Protein Alignment para and cacna1bb

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_017208482.3
• Gene: cacna1bb / 562796
• ZFINID: ZDB-GENE-090514-4
• Length: 2447
• Species: Danio rerio
• Alignment Length: 2053
• Identity: 501/2053 - (24%)
• Similarity: 846/2053 - (41%)
• Gaps: 580/2053 - (28%)

  Fly   127 FSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 181
            |:.::::::....|.||:.|..|...|.|...|:|||:.|||::.:          |.:..::.|
Zfish   176 FTVNRSLFIFSEDNVIRKYAKRITEWPPFEYLILTTIIANCIVLALEQHLPALDKTPMSERLDDT 240

  Fly   182 EVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLR 246
            |..|.||:.||:.:|::|.||:....:|||:.||.:||||:....:|......:|..||..||||
Zfish   241 EPYFIGIFCFEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVTGILTTVGSQFDLRTLRAVRVLR 305

  Fly   247 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW 311
            .||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::|::.|||.....|   |.:|
Zfish   306 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKFHFTC---FKVD--- 364

  Fly   312 GNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGW 376
                               :.::.:.:| ||....:..|.....|.: :...||:|.|:||:..:
Zfish   365 -------------------TGEKAVDYP-CGAEPPSRSCPVGTNCTE-YWKGPNFGITNFDNILF 408

  Fly   377 AFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAE 440
            |.|:.|:.:|.:.|.| ||.....|...|:.|:||.:|.:|||:::||:|.:::   .|..|:.|
Zfish   409 AILTVFQCITMEGWTDVLYHTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS---GEFAKERE 470

  Fly   441 EEEAAEE------------------EAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALH 487
            ..|..:|                  |.|.:|||...|     ||..||:.::..|.|.......:
Zfish   471 RVEKRQEFLKLRRQQQIERELTGYLEWICKAEEVLLA-----EEDQNAEEKSPLDGAWYRRKQNN 530

  Fly   488 PEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKV 552
            |.:.::.:            .||.:|       :.|.|...|..:.|
Zfish   531 PVLKRTKS------------RKGRND-------LISAEEGDEHFTDI------------------ 558

  Fly   553 STTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVT 617
              :|::.|||||  .|.|..|.|                                   :||
Zfish   559 --SSVAPPGSPF--ARASLKSSK-----------------------------------NDS---- 580

  Fly   618 PMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLR---NRN 679
                                  |||...                         ||.::|   .|.
Zfish   581 ----------------------SSYFRR-------------------------KEKRIRFFIRRM 598

  Fly   680 TRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744
            .:.||
Zfish   599 VKAQS------------------------------------------------------------ 603

  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809
                                 :|
Zfish   604 ---------------------FY------------------------------------------ 605

  Fly   810 WVSLIVFDPFVELFITLCIV-VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMS 873
            |             |.||:| :|||.:|:.|:|..:.:.:.|....:.|...|..|.|:|:..:.
Zfish   606 W-------------IVLCLVGLNTMCVAIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLG 657

  Fly   874 PKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL-NLLISI 932
            |:.||...:|.|||.::..|:.|:....:|     |:||||:.||||:||:.|.|.:| ||::|:
Zfish   658 PRNYFHSSFNCFDFGVIVGSIFEVIWAAIQPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSL 722

  Fly   933 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVL 997
            : .:|.::.:|.|:|.:.|.:||::||||||..::     |.| :.|..||..|..:.|.||::|
Zfish   723 L-NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-----FED-ETPTTNFDSFPAAIMTVFQIL 780

  Fly   998 CGE-W-------IESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD 1054
            .|| |       |||.....  |.:....:|:...:.||..:||:|||:.:.|..::  ...|.|
Zfish   781 TGEDWNAVMYHGIESQGGVR--GGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANA--QELTKD 841

  Fly  1055 NDTNKIAE----AFNRIGRFK-----SWVKRNIADCFKLIRNKLTNQIS---------DQPS--- 1098
            .:..:.|.    |..:....|     |....:||...|..|:.::.:.|         .|.|
Zfish   842 EEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAFVKQNRDAISRRSSVCSVHSPKEQQRSLQK 906

  Fly  1099 ----GERTNQIS-----------WIWSEGKGVCRCISAEHGDNELELGHDEILA----------- 1137
                .:||||:.           :...|.:...|..||.|...:::..||..|.
Zfish   907 LSIWEQRTNQLRRHNLRSSSEALYNELEPEERLRVSSALHLRPDMKTHHDRPLVVEHRDSVDNLR 971

  Fly  1138 ---DGLIKKG------IKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYG 1193
               ||...:|      .::..:.....||..|..:|.....|:..:.. |..:...|....|.:.
Zfish   972 SDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRHHSQNRENQGG-LERSNSQDGGQRNHHR 1035

  Fly  1194 S------------------HKNRPFK---------------------DESHKGSAE--------- 1210
            |                  |..||.:                     .|...|:.|
Zfish  1036 SSGSPEEGIGIEEREHRHHHSRRPREVNGNGNGVIGNGGRGERIRGHREGEGGNGERRRHRPRVK 1100

  Fly  1211 ---TMEGEEKRDASKEDLGLDEELDE------EGECEEGP------------------------- 1241
               |::|:|.|:...:......|.|.      :...||.|
Zfish  1101 AQSTLDGDECRENGGKRRSRPTETDSLTTSPLQSPSEEKPEDKDNLKNSTRVGPSGVNIPVTITA 1165

  Fly  1242 ------------LDGDIIIHAHDEDILDEY----PADCCPDSYYKKFPILAGDDDSPFWQGWGN- 1289
                        :|||.::...::..|||.    |....|.|             |.|..|..|
Zfish  1166 PPGETTVIPMNNIDGDSLLLNEEKKDLDELNQNAPKHILPYS-------------SMFVFGPTNP 1217

  Fly  1290 LRLKTFQLIENKYFETAVITMILMSSLALALED---VHLPQRPILQDILYYMDRIFTVIFFLEML 1351
            :|.....::..:|||..::|:|.|||:|||.||   .|.|:    .|:|.|:|.:||.:|..||:
Zfish  1218 VRRLCHYVVNLRYFEMCILTVITMSSIALAAEDPVQAHAPR----NDVLKYLDYVFTGVFTFEMV 1278

  Fly  1352 IKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSR 1412
            ||.:.||..:    ||.:.|..|||::|..:|:.|..|......|...|::|.||.||||:.:.|
Zfish  1279 IKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSGTKGKDINTIKSLRVLRVLRPLKTIKR 1343

  Fly  1413 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSH 1469
            :..::.|.:.:|.::.::.|:|:|.::|..|||::.||||.||:|.|        :|..|..|.:
Zfish  1344 LPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFHCTDESKALEKDCRGQFLEY 1408

  Fly  1470 EIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPI----R 1530
               .:.....::...|.....::|:|..|:|.||.|:|.:||..::..::|:...|:.|.    .
Zfish  1409 ---GSDGVAMTQPREWKKYDFHYDNVLWAFLTLFTVSTGEGWPLVLKHSVDATYEDQGPSPGYRM 1470

  Fly  1531 ETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1595
            ||:|:   |.|:||:| .||.:|:|:.:||..|.||..||.....:     :|.....:....:.
Zfish  1471 ETSIF---YVVYFIVF-PFFFVNIFVALIIITFQEQGDKAMSECSL-----EKNERACIDFAINA 1526

  Fly  1596 KPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFV 1659
            ||| :.:|:.:...|..:::.|....|:..|:..|.:|...:.:..:.|...|..:|.:||.||.
Zfish  1527 KPLTRYMPQDKNSYQYKMWKFVVSTPFEYSILTMIAINTVVLMMKFHGAPKPYEDMLKWLNIIFT 1591

  Fly  1660 VIFSSECLLKIFAL-RYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGR 1723
            .:|:.||:||:.|. ..:|..|.||:||.|.|:.||..:::::|.:|. ::.:.||:.|.|   |
Zfish  1592 ALFTLECVLKVIAFGPLNYLKEAWNIFDFVTVLGSITDILVTEIKDKR-INLSFLRLFRAA---R 1652

  Fly  1724 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV---KEKSGINDVYNF 1785
            :::|::....||.||:....|..||..:|||:.::.||:||.||..|.::   .|.|.||...||
Zfish  1653 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALNNEDSAINIHNNF 1717

  Fly  1786 KTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG-NCGSATVGITFLLSYLVISFL 1849
            :||.|:::|||:.:|...|..::.|.::|..|   |.:.||.| .||| .....:.:|::.:...
Zfish  1718 RTFFQALMLLFRSATGEAWHEIMLACLSERYC---DIESGYSGKECGS-DFAYFYFVSFIFLCSF 1778

  Fly  1850 IVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQ 1914
            :::|:::|||::|:...|.|... |.....|.:..:|.::||.....:.|..:.|.|..:.|||.
Zfish  1779 LMLNLFVAVIMDNFEYLTRDASI-LGPHHLDEFIRVWAEYDPAACGRMSYLDMYEMLRHMSPPLG 1842

  Fly  1915 IHK--PNK--YK-IISMDIPICRGDLMYCVDILDALTK 1947
            :.|  |.:  || ::.|::||...:.::....|.||.:
Zfish  1843 LGKKCPPRIAYKRLVRMNMPIAEDNTVHFTSTLMALIR 1880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	87/294 (30%)
		Na_trans_cytopl	555..740	CDD:463401	21/187 (11%)
		Ion_trans	817..1028	CDD:459842	74/225 (33%)
		Na_trans_assoc	1054..1296	CDD:461936	65/396 (16%)
		Ion_trans	1300..1571	CDD:459842	100/289 (35%)
		Na_channel_gate	1561..1613	CDD:240441	11/52 (21%)
		Ion_trans	1621..1871	CDD:459842	84/254 (33%)
		GPHH	1882..1929	CDD:465306	14/51 (27%)
cacna1bb	XP_017208482.3	None