DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and scn1laa

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_956426.2	Gene:	scn1laa / 393101	ZFINID:	ZDB-GENE-040426-751	Length:	1955	Species:	Danio rerio

Alignment Length:	2133	Identity:	930/2133 - (43%)
Similarity:	1263/2133 - (59%)	Gaps:	281/2133 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQ 81
            |.||||||..||.|||.|:.|                  |.|..|.|  ::|.:...:|:..||.
Zfish    14 RKFTRESLKAIESRIAEENAK------------------KSKNTEER--NKDNECSRKPNSGLEA 58

  Fly    82 GVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVA 146
            |..:|. :.|..|..|.||||||:|.:|||..||:||||.|:|:||:|:.|:::...||.:||::
Zfish    59 GKTLPF-IYGEVPKGLVSTPLEDLDQFYSNHTTFIVVSKKKEIYRFNATPALYIFSSFNLLRRIS 122

  Fly   147 IYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTYL 210
            |.||||.||:..||.|||.||..|:...||. .::.|.:||||||.|:.||:.||||.:..||:|
Zfish   123 IQILVHFLFNFIIICTILANCAFMVYTQTPDWAKNVEYVFTGIYTLEALVKITARGFCVGRFTFL 187

  Fly   211 RDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275
            ||.||||||:||.:||||..:|||:::|||.|||||||||:::||||||||||:|:|||.|.||:
Zfish   188 RDPWNWLDFIVIVMAYVTEFVDLGSVSALRAFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVM 252

  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFPL----DGSWGNLTDENWDYHNRNSSNWYSEDEGI 336
            |||:|.||||||:|||::||:|.|||:.....    :..:.|.|..  ||.| |.||.|......
Zfish   253 ILTLFCLSVFALVGLQLFMGILKQKCVYSTSFTENKEACYKNKTCR--DYIN-NPSNQYFLPGKK 314

  Fly   337 SFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAA 401
            ...:|||.|.||||.:.|.||:. |.||:|||||||||||||||.||||||||||:|||..||||
Zfish   315 DALICGNSSDAGQCPEGYTCLKA-GKNPDYGYTSFDSFGWAFLSLFRLMTQDFWENLYQQTLRAA 378

  Fly   402 GPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ--------KKAEEEEAAEEEAIREAEEA-A 457
            |..:|:||:::||||||||||||||:|||:|||..        ||.||..|..|:..|:.:|| |
Zfish   379 GKTYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIDEALKKEEEFNAMLEQITRQEQEAEA 443

  Fly   458 AAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIR 522
            ||:.:|.|..:..:..:::||:.                        :..:...:..|::|....
Zfish   444 AAEQSKCEGLSGEKTDSSSDASK------------------------LSSKSAKERRNRKKKRQH 484

  Fly   523 SVEVESESVSVIQ---RQPAPTTAHQATKVRKV---STTS-----LSLPGSPFNIRRGSRSSHKY 576
            ..|.|.|..|:.:   |:|..|.|... |:|:.   |.||     ||..||....||.|::|
Zfish   485 QGESEKEEDSIKEGNDRKPNFTFAVDG-KIRRSRDRSYTSPRQSPLSFQGSLLTPRRDSKAS--- 545

  Fly   577 TIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENG----AIIVPVYYGNLGS 637
             :.:.|||.   .||..               ||||..:   |.||.|    ::.:|       :
Zfish   546 -VFSFRGRI---HSDNN---------------YADDEQS---MFEETGSRRDSLFLP-------T 581

  Fly   638 RHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLD 702
            |.....|:.|:.|.|.|  ||          :....|.|..:..|..|..|:|.:.   .|..:
Zfish   582 RPERLFSNVSKSSLTPH--LL----------LPSNGKARYVDDSNGMVMVTSGASA---PNSPV- 630

  Fly   703 HRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYY 767
                 |.|...:.:.|....|:         |..|..|            .|.||.:.:..|..|
Zfish   631 -----IALNTPEVSRKRAMFDD---------TCADSDD------------ERRSRCNSQNFSKAY 669

  Fly   768 ------------FPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFV 820
                        ..:.:..|....||.:..|...:..:.:.:|||...||:.:|.|.:||.|||.
Zfish   670 RQSMRERALSVASGSNNPAECSEIFKQRCEEWWFEFAENYLIWDCSPTWLRIKEVVHMIVMDPFA 734

  Fly   821 ELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIF 885
            :||||:|||:||:||||:.:.|:.....:|.:.|..|...|..|...|::|:.|..||.||||||
Zfish   735 DLFITICIVINTVFMAMECYPMDGPYSSMLSTANVVFIGIFTAEMIFKVIALDPYSYFLEGWNIF 799

  Fly   886 DFIIVALSLLELGLEGV-QGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCI 949
            |.|||.|||:||.|..| .|:..||.|||||||||||||||||:||.|:|.::|||.|||.||.|
Zfish   800 DSIIVTLSLMELCLANVLSGIGFLRPFRLLRVFKLAKSWPTLNMLIKIIGNSLGALSNLTLVLAI 864

  Fly   950 IIFIFAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-G 1012
            |:|||||:|||||||:|.:...:. .|..||||:..||.|||:||||||||||||:|||||.| |
Zfish   865 IVFIFAVVGMQLFGKSYGECVCKISSDCMLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 929

  Fly  1013 DVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRN 1077
            ...|:..|:..:|||||||||||||||||:|.:.:| |.:.:.|.|.:..|..||.:..:::|..
Zfish   930 QPLCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNL-AVSGEEDENNLQIAVRRIRKGFTFIKTC 993

  Fly  1078 IADCFK--LIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRC----ISAEH---------GDNE 1127
            :...|:  .:|.|      .|.|           ::|..:..|    .|..|         |..:
Zfish   994 LQSFFRSGCLRKK------KQKS-----------ADGNMIVNCKERKDSTNHTTIELVKSTGGTD 1041

  Fly  1128 LELGHDEILADGLIKKGI---KEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASI 1189
            |:...:..:::..:...:   .|::..|....:... ::..|::.:|.|.|         |.||.
Zfish  1042 LDSDTENFISNPSLTVSVPIAAEESDFECLNTEDFS-SLSSDLEEDKEKLS---------DVASS 1096

  Fly  1190 NSYGSHKN-RPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDE 1253
            .|.||..: ||.             |::..||      |:..|:||.
Zfish  1097 FSEGSTVDLRPL-------------GKDGEDA------LELVLEEEA------------------ 1124

  Fly  1254 DILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLAL 1318
                 ||..|......::|.....|::...|:.|..||...:.::|:.:|||.::.|||:||.||
Zfish  1125 -----YPEPCFTAGCVRRFRCCQVDEEKGIWKKWWLLRQTCYNIVEHSWFETFIVFMILLSSGAL 1184

  Fly  1319 ALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFV 1383
            |.||::|..|..::.||.:.|::||.||.||||:||:|.||..||||.|||||||||.||||:.|
Zfish  1185 AFEDIYLDTRKSVKTILEFADKVFTYIFILEMLLKWVAYGFAKYFTNLWCWLDFVIVDVSLISLV 1249

  Fly  1384 ASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMG 1448
            |:.:....:.|.|::|||||.|||||:||..|||||||||:.|||||.|||||||||||||:|:|
Zfish  1250 ANALNYSELSAIKSLRTLRAFRPLRALSRFDGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIVG 1314

  Fly  1449 VQLFAGKYFKCEDMNGT---KLSHEIIPNRNACE--SENYTWVNSAMNFDHVGNAYLCLFQVATF 1508
            |..||||:.:|  :|.|   :|....:.|:..||  .:...|.|..:|||:|||.||.|.|||||
Zfish  1315 VNFFAGKFSEC--INITTEQRLPVSEVYNKTDCERMGKGVRWRNVIINFDNVGNGYLALLQVATF 1377

  Fly  1509 KGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGS 1573
            |||:.||..|:|||..::||..|.|:|||||||.|||.|:||||||||||||||||:||||.||.
Zfish  1378 KGWMPIMYAAVDSRNPEEQPEYEVNLYMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKKFGGQ 1442

  Fly  1574 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTL 1638
             ::||||:||||||||||:|||||.|.||||:.:.|.::|::||.:.|||.||:.|.|||.||.|
Zfish  1443 -DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPKNKIQGLIFDLVTKQAFDIFIMVLIWLNMVTMML 1506

  Fly  1639 DRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDII 1703
            :..|.|......|.::|.||:|:|::||:||:.|||:::|...||:||.:||||||:|:.|:::|
Zfish  1507 ETEDQSIEMTRALYWINVIFIVLFTTECVLKMIALRHYFFTVGWNVFDFIVVILSIVGMSLTEVI 1571

  Fly  1704 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMS 1768
            :||||||||.||:|:|::||||||::.|||||||||||.|||||||||.|||||||||:||||||
Zfish  1572 KKYFVSPTLFRVIRLARIGRVLRLIRSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1636

  Fly  1769 FFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEA--CDPPDNDKG--YPGN 1829
            .|.:||:.:||:|::||:||..||:.|||::||.||||:|..::|.:.  |||..|..|  ..|:
Zfish  1637 NFAYVKKTAGIDDMFNFETFPNSMLCLFQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGSSVVGD 1701

  Fly  1830 CGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGT 1894
            ||:.::||.|.:||::|.||||:||||||||||:|.|||:..|.|::||:|.:||:|::|||:.|
Zfish  1702 CGNPSIGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFDRFYEVWEKFDPKAT 1766

  Fly  1895 QYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEE 1959
            |::.|.:||:|.|.|:|||:|.|||:::::|||:|:..||.::|:|||.|.||......|.....
Zfish  1767 QFMEYGKLSDFADSLDPPLRIPKPNRFQLMSMDLPMVTGDRIHCLDILFAFTKRVLGEGGEMDML 1831

  Fly  1960 TGEIGE--IAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARG--EGGGSFEPDTDHGDG 2020
            .|::.:  :.:.|....|||:::||.|:.|:..|.:||.|:|||..|.  :...:|:....|.:|
Zfish  1832 HGQMEDRFMQSNPSKSSYEPITTTLRRKHEDMSAAVIQRAFRKHLVRDSMKKVRNFKKKNKHQNG 1896

  Fly  2021 GDPDAGDPAPD---EATDGDAPAGGDGSVNGTAEGA-----ADADESNVNSPG 2065
            ..|.......|   |.:|..|......|.:...|.|     .|..|..|...|
Zfish  1897 KVPSNQSMDKDMCNEDSDATAATSSPPSYSSITENAKNKYEKDKHEKEVGDKG 1949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	166/275 (60%)
		Na_trans_cytopl	515..648	CDD:288761	39/147 (27%)
		Ion_trans	835..1028	CDD:278921	111/195 (57%)
		Na_trans_assoc	1054..1296	CDD:284034	47/260 (18%)
		Ion_trans	1318..1571	CDD:278921	156/257 (61%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1636..1871	CDD:278921	139/238 (58%)
		GPHH	1880..1930	CDD:293510	25/49 (51%)
scn1laa	NP_956426.2	Ion_trans	150..416	CDD:278921	163/269 (61%)
		Na_trans_cytopl	483..594	CDD:288761	38/143 (27%)
		Ion_trans	749..945	CDD:278921	111/195 (57%)
		Na_trans_assoc	972..1161	CDD:284034	47/257 (18%)
		Ion_trans	1184..1438	CDD:278921	154/255 (60%)
		Na_channel_gate	1430..1482	CDD:240441	35/52 (67%)
		Ion_trans	1504..1742	CDD:278921	139/237 (59%)
		GPHH	1752..1801	CDD:293510	25/48 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1619	1.000	Inparanoid score	I77
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24873
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980