DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and cacna1fb

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_021333942.1 Gene:cacna1fb / 559964 ZFINID:ZDB-GENE-031104-1 Length:2068 Species:Danio rerio


Alignment Length:2268 Identity:510/2268 - (22%)
Similarity:908/2268 - (40%) Gaps:701/2268 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 EHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPT-------------LEQGVPI 85
            |.|...|.|.:..||.....|..:..||.: |:.||::.|:.:.|             .::...:
Zfish    15 EEEGGGEAEEEEEEGGEGGGGGDEGDKEEK-DEWDEEDRPKMNRTETLMSTTSSTATQKKKSQHV 78

  Fly    86 PVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYIL 150
            ..::|||                             ..:.|  |.:|::.|...|||||.|::::
Zfish    79 KKQVQGS-----------------------------NQVQR--APRALYCLKLNNPIRRAALHLV 112

  Fly   151 VHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILC 205
            ....|.:||:..|..||:.:.:          .|...:|..|.:|..|:|.|:.:|::|.|.::.
Zfish   113 EWKPFDIFILLAIFANCVALGVSKPFPEDDSNATNHDLEQVEYVFLIIFTIETFLKILAYGLVMH 177

  Fly   206 PFTYLRDAWNWLDFVVIALAYVTM---------------------GIDLGNLAALRTFRVLRALK 249
            |.:|:|:.||.||||::.:...::                     |:|   :.|||.|||||.|:
Zfish   178 PSSYIRNGWNLLDFVIVIVGLFSVVLETVTHKSGETTSHTPGKPGGLD---VKALRAFRVLRPLR 239

  Fly   250 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNL 314
            .|:.||.|:.::.::::::..|..:.:|.:|.:.::|::||::::|.:.:.|.    ..|     
Zfish   240 LVSGVPSLQIVLNSIMKAMVPLLHISLLVLFVIIIYAIIGLELFIGRMHRTCF----FIG----- 295

  Fly   315 TDENWDYHNRNSSNWYSEDEGISFPLCGNISGAG-QCDDDYV----CLQGFGPNPNYGYTSFDSF 374
            ||.            |::|:    ||....:|.| ||   ||    | :|....||.|.|:||:|
Zfish   296 TDN------------YADDD----PLPCAFAGHGRQC---YVNGSEC-RGKWEGPNGGITNFDNF 340

  Fly   375 GWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 436
            .:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||:::||:|.:::..:.:.:
Zfish   341 FFAMLTVFQCITMEGWTDVLYWMNDAIGFELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKER 403

  Fly   437 KKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISY 501
            :||:..  .:.:.:||.::        :||...........|...:|.                 
Zfish   404 EKAKAR--GDFQKLREKQQ--------MEEDLCGYMDWITQAEDIDEF----------------- 441

  Fly   502 ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNI 566
                      |::...::::|.:..:.                                      
Zfish   442 ----------DEDGNRRVTLRDLADKK-------------------------------------- 458

  Fly   567 RRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVY 631
                           ||:||                   ...::::::|..|.||          
Zfish   459 ---------------RGKFG-------------------WFSHSNETHASLPASE---------- 479

  Fly   632 YGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLD 696
                                                       ..:.||.|              
Zfish   480 -------------------------------------------TASENTEN-------------- 487

  Fly   697 TNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDR 761
                :|....:....|.....||     |....::..               .:...|:.|.:.:
Zfish   488 ----IDEEHTDCCAACCARIMKI-----PCCRALRRW---------------NRCIRRNCRTAVK 528

  Fly   762 GVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITL 826
            .|:.|                                     ||     |.::||          
Zfish   529 SVTFY-------------------------------------WL-----VLILVF---------- 541

  Fly   827 CIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA 891
               :||...|.:|::..:.:..|....|....:.|.:|..:|:.::..:.||...:|.||..:|.
Zfish   542 ---LNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEMLLKMYSLGLQVYFVAFFNRFDCFVVC 603

  Fly   892 LSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 951
            ..:||..|..::     |:||||..||||:||:.:.|..|:.|::.:..:|.::.:|..:|.:.:
Zfish   604 GGILETVLVEMEIMPPLGISVLRCVRLLRIFKVTRHWTALSNLVASLLNSMKSIASLLLLLFLFL 668

  Fly   952 FIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD-------C 1008
            .|||::||||||..::     |.:....|..|..|..:.:..|::|.|| |...|:|       .
Zfish   669 IIFALLGMQLFGGKFN-----FDETQTKRSTFDSFPQALLTCFQILTGEDWNVVMYDGIMAYGGP 728

  Fly  1009 MYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSW 1073
            ::.|.:.|: :|:...:.||.::||:|||:.:.|                               
Zfish   729 VFPGMIVCL-YFVILFICGNYILLNVFLAIAVDN------------------------------- 761

  Fly  1074 VKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILAD 1138
                                                                             
Zfish   762 ----------------------------------------------------------------- 761

  Fly  1139 GLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDE 1203
                          :|.||       ||.|.|:.||                            |
Zfish   762 --------------LAGGD-------GDNKKNEEKK----------------------------E 777

  Fly  1204 SHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG-PLDGDIIIHAHDEDILDEYPADCCPDS 1267
            .....||...||.|.|       :|||.:||.|.||| ..:|.|.::.          ||..|  
Zfish   778 GEAEPAEEENGEVKVD-------MDEEYEEEEEPEEGDDEEGKIQLNV----------ADFAP-- 823

  Fly  1268 YYKKFPILAGDDDSPFW--QGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR-- 1328
              .|..||...:.|.|:  .....:|:....||.:..|...::..|::||::||.||   |.|  
Zfish   824 --PKEKILPIPEGSAFFCLSKTNPIRVGCHTLIHHHIFTNLILVFIILSSISLAAED---PIRAH 883

  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC--W---LDFVIVMVSLINFVASLVG 1388
            ....::|.|.|..||.||.:|:|:|....|..:: ..::|  |   ||.::|.|||::|   .:.
Zfish   884 SFRNNVLGYADYAFTSIFTVEILLKMTVHGAFLH-EGSFCRNWFNLLDLLVVSVSLVSF---FLH 944

  Fly  1389 AGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1453
            :..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|:::|..:...:||.:|||||.
Zfish   945 SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK 1009

  Fly  1454 GKYFKC--------EDMNGT-------KLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLF 1503
            ||:::|        |...||       .:||.::..|        .|:||..|||:|....:.||
Zfish  1010 GKFYRCTDEAKNTPEQCKGTFVVYKDGDVSHPMVRER--------IWLNSDFNFDNVLMGMMALF 1066

  Fly  1504 QVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKK 1568
            .|:||:||..::..|||:...:..||....:.:.::|:.:||..:||.:|:|:|.:|..|.||  
Zfish  1067 TVSTFEGWPALLYKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITFREQ-- 1129

  Fly  1569 KAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKA-IPRPRWRP-QAIVFEIVTDKKFDIIIMLFIGL 1631
               |..|....|..|.....::.....:|||. ||:   .| |...:.|:....|:.::.:.|.|
Zfish  1130 ---GEAEFKNCELDKNQRQCVEYALKAQPLKLYIPK---NPVQYKFWSIINSTGFEYVMFVLILL 1188

  Fly  1632 NMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSIL 1695
            |..|:.:..||.|..::.|:|.||.:|..:|:.|.::|:.|||. |||::.||.||.::|:.|::
Zfish  1189 NTVTLAVQHYDQSKFFSQVMDILNMVFTGLFTVEMIIKLMALRLRHYFVDAWNSFDALIVVGSVV 1253

  Fly  1696 GLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1760
            .:|:::.......|...:...|:.:|.|:::|:...:||||||:....||.||..:.||:.::.|
Zfish  1254 DIVVTEFSSSEDSSRVSITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFF 1318

  Fly  1761 IFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACD-PPDN 1822
            |:|:.||..|  :.:::.:.||...||:||.|:::|||:.:|...|..::.|.:..:.|| ..|.
Zfish  1319 IYAVIGMQTFGKIAMQDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGKRCDAESDF 1383

  Fly  1823 DKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQ 1887
            :.|...:||| .:.|.:.:|:.::...::||:::|||::|:...|.| ...|.....|.:..||.
Zfish  1384 EPGEEFSCGS-NIAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWS 1446

  Fly  1888 QFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDLMYCVDILDALTK 1947
            ::|||....|::..:...|..::|||...|  |::.   ::::|::|:.....:.....|.||.:
Zfish  1447 EYDPEAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNADGTVTFNATLFALVR 1511

  Fly  1948 DFFARK--GNPIEETGEIGEIAARPDTEGYEPVSSTLWRQ--------------REE------YC 1990
            .....|  |||.:|..|:..|..:            :|::              .||      |.
Zfish  1512 TALKIKTDGNPDQENEELRIIIKK------------IWKRTKPKVLDEVIPPPAEEEVTVGKFYA 1564

  Fly  1991 ARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDP-----DAG-------DPAPDEATDGDAPAGGD 2043
            ..|||..:||.:.|.|..|..|    .|:|...     .||       .|....|.:.|.....:
Zfish  1565 TFLIQDYFRKFRKRKEKVGLEE----EGNGNPTALQLCQAGLRTLQELGPEMRLAMNEDLEEEEE 1625

  Fly  2044 GSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGA--------GSAGRQTAV 2100
            |     .:...:.|:::..:....|.....:.:..::..||..|:|..        |..||::::
Zfish  1626 G-----LDEEQEEDDAHYKNENGYAHTEPLSRSRRSSLATTPIGAPVPVPGDGILNGGLGRRSSL 1685

  Fly  2101 --------LVESDGFVTKNGHKVVIHSRSPSITSRTADVXARP-RP-----PLQDARE 2144
                    .:|::.|..::..:..||.:     .:...:...| ||     |.:|:|:
Zfish  1686 AKTPNGNGALENENFRRRDSMRSSIHYQ-----HKNGVIDQLPKRPSYYKYPRRDSRD 1738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 83/309 (27%)
Na_trans_cytopl 515..648 CDD:288761 9/132 (7%)
Ion_trans 835..1028 CDD:278921 56/205 (27%)
Na_trans_assoc 1054..1296 CDD:284034 36/244 (15%)
Ion_trans 1318..1571 CDD:278921 93/274 (34%)
Na_channel_gate 1561..1613 CDD:240441 14/53 (26%)
Ion_trans 1636..1871 CDD:278921 77/238 (32%)
GPHH 1880..1930 CDD:293510 14/54 (26%)
cacna1fbXP_021333942.1 Ion_trans 114..407 CDD:306908 88/326 (27%)
Ion_trans 532..763 CDD:306908 72/401 (18%)
Ion_trans 856..1093 CDD:306908 84/251 (33%)
Ion_trans 1178..1431 CDD:306908 82/254 (32%)
GPHH 1432..1502 CDD:318993 16/69 (23%)
Ca_chan_IQ 1504..1575 CDD:312334 18/82 (22%)
CAC1F_C 1601..2067 CDD:318975 24/148 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.