DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Cacna1f

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_062528.2 Gene:Cacna1f / 54652 MGIID:1859639 Length:1984 Species:Mus musculus


Alignment Length:2057 Identity:496/2057 - (24%)
Similarity:848/2057 - (41%) Gaps:575/2057 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 EDEGPQPDPTLEQGVPIPVRLQGSFPPELAS---------TPLEDIDPYYSNVLTFVVVSKGKDI 124
            :|..|:|.|....| |.|.......||.:.:         ||.....  ::...|..|.|..:  
Mouse     8 KDTTPEPSPANGTG-PGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQ--HNKHKTVAVASAQR-- 67

  Fly   125 FRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVE 179
                :.:|::.|...|||||..|.|:....|.:.|:.||..||:.:  .:|        ....:|
Mouse    68 ----SPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLE 128

  Fly   180 STEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG---------- 234
            ..|.:|..|:|.|:.:|::|.|.:|.|..|:|:.||.|||:::.:...::.::.|          
Mouse   129 QVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHT 193

  Fly   235 -------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 292
                   ::.|||.|||||.|:.|:.||.|..::.::::::..|..:.:|.:|.:.::|::||::
Mouse   194 GGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258

  Fly   293 YMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CDDDYVC 356
            ::|.:.:.|                    :...|.....||..   | |.: ||:|: |..::..
Mouse   259 FLGRMHKTC--------------------YFLGSDMEAEEDPS---P-CAS-SGSGRSCTLNHTE 298

  Fly   357 LQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSF 418
            .:|..|.||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||
Mouse   299 CRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSF 361

  Fly   419 YLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEE 483
            :::||:|.:::..:.:.::||:..  .:.:.:||.::        :||...........   |||
Mouse   362 FVLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------MEEDLRGYLDWITQ---AEE 413

  Fly   484 AALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATK 548
            ..||..                                                           
Mouse   414 LDLHDP----------------------------------------------------------- 419

  Fly   549 VRKVSTTSLSLPGSPFNIRRGSRSSHKYTI------RNGRGRFGIPGSDRKPLVLSTYQDAQQHL 607
                     |:.|:..::....|:.|:..:      |.||.|:                      
Mouse   420 ---------SVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRW---------------------- 453

  Fly   608 PYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKE 672
                                         ..||:.::|    |.:||.                 
Mouse   454 -----------------------------FSHSTRSTH----STSSHA----------------- 468

  Fly   673 SKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVD 737
                       |:.|::.|:..                            |.|..|..:..|:..
Mouse   469 -----------SLPASDTGSMT----------------------------DTPGDEDEEEGTMAS 494

  Fly   738 MKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCW 802
            .  ...||.|::....||.|.::||:                 :.:....:....       |.|
Mouse   495 C--TRCLNKIMKTRICRHFRRANRGL-----------------RARCRRAVKSNA-------CYW 533

  Fly   803 VWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATM 867
            .       |.|:||             :||:.:|.:||.....:.:..:..|......|.:|..:
Mouse   534 A-------VLLLVF-------------LNTLTIASEHHGQPLWLTQTQEYANKVLLCLFTVEMLL 578

  Fly   868 KLMAMSPKYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLN 927
            ||..:.|..|....:|.||..:|.     .:|:|:|.....|:||||..||||:||:.:.|.:|:
Mouse   579 KLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLS 643

  Fly   928 LLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMI 992
            .|::.:..:|.::.:|..:|.:.|.||:::||||||..::     |......|..|..|..:.:.
Mouse   644 NLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDQTHTKRSTFDTFPQALLT 703

  Fly   993 VFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLS 1049
            ||::|.|| |...|:|.:       :.|.:.|: :|:...:.||.::||:|||:.:.|..|.  .
Mouse   704 VFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCV-YFIILFICGNYILLNVFLAIAVDNLASG--D 765

  Fly  1050 APTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKG 1114
            |.||.:.           ||.||                                     |||  
Mouse   766 AGTAKDK-----------GREKS-------------------------------------SEG-- 780

  Fly  1115 VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLN 1179
                                                                   |.||::|.|.
Mouse   781 -------------------------------------------------------NPPKENKVLV 790

  Fly  1180 NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDG 1244
            ...:::.|             |....:|:|..||.||:.         :||.:||.|.|.|.   
Mouse   791 PGGENEDA-------------KGARSEGAAPGMEEEEEE---------EEEEEEEEEEENGA--- 830

  Fly  1245 DIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFW--QGWGNLRLKTFQLIENKYFETAV 1307
                 .|.|.:.:..|.:       |..||..|   |.|:  .....||.....||.:..|.:.:
Mouse   831 -----GHVELLQEVVPKE-------KVVPIPEG---SAFFCLSQTNPLRKACHTLIHHHIFTSLI 880

  Fly  1308 ITMILMSSLALALEDVHLPQR--PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVY---FTNAW 1367
            :..|::||::||.||   |.|  .....||.|.|..||.||.:|:|:|....|..::   |..:|
Mouse   881 LVFIILSSVSLAAED---PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSW 942

  Fly  1368 C-WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1431
            . .||.::|.||||:|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.
Mouse   943 FNLLDLLVVSVSLISFG---IHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG 1004

  Fly  1432 NVLLVCLIFWLIFAIMGVQLFAGKYFKCED-----MNGTKLSHEIIPNRNACES--ENYTWVNSA 1489
            |:::|..:...:||.:|||||.||::.|.|     :...|.|..|.|:.:....  ....||||.
Mouse  1005 NIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSD 1069

  Fly  1490 MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNL 1554
            .|||:|.:|.:.||.|:||:||..::..|||:...|:.||...::.:.::|:.:||..:||.:|:
Mouse  1070 FNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNI 1134

  Fly  1555 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QAIVFEI 1615
            |:|.:|..|..|.::...:.|:...:.|...|          .|||.|..|:.|    |..|:..
Mouse  1135 FVGFVIITFRAQGEQEYQNCELDKNQRQCVEY----------ALKAQPLRRYIPKNPHQYRVWAT 1189

  Fly  1616 VTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYFI 1679
            |....|:.::.|.|.||...:.:..|:.:..:|..:|.||.:|..:|:.|.:|||.|.: .|||.
Mouse  1190 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFA 1254

  Fly  1680 EPWNLFDVVVVILSILGLVLSDI----------IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1734
            :.||.||.::|:.|::.:.::::          .:...:|.|..|:.||.   |:::|:...:||
Mouse  1255 DAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVM---RLVKLLSKGEGI 1316

  Fly  1735 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQSMILLFQ 1797
            ||||:....|..||..:.||:.::.||:|:.||..|..|..:.|  ||...||:||.|:::|||:
Mouse  1317 RTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFR 1381

  Fly  1798 MSTSAGWDGVLDAIINEEACDPPDNDKGYPG---NCGSATVGITFLLSYLVISFLIVINMYIAVI 1859
            .:|...|..::.|.:....|| |::|.| ||   .||| :..|.:.:|:.::...::||:::|||
Mouse  1382 CATGEAWQEIMLASLPGNRCD-PESDFG-PGEEFTCGS-SFAIVYFISFFMLCAFLIINLFVAVI 1443

  Fly  1860 LENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY- 1921
            ::|:...|.| ...|.....|.:..||.::||.....|::..:...|..::|||...|  |::. 
Mouse  1444 MDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVA 1507

  Fly  1922 --KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGE----------------IGEI 1966
              ::::|::|:.....:.....|.||.:.....|  ||..:...|                :.|:
Mouse  1508 CKRLVAMNVPLNSDGTVTFNATLFALVRTSLKIKTEGNLDQANQELRMVIKKIWKRIKQKLLDEV 1572

  Fly  1967 AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGG 2008
            ...||.|     ..|:.:   .|...|||..:||.:.|.|.|
Mouse  1573 IPPPDEE-----EVTVGK---FYATFLIQDYFRKFRRRKEKG 1606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 78/301 (26%)
Na_trans_cytopl 515..648 CDD:288761 11/138 (8%)
Ion_trans 835..1028 CDD:278921 58/205 (28%)
Na_trans_assoc 1054..1296 CDD:284034 38/243 (16%)
Ion_trans 1318..1571 CDD:278921 96/265 (36%)
Na_channel_gate 1561..1613 CDD:240441 12/55 (22%)
Ion_trans 1636..1871 CDD:278921 80/250 (32%)
GPHH 1880..1930 CDD:293510 13/54 (24%)
Cacna1fNP_062528.2 Ion_trans 109..383 CDD:278921 77/300 (26%)
Ion_trans 546..763 CDD:278921 66/222 (30%)
Ion_trans 891..1110 CDD:278921 84/224 (38%)
Ion_trans 1210..1455 CDD:278921 80/251 (32%)
GPHH 1463..1526 CDD:293510 14/62 (23%)
Ca_chan_IQ 1528..1599 CDD:285917 17/78 (22%)
CAC1F_C 1623..1981 CDD:293490
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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