Protein Alignment para and Ca-alpha1D

DIOPT Version :10

• Sequence 1: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Sequence 2: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Alignment Length: 2393
• Identity: 525/2393 - (21%)
• Similarity: 892/2393 - (37%)
• Gaps: 816/2393 - (34%)

  Fly     1 MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQ------ 59
            :||:.|  .|:|.:.:..|.||               .:||:.:..||.......:::|
  Fly   551 ITEEDD--DEDENADYGDFDRE---------------DQELDDEEPEGTTIDIDEQEQQHDQGDS 598

  Fly    60 KEIRYDDEDEDE--GPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPY------YSNVLTFV 116
            .|...||||.||  ..:.|.|            .:|.| ..|:..|.||.:      :.|::.|.
  Fly   599 AEEEDDDEDVDEYFEEEEDDT------------QAFSP-FYSSSAELIDNFGGGAGKFFNIMDFE 650

  Fly   117 VVSKGK--------------DIFRFS--------------------------------------- 128
            ..:.|:              |:.|.:
  Fly   651 RGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSG 715

  Fly   129 ----------------------------ASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILV 165
                                        ..:|::.|...||:|.:.|.|:....|...|:.||..
  Fly   716 AGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFA 780

  Fly   166 NCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFV 220
            |||.:.:          .|..|:|..|.:|..|:|.|..:|::|.||:|....|||:.||.|||.
  Fly   781 NCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFT 845

  Fly   221 VIALAYVTMGI-----DLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMF 280
            ::.:..::..:     |..::.|||.|||||.|:.|:.||.|:.::.::::::..|..:.:|.:|
  Fly   846 IVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLF 910

  Fly   281 SLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNIS 345
            .:.::|::||:::.|.|.:.|..:         :|.|            |.|          ||.
  Fly   911 VIIIYAIIGLELFSGKLHKACRDE---------ITGE------------YEE----------NIR 944

  Fly   346 GAG---QCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWED-LYQLVLRAAGPWHM 406
            ..|   ||...|.|..|: ..||.|.|:||:||.|.|:.|:.:|.:.|.| ||.:.......|..
  Fly   945 PCGVGYQCPPGYKCYGGW-DGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQW 1008

  Fly   407 LFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ 471
            ::||.::.||:|:::||||.:::..:.:.:.||:
  Fly  1009 MYFISMVILGAFFVMNLILGVLSGEFSKERNKAK------------------------------- 1042

  Fly   472 AQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQR 536
                                                .:|:....:||..|.
  Fly  1043 ------------------------------------NRGDFQKLREKQQIE-------------- 1057

  Fly   537 QPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQ 601
                                                                            :
  Fly  1058 ----------------------------------------------------------------E 1058

  Fly   602 DAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGV 666
            |.:.:|.:...:..:.|                                     |.:||:...|.
  Fly  1059 DLRGYLDWITQAEDIEP-------------------------------------DAVGGLISDGK 1086

  Fly   667 STMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQ 731
            .....|                                     ::.|:..|:    :.|.::..:
  Fly  1087 GKQPNE-------------------------------------MDSTENLGE----EMPEVQMTE 1110

  Fly   732 TQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFC 796
            ::.....||       .::...|..||..:.|                 |.:|
  Fly  1111 SRWRKMKKD-------FDRVNRRMRRACRKAV-----------------KSQA------------ 1139

  Fly   797 VWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATF 861
                 :.||                  |.:.:.:||..:|.:|:.....::...:..|.||...|
  Fly  1140 -----FYWL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLF 1181

  Fly   862 AIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLE-----LGLEGVQGLSVLRSFRLLRVFKLAK 921
            ..|..:|:.::..:.||...:|.||..:|..|:.|     .|:....|:||||..|||||||:.|
  Fly  1182 TCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTK 1246

  Fly   922 SWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK--NYHDHKDRFPDGDLPRWNFT 984
            .|.:|:.|::.:..::.::.:|..:|.:.|.|||::|||:||.  |:...::::      |.||.
  Fly  1247 YWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY------RMNFD 1305

  Fly   985 DFMHSFMIVFRVLCGEWIESMWDC-MYV-----------GDVSCIPFFLATVVIGNLVVLNLFLA 1037
            .|..:.:.||:::.||    .|:. |||           |.::|| :|:...:.||.::||:|||
  Fly  1306 CFWQALLTVFQIMTGE----DWNAVMYVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLA 1365

  Fly  1038 LLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERT 1102
            :.:.|..           |.:.::|.                            :..::|
  Fly  1366 IAVDNLA-----------DADSLSEV----------------------------EKEEEP----- 1386

  Fly  1103 NQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGME--FTIHG 1165
                                         |||         ..::::.......|||:  .:|..
  Fly  1387 -----------------------------HDE---------SAQKKSHSPTPTIDGMDDHLSIDI 1413

  Fly  1166 DMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEE 1230
            ||:..:                             .|:..|...||:..||.|:..:|    :||
  Fly  1414 DMEQQE-----------------------------LDDEDKMDHETLSDEEVREMCEE----EEE 1445

  Fly  1231 LDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTF 1295
            :||||           :|.|....:.:...|.       |..||..|.....|.| ....|:...
  Fly  1446 VDEEG-----------MITARPRRMSEVNTAT-------KILPIPPGTSFFLFSQ-TNRFRVFCH 1491

  Fly  1296 QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFK 1360
            .|..:..|...::..|:.||..||.|: .|.....|..:|...|..||.:|.:|:::|.::.||
  Fly  1492 WLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGF- 1554

  Fly  1361 VYFTNAWC-----WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVV 1420
            |....|:|     .||.::|.||||:.|:|   :..|...|.:|.||.||||||::|.:|::.||
  Fly  1555 VLHDGAFCRSAFNLLDLLVVCVSLISLVSS---SNAISVVKILRVLRVLRPLRAINRAKGLKHVV 1616

  Fly  1421 NALVQAIPSIFNVLLV-CLIFWL-----------------------------------IFAIMGV 1449
            ..::.|:.:|.|::|| ||:.::                                   :||::||
  Fly  1617 QCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGV 1681

  Fly  1450 QLFAGKYFKCEDMNGTKLSHEIIPNRNAC------------------ESENYTWVNSAMNFDHVG 1496
            |||.||:|||.|  |:|::      ::.|                  |.|   |.|:..:||.|.
  Fly  1682 QLFKGKFFKCTD--GSKMT------QDECYGTYLVYDDGDVHKPRLRERE---WSNNRFHFDDVA 1735

  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561
            ...|.||.|:||:||..::..:|||.:.:..||......:..|::.:||..:||.:|:|:|.:|
  Fly  1736 KGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI- 1799

  Fly  1562 NFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKK----PLKAIPRPRWRP----QAIVFEIVTD 1618
                         ..|..|.:::|.|.......:.    .|||.|..|:.|    |..|:..||.
  Fly  1800 -------------VTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTS 1851

  Fly  1619 KKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPW 1682
            ..|:..|.:.|.:|..|:.:..|:....|..:||.||.||..:|:.|.:.|:.|.|: :||.:.|
  Fly  1852 SSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAW 1916

  Fly  1683 NLFDVVVVILSILGLVLS-------------DIIE-----KYFVSPTLLRV--VRVAKVGRVLRL 1727
            |:||.::|:.|.:.:|.|             ||:|     |......|:.:  .|:.:|.|:::|
  Fly  1917 NVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKL 1981

  Fly  1728 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQ 1790
            :...:||||||:....|..||..:.||:.|:.||:|:.||..|..:....|  |....||:||.|
  Fly  1982 LSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQ 2046

  Fly  1791 SMILLFQMSTSAGWDGVLDAIINEE--ACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVIN 1853
            ::::||:.:|...|..::.:...:.  .||...:..|.|  |||:.....|:..|::.|||| ||
  Fly  2047 AVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP--CGSSIAYPYFISFYVLCSFLI-IN 2108

  Fly  1854 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK- 1917
            :::|||::|:...|.| ...|.....|.:..:|.::||:....|::..:...|..:.|||...|
  Fly  2109 LFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKL 2172

  Fly  1918 -PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARKGNPIEETGE-----IGEIAARPDT 1972
             |::.   :::||::|: ..|.:::...:...:......:....|::...     |.:|..|.:.
  Fly  2173 CPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNP 2237

  Fly  1973 EGYEPVSSTLWRQREE-----YCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAG------ 2026
            :..:.|........|.     |...|||..:|:.|.|.|         ..|..|.||:.
  Fly  2238 KLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKE---------QEGKEGHPDSNTVTLQA 2293

  Fly  2027 --------DPAPDEATDGDAPAGGD-------------GSV--------NGTAEGAADADESNVN 2062
                    .||...|..|:......             |||        |||...:|.|..|..|
  Fly  2294 GLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSN 2358

  Fly  2063 SPGEDAAAAAAAAAAAAAAGTTTAGS--PGAGSAGRQTAVLVESDGF--VTKN 2111
              |..|...:|:||......:...||  |..|.....|.....:||.  :|:|
  Fly  2359 --GALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRN 2409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	89/302 (29%)
		Na_trans_cytopl	555..740	CDD:463401	11/184 (6%)
		Ion_trans	817..1028	CDD:459842	64/229 (28%)
		Na_trans_assoc	1054..1296	CDD:461936	36/243 (15%)
		Ion_trans	1300..1571	CDD:459842	97/329 (29%)
		Na_channel_gate	1561..1613	CDD:240441	11/59 (19%)
		Ion_trans	1621..1871	CDD:459842	87/274 (32%)
		GPHH	1882..1929	CDD:465306	12/51 (24%)
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	90/306 (29%)
		Ion_trans	1137..1379	CDD:459842	76/298 (26%)
		Ion_trans	1496..1809	CDD:459842	99/342 (29%)
		Ion_trans	1851..2126	CDD:459842	87/278 (31%)
		GPHH	2135..2188	CDD:465306	12/52 (23%)
		Ca_chan_IQ	2198..2273	CDD:462591	11/74 (15%)