DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and cacna1da

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_021335251.1	Gene:	cacna1da / 403310	ZFINID:	ZDB-GENE-030616-135	Length:	2093	Species:	Danio rerio

Alignment Length:	2069	Identity:	477/2069 - (23%)
Similarity:	835/2069 - (40%)	Gaps:	653/2069 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASK------------AMWML 136
            |.|.....:.|| .|:.|:..:.|..|      :..|.:  .:::.||            |::.|
Zfish     6 PAPPAATPAAPP-AAAVPVPSVVPVGS------LAQKKR--AQYAKSKKQGSSANTRPQRALFCL 61

  Fly   137 DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTF 191
            :..|||||..|.::....|.:||:..|..||:.:.:          .|...:|:.|..|..|:|.
Zfish    62 NLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTI 126

  Fly   192 ESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDL------------GNLA------- 237
            |:.:|::|.|.::....|:|:.||.||||::.:...::.:::            .||:
Zfish   127 ETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGK 191

  Fly   238 -------ALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 295
                   |||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::||::::|
Zfish   192 PGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIG 256

  Fly   296 VLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CD-DDYVCLQ 358
            .:...|.    ..|     ||             ..|||    |....::|.|: |. :..:|.:
Zfish   257 KMHASCY----FQG-----TD-------------ILEDE----PAPCAVNGHGRTCPINGTLCKE 295

  Fly   359 GFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSFYL 420
            |: ..||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||::
Zfish   296 GW-QGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPW--VYFVSLVIFGSFFV 357

  Fly   421 VNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAA 485
            :||:|.:::..:.:.::||:..  .:.:.:||.::        |||...
Zfish   358 LNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------LEEDLK---------------- 396

  Fly   486 LHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVR 550
                          .|..::...:..|..|:|:        |.||                 |..
Zfish   397 --------------GYLDWITQAEDIDPENEEE--------EEES-----------------KRN 422

  Fly   551 KVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNA 615
            :|:..||              ...|   :.|.|.|.                      .:.|::|
Zfish   423 RVTLASL--------------MEKK---KKGFGWFS----------------------QSSDTHA 448

  Fly   616 VTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNT 680
            ..|.||                                                  ...:...|.
Zfish   449 SMPASE--------------------------------------------------TESMNTENE 463

  Fly   681 RNQSVGATNGGTTCLD-TNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744
            :.:...||..|.||.. :..|...|.......|.
Zfish   464 KGEDEKATCCGPTCQKISKSKFSRRWRRWNRLCR------------------------------- 497

  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809
                     |:.|.:.:.|..|                                     ||
Zfish   498 ---------RNCRLAVKSVPFY-------------------------------------WL---- 512

  Fly   810 WVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSP 874
             |.::||             :||:.::.:|::....:.:|....|....|.|..|..:|:.::..
Zfish   513 -VIILVF-------------LNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGL 563

  Fly   875 KYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMG 934
            :.||...:|.||..:|.     ..|:|..:....|:||.|..||||:||:.:.|.:|:.|::.:.
Zfish   564 QAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLL 628

  Fly   935 RTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCG 999
            .:|.::.:|..:|.:.|.||:::|||:||..::     |.:....|..|.:|..:.:.||::|.|
Zfish   629 NSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFN-----FDETQTKRSTFDNFPQALLTVFQILTG 688

  Fly  1000 E-WIESMWDCMYV-------GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSLSAPTADN 1055
            | |...|:|.:..       |.:.|| :|:...:.||.::||:|||:.:.|.. :.||:.    :
Zfish   689 EDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNT----D 748

  Fly  1056 DTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCIS 1120
            ||.|..|.
Zfish   749 DTKKPDEI--------------------------------------------------------- 756

  Fly  1121 AEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDD 1185
                        |||
Zfish   757 ------------DEI-------------------------------------------------- 759

  Fly  1186 TASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD--GDIII 1248
                           :||:..|.      |:::|.::||       :||.:...||..  .:::
Zfish   760 ---------------EDEAKAGE------EDEKDNAEED-------EEEPDVPAGPRPKISELV- 795

  Fly  1249 HAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPF--WQGWGNLRLKTFQLIENKYFETAVITMI 1311
                                 ||..|....:.|.|  :.....:|:...:||.:..|...::..|
Zfish   796 ---------------------KKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFI 839

  Fly  1312 LMSSLALALEDV--HLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC-----W 1369
            ::||.:||.||.  :...|.|   ||.|.|..||.||.:|:::|....|..:: ..|:|     .
Zfish   840 MLSSASLAAEDPIRNFSARNI---ILGYFDYAFTAIFTVEIVLKMTTYGAFLH-KGAFCRNYFNL 900

  Fly  1370 LDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVL 1434
            ||.::|.|||::|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::
Zfish   901 LDLLVVGVSLVSFG---IQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIM 962

  Fly  1435 LVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHE-------IIPNRNACESENYT 1484
            :|..:...:||.:|||||.||:::|        |:..||.:.::       ||..|:
Zfish   963 IVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQPIIQKRH-------- 1019

  Fly  1485 WVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSF 1549
            |.||..|||:|..|.:.||.|:||:||..::..||||...:..||....:.:.::|:.:||..:|
Zfish  1020 WHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAF 1084

  Fly  1550 FTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QA 1610
            |.:|:|:|.:|..|.||.:|...:.|:...:.|...|          .|||.|..|:.|    |.
Zfish  1085 FMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY----------ALKARPLRRYIPKNPYQY 1139

  Fly  1611 IVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR- 1674
            ..:.:|....|:.|:.:.|.||...:.:..|..|:.:|.|:|.||.:|..:|:.|.:||:.|.:
Zfish  1140 KFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKP 1204

  Fly  1675 YHYFIEPWNLFDVVVVILSILGLVLSDI--------------IEKYFVSPTLLRVVRVAKVGRVL 1725
            .|||.:.||.||.::|:.|::.:.::::              .:...:|.|..|:.||.   |::
Zfish  1205 RHYFTDAWNTFDALIVVGSVVDIAITEVNPTEAPQVDESGNTEDSARISITFFRLFRVM---RLV 1266

  Fly  1726 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTF 1788
            :|:...:||||||:....|..||..:.||:.::.||:|:.||..|  :.:.:.:.||...||:||
Zfish  1267 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTF 1331

  Fly  1789 GQSMILLFQMSTSAGWDGVLDAIINEEACDP-PDNDKGYPGNCGSATVGITFLLSYLVISFLIVI 1852
            .|:::|||:.:|...|..::.|.:..:.||| .|.:.|....|||:...|.|:..|::.:||| |
Zfish  1332 PQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLCAFLI-I 1395

  Fly  1853 NMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK 1917
            |:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||...|
Zfish  1396 NLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK 1459

  Fly  1918 --PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEG 1974
              |::.   ::::|::|: ..|.:|:...:. ||.:.....|  || :|:..|  |:.|
Zfish  1460 LCPHRVACKRLVAMNMPLNSDGTVMFNATLF-ALVRTALKIKTEGN-LEQANE--ELRA------ 1514

  Fly  1975 YEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGG 2008
               |...:|::.                    :.|...|||..:||.|.|.|.|
Zfish  1515 ---VIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEEG 1565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	80/311 (26%)
		Na_trans_cytopl	515..648	CDD:288761	18/132 (14%)
		Ion_trans	835..1028	CDD:278921	55/205 (27%)
		Na_trans_assoc	1054..1296	CDD:284034	24/245 (10%)
		Ion_trans	1318..1571	CDD:278921	96/274 (35%)
		Na_channel_gate	1561..1613	CDD:240441	14/55 (25%)
		Ion_trans	1636..1871	CDD:278921	81/252 (32%)
		GPHH	1880..1930	CDD:293510	14/54 (26%)
cacna1da	XP_021335251.1	Ion_trans	77..377	CDD:306908	85/328 (26%)
		Ion_trans	509..744	CDD:306908	71/295 (24%)
		Ion_trans	828..1105	CDD:306908	99/291 (34%)
		Ion_trans	1150..1414	CDD:306908	86/268 (32%)
		GPHH	1415..1485	CDD:318993	17/69 (25%)
		Ca_chan_IQ	1487..1558	CDD:312334	16/83 (19%)
		CAC1F_C	1583..2092	CDD:318975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910