DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and cacna1bb

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_021324711.1 Gene:cacna1bb / 562796 ZFINID:ZDB-GENE-090514-4 Length:2345 Species:Danio rerio


Alignment Length:2064 Identity:502/2064 - (24%)
Similarity:846/2064 - (40%) Gaps:590/2064 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 FSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 181
            |:.::::::....|.||:.|..|...|.|...|:|||:.|||::.:          |.:..::.|
Zfish    62 FTVNRSLFIFSEDNVIRKYAKRITEWPPFEYLILTTIIANCIVLALEQHLPALDKTPMSERLDDT 126

  Fly   182 EVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLR 246
            |..|.||:.||:.:|::|.||:....:|||:.||.:||||:....:|......:|..||..||||
Zfish   127 EPYFIGIFCFEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVTGILTTVGSQFDLRTLRAVRVLR 191

  Fly   247 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW 311
            .||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::|::.|||.....|   |.:|   
Zfish   192 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKFHFTC---FKVD--- 250

  Fly   312 GNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGW 376
                               :.::.:.:| ||....:..|.....|.: :...||:|.|:||:..:
Zfish   251 -------------------TGEKAVDYP-CGAEPPSRSCPVGTNCTE-YWKGPNFGITNFDNILF 294

  Fly   377 AFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAE 440
            |.|:.|:.:|.:.|.| ||.....|...|:.|:||.:|.:|||:::||:|.:::   .|..|:.|
Zfish   295 AILTVFQCITMEGWTDVLYHTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS---GEFAKERE 356

  Fly   441 EEEAAEE------------------EAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALH 487
            ..|..:|                  |.|.:|||...|     ||..||:.::..|.|.......:
Zfish   357 RVEKRQEFLKLRRQQQIERELTGYLEWICKAEEVLLA-----EEDQNAEEKSPLDGAWYRRKQNN 416

  Fly   488 PEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKV 552
            |.:.::.:            .||.:|       :.|.|...|..:.|                  
Zfish   417 PVLKRTKS------------RKGRND-------LISAEEGDEHFTDI------------------ 444

  Fly   553 STTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVT 617
              :|::.|||||  .|.|..|.|                                   :||    
Zfish   445 --SSVAPPGSPF--ARASLKSSK-----------------------------------NDS---- 466

  Fly   618 PMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLR---NRN 679
                                  |||...                         ||.::|   .|.
Zfish   467 ----------------------SSYFRR-------------------------KEKRIRFFIRRM 484

  Fly   680 TRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744
            .:.||                                                            
Zfish   485 VKAQS------------------------------------------------------------ 489

  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809
                                 :|                                          
Zfish   490 ---------------------FY------------------------------------------ 491

  Fly   810 WVSLIVFDPFVELFITLCIV-VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMS 873
            |             |.||:| :|||.:|:.|:|..:.:.:.|....:.|...|..|.|:|:..:.
Zfish   492 W-------------IVLCLVGLNTMCVAIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLG 543

  Fly   874 PKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL-NLLISI 932
            |:.||...:|.|||.::..|:.|:....:|     |:||||:.||||:||:.|.|.:| ||::|:
Zfish   544 PRNYFHSSFNCFDFGVIVGSIFEVIWAAIQPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSL 608

  Fly   933 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVL 997
            : .:|.::.:|.|:|.:.|.:||::||||||..::     |.| :.|..||..|..:.|.||::|
Zfish   609 L-NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-----FED-ETPTTNFDSFPAAIMTVFQIL 666

  Fly   998 CGE-W-------IESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD 1054
            .|| |       |||.....  |.:....:|:...:.||..:||:|||:.:.|..::  ...|.|
Zfish   667 TGEDWNAVMYHGIESQGGVR--GGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANA--QELTKD 727

  Fly  1055 NDTNKIAE----AFNRIGRFK-----SWVKRNIADCFKLIRNKLTNQIS---------DQPS--- 1098
            .:..:.|.    |..:....|     |....:||...|..|:.::.:.|         .|.|   
Zfish   728 EEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAFVKQNRDAISRRSSVCSVHSPKEQQRSLQK 792

  Fly  1099 ----GERTNQIS-----------WIWSEGKGVCRCISAEHGDNELELGHDEILA----------- 1137
                .:||||:.           :...|.:...|..||.|...:::..||..|.           
Zfish   793 LSIWEQRTNQLRRHNLRSSSEALYNELEPEERLRVSSALHLRPDMKTHHDRPLVVEHRDSVDNLR 857

  Fly  1138 ---DGLIKKG------IKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYG 1193
               ||...:|      .::..:.....||..|..:|.....|:..:.. |..:...|....|.:.
Zfish   858 SDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRHHSQNRENQGG-LERSNSQDGGQRNHHR 921

  Fly  1194 S------------------HKNRPFK---------------------DESHKGSAE--------- 1210
            |                  |..||.:                     .|...|:.|         
Zfish   922 SSGSPEEGIGIEEREHRHHHSRRPREVNGNGNGVIGNGGRGERIRGHREGEGGNGERRRHRPRVK 986

  Fly  1211 ---TMEGEEKRDASKEDLGLDEELDE------EGECEEGP------------------------- 1241
               |::|:|.|:...:......|.|.      :...||.|                         
Zfish   987 AQSTLDGDECRENGGKRRSRPTETDSLTTSPLQSPSEEKPEDKDNLKNSTRVGPSGVNIPVTITA 1051

  Fly  1242 ------------LDGDIIIHAHDEDILDEY----PADCCPDSYYKKFPILAGDDDSPFWQGWGN- 1289
                        :|||.::...::..|||.    |....|.|             |.|..|..| 
Zfish  1052 PPGETTVIPMNNIDGDSLLLNEEKKDLDELNQNAPKHILPYS-------------SMFVFGPTNP 1103

  Fly  1290 LRLKTFQLIENKYFETAVITMILMSSLALALED---VHLPQRPILQDILYYMDRIFTVIFFLEML 1351
            :|.....::..:|||..::|:|.|||:|||.||   .|.|:    .|:|.|:|.:||.:|..||:
Zfish  1104 VRRLCHYVVNLRYFEMCILTVITMSSIALAAEDPVQAHAPR----NDVLKYLDYVFTGVFTFEMV 1164

  Fly  1352 IKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLV---------GAGG--IQAFKTMRTL 1401
            ||.:.||..:    ||.:.|..|||::|..:|:.|..|..         |..|  |...|::|.|
Zfish  1165 IKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSSFMGSQQSVTRGTKGKDINTIKSLRVL 1229

  Fly  1402 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC------- 1459
            |.||||:.:.|:..::.|.:.:|.::.::.|:|:|.::|..|||::.||||.||:|.|       
Zfish  1230 RVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFHCTDESKAL 1294

  Fly  1460 -EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSRE 1523
             :|..|..|.:   .:.....::...|.....::|:|..|:|.||.|:|.:||..::..::|:..
Zfish  1295 EKDCRGQFLEY---GSDGVAMTQPREWKKYDFHYDNVLWAFLTLFTVSTGEGWPLVLKHSVDATY 1356

  Fly  1524 VDKQPI----RETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1584
            .|:.|.    .||:|:   |.|:||:| .||.:|:|:.:||..|.||..||.....:     :|.
Zfish  1357 EDQGPSPGYRMETSIF---YVVYFIVF-PFFFVNIFVALIIITFQEQGDKAMSECSL-----EKN 1412

  Fly  1585 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYN 1648
            ....:....:.||| :.:|:.:...|..:::.|....|:..|:..|.:|...:.:..:.|...|.
Zfish  1413 ERACIDFAINAKPLTRYMPQDKNSYQYKMWKFVVSTPFEYSILTMIAINTVVLMMKFHGAPKPYE 1477

  Fly  1649 AVLDYLNAIFVVIFSSECLLKIFAL-RYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTL 1712
            .:|.:||.||..:|:.||:||:.|. ..:|..|.||:||.|.|:.||..:::::|.....::.:.
Zfish  1478 DMLKWLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIFDFVTVLGSITDILVTEIKTDKRINLSF 1542

  Fly  1713 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV---K 1774
            ||:.|.|   |:::|::....||.||:....|..||..:|||:.::.||:||.||..|.::   .
Zfish  1543 LRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALNN 1604

  Fly  1775 EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG-NCGSATVGIT 1838
            |.|.||...||:||.|:::|||:.:|...|..::.|.::|..|   |.:.||.| .||| .....
Zfish  1605 EDSAINIHNNFRTFFQALMLLFRSATGEAWHEIMLACLSERYC---DIESGYSGKECGS-DFAYF 1665

  Fly  1839 FLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLS 1903
            :.:|::.:...:::|:::|||::|:...|.|... |.....|.:..:|.::||.....:.|..:.
Zfish  1666 YFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDASI-LGPHHLDEFIRVWAEYDPAACGRMSYLDMY 1729

  Fly  1904 EFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDLMYCVDILDALTK 1947
            |.|..:.|||.:.|  |.:  || ::.|::||...:.::....|.||.:
Zfish  1730 EMLRHMSPPLGLGKKCPPRIAYKRLVRMNMPIAEDNTVHFTSTLMALIR 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 81/281 (29%)
Na_trans_cytopl 515..648 CDD:288761 19/132 (14%)
Ion_trans 835..1028 CDD:278921 67/206 (33%)
Na_trans_assoc 1054..1296 CDD:284034 65/396 (16%)
Ion_trans 1318..1571 CDD:278921 93/282 (33%)
Na_channel_gate 1561..1613 CDD:240441 11/52 (21%)
Ion_trans 1636..1871 CDD:278921 79/239 (33%)
GPHH 1880..1930 CDD:293510 15/54 (28%)
cacna1bbXP_021324711.1 Ion_trans 87..359 CDD:306908 89/301 (30%)
Ion_trans 487..726 CDD:306908 86/385 (22%)
Ion_trans 1115..1404 CDD:306908 102/299 (34%)
Ion_trans 1447..1698 CDD:306908 83/257 (32%)
GPHH 1699..1769 CDD:318993 18/70 (26%)
Ca_chan_IQ 1771..1845 CDD:312334 3/8 (38%)
Transformer <2074..>2135 CDD:253769
THRAP3_BCLAF1 2109..>2285 CDD:317794
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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