DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and Scn3a

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_008760136.1	Gene:	Scn3a / 497770	RGDID:	3635	Length:	1983	Species:	Rattus norvegicus

Alignment Length:	2127	Identity:	966/2127 - (45%)
Similarity:	1315/2127 - (61%)	Gaps:	253/2127 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||:|.|.|..|                 :.||:::|  |||::   |:|:..||
  Rat    14 FRLFTRESLAAIEKRAAEEKAK-----------------KPKKEQDI--DDENK---PKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.:..||||::|||.||||||:.|:::|.|.||:|::
  Rat    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRFSATSALYILTPLNPVRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.:...|. .::.|..|||||||||.:|::||||.|..||:
  Rat   121 AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
  Rat   186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLD------------------GSWGNLTDE--NW 319
            :|||:|.||||||:|||::||.|..||::..|.|                  |::.|:|..  ||
  Rat   251 MILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNW 315

  Fly   320 DYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            ..:..:.|::|..| |...| ||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
  Rat   316 KDYIADDSHFYVLD-GQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 378

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            |||||:||:||||.|||||..:|:||:::||||||||||||||:|||:|:| |.:|..|||.::|
  Rat   379 LMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKE 442

  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAAL---------HPEMAKSPTYSCISY--- 501
            |  |.::.......:.||   |||.|||.||:.:.:.:         ..|.:|..:.|...:
  Rat   443 A--EFQQMLEQLKKQQEE---AQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNR 502

  Fly   502 -------ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSL 559
                   |...|..:.:.|...:..|..||:..|..:|:   ...|.|..:  |:.....:.||:
  Rat   503 RKKRRQREHLEGNHRADGDRFPKSESEDSVKRRSFLLSL---DGNPLTGDK--KLCSPHQSLLSI 562

  Fly   560 PGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE-EN 623
            .||.|:.||.|::|    |.:.|||....||:.               .:|||.::....|| ..
  Rat   563 RGSLFSPRRNSKTS----IFSFRGRAKDVGSEN---------------DFADDEHSTFEDSESRR 608

  Fly   624 GAIIVPVYYGNLGSRHSSYTSHQSRI--SYTSHGDLLGGMAVMGVSTM--TKESKLRNRNTRNQS 684
            .::.||...|...:.:.|..|..||:  ...::|.:...:...||.::  |.|:::|.|...:
  Rat   609 DSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLGTTTETEVRKRRLSS-- 671

  Fly   685 VGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIE 749
                                 |:|.:|                                   ::|
  Rat   672 ---------------------YQISME-----------------------------------MLE 680

  Fly   750 QAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWV 811
            .::||     .|.:|:....|   |:.:|.    :.|......:..:||.:||||..|||.:..|
  Rat   681 DSSGR-----QRAMSIASILTNTMEELEES----RQKCPPCWYRFANVFLIWDCCDAWLKVKHLV 736

  Fly   812 SLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKY 876
            :|||.||||:|.||:|||:||:||||:|:.|.::...||..||..||..|..|..:|::||.|.|
  Rat   737 NLIVMDPFVDLAITICIVLNTLFMAMEHYPMTQQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYY 801

  Fly   877 YFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALG 941
            ||||||||||.|||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::||||
  Rat   802 YFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 866

  Fly   942 NLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESM 1005
            |||.||.||:|||||:|||||||:|.:...:. .|..||||:..||.|||:||||||||||||:|
  Rat   867 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIETM 931

  Fly  1006 WDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGR 1069
            ||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...||:.|.:..|..|:.:
  Rat   932 WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQK 996

  Fly  1070 FKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHD- 1133
            ...:||..|.:||:....:....|..|              ||..:..|:|...|   :|:..:
  Rat   997 GIDFVKNKIRECFRKAFFRKPKVIEIQ--------------EGNKIDSCMSNNTG---IEISKEL 1044

  Fly  1134 EILADGL-IKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKN 1197
            ..|.||. ...|:...:.:|..:.|..::             ..::||.:...|..| :.|....
  Rat  1045 NYLKDGNGTTSGVGTGSSVEKYVIDENDY-------------MSFINNPSLTVTVPI-AVGESDF 1095

  Fly  1198 RPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPAD 1262
            .....|.....:|..|.:||.:|:....|...::....|.|:..::       .:||:   .|..
  Rat  1096 ENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQAEIE-------PEEDL---KPEA 1150

  Fly  1263 CCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQ 1327
            |..:...||||......:....:.|.|||...:.::|:.:|||.::.|||:||.|||.||:::.|
  Rat  1151 CFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ 1215

  Fly  1328 RPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGI 1392
            |..::.:|.|.|::||.||.||||:||:|.||:.|||||||||||:||.|||::.||:.:|...:
  Rat  1216 RKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSEL 1280

  Fly  1393 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF 1457
            .|.|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:||||.|||||::
  Rat  1281 GAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1345

  Fly  1458 KC-EDMNGTKLSHEIIPNRNACES--ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAI 1519
            .| ....|.....:.:.|.:.|::  :...|.|..:|||:||..||.|.||||||||:.||..|:
  Rat  1346 HCVNTTTGNMFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1410

  Fly  1520 DSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1584
            |||:|..|||.|.|:|||||||.||||||||||||||||||||||:||||.||. ::||||:|||
  Rat  1411 DSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKK 1474

  Fly  1585 YYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNA 1649
            |||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:.|.|||.||.::..|.|.....
  Rat  1475 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSKYMTL 1539

  Fly  1650 VLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLR 1714
            ||..:|.:|:|:|:.|.|||:.:|||:||...||:||.|||||||:|:.|:::||||||||||.|
  Rat  1540 VLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1604

  Fly  1715 VVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGI 1779
            |:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:||||||.|.:||:::||
  Rat  1605 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGI 1669

  Fly  1780 NDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDNDKGYP-----GNCGSATVGI 1837
            :|::||:|||.|||.|||::|||||||:|..|:|...  |||   |..:|     |:||:.:|||
  Rat  1670 DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDP---DAIHPGSSVKGDCGNPSVGI 1731

  Fly  1838 TFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQL 1902
            .|.:||::||||:|:||||||||||:|.|||:..|.|::||::|:||:|::|||:.||:|.:.:|
  Rat  1732 FFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKL 1796

  Fly  1903 SEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEI- 1966
            |:|...|:|||.|.||||.::|:||:|:..||.::|:|||.|.||       ..:.|:||:..:
  Rat  1797 SDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK-------RVLGESGEMDALR 1854

  Fly  1967 --------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH--KARGEG-GGSFEPDTDHGDG 2020
                    |:.|....|||:::||.|::||..|.:||..:|.:  |.|.:. ...::.:|..|..
  Rat  1855 IQMEERFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISSKYDKETIKGRI 1919

  Fly  2021 GDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGED 2067
            ..|..||...|:......|...|||.:.|:..:.|    :|..|.::
  Rat  1920 DLPIKGDMVIDKLNGNSTPEKTDGSSSTTSPPSYD----SVTKPDKE 1962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	168/292 (58%)
		Na_trans_cytopl	515..648	CDD:288761	33/133 (25%)
		Ion_trans	835..1028	CDD:278921	124/194 (64%)
		Na_trans_assoc	1054..1296	CDD:284034	50/243 (21%)
		Ion_trans	1318..1571	CDD:278921	160/255 (63%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	147/241 (61%)
		GPHH	1880..1930	CDD:293510	25/49 (51%)
Scn3a	XP_008760136.1	Ion_trans	149..434	CDD:278921	166/287 (58%)
		Na_trans_cytopl	510..629	CDD:288761	35/142 (25%)
		Ion_trans	760..955	CDD:278921	124/194 (64%)
		Na_trans_assoc	981..1183	CDD:284034	50/242 (21%)
		Ion_trans	1206..1460	CDD:278921	158/253 (62%)
		Na_channel_gate	1452..1504	CDD:240441	36/52 (69%)
		Ion_trans	1526..1764	CDD:278921	147/240 (61%)
		ChtBD1	1691..>1726	CDD:302575	16/37 (43%)
		GPHH	1776..1831	CDD:293510	27/54 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1036
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1645	1.000	Inparanoid score	I74
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm45846
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880