Protein Alignment para and Scn3a

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: XP_008760137.1
• Gene: Scn3a / 497770
• RGDID: 3635
• Length: 1983
• Species: Rattus norvegicus
• Alignment Length: 2127
• Identity: 966/2127 - (45%)
• Similarity: 1315/2127 - (61%)
• Gaps: 253/2127 - (11%)

  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80
            ||.||||||..||:|.|.|..|                 :.||:::|  |||::   |:|:..||
  Rat    14 FRLFTRESLAAIEKRAAEEKAK-----------------KPKKEQDI--DDENK---PKPNSDLE 56

  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145
            .|..:|. :.|..|||:.|.||||:||||.:..||||::|||.||||||:.|:::|.|.||:|::
  Rat    57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRFSATSALYILTPLNPVRKI 120

  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209
            ||.||||.|||:.|:.|||.||:.|.:...|. .::.|..|||||||||.:|::||||.|..||:
  Rat   121 AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274
            |||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
  Rat   186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250

  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLD------------------GSWGNLTDE--NW 319
            :|||:|.||||||:|||::||.|..||::..|.|                  |::.|:|..  ||
  Rat   251 MILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNW 315

  Fly   320 DYHNRNSSNWYSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383
            ..:..:.|::|..| |...| ||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
  Rat   316 KDYIADDSHFYVLD-GQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 378

  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448
            |||||:||:||||.|||||..:|:||:::||||||||||||||:|||:|:| |.:|..|||.::|
  Rat   379 LMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKE 442

  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAAL---------HPEMAKSPTYSCISY--- 501
            |  |.::.......:.||   |||.|||.||:.:.:.:         ..|.:|..:.|...:
  Rat   443 A--EFQQMLEQLKKQQEE---AQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNR 502

  Fly   502 -------ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSL 559
                   |...|..:.:.|...:..|..||:..|..:|:   ...|.|..:  |:.....:.||:
  Rat   503 RKKRRQREHLEGNHRADGDRFPKSESEDSVKRRSFLLSL---DGNPLTGDK--KLCSPHQSLLSI 562

  Fly   560 PGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE-EN 623
            .||.|:.||.|::|    |.:.|||....||:.               .:|||.::....|| ..
  Rat   563 RGSLFSPRRNSKTS----IFSFRGRAKDVGSEN---------------DFADDEHSTFEDSESRR 608

  Fly   624 GAIIVPVYYGNLGSRHSSYTSHQSRI--SYTSHGDLLGGMAVMGVSTM--TKESKLRNRNTRNQS 684
            .::.||...|...:.:.|..|..||:  ...::|.:...:...||.::  |.|:::|.|...:
  Rat   609 DSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLGTTTETEVRKRRLSS-- 671

  Fly   685 VGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIE 749
                                 |:|.:|                                   ::|
  Rat   672 ---------------------YQISME-----------------------------------MLE 680

  Fly   750 QAAGRHSRASDRGVSVYYFPT---EDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWV 811
            .::||     .|.:|:....|   |:.:|.    :.|......:..:||.:||||..|||.:..|
  Rat   681 DSSGR-----QRAMSIASILTNTMEELEES----RQKCPPCWYRFANVFLIWDCCDAWLKVKHLV 736

  Fly   812 SLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKY 876
            :|||.||||:|.||:|||:||:||||:|:.|.::...||..||..||..|..|..:|::||.|.|
  Rat   737 NLIVMDPFVDLAITICIVLNTLFMAMEHYPMTQQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYY 801

  Fly   877 YFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALG 941
            ||||||||||.|||:|||:||||..|:||||||||||||||||||||||||:||.|:|.::||||
  Rat   802 YFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 866

  Fly   942 NLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESM 1005
            |||.||.||:|||||:|||||||:|.:...:. .|..||||:..||.|||:||||||||||||:|
  Rat   867 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIETM 931

  Fly  1006 WDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGR 1069
            ||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...||:.|.:..|..|:.:
  Rat   932 WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQK 996

  Fly  1070 FKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHD- 1133
            ...:||..|.:||:....:....|..|              ||..:..|:|...|   :|:..:
  Rat   997 GIDFVKNKIRECFRKAFFRKPKVIEIQ--------------EGNKIDSCMSNNTG---IEISKEL 1044

  Fly  1134 EILADGL-IKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKN 1197
            ..|.||. ...|:...:.:|..:.|..::             ..::||.:...|..| :.|....
  Rat  1045 NYLKDGNGTTSGVGTGSSVEKYVIDENDY-------------MSFINNPSLTVTVPI-AVGESDF 1095

  Fly  1198 RPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPAD 1262
            .....|.....:|..|.:||.:|:....|...::....|.|:..::       .:||:   .|..
  Rat  1096 ENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQAEIE-------PEEDL---KPEA 1150

  Fly  1263 CCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQ 1327
            |..:...||||......:....:.|.|||...:.::|:.:|||.::.|||:||.|||.||:::.|
  Rat  1151 CFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ 1215

  Fly  1328 RPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGI 1392
            |..::.:|.|.|::||.||.||||:||:|.||:.|||||||||||:||.|||::.||:.:|...:
  Rat  1216 RKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSEL 1280

  Fly  1393 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF 1457
            .|.|::|||||||||||:||.:||||||||||.|||||.|||||||||||||:||||.|||||::
  Rat  1281 GAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1345

  Fly  1458 KC-EDMNGTKLSHEIIPNRNACES--ENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAI 1519
            .| ....|.....:.:.|.:.|::  :...|.|..:|||:||..||.|.||||||||:.||..|:
  Rat  1346 HCVNTTTGNMFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1410

  Fly  1520 DSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1584
            |||:|..|||.|.|:|||||||.||||||||||||||||||||||:||||.||. ::||||:|||
  Rat  1411 DSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKK 1474

  Fly  1585 YYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNA 1649
            |||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:.|.|||.||.::..|.|.....
  Rat  1475 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSKYMTL 1539

  Fly  1650 VLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLR 1714
            ||..:|.:|:|:|:.|.|||:.:|||:||...||:||.|||||||:|:.|:::||||||||||.|
  Rat  1540 VLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1604

  Fly  1715 VVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGI 1779
            |:|:|::||:|||:|||||||||||||.|||||||||.|||||||||:||||||.|.:||:::||
  Rat  1605 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGI 1669

  Fly  1780 NDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDNDKGYP-----GNCGSATVGI 1837
            :|::||:|||.|||.|||::|||||||:|..|:|...  |||   |..:|     |:||:.:|||
  Rat  1670 DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDP---DAIHPGSSVKGDCGNPSVGI 1731

  Fly  1838 TFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQL 1902
            .|.:||::||||:|:||||||||||:|.|||:..|.|::||::|:||:|::|||:.||:|.:.:|
  Rat  1732 FFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKL 1796

  Fly  1903 SEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEI- 1966
            |:|...|:|||.|.||||.::|:||:|:..||.::|:|||.|.||       ..:.|:||:..:
  Rat  1797 SDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK-------RVLGESGEMDALR 1854

  Fly  1967 --------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKH--KARGEG-GGSFEPDTDHGDG 2020
                    |:.|....|||:::||.|::||..|.:||..:|.:  |.|.:. ...::.:|..|..
  Rat  1855 IQMEERFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISSKYDKETIKGRI 1919

  Fly  2021 GDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGED 2067
            ..|..||...|:......|...|||.:.|:..:.|    :|..|.::
  Rat  1920 DLPIKGDMVIDKLNGNSTPEKTDGSSSTTSPPSYD----SVTKPDKE 1962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	176/305 (58%)
		Na_trans_cytopl	555..740	CDD:463401	37/189 (20%)
		Ion_trans	817..1028	CDD:459842	137/212 (65%)
		Na_trans_assoc	1054..1296	CDD:461936	50/243 (21%)
		Ion_trans	1300..1571	CDD:459842	169/273 (62%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1621..1871	CDD:459842	157/256 (61%)
		GPHH	1882..1929	CDD:465306	24/46 (52%)
Scn3a	XP_008760137.1	Ion_trans	127..434	CDD:459842	177/309 (57%)
		Na_trans_cytopl	558..693	CDD:463401	42/216 (19%)
		Ion_trans	742..955	CDD:459842	137/212 (65%)
		Na_trans_assoc	981..1183	CDD:461936	50/242 (21%)
		Ion_trans	1188..1460	CDD:459842	167/271 (62%)
		Na_channel_gate	1452..1504	CDD:240441	36/52 (69%)
		Ion_trans	1508..1764	CDD:459842	157/258 (61%)