DRSC/TRiP Functional Genomics Resources

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Protein Alignment para and Cacna1e

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_038946935.1 Gene:Cacna1e / 54234 RGDID:2246 Length:2465 Species:Rattus norvegicus


Alignment Length:2241 Identity:524/2241 - (23%)
Similarity:889/2241 - (39%) Gaps:670/2241 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 SLFRPFTRESLVQ-----IEQR--IAAE--HEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDE 69
            |.|.|.:.|.:.:     ||||  |.|.  |:.|...:.:|.|.|:.::|...........|.|.
  Rat   102 SPFLPVSPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVVGRPGSGDGDS 166

  Fly    70 DEGPQPDPTLEQGVPIP-----VRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSA 129
            |:...     .||.|:|     ...:.|......:..|.:..|...|.              |:.
  Rat   167 DQSRN-----RQGTPVPASGPAAAYKQSKAQRARTMALYNPIPVRQNC--------------FTV 212

  Fly   130 SKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVI 184
            ::::::....|.:|:.|..::..|.|...|:.||:.|||::.:          |.:..:|.||..
  Rat   213 NRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPY 277

  Fly   185 FTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYV-TMGIDLG---NLAALRTFRVL 245
            |.||:.||:.:|::|.|||....:|||:.||.:||:|:....: |.|....   :|..||..|||
  Rat   278 FIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVL 342

  Fly   246 RALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS 310
            |.||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::||:.|.|.|.:.|.        
  Rat   343 RPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACF-------- 399

  Fly   311 WGNLTDENWDYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSF 374
                         .|:|...   ||...| .|| :.|   |...|.|....|||.  |.|.||:.
  Rat   400 -------------MNNSGIL---EGFDPPHPCG-VQG---CPAGYECKDWIGPND--GITQFDNI 442

  Fly   375 GWAFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK 438
            .:|.|:.|:.:|.:.|.. ||.........|:.|:||.:|.:|||:::||:|.:::..:.:.:::
  Rat   443 LFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 507

  Fly   439 AEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYEL 503
            .|...|..:  :|..::        :|...|.. :|..|  .|||..|..|...|.|        
  Rat   508 VENRRAFMK--LRRQQQ--------IERELNGY-RAWID--KAEEVMLAEENKNSGT-------- 551

  Fly   504 FVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRR 568
                                     .::.|::|         || :::..|.:::         |
  Rat   552 -------------------------SALEVLRR---------AT-IKRSRTEAMT---------R 572

  Fly   569 GSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYG 633
            .|...|                                  ..|.|:..||:              
  Rat   573 DSSDEH----------------------------------CVDISSVGTPL-------------- 589

  Fly   634 NLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTN 698
               :|.|..::.....||..|                ||..||.                     
  Rat   590 ---ARASIKSTKVDGASYFRH----------------KERLLRI--------------------- 614

  Fly   699 HKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGV 763
                               .|:|       .|::|                              
  Rat   615 -------------------SIRH-------MVKSQ------------------------------ 623

  Fly   764 SVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCI 828
             |:|                                          |:.|.|            :
  Rat   624 -VFY------------------------------------------WIVLSV------------V 633

  Fly   829 VVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALS 893
            .:||..:|:.||:..:.:..:|....:.|...|.:|.::|:..|.|:.||...:|.|||.:...|
  Rat   634 ALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGS 698

  Fly   894 LLE----LGLEGVQ-GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIF 952
            :.|    :...|.. |:||||:.||||:||:.|.|.:| ||::|:|. :|.::.:|.|:|.:.|.
  Rat   699 IFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIV 762

  Fly   953 IFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE------------- 1003
            :||::||||||..::     |.|| .|..||..|..:.|.||::|.|| |.|             
  Rat   763 VFALLGMQLFGGRFN-----FNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVS 821

  Fly  1004 -SMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRI 1067
             .||..:|         |:...:.||..:||:|||:.:.|..    :|.....|..:..||||: 
  Rat   822 SGMWSAIY---------FIVLTLFGNYTLLNVFLAIAVDNLA----NAQELTKDEQEEEEAFNQ- 872

  Fly  1068 GRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQIS-W-----------------IWSEGKG 1114
                   |..:....::......|..|.:....|.:.:| |                 :|.:...
  Rat   873 -------KHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTS 930

  Fly  1115 VCR---CISAEHGDNELEL-------------------GHDEI---------LADGLIKKGIKEQ 1148
            ..|   .:|::...|:.|.                   .|..:         ||.||   |:::.
  Rat   931 QLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSPLNPLNAHPSLYRRPRPIEGLALGL---GLEKC 992

  Fly  1149 TQLEVAIGDGMEFTIHG--DMKNNK--------------PKKSKYLNNATDDDTASINSYGSHKN 1197
            .:..::.|..::..|.|  .:.:|:              |:......:.|..:|....:..:.::
  Rat   993 EEERISRGGSLKGDIGGLTSVLDNQRSPLSLGKREPPWLPRSCHGNCDPTQQETGGGETVVTFED 1057

  Fly  1198 RPFKDESHKGSAE---TMEGEEKRDASK-----EDLGLDEELDEEGECEEGPLD----------- 1243
            |....:|.:.|..   ..||:|...||:     ::..|||.:..:||.|..|..           
  Rat  1058 RARHRQSQRRSRHRRVRTEGKESASASRSRSASQERSLDEGVSIDGEKEHEPQSSHRSKEPTIHE 1122

  Fly  1244 -----------------GDIIIHAHDE-----------------------------------DI- 1255
                             |..::.|.||                                   |: 
  Rat  1123 EERTQDLRRTNSLMVPRGSGLVGALDEAETPLVQPQPELEVGKDAALTEQEAEGSSEQALLADVQ 1187

  Fly  1256 LD--------EYPADCCPDSYYK------KFPILAGDDD------------------SP------ 1282
            ||        |....|...:..|      ...:...|.|                  ||      
  Rat  1188 LDVGRGISQSEPDLSCMTTNMDKATTESTSVTVAIPDMDPLVDSTVVNISNKTDGEASPLKEAET 1252

  Fly  1283 ------------------------------FWQGWGNLRLKTFQLIENKYFETAVITMILMSSLA 1317
                                          .:.....:|.....::..:|||..::.:|..||:|
  Rat  1253 KEEEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIA 1317

  Fly  1318 LALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFV 1373
            ||.||      |:|.:     :|.|.|.:||.:|..||:||.:..|..:    ||.:.|..||||
  Rat  1318 LAAED------PVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFV 1376

  Fly  1374 IVMVSLINF-VASLVGAG---GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVL 1434
            :|:.:|:.| :|:.:|..   .|:..|::|.||.||||:.:.|:..::.|.:.:|.::.::||:|
  Rat  1377 VVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNIL 1441

  Fly  1435 LVCLIFWLIFAIMGVQLFAGKYFKCEDMN--------GTKLSHEIIPNRNACESENYTWVNSAMN 1491
            :|..:|..|||::.||||.||:|.|.|.:        |..:.||    :|..|.:...|.....:
  Rat  1442 IVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHE----KNKMEVKGREWKRHEFH 1502

  Fly  1492 FDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFI 1556
            :|::..|.|.||.|:|.:||.|::..::|..|.|:.|.|...:.|.:::|.:.:...||.:|:|:
  Rat  1503 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1567

  Fly  1557 GVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVT 1617
            .:||..|.||..|        |.|:   :|.....:....|.||| :.:|:.|...|..|:..|.
  Rat  1568 ALIIITFQEQGDK--------MMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV 1624

  Fly  1618 DKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEP 1681
            ...|:..||..|.||...:.:..|.|..||...|.|||..|.::||.||:||:.|..: :||.:.
  Rat  1625 SPSFEYTIMAMIALNTVVLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDT 1689

  Fly  1682 WNLFDVVVVILSILGLVLSD--IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMS 1744
            ||:||.:.||.||..::|:|  ::.....:.:.|::.|.|   |:::|::....||.||:....|
  Rat  1690 WNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQS 1751

  Fly  1745 LPALFNICLLLFLVMFIFAIFGMSFFMHVK--EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGV 1807
            ..||..:|||:.::.||:||.||..|.::|  |:|.||...||::|..|::|||:.:|...|..:
  Rat  1752 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEI 1816

  Fly  1808 LDAIINEEACDPPDNDKGYPG------NCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQA 1866
            :.:.:.|:.|:|   |...|.      .||: .:...:.:|::.....:::|:::|||::|:...
  Rat  1817 MLSCLGEKGCEP---DTTAPSGQNESERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1877

  Fly  1867 TEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISM 1926
            |.| ...|.....|.:..:|.::|......|.|.::.|.|.::.|||.:.|  |:|  || ::.|
  Rat  1878 TRD-SSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLM 1941

  Fly  1927 DIPICRGDLMYCVDILDALTK---DFFARKG 1954
            ::|:.....::....|.||.:   |....||
  Rat  1942 NMPVAEDMTVHFTSTLMALIRTALDIKIAKG 1972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 86/286 (30%)
Na_trans_cytopl 515..648 CDD:288761 14/132 (11%)
Ion_trans 835..1028 CDD:278921 69/213 (32%)
Na_trans_assoc 1054..1296 CDD:284034 59/446 (13%)
Ion_trans 1318..1571 CDD:278921 91/273 (33%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 79/245 (32%)
GPHH 1880..1930 CDD:293510 16/54 (30%)
Cacna1eXP_038946935.1 Ion_trans 235..509 CDD:395416 91/303 (30%)
Ion_trans 622..861 CDD:395416 86/343 (25%)
Ion_trans 1301..1535 CDD:395416 82/243 (34%)
Ion_trans 1625..1882 CDD:395416 85/264 (32%)
GPHH 1891..1944 CDD:407139 15/52 (29%)
Ca_chan_IQ 1955..2028 CDD:400901 6/18 (33%)
Atrophin-1 2170..>2429 CDD:397323
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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