DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment para and CATSPER3

DIOPT Version :9

Sequence 1:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster
Sequence 2:	NP_821138.1	Gene:	CATSPER3 / 347732	HGNCID:	20819	Length:	398	Species:	Homo sapiens

Alignment Length:	402	Identity:	90/402 - (22%)
Similarity:	165/402 - (41%)	Gaps:	92/402 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1609 QAIVFEIVTDKKFDIIIMLFIGLNMFTMTL-DRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFA 1672
            :|.|..::..:.|.||::..:..|.|.|.| ..||.......:|::....||.|.:||..:|::.
Human    40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV 104

  Fly  1673 LRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTL 1737
            ...:|:...:||.||:::|:..|...|..::.|.|   |.|.:....:..|:|:|:..::|||||
Human   105 DPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIADGMQSLRILKLIGYSQGIRTL 166

  Fly  1738 LFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSA 1802
            :.|:..::..:.::.|||||:|:||||.|  |.:.....:|.:|  |:.....:...||.::|..
Human   167 ITAVGQTVYTVASVLLLLFLLMYIFAILG--FCLFGSPDNGDHD--NWGNLAAAFFTLFSLATVD 227

  Fly  1803 GWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQAT 1867
            ||..:...:.|.|                 ..:...|.:.:::::..|.:||::.|::.:    |
Human   228 GWTDLQKQLDNRE-----------------FALSRAFTIIFILLASFIFLNMFVGVMIMH----T 271

  Fly  1868 ED------------VQEGLTDD----------------------DYDMYYEIWQQF--------- 1889
            ||            .||.|..:                      |...:.|:.:.|
Human   272 EDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDP 336

  Fly  1890 ---DPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMY-CVDILDALTKDFF 1950
               |..||..       .|:|:....|.......:|:         .:|.| .|.:|..:.:|..
Human   337 MVLDDFGTSL-------PFIDIYFSTLDYQDTTVHKL---------QELYYEIVHVLSLMLEDLP 385

  Fly  1951 ARKGNPIEETGE 1962
            ..|...:|:..|
Human   386 QEKPQSLEKVDE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034
		Ion_trans	1318..1571	CDD:278921
		Na_channel_gate	1561..1613	CDD:240441	1/3 (33%)
		Ion_trans	1636..1871	CDD:278921	62/247 (25%)
		GPHH	1880..1930	CDD:293510	9/61 (15%)
CATSPER3	NP_821138.1	Ion_trans	72..269	CDD:278921	57/220 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810