DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and cacna1g

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_021336019.1 Gene:cacna1g / 563904 ZFINID:ZDB-GENE-090514-2 Length:2503 Species:Danio rerio


Alignment Length:2241 Identity:528/2241 - (23%)
Similarity:914/2241 - (40%) Gaps:563/2241 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTFESAVK 196
            |...:.::.:|.|....:..||:||:.  |..|...:         :|..:......:..|..:|
Zfish    90 RSWCLKMVCNPWFERASMLVILLNCVTLGMFHPCEDSHCDSERCKILEDFDDFIFAFFAVEMVIK 154

  Fly   197 VMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNL--AALRTFRVLRALKTVAIVPGLKT 259
            ::|.| |.....||.|.||.|||.::....:...::|.|:  :|:||.||||.|:.:..||.::.
Zfish   155 MVALG-IFGKKCYLGDTWNRLDFFIVLAGMLEYSLNLQNVSFSAVRTVRVLRPLRAINRVPSMRI 218

  Fly   260 IVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNR 324
            :|..:::::..|.:|::|..|...:|.::|:|::.|:|..:|.  .|.:.|.....:....||..
Zfish   219 LVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF--LPENFSLPTSLELRKYYHTE 281

  Fly   325 NSSNWYSEDEG---ISFP------LCGNI----SGAGQCD---------DDYVCL---------Q 358
            |      :||.   .|.|      ||.::    ....||.         |:..|:         .
Zfish   282 N------DDENPFICSQPRENGMRLCTSVPTLHEEGRQCQLDMASYNSTDNTTCVNWNKYYTNCS 340

  Fly   359 GFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNL 423
            ....||..|..:||:.|:|:::.|:::|.:.|.|:...|:.|...::.::||::|.:|||:::||
Zfish   341 AGEANPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINL 405

  Fly   424 ILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKA------------------AKLEERANA 470
            .|.::|..:.|  .|..|.:..:|:.:|....|:...:                  .:...|..|
Zfish   406 CLVVIATQFSE--TKQRESQLMKEQRVRFRSNASTLNSYSEPGSCYDELLKYLVHVIRKGTRQIA 468

  Fly   471 QAQAAADAAAAEEAALHPEMAKSPT-------------------YSCISYELFVGGEKGNDDNNK 516
            ....||...|.......|.:...||                   :..:.:...:|......|..:
Zfish   469 HLIRAAGRRAGLRICASPPLEAPPTKRRRQKQRQGSIRHIMHHHHHHLHHHYHLGNGSVRSDGGR 533

  Fly   517 EKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLP-----GSPFNIRRGSRSSHK- 575
                    ||::.|.|.|              |.|....:|.||     ...|:...|..|:.. 
Zfish   534 --------EVDNPSQSGI--------------VNKSGNVNLMLPVIVPQQDAFSGSFGHSSAESV 576

  Fly   576 YTIRNGRGRFGIP---GSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGS 637
            :::....|... |   |....|.||..|:  :..:|:|                 .||       
Zfish   577 HSVYQVSGHLE-PLRCGPSPSPTVLHAYK--RNSVPFA-----------------APV------- 614

  Fly   638 RHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSV-GATNGGTTCLDTNHKL 701
             |.:|.:.||.::.                     .:||.|.....|| .:.|.....::|:..|
Zfish   615 -HKNYPTLQSSLAL---------------------EQLRQRILDPASVLTSLNIPPNPINTSQCL 657

  Fly   702 DHRDYEIGLECTDEAGKIKHHD---NPFIEPVQTQTVVDMKDV-----MVLNDIIEQAAGRHSRA 758
                    :|.....||:...|   |.....:.|....|.:..     .:.|| .|...|..:..
Zfish   658 --------VETQGPPGKVISKDALMNCSSTNIDTALTYDPETCPYCAKSMAND-SEGIDGNETAD 713

  Fly   759 SD-RGV---SVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWD-CCWVWLKFQEWVSLIVFDP 818
            || .||   .|.::    .|..||. |.|...:..:...|...|. .|..:.|       ||...
Zfish   714 SDSEGVYETQVAHY----RDSRGPK-KKKKFALGARATKVIDFWRLVCGTFRK-------IVDSK 766

  Fly   819 FVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWN 883
            :....|.:.|::||:.|.:::|:...|:...|:..|..||:.|.:|..:||:...|..|.:..:|
Zfish   767 YFGQGIMIAILINTLSMGIEYHEQPDELTNALEISNIVFTSLFVLEMLLKLLVYGPFGYIKNPYN 831

  Fly   884 IFDFIIVALSLLEL-GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVL 947
            |||.|||.:|:.|: |.:| .||||||:|||:||.||.:..|.|...:.::.:||..:.....:|
Zfish   832 IFDGIIVVISVWEIVGQQG-GGLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMDNVATFCMLL 895

  Fly   948 CIIIFIFAVMGMQLFGKNYHDHKDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGEWIESMWD-CM 1009
            .:.||||:::||.|||..:...:    ||| || |.||...:.:.:.||::|..|    .|: .:
Zfish   896 MLFIFIFSILGMHLFGCKFGSER----DGDTLPDRKNFDSLLWAIVTVFQILTQE----DWNKVL 952

  Fly  1010 YVGDVSCIP----FFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRF 1070
            |.|..|..|    :|:|.:..||.|:.||.:|:|:..|            .|.:|.:..:..|:.
Zfish   953 YNGMASTSPVAALYFIALMTFGNYVLFNLLVAILVEGF------------QTEEITKRDDLHGQL 1005

  Fly  1071 KSWVKRNIADCFKL----------IR------NKLTNQISDQPSGERTNQISWIWSEGKGVCRCI 1119
                     .|.:|          :|      :.::..:|...:|:                   
Zfish  1006 ---------SCIQLPIDSGKGHVGVRIVKPNPDTMSTVLSSDLAGD------------------- 1042

  Fly  1120 SAEHGDNELEL---------GH-DEILADGLIKKGIKEQTQLEVAI------------------- 1155
             |...|:|.::         || .::.|..::.  |.....|:.::                   
Zfish  1043 -ASKSDSEADIYARSLEDVSGHKKDMSASSVVP--INGHVDLKSSLTPPLITHTAATPMPIPKIS 1104

  Fly  1156 --GD---------GMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSA 1209
              ||         |...::..:.::..|..::...||.....:|.||..|..|       ..|.|
Zfish  1105 GGGDSALSQESRRGSSVSMEPNGQDKSPSSARSSPNAPLSSASSWNSRRSSWN-------SLGRA 1162

  Fly  1210 ETMEGEEKRDASKEDL--GLDEELDEEGECEE---GPLDGDIIIHAHDEDILDEYPA-------- 1261
            .:::.::.:...:..|  |..:...:||:..|   |..:||....|. .|.|.:.|.        
Zfish  1163 PSLKRQKHQSGERRSLLSGDGQSSSDEGDAGESMGGMSEGDDASLAR-TDSLGQRPRHRRMESLE 1226

  Fly  1262 -----DCCPDSYYKKFPILAG--------------------------------DDDS-------- 1281
                 |..||:....:|..:|                                :||:        
Zfish  1227 TRSSFDLHPDTLQVPYPHRSGSIHSARPPNFLSNGKTSPSAATTQLSLDEHHSEDDNADEEGNLS 1291

  Fly  1282 -------------PFW----QGW--------GNLRLKTFQLIENKYFETAVITMILMSSLALALE 1321
                         |.|    ..|        ...|:...::|.:|.|:..|:.:|.::.:.:|:|
Zfish  1292 RRARLYRWLEHKQPEWCRQRVTWSLYLFPPESRFRVTCNKIITHKMFDHVVLVIIFLNCITIAME 1356

  Fly  1322 DVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSLINF 1382
            ...:......:..|...:.|||.||..||.||.:||||    |.|..::|..||.::||:|:|:.
Zfish  1357 RPRIDPSSAERIFLTLSNYIFTAIFVTEMTIKVVALGFCFGEKTYLKSSWNILDGMLVMISVIDI 1421

  Fly  1383 VASLVGAGG---IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIF 1444
            :.||:...|   :...:.:|.||.|||||.:||..|:::||..|:.::..|.|::::|..|::||
Zfish  1422 LVSLISNSGTKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLMSSLKPIGNIVVICCAFFIIF 1486

  Fly  1445 AIMGVQLFAGKYFKC--EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVAT 1507
            .|:|||||.||:|.|  :|...       |.|::.|...||.||....|||::|.|.:.||.:|:
Zfish  1487 GILGVQLFKGKFFVCHGDDTRN-------ITNKSDCLLANYKWVRHKYNFDNLGQALMSLFVLAS 1544

  Fly  1508 FKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNF-----NEQK 1567
            ..||:.||.|.:|:..||:||:...|.:|.|||:.|::..:||.||:|:||:::||     |:::
Zfish  1545 KDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRRNQEE 1609

  Fly  1568 KKAGGSLEMFMTEDQKKYYNAM-----------KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKF 1621
            ::|............||..|.|           .:....||..:...|..|   :::.:...:..
Zfish  1610 EEAKRREAKRQKRRDKKRRNIMLTGVSWSSPDHTQEAQSKPFYSDYCPTRR---LIYNMCKSQYL 1671

  Fly  1622 DIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPWNLF 1685
            |:.|.:.|.||:.||:::.|......:..|...|.||.|||..|.:.|:.|..: .:|.:.||..
Zfish  1672 DLFITIVIALNVITMSMEHYHQPKVLSDSLKICNYIFTVIFVLESIFKLVAFGFRRFFKDRWNQL 1736

  Fly  1686 DVVVVILSILGLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPAL 1748
            |:.:|:|||:|:.|.:|  .....::||::|::||.::.|||:|:|.|.|:|.||..:..:||.:
Zfish  1737 DLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRITRVLKLLKMAVGMRALLDTVMQALPQV 1801

  Fly  1749 FNICLLLFLVMFIFAIFGMSFF-------MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDG 1806
            .|:.||..|:.||||..|:..|       :|..|  |:.....||.||.:.:|||::||...|:|
Zfish  1802 GNLGLLFMLLFFIFAALGVELFGDLICDELHPCE--GLGRYATFKNFGMAFLLLFRVSTGDNWNG 1864

  Fly  1807 VLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQ 1871
            ::...:.:.:.|        .|.|.:..|...:.:|:::.:..:::|:.|||::::..::.::.:
Zfish  1865 IMKDTLRDCSQD--------TGICYNTVVSPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1921

  Fly  1872 EGLTDDDYDMYYEIWQQFD-----------------------PEGTQYIRYDQL----------S 1903
            |.    :.:...|:.|:.:                       |.|:.:|..|..          |
Zfish  1922 EA----EAEAELELEQEMEALGRDREMQRGHMPRLGSGDLGGPGGSPWISRDHRDLSGPLYPIDS 1982

  Fly  1904 EFLDV-----------------LEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFA 1951
            ...|:                 |||||: .:| .:..:|:   :.:|.|...:.::|.|      
Zfish  1983 PTADIRRDFEDHLRTDPDPPPNLEPPLE-RRP-MFDSVSL---VIQGSLEGELSLMDNL------ 2036

  Fly  1952 RKGNPIEETGEIGEIAARPD------TEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGS 2010
                    :|.|....|.|.      ||...|::..      |..:...:.:|............
Zfish  2037 --------SGSICHYYALPPLPNKHCTEKQIPLAEM------EALSLASEKSWSLALTDDSVPDD 2087

  Fly  2011 FEP---------DTDHGDGGDPDAGDPAPDE 2032
            |.|         .||..|..|....|...||
Zfish  2088 FNPLLLTSQECNTTDPSDPPDTRQADEPTDE 2118

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 80/314 (25%)
Na_trans_cytopl 515..648 CDD:288761 27/141 (19%)
Ion_trans 835..1028 CDD:278921 70/200 (35%)
Na_trans_assoc 1054..1296 CDD:284034 52/380 (14%)
Ion_trans 1318..1571 CDD:278921 100/266 (38%)
Na_channel_gate 1561..1613 CDD:240441 12/67 (18%)
Ion_trans 1636..1871 CDD:278921 73/244 (30%)
GPHH 1880..1930 CDD:293510 15/99 (15%)
cacna1gXP_021336019.1 Ion_trans 99..422 CDD:306908 85/333 (26%)
Ion_trans 765..998 CDD:306908 84/253 (33%)
Ion_trans 1335..1607 CDD:306908 103/278 (37%)
Ion_trans 1668..1910 CDD:306908 79/251 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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