DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment para and Catsper2

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_001012220.1	Gene:	Catsper2 / 366174	RGDID:	1307620	Length:	584	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	75/308 - (24%)
Similarity:	145/308 - (47%)	Gaps:	51/308 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1284 WQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALE-----DVHLPQRPILQDILYYMDRIFT 1343
            |.||         ::::..|...:|::|.:::..|.:|     ..:....| |:..|...|....
  Rat    98 WAGW---------VLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWP-LKLALEVTDWFIL 152

  Fly  1344 VIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAF-KTMRTLRALRPL 1407
            :.|.:|:|:.||| .|.:::.|||...|||:.|:||:.....|:|......: :.:|..|.||.|
  Rat   153 LSFIVEILLMWLA-SFFLFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSL 216

  Fly  1408 RAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEII 1472
            :..:|...::|::.|||:|:.|:..:|::.|||:.:||:.||..|. :|
  Rat   217 KLFARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFK-EY---------------- 264

  Fly  1473 PNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMY 1537
             :|:..|:..|.     |.|..:.|:.:.:|.:.|...|..::.|      |.|.| ..:.::..
  Rat   265 -SRSTIENLEYN-----MFFSDLLNSLVTVFILFTLDHWYAVLQD------VWKVP-EASRVFSS 316

  Fly  1538 LYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKY 1585
            :|.:.:::.||....|:.:.:::.||...:.:    |...||..:.:|
  Rat   317 IYVILWLLLGSIIFRNIIVAMMVTNFQNIRNE----LHEEMTHLEVQY 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034	3/11 (27%)
		Ion_trans	1318..1571	CDD:278921	65/258 (25%)
		Na_channel_gate	1561..1613	CDD:240441	6/25 (24%)
		Ion_trans	1636..1871	CDD:278921
		GPHH	1880..1930	CDD:293510
Catsper2	NP_001012220.1	Ion_trans	138..348	CDD:278921	63/241 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..460
		HSP90	419..>463	CDD:278607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810