DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment para and Nalcn

DIOPT Version :9

Sequence 1:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster
Sequence 2:XP_036014574.1 Gene:Nalcn / 338370 MGIID:2444306 Length:1787 Species:Mus musculus


Alignment Length:2248 Identity:439/2248 - (19%)
Similarity:768/2248 - (34%) Gaps:709/2248 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 RLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVH 152
            |.|.|   .:.:.|:.|..|..|       :|...||        :|:..|:           ||
Mouse    20 RKQSS---RVEAQPVTDFGPDES-------LSDNADI--------LWINKPW-----------VH 55

  Fly   153 PLFSLFIITTILVNCILMIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFILCPF 207
            .|..:..|.:::..|    |.|..|.|          :.:.:...:||.|...|:..||.:....
Mouse    56 SLLRICAIISVISVC----MNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDS 116

  Fly   208 TYLRDAWNWLDFVVIALAYVTMGIDLGNLA-------------------ALRTFRVLRALKTVAI 253
            :|::|.|...|..::...:|::.:.:..:|                   .:|.||:....:    
Mouse   117 SYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFE---- 177

  Fly   254 VPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDEN 318
            :|..: |...:..|.:.:..|.|..:|.|.::.::|:|:: |..|..|:..   |...||:|   
Mouse   178 LPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVN---DTKPGNVT--- 234

  Fly   319 WDYHNRNSSNWYSEDEGISFP--LCG-NISGAGQCDDDYVC--LQGFG-PNPNYGYTSFDSFGWA 377
                      |.|    ::.|  .|. .:....||...:.|  |:..| .....||:.|:..|.:
Mouse   235 ----------WNS----LAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTS 285

  Fly   378 FLSAFRLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEE 441
            ..:.:...:|:.|..|....:.:...|...| ||.:||..::.:.|:.:|::..::.|::.:   
Mouse   286 IFTVYEASSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ--- 347

  Fly   442 EEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVG 506
                                                                             
Mouse   348 ----------------------------------------------------------------- 347

  Fly   507 GEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSR 571
                                                                     |....|:|
Mouse   348 ---------------------------------------------------------FQQMWGTR 355

  Fly   572 SSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636
            ||                                     ..|.|.|.|                 
Mouse   356 SS-------------------------------------TTSTATTQM----------------- 366

  Fly   637 SRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701
                            .|.|..||..::.|.....:.:                ...||      
Mouse   367 ----------------FHEDAAGGWQLVAVDVNKPQGR----------------APACL------ 393

  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV-MVLNDIIEQAAGRHSRASDRGVSV 765
                                      :.:...:|..|..: ||..|:|..|            |.
Mouse   394 --------------------------QKMMRSSVFHMFILSMVTVDVIVAA------------SN 420

  Fly   766 YYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVV 830
            ||        .|..|:.:                                :|.|           
Mouse   421 YY--------KGENFRRQ--------------------------------YDEF----------- 434

  Fly   831 NTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLL 895
               ::|                 ...||..|.:||.:|:..:....|.....:.|:.::|..:.|
Mouse   435 ---YLA-----------------EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTL 479

  Fly   896 ELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGM 959
            .:..:...  |....|::|||.:|.|..|.| :.:..|.|... .||:|......::.:.:.:.:
Mouse   480 HVYPDLYH--SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGK-KLGSLVVFTASLLIVMSAISL 541

  Fly   960 QLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIP----F 1019
            |:|  .:.:..||          ||.|..:||.:|::|..| |::.|...:........|    :
Mouse   542 QMF--CFVEELDR----------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIY 594

  Fly  1020 FLATVVIGNLVVLNLFLALLLSN------------FGSSSLSAPT-------------------- 1052
            |:...:...|::|:||:|::|.|            ...|..:|.|                    
Mouse   595 FILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQM 659

  Fly  1053 -------ADNDTNKIAEAFNRIGRFKSWVKRNIAD--CFKLIRNKLTNQISDQPSGERTNQISWI 1108
                   :|....||.|:|     .|.::.|...|  |...|....::...|.|.........:|
Mouse   660 VKISKLPSDFTVPKIRESF-----MKQFIDRQQQDTCCLFRILPSTSSSSCDNPKKPTAEDNKYI 719

  Fly  1109 WSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPK 1173
                            |.:|......|.|..|::   ||....::......:..:.|..:....|
Mouse   720 ----------------DQKLRKSVFSIRARNLLE---KETAVTKILRACTRQRMLSGSFEGQPAK 765

  Fly  1174 KSKYLN--NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEK-----RDASKED--LGLDE 1229
            :...|:  :....:..|:. :||:..|    .|...|.||:..:..     |:|.:||  :.:.:
Mouse   766 ERSILSVQHHIRQERRSLR-HGSNSQR----ISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQ 825

  Fly  1230 ELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCP------DSYYKKF---------------P 1273
            |..|:.|.:.         ...:|::.:.:|....|      :..::.|               |
Mouse   826 EKKEQAEMKR---------KVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDP 881

  Fly  1274 ILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQ-DILYY 1337
            :.....::.:.|.:..|.|.|       |.:..:||:.:.|.:::..|.   |.|.::. ..|..
Mouse   882 VTGAVKNTKYHQLYDLLGLVT-------YLDWVMITVTICSCISMMFES---PFRRVMHAPTLQI 936

  Fly  1338 MDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDF------VIVMVSLINFVA----SLVGAGGI 1392
            .:.:|.:...:|:.:|.:|.|  ::||......||      .|.:|||| |:.    ::....|.
Mouse   937 AEYVFVIFMSIELNLKIMADG--LFFTPTAVIRDFGGVMDIFIYLVSLI-FLCWMPQNVPAESGA 998

  Fly  1393 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF 1457
            |   .:..||.|||||....:..||.||..|......||.|.::.|...|:||..||||||||..
Mouse   999 Q---LLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLA 1060

  Fly  1458 KC--------EDMNGTKLSHEIIPNRNACESENY-----------------TWVNSA-MNFDHVG 1496
            ||        ||.||       |...|...|:|.                 .|.|.. .|||:||
Mouse  1061 KCNDPNIIRREDCNG-------IFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVG 1118

  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561
            ||.|.||:|.:.|||::: .|.|..|   ..||.  .||:::    |:..|....|.||:||:|.
Mouse  1119 NAMLALFEVLSLKGWVEV-RDVIIHR---VGPIH--GIYIHV----FVFLGCMIGLTLFVGVVIA 1173

  Fly  1562 NFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP---RWRPQAIVFEIVTDKKFDI 1623
            ||||.|..|      .:|.||:::.:...::...:||...|||   .:|  |.:::|.....|..
Mouse  1174 NFNENKGTA------LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR--AKMYDITQHPFFKR 1230

  Fly  1624 IIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPW----NL 1684
            .|.|.: |....:...::|..|.....|..::.:|..||..|..:||.|:....|   |    |.
Mouse  1231 TIALLV-LAQSVLLSVKWDVDDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGF---WQSRRNR 1291

  Fly  1685 FDVVVVILSILGLVLS-DIIEKY-FVSPTLLRVVRVAKV-GRVLRLVKGAKGIRTLLFALAMSLP 1746
            :|::|..|.::.:||. .::..| ::....:.|.|...: |:.:.|       :.||..:.:|:.
Mouse  1292 YDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTL-------KMLLLTVVVSMY 1349

  Fly  1747 ALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVL-DA 1810
            ..|.|.:.:||::..:|..|:..|..||....||...||.:.|:::.:||::.|...|:.:: |.
Mouse  1350 KSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDC 1414

  Fly  1811 IINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYS--QATEDVQEG 1873
            ::....| .||....:..:||:....:.:..|:.||...|::|:.:|:|:||:|  .:||:.|. 
Mouse  1415 MVQPPFC-TPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQL- 1477

  Fly  1874 LTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPN-----KYKIISMDIPICRG 1933
            |:.:|...:..||...|.:....|...::...|.:|...|::....     |:....|:.....|
Mouse  1478 LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGG 1542

  Fly  1934 DLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGY---EPVSSTLWRQREEYCARLIQ 1995
            |:.: .|:|..|     :.:...|.::.::.|:.||...| |   |.|:....|...:.|.:.|:
Mouse  1543 DVTF-HDVLSML-----SYRSVDIRKSLQLEELLAREQLE-YTIEEEVAKQTIRMWLKKCLKRIR 1600

  Fly  1996 ----------HAWRKHKARGEGGGSF---------EPDTDHGDGGDPDAGDPAPDEATDGDAPAG 2041
                      |:.|:.:.: |....|         :|..|........:..|.........:|..
Mouse  1601 AKQQQSCSIIHSLRESQEQ-ERSRLFLNPPSIETTQPSEDSNANSQDHSMQPETSSQQQLLSPTL 1664

  Fly  2042 GDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDG 2106
            .|.  .|:.:.|||..:.. ...|:....:||.|...|.....:..|........:.     |.|
Mouse  1665 SDR--GGSRQDAADTGKPQ-RKIGQWRLPSAAIAEKTAPVNKMSGYSQDPEREEEEV-----SKG 1721

  Fly  2107 FVTKNGHKVVIHSRSP-------SITSRTADVXARPRP 2137
            |:..   |.:.||.|.       ..|.:|......|.|
Mouse  1722 FLAP---KPISHSVSSVNLRFGGRTTMKTVVCKMNPMP 1756

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 61/306 (20%)
Na_trans_cytopl 515..648 CDD:288761 9/132 (7%)
Ion_trans 835..1028 CDD:278921 41/198 (21%)
Na_trans_assoc 1054..1296 CDD:284034 47/273 (17%)
Ion_trans 1318..1571 CDD:278921 94/289 (33%)
Na_channel_gate 1561..1613 CDD:240441 16/54 (30%)
Ion_trans 1636..1871 CDD:278921 62/244 (25%)
GPHH 1880..1930 CDD:293510 9/54 (17%)
NalcnXP_036014574.1 Ion_trans 52..347 CDD:395416 66/335 (20%)
Ion_trans 399..619 CDD:395416 62/317 (20%)
Ion_trans 903..1177 CDD:395416 95/299 (32%)
Ion_trans 1225..1474 CDD:395416 65/260 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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