DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment para and Catsper4

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	XP_342942.5	Gene:	Catsper4 / 362623	RGDID:	1565213	Length:	448	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	86/379 - (22%)
Similarity:	166/379 - (43%)	Gaps:	73/379 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1296 QLIENKYFETAVITMILMSSLALALE-DVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF 1359
            ||:.:..|:..:..:::.:::.:||. :.:|.|:.  .::...:|.|...|...|:|:.||. ||
  Rat    63 QLLRHPAFQLLLAFLLVTNAITIALRTNSYLGQKH--YELFSTIDDIVLTILICEVLLGWLN-GF 124

  Fly  1360 KVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALV 1424
            .:::.:.|..|:|.||.:..:.|....:.    :.|.|. .|||||.:.....::.:..::..::
  Rat   125 WIFWKDGWNILNFAIVFILFMGFFIKQLN----ETFITY-PLRALRLVHVCMAVEPLARIIRVIL 184

  Fly  1425 QAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSA 1489
            |::|.:.||:.:.|.|.|:|::.||.||..                .:|.
  Rat   185 QSMPDLANVMALILFFMLVFSVFGVTLFGA----------------FVPK--------------- 218

  Fly  1490 MNFDHVGNAYLCLFQVATFKGWIQI-MNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLN 1553
             :|.::|.|...||...|..||:.| |:..::.||...:      :...:||..||..|:|..||
  Rat   219 -HFQNMGVALYTLFICITQDGWLDIYMDFQVEEREYAME------VGGAIYFAIFITLGAFIGLN 276

  Fly  1554 LFIGVIIDNFNEQKKKAG---GSLEMFM-------TEDQKKYYNAMKKMGSKKPLKAIPRPRWRP 1608
            ||:.|:..|. ||..|.|   |.|:...       .||.......:....::|...|:|:
  Rat   277 LFVVVVTTNL-EQMMKTGEEEGHLQPITFNEKDAEEEDWTDELPLVHCTEARKETSAVPQ----- 335

  Fly  1609 QAIV---FEIVTDKKFD--IIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAI 1657
            :.:|   ...:::|..|  .:::..|..|:    |:..:..|..|.:::.:.:|
  Rat   336 EPLVGGPLRNLSEKTCDNFCLVLEAIQENL----LEYKEIRDELNTIMEEVRSI 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034	86/379 (23%)
		Ion_trans	1318..1571	CDD:278921	66/254 (26%)
		Na_channel_gate	1561..1613	CDD:240441	13/64 (20%)
		Ion_trans	1636..1871	CDD:278921	4/22 (18%)
		GPHH	1880..1930	CDD:293510
Catsper4	XP_342942.5	Ion_trans	91..289	CDD:278921	62/244 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810