DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Ca-alpha1D

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster


Alignment Length:2393 Identity:525/2393 - (21%)
Similarity:892/2393 - (37%) Gaps:816/2393 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQ------ 59
            :||:.|  .|:|.:.:..|.||               .:||:.:..||.......:::|      
  Fly   551 ITEEDD--DEDENADYGDFDRE---------------DQELDDEEPEGTTIDIDEQEQQHDQGDS 598

  Fly    60 KEIRYDDEDEDE--GPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPY------YSNVLTFV 116
            .|...||||.||  ..:.|.|            .:|.| ..|:..|.||.:      :.|::.|.
  Fly   599 AEEEDDDEDVDEYFEEEEDDT------------QAFSP-FYSSSAELIDNFGGGAGKFFNIMDFE 650

  Fly   117 VVSKGK--------------DIFRFS--------------------------------------- 128
            ..:.|:              |:.|.:                                       
  Fly   651 RGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSG 715

  Fly   129 ----------------------------ASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILV 165
                                        ..:|::.|...||:|.:.|.|:....|...|:.||..
  Fly   716 AGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFA 780

  Fly   166 NCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFV 220
            |||.:.:          .|..|:|..|.:|..|:|.|..:|::|.||:|....|||:.||.|||.
  Fly   781 NCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFT 845

  Fly   221 VIALAYVTMGI-----DLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMF 280
            ::.:..::..:     |..::.|||.|||||.|:.|:.||.|:.::.::::::..|..:.:|.:|
  Fly   846 IVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLF 910

  Fly   281 SLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNIS 345
            .:.::|::||:::.|.|.:.|..:         :|.|            |.|          ||.
  Fly   911 VIIIYAIIGLELFSGKLHKACRDE---------ITGE------------YEE----------NIR 944

  Fly   346 GAG---QCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWED-LYQLVLRAAGPWHM 406
            ..|   ||...|.|..|: ..||.|.|:||:||.|.|:.|:.:|.:.|.| ||.:.......|..
  Fly   945 PCGVGYQCPPGYKCYGGW-DGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQW 1008

  Fly   407 LFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ 471
            ::||.::.||:|:::||||.:::..:.:.:.||:                               
  Fly  1009 MYFISMVILGAFFVMNLILGVLSGEFSKERNKAK------------------------------- 1042

  Fly   472 AQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQR 536
                                                .:|:....:||..|.              
  Fly  1043 ------------------------------------NRGDFQKLREKQQIE-------------- 1057

  Fly   537 QPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQ 601
                                                                            :
  Fly  1058 ----------------------------------------------------------------E 1058

  Fly   602 DAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGV 666
            |.:.:|.:...:..:.|                                     |.:||:...|.
  Fly  1059 DLRGYLDWITQAEDIEP-------------------------------------DAVGGLISDGK 1086

  Fly   667 STMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQ 731
            .....|                                     ::.|:..|:    :.|.::..:
  Fly  1087 GKQPNE-------------------------------------MDSTENLGE----EMPEVQMTE 1110

  Fly   732 TQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFC 796
            ::.....||       .::...|..||..:.|                 |.:|            
  Fly  1111 SRWRKMKKD-------FDRVNRRMRRACRKAV-----------------KSQA------------ 1139

  Fly   797 VWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATF 861
                 :.||                  |.:.:.:||..:|.:|:.....::...:..|.||...|
  Fly  1140 -----FYWL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLF 1181

  Fly   862 AIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLE-----LGLEGVQGLSVLRSFRLLRVFKLAK 921
            ..|..:|:.::..:.||...:|.||..:|..|:.|     .|:....|:||||..|||||||:.|
  Fly  1182 TCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTK 1246

  Fly   922 SWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK--NYHDHKDRFPDGDLPRWNFT 984
            .|.:|:.|::.:..::.::.:|..:|.:.|.|||::|||:||.  |:...::::      |.||.
  Fly  1247 YWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY------RMNFD 1305

  Fly   985 DFMHSFMIVFRVLCGEWIESMWDC-MYV-----------GDVSCIPFFLATVVIGNLVVLNLFLA 1037
            .|..:.:.||:::.||    .|:. |||           |.::|| :|:...:.||.::||:|||
  Fly  1306 CFWQALLTVFQIMTGE----DWNAVMYVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLA 1365

  Fly  1038 LLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERT 1102
            :.:.|..           |.:.::|.                            :..::|     
  Fly  1366 IAVDNLA-----------DADSLSEV----------------------------EKEEEP----- 1386

  Fly  1103 NQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGME--FTIHG 1165
                                         |||         ..::::.......|||:  .:|..
  Fly  1387 -----------------------------HDE---------SAQKKSHSPTPTIDGMDDHLSIDI 1413

  Fly  1166 DMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEE 1230
            ||:..:                             .|:..|...||:..||.|:..:|    :||
  Fly  1414 DMEQQE-----------------------------LDDEDKMDHETLSDEEVREMCEE----EEE 1445

  Fly  1231 LDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTF 1295
            :||||           :|.|....:.:...|.       |..||..|.....|.| ....|:...
  Fly  1446 VDEEG-----------MITARPRRMSEVNTAT-------KILPIPPGTSFFLFSQ-TNRFRVFCH 1491

  Fly  1296 QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFK 1360
            .|..:..|...::..|:.||..||.|: .|.....|..:|...|..||.:|.:|:::|.::.|| 
  Fly  1492 WLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGF- 1554

  Fly  1361 VYFTNAWC-----WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVV 1420
            |....|:|     .||.::|.||||:.|:|   :..|...|.:|.||.||||||::|.:|::.||
  Fly  1555 VLHDGAFCRSAFNLLDLLVVCVSLISLVSS---SNAISVVKILRVLRVLRPLRAINRAKGLKHVV 1616

  Fly  1421 NALVQAIPSIFNVLLV-CLIFWL-----------------------------------IFAIMGV 1449
            ..::.|:.:|.|::|| ||:.::                                   :||::||
  Fly  1617 QCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGV 1681

  Fly  1450 QLFAGKYFKCEDMNGTKLSHEIIPNRNAC------------------ESENYTWVNSAMNFDHVG 1496
            |||.||:|||.|  |:|::      ::.|                  |.|   |.|:..:||.|.
  Fly  1682 QLFKGKFFKCTD--GSKMT------QDECYGTYLVYDDGDVHKPRLRERE---WSNNRFHFDDVA 1735

  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561
            ...|.||.|:||:||..::..:|||.:.:..||......:..|::.:||..:||.:|:|:|.:| 
  Fly  1736 KGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI- 1799

  Fly  1562 NFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKK----PLKAIPRPRWRP----QAIVFEIVTD 1618
                         ..|..|.:::|.|.......:.    .|||.|..|:.|    |..|:..||.
  Fly  1800 -------------VTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTS 1851

  Fly  1619 KKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPW 1682
            ..|:..|.:.|.:|..|:.:..|:....|..:||.||.||..:|:.|.:.|:.|.|: :||.:.|
  Fly  1852 SSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAW 1916

  Fly  1683 NLFDVVVVILSILGLVLS-------------DIIE-----KYFVSPTLLRV--VRVAKVGRVLRL 1727
            |:||.::|:.|.:.:|.|             ||:|     |......|:.:  .|:.:|.|:::|
  Fly  1917 NVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKL 1981

  Fly  1728 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQ 1790
            :...:||||||:....|..||..:.||:.|:.||:|:.||..|..:....|  |....||:||.|
  Fly  1982 LSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQ 2046

  Fly  1791 SMILLFQMSTSAGWDGVLDAIINEE--ACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVIN 1853
            ::::||:.:|...|..::.:...:.  .||...:..|.|  |||:.....|:..|::.|||| ||
  Fly  2047 AVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP--CGSSIAYPYFISFYVLCSFLI-IN 2108

  Fly  1854 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK- 1917
            :::|||::|:...|.| ...|.....|.:..:|.::||:....|::..:...|..:.|||...| 
  Fly  2109 LFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKL 2172

  Fly  1918 -PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARKGNPIEETGE-----IGEIAARPDT 1972
             |::.   :::||::|: ..|.:::...:...:......:....|::...     |.:|..|.:.
  Fly  2173 CPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNP 2237

  Fly  1973 EGYEPVSSTLWRQREE-----YCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAG------ 2026
            :..:.|........|.     |...|||..:|:.|.|.|         ..|..|.||:.      
  Fly  2238 KLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKE---------QEGKEGHPDSNTVTLQA 2293

  Fly  2027 --------DPAPDEATDGDAPAGGD-------------GSV--------NGTAEGAADADESNVN 2062
                    .||...|..|:......             |||        |||...:|.|..|..|
  Fly  2294 GLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSN 2358

  Fly  2063 SPGEDAAAAAAAAAAAAAAGTTTAGS--PGAGSAGRQTAVLVESDGF--VTKN 2111
              |..|...:|:||......:...||  |..|.....|.....:||.  :|:|
  Fly  2359 --GALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRN 2409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 85/289 (29%)
Na_trans_cytopl 515..648 CDD:288761 6/132 (5%)
Ion_trans 835..1028 CDD:278921 61/211 (29%)
Na_trans_assoc 1054..1296 CDD:284034 36/243 (15%)
Ion_trans 1318..1571 CDD:278921 93/311 (30%)
Na_channel_gate 1561..1613 CDD:240441 11/59 (19%)
Ion_trans 1636..1871 CDD:278921 82/259 (32%)
GPHH 1880..1930 CDD:293510 13/54 (24%)
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 90/306 (29%)
Ion_trans 1137..1379 CDD:395416 76/298 (26%)
Ion_trans 1496..1809 CDD:395416 99/342 (29%)
Ion_trans 1851..2126 CDD:395416 87/278 (31%)
GPHH 2135..2188 CDD:407139 12/52 (23%)
Ca_chan_IQ 2199..2271 CDD:400901 11/71 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439101
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
54.920

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