DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and cacna1ha

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_021330381.1	Gene:	cacna1ha / 560875	ZFINID:	ZDB-GENE-130103-1	Length:	2198	Species:	Danio rerio

Alignment Length:	1904	Identity:	486/1904 - (25%)
Similarity:	852/1904 - (44%)	Gaps:	381/1904 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 ILVNCIL--MIMPTTP---------TVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNW 216
            ||:||:.  |..|...         .:::.:......:..|..:|::|.| |.....||.|.||.
Zfish     4 ILLNCVTLGMYQPCEDLKCQSEWCIVLQAFDDCIFAFFAVEMVIKMIALG-IFGINGYLGDTWNR 67

  Fly   217 LDFVVIALAYVTMGIDLGN--LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTM 279
            |||.::....:...:|..|  |:|:||.||||.|:.:..||.::.:|..:::::..|.:|::|..
Zfish    68 LDFFIVMAGMMEYSLDGHNASLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCF 132

  Fly   280 FSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSN-----WYSEDEGISF- 338
            |...:|.::|:|::.|:|..:|.....:...: ||:..:..|.|.:..:     ..|:|.|:..
Zfish   133 FVFFIFGIVGVQLWAGLLRNRCFMPSKVRDQY-NLSYMSLYYENEDGEDNPFICSSSKDNGMKRC 196

  Fly   339 ----PL-----C-----------GNISGAGQCDDDYVCL---QGFGP------NPNYGYTSFDSF 374
                ||     |           ..:||.|    :|.|:   |.:..      ||:.|..:||:.
Zfish   197 SAVPPLKEGVECTLNASFLGHVYSGLSGTG----NYSCVNWNQYYSECKPGDLNPHKGAVNFDNI 257

  Fly   375 GWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKA 439
            |:|:::.|:::|.:.|.|:...|:.|...::.::||::|.:|||:::||.|.::|..:.|.:::
Zfish   258 GYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFAETKQR- 321

  Fly   440 EEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAK--SPTYSCISYE 502
                   |..:.:            |:||..::..:..|:.:|..:.:.||.|  |..|..:...
Zfish   322 -------ENMLMK------------EQRARYRSNDSTLASYSEPGSCYEEMLKYVSHLYRKVKRR 367

  Fly   503 L--------------------FVGGEKGNDDNNKEKMSIRSVEVESESVSVIQR----------- 536
            |                    ..||..|:..:......::|:.      |:||:
Zfish   368 LSRIYNSWQSKRRKKVNPNTGAGGGANGHSRHRGYGHWVQSIH------SLIQQHQRQHCHLSNG 426

  Fly   537 QPAP---TTAHQATKVRKVST----TSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKP 594
            .|:|   |.:.:|.::|.::.    |..|.|.:..|:...::|.|...    :|.|.....:|.|
Zfish   427 SPSPVATTGSSEALEMRSITAGQQLTVSSQPTATHNLSSSTQSVHSIY----QGDFREAPQERTP 487

  Fly   595 LVLSTYQDAQQHLPYADDSNAVTP-MSEENGAIIVPVYY----------GNLG---SRHSSYTSH 645
                              :|...| :|..||.:..|...          |:||   .:..:.|.|
Zfish   488 ------------------TNVAVPALSRLNGGMNYPTILPSLICNYSGGGSLGKERGKSDANTGH 534

  Fly   646 Q---------SRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
            :         .:|...||..:|..||.:..:.:..|.                  .:|......|
Zfish   535 EVIQDFDKLHQQIEAHSHSRVLLQMAGVVPTQLLLEV------------------MSCPYCVRAL 581

  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVY 766
            :..|.|||           ..|.|..|                                 |..||
Zfish   582 ESMDLEIG-----------DSDYPRSE---------------------------------GDMVY 602

  Fly   767 YFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVN 831
            .|..:.....|.:...|..|...:.:.         .|..|:|.::.||...:....|.:.|::|
Zfish   603 EFSYDAGFITGRSAHHKMQEKQNRLVQ---------FWEDFRERLTRIVDSKYFNRGIMIAILIN 658

  Fly   832 TMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLE 896
            |:.|.:::|:..:|:..:|:..|..||:.|.:|...||:|.....|.:..:||||.:||.:|:.|
Zfish   659 TLSMGIEYHEQPEELTNILEISNIVFTSMFVLEMLFKLLAFGIFGYIRNPYNIFDGVIVVISVWE 723

  Fly   897 LGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 961
            :......||||||:||||||.||.:..|.|...:.::.:||..:.....:|.:.||.|:::||.|
Zfish   724 IIGHADGGLSVLRTFRLLRVLKLVRFLPALRRQLLVLMKTMDNVATFCMLLMLFIFTFSILGMHL 788

  Fly   962 FGKNYH---DHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVGDVSCIP---- 1018
            ||..:.   ::.|..||    |.||...:.:.:.||::|..|    .|: .:|.|..|..|
Zfish   789 FGCKFSLKMENGDTIPD----RKNFDSLLWAIVTVFQILTQE----DWNVVLYNGMASTSPWAAL 845

  Fly  1019 FFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIA-EAFNRIGRFKSWVKRNIAD-C 1081
            :|:|.:..||.|:.||.:|:|:..|.:.. .|..:|.|..|.: .:..::.:.:|....:|:| .
Zfish   846 YFVALMTFGNYVLFNLLVAILVEGFQAEG-DANKSDGDEEKTSVNSEEKMEQLQSSEPLSISDPD 909

  Fly  1082 FKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIK 1146
            .|.....|:......|.|.....|         :.|..:......:..||.:.:.       .:.
Zfish   910 LKFYSLMLSANGHVDPCGTLPPPI---------IMRTAATPMPTPKSSLGPESVF-------DLT 958

  Fly  1147 EQTQLEVAIGDGMEFTIHGDMKN-NKPKKSKYLNNATDDD----TASINSYGSHKNRPFKDESHK 1206
            |..:......|...|    |.|: :.|::|......:..:    .:|.||.|...:...||.|
Zfish   959 ESRRGSAVSIDPNAF----DQKSLSSPRRSPCHPRGSGSNWGSRRSSWNSLGRAPSLKRKDTS-- 1017

  Fly  1207 GSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDI-----LDEYPADCCPD 1266
                   ||.:...|.|..|..|:.|.|.| :...:.|..:.|....||     :.|| .||...
Zfish  1018 -------GERESLLSGEGRGSFEDDDIEAE-KLTNISGGSLQHPSSLDIPELPQMGEY-LDCNGR 1073

  Fly  1267 SYY----------KKFPILAGD-DDS-------------PFW----QGW--------GNLRLKTF 1295
            |.:          |:..|...| |||             |.|    :.|        ...|:...
Zfish  1074 SQHILADLSASLNKEDSIAEEDLDDSFCFRLRRTLAAYKPKWCKDHEEWSLYLFSPHNKFRMMCQ 1138

  Fly  1296 QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF- 1359
            :||.:|.|:..|:..|.::.:.:|||..|:.|...|  .|...:.:|||||..||.:|.:||||
Zfish  1139 KLISHKMFDYVVLVFIFLNCITIALERPHIQQSERL--FLLVSNYVFTVIFVAEMTVKVVALGFY 1201

  Fly  1360 ---KVYFTNAWCWLDFVIVMVSLINFVASLVGAG----GIQAFKTMRTLRALRPLRAMSRMQGMR 1417
               :.|..:.|..||.|:|.||||:.:.||...|    ||  .:.:|.||.|||||.:||..|::
Zfish  1202 SGNQSYLKSTWNVLDGVLVFVSLIDILVSLAWTGNRIFGI--LRVLRLLRTLRPLRVISRAPGLK 1264

  Fly  1418 VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESEN 1482
            :||..|:.::..|.|::|:|..|:::|.|:|||||.||:|.||..:...     |.|::.|...|
Zfish  1265 LVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKFFHCEGGDTRN-----ITNKSDCLQAN 1324

  Fly  1483 YTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFG 1547
            ..|:....|||::|.|.:.||.::...||:.||.|.:|:..||:||.|..|.:|.|||:.|::..
Zfish  1325 LKWIRRKYNFDNLGQALMSLFVLSCKDGWVNIMYDGLDAVGVDQQPERNHNPWMLLYFISFLLIV 1389

  Fly  1548 SFFTLNLFIGVIIDNFN----EQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWR- 1607
            |||.||:|:||:::||:    :|::.....||:...:..:|...:.:..||    :|:.||.:.
Zfish  1390 SFFVLNMFVGVVVENFHKCRQDQEEVEARLLELKRQKLMEKKRRSKENCGS----EALRRPYYAD 1450

  Fly  1608 ---PQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLK 1669
               .:..:..:.|:...|:.|...|.:|:.||:::.::.....:..|.|.|.:|.:||..|.|||
Zfish  1451 YSPARLYIHTLCTNHYLDLFITGIICINVVTMSIEHFNQPSYLDEALKYCNYVFTIIFIIEALLK 1515

  Fly  1670 I--FALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYF--VSPTLLRVVRVAKVGRVLRLVKG 1730
            :  |.:| .:|.:.||..|:.:|:|||:|:.|.:|.....  ::||::|::||.::.|||:|:|.
Zfish  1516 LVAFGIR-RFFKDRWNQLDLAIVLLSIMGITLEEIKMNAALPINPTIIRIMRVLRIARVLKLLKM 1579

  Fly  1731 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKS---GINDVYNFKTFGQ 1790
            |.|:|:||..:..:||.:.|:.||..|:.||:|..|:..|  :...|.:   |::....|:.||.
Zfish  1580 ATGMRSLLDTVMQALPQVGNLGLLFMLLFFIYAALGVELFGKLECTENNPCEGLSPHATFENFGM 1644

  Fly  1791 SMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGS--ATVGITFLLSYLVISFLIVIN 1853
            :.:.||::||...|:|::...:.|  |.|.:.      .|.|  ..|...:.:::::::..:::|
Zfish  1645 AFLTLFRVSTGDNWNGIMKDTLRE--CLPSET------QCLSYLPWVSPIYFVTFVLMAQFVLVN 1701

  Fly  1854 MYIAVILENYSQATEDVQE 1872
            :.:||::::..::.::.:|
Zfish  1702 VVVAVLMKHLEESNKEAKE 1720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	81/318 (25%)
		Na_trans_cytopl	515..648	CDD:288761	30/173 (17%)
		Ion_trans	835..1028	CDD:278921	65/200 (33%)
		Na_trans_assoc	1054..1296	CDD:284034	56/289 (19%)
		Ion_trans	1318..1571	CDD:278921	105/264 (40%)
		Na_channel_gate	1561..1613	CDD:240441	11/59 (19%)
		Ion_trans	1636..1871	CDD:278921	70/245 (29%)
		GPHH	1880..1930	CDD:293510
cacna1ha	XP_021330381.1	Ion_trans	1..323	CDD:306908	83/332 (25%)
		Ion_trans	644..871	CDD:306908	76/234 (32%)
		Ion_trans	1143..1413	CDD:306908	108/278 (39%)
		Ion_trans	1464..1695	CDD:306908	72/239 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810