DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and cacna1aa

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_021330047.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2371 Species:Danio rerio


Alignment Length:2385 Identity:553/2385 - (23%)
Similarity:917/2385 - (38%) Gaps:750/2385 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 FSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 181
            |:.::::::....|.:|:.|..|...|.|...|:.||:.|||::.:          |.:..:|.|
Zfish    65 FTVNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLEDT 129

  Fly   182 EVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNLAALRTFRVL 245
            |..|.||:.|||.:|::|.||.....:|||:.||.:||||:....: |:|.|. :|..||..|||
Zfish   130 EPYFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSDF-DLRTLRAVRVL 193

  Fly   246 RALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS 310
            |.||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::||:.|||.....|..|      
Zfish   194 RPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDK------ 252

  Fly   311 WGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFG 375
               :|||..:                .|| ||....|..|.:..|| :.:...||||.|.||:..
Zfish   253 ---ITDEIRE----------------EFP-CGEEVPARICPNGTVC-KKYWLGPNYGITQFDNIL 296

  Fly   376 WAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKA 439
            :|.|:.|:.:|.:.|.||......||| .|:.::||.:|.:|||:::||:|.:::..:      |
Zfish   297 FAVLTVFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLVLGVLSGEF------A 355

  Fly   440 EEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELF 504
            :|.|..|    ..:|.....:..::|...|...:                      :.|.:.|:.
Zfish   356 KERERVE----NRSEFLKLKRQQQIERELNGYLE----------------------WICKAEEVI 394

  Fly   505 VGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRG 569
            :..|..:.|:.                                              .||:    
Zfish   395 LADEDNDPDDR----------------------------------------------MPFD---- 409

  Fly   570 SRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGN 634
                               ||.|:|    |.:.::..|..|:|.:                  |:
Zfish   410 -------------------GSRRRP----TIKKSKTDLLDAEDGD------------------GD 433

  Fly   635 LGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNH 699
            :||..             :.|.|             |.|||                        
Zfish   434 IGSPF-------------ARGSL-------------KSSKL------------------------ 448

  Fly   700 KLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVS 764
                                                                             
Zfish   449 ----------------------------------------------------------------- 448

  Fly   765 VYYFPTEDDDEDGPTF--KDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLC 827
                       :|.:|  |::.|...::.|            :|.|.:           .:..||
Zfish   449 -----------EGSSFHKKERRLRFFIRRI------------VKTQAF-----------YWTVLC 479

  Fly   828 IV-VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA 891
            :| :||:.:|:.|:|..:.:...|....:.|...|..|..:|:..:..:.||...:|.||.|::.
Zfish   480 LVGLNTLCVAVVHYDQPETLSDFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVIC 544

  Fly   892 LSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCII 950
            .|:.|:....:|     |:||||:.||||:||:.|.|.:| ||::|:: .:|.::.:|.|:|.:.
Zfish   545 GSIFEVLWAMIQPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLL-NSMKSIISLLFLLFLF 608

  Fly   951 IFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD------C 1008
            |.:||::||||||..::     |..| .|..||..|..:.|.||::|.|| |...|:|      .
Zfish   609 IVVFALLGMQLFGGQFN-----FEAG-TPPTNFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGG 667

  Fly  1009 MYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSS--------------------------- 1046
            :..|.|..: ||:...:.||..:||:|||:.:.|..::                           
Zfish   668 VKKGMVFSV-FFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEQAANKKMALQTAKEVA 731

  Fly  1047 ----------SLSAPTADNDTNKIAEAF--------NRIGRFKSWVKR----------------- 1076
                      |::|.|.:::.....|.|        |..|....|.:|                 
Zfish   732 EVSPLSAANLSIAAVTVNSERLDATEHFLDCKEQQKNHKGCKSVWEQRTSELRRQTLVNSREALY 796

  Fly  1077 ---NIADCFKL---------IRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELE 1129
               :..|.:|:         ::..|...:...|...|.|..:             ....||.:.:
Zfish   797 NELDPEDRWKVSYSRHIRPDMKTHLDRPLVVDPQENRNNNTN-------------KTRPGDGQPQ 848

  Fly  1130 LGHDEILADGLIKK-------------GIKEQTQLEVAIGD---------GMEFTIHGDMKNNKP 1172
            ..|.      |:.|             |.:....||  .||         |.|....|...:.:.
Zfish   849 HSHQ------LLHKQPNFNEAETGGGGGSESWPALE--RGDSTGSRRSLLGSEHYEEGRESHRRH 905

  Fly  1173 KKSKYLNNATDDDTAS-----------------------INSYGSHKNRPFKDESHKGSAETMEG 1214
            :.|::.:.|.....|:                       .:..|..|:|..:.|........:..
Zfish   906 QHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRH 970

  Fly  1215 EEKRDA-----------------SKEDLGLDEELDE--EGECEEGPLDGDI----------IIHA 1250
            ..:||.                 |::|....|:||.  ..:....|.|..:          :.|.
Zfish   971 RNRRDGHASGPTLSTTRPIQKTLSRQDSQYSEDLDNAMNNKLATQPHDSLLNLANTAHSAGLAHT 1035

  Fly  1251 HDEDIL---------------------DEYPADCCPDSYYKKFPIL-----------------AG 1277
            ..|..|                     .||.|...|..:.....||                 .|
Zfish  1036 GTESSLILTNPSSTIANVTSIGHLGMKPEYTAVDIPPMFPSSNAILQVNKNANTEPLPKKEDTKG 1100

  Fly  1278 DDD------------------------SPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLAL 1318
            |||                        :||       |.....::..:|||..::.:|.|||:||
Zfish  1101 DDDDDEKDDGGPKPMPPYTSMFILTTTNPF-------RRLCHYIVTLRYFEMCILLVIAMSSIAL 1158

  Fly  1319 ALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSL 1379
            |.||...|:.| ..::|.|.|.:||.:|..|||||.:.||..:    ||.:.|..|||::|..:|
Zfish  1159 AAEDPVWPESP-RNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGAL 1222

  Fly  1380 INFVASLVGAGG------IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1438
            :.| |...|:||      |...|::|.||.||||:.:.|:..::.|.:.:|.::.::.|:|:|.:
Zfish  1223 VAF-AFTGGSGGSSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYM 1286

  Fly  1439 IFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHV 1495
            :|..|||::.||||.|::|.|        .|..|..|.:|   ..|...|:...|.....::|:|
Zfish  1287 LFMFIFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYE---RDNEVRSQKREWKKYDFHYDNV 1348

  Fly  1496 GNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPI----RETNIYMYLYFVFFIIFGSFFTLNLFI 1556
            ..|.|.||.|:|.:||.|::..::|:...::.|.    .|.:|:   |.|:|::| .||.:|:|:
Zfish  1349 LWALLTLFTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIF---YVVYFVVF-PFFFVNIFV 1409

  Fly  1557 GVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVT 1617
            .:||..|.||..|        |.||   :|.....:....:.||| :.:|:.:...|..::|.|.
Zfish  1410 ALIIITFQEQGDK--------MMEDYSLEKNERACIDFAINAKPLTRHMPQNKQTFQYRMWEFVV 1466

  Fly  1618 DKKFDIIIMLFIGLNMFTMTLDRYD-ASDTYNAVLDYLNAIFVVIFSSECLLKIFAL-RYHYFIE 1680
            ...|:..||..|.||...:.: :|| ||.||..||.|||.:|..:||.||:|||.|. ..:||.:
Zfish  1467 SPPFEYTIMALIALNTIVLMM-KYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKD 1530

  Fly  1681 PWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1745
            .||:||.|.|:.||..::::::....|::.:.||:.|.|   |:::|::..:.||.||:....|.
Zfish  1531 AWNIFDCVTVLGSITDILVTELGMNNFINLSFLRLFRAA---RLIKLLRQGETIRILLWTFVQSF 1592

  Fly  1746 PALFNICLLLFLVMFIFAIFGMSFFMHVK----EKSGINDVYNFKTFGQSMILLFQMSTSAGWDG 1806
            .||..:|||:.::.||:||.||..|.::|    ..|.|....||:||.|:::|||:.:|...|..
Zfish  1593 KALPYVCLLIAMLFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSATGEAWHD 1657

  Fly  1807 VLDAIINEEACD-PPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDV 1870
            ::.:.:.::.|| ..||.|   ..|||....:.| :|::.:...:::|:::|||::|:...|.| 
Zfish  1658 IMLSCLGKKPCDILSDNPK---PECGSEFAYLYF-VSFIFLCSFLMLNLFVAVIMDNFEYLTRD- 1717

  Fly  1871 QEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPI 1930
            ...|.....|.|..||.::||.....|.|..:...|.|::|||.:.|  |::.   :::.||:|:
Zfish  1718 SSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPV 1782

  Fly  1931 CRGDLMYCVDILDALTK---DFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE---- 1988
            ...:.::....|.||.:   |....||      ||.|....:.|.|..:.:.: :|....:    
Zfish  1783 ADDNTVHFNSTLMALIRTALDIKIAKG------GEGGVDKHQMDAELRKEMMA-IWPNLSQKNLD 1840

  Fly  1989 -----------------YCARLIQHAWRKHKARGEGGGSFE---------------PDTDHGDG- 2020
                             |.|.:|...:|:.||:.......|               |..|.|.| 
Zfish  1841 LLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKRTQALHDEQNRTPLMFQRLEPPSPSQDVGPGL 1905

  Fly  2021 -GDPD--------------------------------AGD-----PAPDEATDGDAPA------- 2040
             |.||                                ||:     ..||:.||....:       
Zfish  1906 TGLPDTQMHPANHLPVDERIPESQSWVTARAQEISQKAGNWSPEGQHPDDTTDNRRQSQTVEMRE 1970

  Fly  2041 -GGDG--------SVNGTAEGAA----DADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAG 2092
             |.||        .:.|....|:    .||.......|..............:....:|.|.|.|
Zfish  1971 MGRDGYSDTEQYLPMEGHGRAASMPRLPADNQQPRRKGRHRGENLTQPITDNSPMKRSASSLGHG 2035

  Fly  2093 SAGRQ-------TAVLVESDGFVTKNGHKVVIHSRSPSITSRTAD 2130
            .|||.       ...::..:|....:.|:...|..|....||..|
Zfish  2036 RAGRSMRGEDYAMERVIPEEGHRHGHRHRDRSHRASERSLSRYTD 2080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 91/282 (32%)
Na_trans_cytopl 515..648 CDD:288761 13/132 (10%)
Ion_trans 835..1028 CDD:278921 66/205 (32%)
Na_trans_assoc 1054..1296 CDD:284034 57/414 (14%)
Ion_trans 1318..1571 CDD:278921 94/274 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 84/241 (35%)
GPHH 1880..1930 CDD:293510 17/54 (31%)
cacna1aaXP_021330047.1 Ion_trans 90..362 CDD:306908 99/305 (32%)
Ion_trans 471..709 CDD:306908 80/256 (31%)
Ion_trans 1141..1377 CDD:306908 85/240 (35%)
Ion_trans 1467..1719 CDD:306908 90/260 (35%)
GPHH 1720..1790 CDD:318993 19/69 (28%)
Ca_chan_IQ 1792..1870 CDD:312334 16/84 (19%)
SOBP <2151..2361 CDD:317654
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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