfish  1829 IMLSCLGEKECEIDTSVNSTTKTIKNDCGT-DFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLT 1892

  Fly  1868 EDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKI-----ISMD 1927
            .| ...|.....|.:..||.::|......:.|.::.:.:..:.|||...|...|::     :.|:
Zfish  1893 RD-SSILGPHHLDEFVRIWGEYDRAACGKLHYKEMYKVVRTISPPLGFGKNCPYRVACKRLVLMN 1956

  Fly  1928 IPICRGDLMYCVDILDALTK---DFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE- 1988
            :|:.....::....|.||.:   |....:|         ||...:.|.|..:.: |.:|....: 
Zfish  1957 MPVDEDMSVHFTSTLMALIRTALDIKIARG---------GEDRGQMDVELQKEI-SVIWPHLSQK 2011

  Fly  1989 -------------------YCARLIQHAWRKHKAR 2004
                               |.|.:|...::::||:
Zfish  2012 SLDLLVPIHKASDMTIGKIYAAMMIMDYYKQNKAK 2046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 88/288 (31%)
Na_trans_cytopl 515..648 CDD:288761 19/132 (14%)
Ion_trans 835..1028 CDD:278921 66/213 (31%)
Na_trans_assoc 1054..1296 CDD:284034 65/464 (14%)
Ion_trans 1318..1571 CDD:278921 86/276 (31%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 78/243 (32%)
GPHH 1880..1930 CDD:293510 11/54 (20%)
cacna1eXP_017212914.2 Ion_trans 247..524 CDD:306908 93/305 (30%)
Ion_trans 640..875 CDD:306908 80/309 (26%)
Atrophin-1 887..>1210 CDD:331285 45/337 (13%)
Ion_trans 1316..1549 CDD:306908 78/246 (32%)
Ion_trans 1639..1896 CDD:306908 82/262 (31%)
GPHH 1897..1967 CDD:318993 13/69 (19%)
Ca_chan_IQ 1969..2043 CDD:312334 14/83 (17%)
Transformer 2203..2368 CDD:253769
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.