DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and scn1lab

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_001038360.2 Gene:scn1lab / 559447 ZFINID:ZDB-GENE-060906-1 Length:1996 Species:Danio rerio


Alignment Length:2141 Identity:970/2141 - (45%)
Similarity:1329/2141 - (62%) Gaps:247/2141 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||||..|||..||||||.|       ..:|.:||             |..|:|::.||:|:..||
Zfish    14 FRPFLPESLAAIEQRIAEE-------VAQRPKGE-------------RRPDDDDENGPKPNRDLE 58

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|.|:|. :.|..||.:.|.||||:|.||||..||:|:::||.||||:|:.|:::|.||||:||:
Zfish    59 AGKPLPF-IYGDVPPHMLSVPLEDLDTYYSNQKTFIVLNRGKAIFRFNATPALYILSPFNPLRRI 122

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            :|.:|||.|||..|:.|||.||..|.:...|. .::.|..|||||||||.:|::||||.:..||:
Zfish   123 SIRVLVHSLFSFVIMCTILTNCAFMTLSNPPEWAKNVEYTFTGIYTFESLIKILARGFCVGKFTF 187

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..::|||::|||||||||||||::::|||||||||:|:|||.|.||
Zfish   188 LRDPWNWLDFSVILMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 252

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNW--YSEDEGIS 337
            :|||:|.||||||:|||::||.|.|||: |.|......||||.:.:.|| ::.||  |..|....
Zfish   253 MILTVFCLSVFALIGLQLFMGNLRQKCV-KMPEVNVTDNLTDYSTELHN-STFNWTEYISDSNNY 315

  Fly   338 F--P------LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLY 394
            :  |      ||||.|.||||.:.:.|::. |.||:|||||||:|.|||||.||||||||||:||
Zfish   316 YFIPGRRDALLCGNSSDAGQCPEGFTCIKA-GRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLY 379

  Fly   395 QLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAA 459
            |..|||||..:|:||:::||||||||||||||:|||:||| |.:|..|||.::|     ||.   
Zfish   380 QQTLRAAGKPYMIFFVLVIFLGSFYLVNLILAVVAMAYDE-QNQATIEEAQQKE-----EEF--- 435

  Fly   460 KAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYS---CISYELFVGGEKGNDDNNKEKMSI 521
             .|.||:....|.:|...||||.|         |..||   .:|.|...||.:.:..:.||:.:.
Zfish   436 -QAMLEQLKRQQEEAQVAAAAATE---------SGEYSGRGGLSEESSSGGSRLSSKSAKERRNR 490

  Fly   522 RSVEVESESVSVIQ-------------RQPA---PTTAHQATKVRKVSTTS---LSLPGSPFNIR 567
            |....:.|......             |:|.   ...|::.:..:|.||.:   ||:.||.|:.|
Zfish   491 RKKRKQREEEEKADQEKFHKSASEDSIRRPGFRFSIDANRLSYEKKCSTPNQSLLSIRGSLFSPR 555

  Fly   568 RGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE-ENGAIIVPVY 631
            |.||:|    :.:.|||....||:.               .:|||.::....|: ..|::.||  
Zfish   556 RNSRAS----LFSFRGRARDFGSEN---------------DFADDEHSTFEDSDSRRGSLFVP-- 599

  Fly   632 YGNLGSRHSSYTSHQS----RISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGT 692
              ....|.||..||.|    ||...::|.:...:...||.::               ||.|:..|
Zfish   600 --RCVERRSSTVSHCSLTAPRIMLPANGKMHCTVDCNGVVSL---------------VGGTSVPT 647

  Fly   693 TCL------DTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQA 751
            :.:      .|..:.|.|....|          .|..:.::|    :||                
Zfish   648 SPIGRLLPEGTTTESDVRKKRSG----------SHQPSDYLE----ETV---------------- 682

  Fly   752 AGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSL 813
                  |..|.:||....|   |:.:|.    :.|......|..:.|.:|||...|||.:|.:::
Zfish   683 ------ARKRAMSVASILTNTMEELEES----RQKCPPCWYKFANSFLIWDCSPAWLKVKEIMNM 737

  Fly   814 IVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYF 878
            ||.||||:|.||:|||:||:||||:|:.|..:...:|..||..||..|..|..:|::|:.|.|||
Zfish   738 IVMDPFVDLAITICIVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTGIFTAEMCLKVIALDPYYYF 802

  Fly   879 QEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNL 943
            ||||||||.|||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::||||||
Zfish   803 QEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 867

  Fly   944 TFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIESMWD 1007
            |.||.||:|||||:|||||||:|.:...:..:. :||||:..||.|||:||||||||||||:|||
Zfish   868 TLVLAIIVFIFAVVGMQLFGKSYRECVCKISESCELPRWHMDDFFHSFLIVFRVLCGEWIETMWD 932

  Fly  1008 CMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGR-- 1069
            ||.| |...|:..|:..:|||||||||||||||||:|.:.:|:|...|::.|.:..|..||.:  
Zfish   933 CMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDSEMNNLQIAVGRIQKGI 997

  Fly  1070 --FKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGH 1132
              .||.:::.:...| |..:|..:...::|..:       :.|:||.  .|:| .|....::|..
Zfish   998 ALVKSTLRQFLQSLF-LAGSKPRSLDEEKPLDD-------LHSDGKE--NCLS-NHAPVAVDLTK 1051

  Fly  1133 DEILADGLIK--KGIKEQTQLEVAIGDGMEFTIHGDMKNNKP---KKSKYLNNATDDDTASINSY 1192
            | .|.:|.:.  .|::...:..:..||.|.|..:..:....|   .:|.:.|..|:|        
Zfish  1052 D-YLKEGCVSPGNGVESHVKYGIEEGDYMSFIHNPSLTVTVPIAVGESDFENLNTED-------- 1107

  Fly  1193 GSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEEL-DEEGECEE--GPLDGDIIIHAHDED 1254
                   |..||     ..:||      |||.|.:|..| ..||...:  .|.:|...:....|:
Zfish  1108 -------FSSES-----SDVEG------SKEKLPVDTVLSSSEGSTVDIRPPGEGAESVELEPEE 1154

  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALA 1319
            .||  |..|..:....:|.....|.:...|:.|..||...|.::|:.:||:.:|.|||:||.|||
Zfish  1155 SLD--PEACFTEGCVMRFQCCQVDVEKGKWKSWWILRKTCFIIVEHNWFESFIIFMILLSSGALA 1217

  Fly  1320 LEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVA 1384
            .||:::.||..::.:|.|.|::||.||.||||:||:|.||..|||||||||||:||.|||::.||
Zfish  1218 FEDIYIEQRKTIKTVLEYADKVFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVA 1282

  Fly  1385 SLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGV 1449
            :.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.|||||||||||||:||||
Zfish  1283 NALGYSELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGV 1347

  Fly  1450 QLFAGKYFKCEDMNGTKL-SHEIIPNRNAC-----ESENYTWVNSAMNFDHVGNAYLCLFQVATF 1508
            .||||||:.|.::...:| ...::.|::.|     .::...|.|..:|||:||..||.|.|||||
Zfish  1348 NLFAGKYYYCVNITNDELFPVSVVNNKSDCYALIQNNDTARWKNVKINFDNVGAGYLALLQVATF 1412

  Fly  1509 KGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGS 1573
            |||:.||..|:|||::::||:.|||:|||||||.||||||||||||||||||||||:||||.||.
Zfish  1413 KGWMDIMYAAVDSRDLEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ 1477

  Fly  1574 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTL 1638
             ::||||:||||||||||:|||||.|.||||..:.|.:||:::|.:.||||||:.|.|||.||.:
Zfish  1478 -DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDIIIMILICLNMVTMMV 1541

  Fly  1639 DRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDII 1703
            :..|.::..:.:|.::|.:|:::|:.||:||:.:||:::|...||:||.|||||||:|:.||::|
Zfish  1542 ETDDQTEDMDNILYWINLVFIILFTGECVLKMISLRHYFFTIGWNVFDFVVVILSIVGMFLSEMI 1606

  Fly  1704 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMS 1768
            |||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:||||||
Zfish  1607 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1671

  Fly  1769 FFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEE--ACDPPDNDKG--YPGN 1829
            .|.:||.::||:|::||:|||.||:.|||::|||||||:|..|:|::  .||......|  |.||
Zfish  1672 NFAYVKREAGIDDMFNFETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDCDSEMEHPGSFYRGN 1736

  Fly  1830 CGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGT 1894
            ||:.:|||.|.:||::|.||||:||||||||||:|.|||:..|.|::||::|:||:|::|||..|
Zfish  1737 CGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPNAT 1801

  Fly  1895 QYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEE 1959
            |::.|::||:|.|.|:|||:|.||||.::|:||:|:..||.::|:|||.|.|......:|.....
Zfish  1802 QFVEYNKLSDFADALDPPLRIAKPNKIQLIAMDLPMVSGDRIHCLDILFAFTLRVLGEEGEMDAL 1866

  Fly  1960 TGEIGE--IAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKAR---GEGGGSFEPDTDHGD 2019
            .|::.:  :|:.|....|||:::||.|::||..|.:||.|:|:|:.|   .:...::......|.
Zfish  1867 RGQMEDRFMASNPSKVSYEPITTTLRRKQEEMSAVVIQRAFRRHRIRQTVKKASEAYRKQLQDGG 1931

  Fly  2020 GGDPDA--------GDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAA 2072
            |..|:.        .:.:..:.||....:....|.|..|:...|..|.. ....||.|..|
Zfish  1932 GHIPEKEVLVIGKFQENSASDKTDMTPSSASPPSYNSVAKSEKDKYEKE-RREKEDKAKDA 1991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 167/281 (59%)
Na_trans_cytopl 515..648 CDD:288761 38/156 (24%)
Ion_trans 835..1028 CDD:278921 121/194 (62%)
Na_trans_assoc 1054..1296 CDD:284034 57/253 (23%)
Ion_trans 1318..1571 CDD:278921 159/258 (62%)
Na_channel_gate 1561..1613 CDD:240441 35/51 (69%)
Ion_trans 1636..1871 CDD:278921 142/238 (60%)
GPHH 1880..1930 CDD:293510 26/49 (53%)
scn1labNP_001038360.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 351 1.000 Domainoid score I972
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H75001
Inparanoid 1 1.050 1619 1.000 Inparanoid score I77
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 1 1.000 - - otm24873
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9280
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1413.910

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